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Bnp single ventricle

Anna Balducci, Tammam Hasan, Andrea Donti, Gabriele Egidy Assenza, Luigi Lovato, Marianna Fabi, Valentina Gesuete, Daniela Prandstraller, Roberto Formigari, Luca Ragni, Emanuela Angeli, Gaetano D Gargiulo, Fernando M Picchio, Marco Bonvicini
BACKGROUND: Proper integration of multiple imaging modalities in the routine follow-up of patients with repaired tetralogy of Fallout (TOF) is poorly supported by data. We report our single center comparative study between cardiac magnetic resonance (CMR) and echocardiography to assess equipoise in the clinical utility of these two imaging methods in an unselected consecutive cohort of TOF patients referred to our outpatient clinic. MATERIAL AND METHODS: In this cross-sectional study, repaired TOF patients who underwent CMR and echocardiography within a 4-week period between 2010 and 2011 at our Center were included...
September 17, 2018: Journal of Cardiovascular Medicine
Craig S Broberg, Anne Marie Valente, Jennifer Huang, Luke J Burchill, Jonathan Holt, Ryan Van Woerkom, Andrew J Powell, George A Pantely, Michael Jerosch-Herold
BACKGROUND: Myocardial dysfunction has been implicated in gradual heart failure in transposition of the great arteries (TGA) with a systemic right ventricle (RV). Fibrosis can be assessed using the extracellular volume fraction (ECV). Our aim was to measure ECV and determine its associations with clinical findings and outcomes. METHODS: We prospectively measured ECV in systemic RV subjects (either D-loop after atrial switch or L-loop) and healthy controls. T1 measurements for a single mid-ventricular short-axis plane before and 3, 7, and 15 min after gadolinium contrast were used to quantify systemic ventricular ECV...
November 15, 2018: International Journal of Cardiology
E D'Elia, P Ferrero, C Vittori, A Iacovoni, A Grosu, M Gori, V Duino, S Perlini, Michele Senni
PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA...
June 15, 2018: Sleep & Breathing, Schlaf & Atmung
Jia-Jun Zhu, Qian Zhao, Hui-Juan Qu, Xiao-Mei Li, Qing-Jie Chen, Fen Liu, Bang-Dang Chen, Yi-Ning Yang
The aim of the present study was to investigate the predictive value of the plasma matrix metalloproteinase-9 (MMP-9) level at admission for in-hospital mortality in patients who received emergency percutaneous coronary intervention (PCI) following AMI. A single blood sample was collected at admission from 155 consecutive AMI patients who underwent emergent PCI. The plasma levels of MMP-9 value (528.9±191.6 ng/ml) were significantly higher in the patients who died (n=24) than in the survivors (385.4±236.0 ng/ml) during 14 days of hospitalization ( P =0...
December 1, 2017: Oncotarget
Magalie Ladouceur, Nadjia Kachenoura, Gilles Soulat, Emilie Bollache, Alban Redheuil, Michel Azizi, Christophe Delclaux, Gilles Chatellier, Pierre Boutouyrie, Laurence Iserin, Damien Bonnet, Elie Mousseaux
OBJECTIVES: We aimed (1) determine if systemic right ventricle filling parameters influence systemic right ventricle stroke volume in adult patients with D-transposition of the great arteries (D-TGA) palliated by atrial switch, using cardiac magnetic resonance imaging and echocardiography, and (2) to study relationship of these diastolic parameters with exercise performance and BNP, in patients with preserved systolic systemic right ventricle function. DESIGN: Single-center, cross-sectional, prospective study...
July 2017: Congenital Heart Disease
Pei-Ni Jone, Sonali S Patel, Courtney Cassidy, David Dunbar Ivy
BACKGROUND: Right ventricular function and biomarkers of B-type natriuretic peptide (BNP) and N-Terminal pro-BNP (NT pro-BNP) are used to determine the severity of right ventricular failure and outcomes from pulmonary hypertension. Real-time three-dimensional echocardiography (3DE) is a novel quantitative measure of the right ventricle and decreases the geometric assumptions from conventional two-dimensional echocardiography (2DE). We correlated right ventricular functional measures using 2DE and single-beat 3DE with biomarkers and hemodynamics to determine the severity of pediatric pulmonary hypertension...
December 2016: Congenital Heart Disease
Kenji Miyamoto, Daiji Takeuchi, Kei Inai, Tokuko Shinohara, Toshio Nakanishi
Although there are many biomarkers for heart failure, limited data are available regarding their prognostic value in adult congenital heart disease (ACHD). We investigated the potential of various biomarkers to predict ACHD mortality in a single-center, retrospective cohort study. Blood levels of neurohormones [angiotensin II, endothelin-1 (ET-1), norepinephrine (NE), aldosterone, and plasma renin activity]; inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), high-sensitivity tumor necrosis factor, soluble TNF receptor type I and II (sTNF-RI and sTNF-RII), and interleukin-6 (IL-6)]; and brain natriuretic peptide (BNP) were measured in 103 ACHD patients (median age 28 years)...
