Shiying Dong, Hongwei Zhao, Meng Nie, Zhuang Sha, Jiancheng Feng, Mingqi Liu, Chuanxiang Lv, Yupeng Chen, Weiwei Jiang, Jiangyuan Yuan, Yu Qian, Honggang Wan, Chuang Gao, Rongcai Jiang
Traumatic brain injury (TBI)-a severe clinical problem-is compounded by a lack of effective treatments and impeded intracranial metabolic waste clearance. The glymphatic system and meningeal lymphatic vessels are instrumental in TBI pathophysiology and crucial for clearing harmful substances. Cannabidiol (CBD) has the potential to address metabolic imbalances and improve cognitive functions in neurodegenerative diseases, but its specific effect on TBI remains unclear. Using a fluid percussion injury model, we adopted a comprehensive approach that included behavioral testing, various imaging techniques, and deep cervical lymph node (dCLN) ligation to evaluate CBD's effects on neurological outcomes and lymphatic clearance in a TBI mouse model...
March 30, 2024: Journal of Neurotrauma