November 2016: Heart and Vessels
Seung Mi Lee, Jeong Eun Kwon, Sang Hoon Song, Gi Beom Kim, Jung Yeon Park, Byoung Jae Kim, Joon Ho Lee, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun
OBJECTIVE: The objective of this study was to determine whether prenatal ultrasound findings and cord blood N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and cardiac troponin T (cTnT) can predict neonatal mortality in single ventricle congenital heart disease. METHODS: The association between neonatal mortality and prenatal ultrasound findings/cord blood biomarkers was evaluated in neonates delivered with a diagnosis of single ventricle congenital heart disease...
April 2016: Prenatal Diagnosis
Fredrik Uhlin, Ingegerd Odar-Cederlöf, Elvar Theodorsson, Anders Fernström
BACKGROUND/AIMS: Plasma concentrations of the N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) are increased in end-stage renal disease. Improvement in hemodynamic stability has been reported when switching from hemodialysis (HD) to on-line hemodiafiltration (ol-HDF). The aim of this study was to investigate plasma concentrations of NT-proBNP, BNP and neuropeptide Y (NPY) during a 1-year follow-up, after a change from high-flux HD to postdilution ol-HDF. Additional variables were also studied, e...
September 2015: Nephron Extra
Luke J Burchill, Andrew N Redington, Candice K Silversides, Heather J Ross, Laura Jimenez-Juan, Seema Mital, Erwin N Oechslin, Andreea Dragulescu, Cameron Slorach, Luc Mertens, Rachel M Wald
BACKGROUND: Adults with single ventricle physiology palliated with a Fontan circulation experience high mortality due to circulatory failure. Renin-angiotensin-aldosterone system (RAAS) genotype contributes to adverse cardiovascular outcomes in acquired heart failure. This study evaluated associations between RAAS genotype, ventricular mass and function in a contemporary cohort of adults with a Fontan circulation. METHODS: This single-center prospective study included adults (n=106) seen after the Fontan operation (mean age 27±9years)...
October 15, 2015: International Journal of Cardiology
Xuesi Chen, Xingxing Chen, Junhua Cheng, Jun Hong, Cheng Zheng, Jinglin Zhao, Jin Li, Jiafeng Lin
OBJECTIVE: This project is designed to explore the potential role of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) in cardiac electrical remodeling induced by pacing at different ventricular positions in dogs. METHODS: An animal model by implanting the pacemakers in beagles was established. According to the different pacing positions, the animals were divided into 4 groups:conditional control group (n=6), left ventricle pacing group (n=6), right ventricle pacing group (n=6) and bi-ventricle pacing group (n=6)...
April 2015: Zhonghua Xin Xue Guan Bing za Zhi
Bing Tang, Guang-xian Chen, Meng-ya Liang, Jian-ping Yao, Zhong-kai Wu
BACKGROUND: Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation and pulmonary artery remodeling are important components in PAH. Ellagic acid (EA) is a phenolic compound with anti-oxidative, anti-inflammatory, and anti-proliferative properties. This study aimed to investigate whether EA could prevent the development of monocrotaline (MCT)-induced PAH in rats. METHODS: Male Sprague-Dawley rats received EA (30 and 50mg/kg/day) or vehicle one day after a single-dose of monocrotaline (MCT, 60mg/kg)...
February 1, 2015: International Journal of Cardiology
Ichiro Nakae, Hideki Hayashi, Tetsuya Matsumoto, Kenichi Mitsunami, Minoru Horie
OBJECTIVE: To investigate clinical usefulness of a novel program "Heart Function View (HFV)" for evaluating left ventricular (LV) function from myocardial perfusion SPECT (MPS), we compared LV functional parameters (F(x)) calculated by HFV with those obtained by the other similar programs QGS and cardioGRAF or by ultrasound echocardiography (UCG) and examined their correlations with clinical markers of heart failure: plasma BNP concentrations (BNPs) and exercise capacity. METHODS: Studied patients (n = 60) underwent technetium-99m tetrofosmin quantitative gated MPS including treadmill exercise for examining heart disease...
October 2014: Annals of Nuclear Medicine
Bin Ning, Xiaoyong Qi, Yingxiao Li, Huiliang Liu, Feifei Zhang, Chen Qin
OBJECTIVE: To compare the effects of biventricular electrical pacing and conventional single-ventricular pacing for cardiac contractility modulation (CCM) on cardiac contractile function and to delineate the underlying molecular mechanisms. METHODS: Forty rabbits were divided into four groups before surgery: healthy control, HF sham, HF left ventricular pacing CCM (LVP-CCM), and HF biventricular pacing CCM (BVP-CCM) groups with n=10 for each group. A rabbit model of chronic heart failure was established by ligating ascending aortic root of rabbits...
2014: Cellular Physiology and Biochemistry
Ryan J Butts, Victor Zak, Daphne Hsu, James Cnota, Steven D Colan, David Hehir, Paul Kantor, Jami C Levine, Renee Margossian, Marc Richmond, Anita Szwast, Derek Williams, Richard Williams, Andrew M Atz
Data regarding the value of B-type natriuretic peptide (BNP) measurements in infants with a single-ventricle (SV) physiology are lacking. This analysis aimed to describe the BNP level changes in infants with an SV physiology before and after superior cavopulmonary connection (SCPC) surgery. Levels of BNP were measured by a core laboratory before SCPC (at 5.0 ± 1.6 months) and at the age of 14 months during a multicenter trial of angiotensin-converting enzyme inhibition therapy for infants with SV. Multivariable longitudinal analysis was used to model the associations between BNP levels and three sets of grouped variables (echocardiography, catheterization, growth)...
June 2014: Pediatric Cardiology
Tomasz Chwyczko, Rafał Dąbrowski, Aleksander Maciąg, Maciej Sterliński, Edyta Smolis-Bąk, Anna Borowiec, Ilona Kowalik, Andrada Łabęcka, Agnieszka Jankowska, Marek Kośmicki, Jadwiga Janas, Mariusz Pytkowski, Hanna Szwed
INTRODUCTION: Right ventricular pacing (RVP) causes ventricular desynchronization and may lead to the development of heart failure (HF). Prolongation of atrioventricular delay (AVD) in DDDR pacemakers reduces unnecessary RV stimulation. The aim of the study was to verify the influence of RVP reduction on HF symptoms. METHODS: The study comprised 31 patients (17 men, mean age: 71.6 ± 8 yrs) with DDDR pacemaker implanted due to sinus node dysfunction (SND). At baseline, 28 patients did not present any symptoms of HF...
July 2013: Annals of Noninvasive Electrocardiology
Micha T Maeder, Peter Ammann
Evaluation of: Vrtovec B, Knezevic I, Poglajen G, Sebesjen M, Okrajsek R, Haddad F. Relation of B-type natriuretic peptide level in heart failure to sudden cardiac death in patients with and without QT interval prolongation. Am. J. Cardiol. 111(6), 886-890 (2013). Guidelines recommend an implantable cardioverter defibrillator (ICD) for patients with chronic heart failure (HF) and left ventricular ejection fraction (LVEF) <35%, and New York Heart Association (NYHA) class II/III, despite optimal medical treatment...
May 2013: Future Cardiology
Ronald G Schwartz, Diwakar Jain, Eugene Storozynsky
The field of cardio-oncology is challenged to address an ever greater spectrum of cardiotoxicity associated with combination chemotherapy, greater dose intensity, extremes of age, and enhanced patient survival which exposes more protracted risk of developing congestive heart failure (CHF). Recent reports of chemotherapy-induced hypertension as a common adverse effect of angiogenesis inhibitors and immunosuppressants clarify the need for routine blood pressure (BP) monitoring and guideline-based management of hypertension as an integral strategy to preserve LV function...
June 2013: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Aleksandra Cieplucha, Olga Trojnarska, Agnieszka Bartczak, Lucyna Kramer, Stefan Grajek
BACKGROUND: Among adults with congenital heart diseases (CHD) evaluation of sudden cardiac death (SCD) risk remains a great challenge. Although microvolt T-wave alternans has been incorporated into SCD risk stratification algorithm, its role in adults with CHD still requires investigation. We sought to determine the incidence of MTWA in this specific group and its coincidence with ventricular arrhythmia (VA) and other clinical findings presumably associated with SCD. METHODS: A case-control study was performed in which 102 patients with CHD characterized by right ventricle pathology or single ventricle physiology (TGA, UVH, Ebstein's anomaly, ccTGA, Eisenmenger syndrome, DORV, CAT, unoperated ToF) were compared to 45 age- and sex-matched controls...
2013: BMC Cardiovascular Disorders
Isabelle Ginon, Evelyne Decullier, Gerard Finet, Jean-Francois Cordier, Denis Marion, Jean-Christophe Saurin, Sophie Dupuis-Girod
BACKGROUND: HHT patients with liver vascular malformations (VMs) may develop high-output cardiac failure requiring liver transplant in few cases. OBJECTIVE: Our aim is to show that echocardiography is a good tool to evaluate the severity of hepatic vascular malformations in HHT and can improve medical management in HHT patients. METHODS: The study is a cross-sectional study of cardiac parameters in HHT patients with dyspnea in a single referral center...
April 2013: European Journal of Internal Medicine
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