Elham Gholipour, Houman Kahroba, Nasim Soltani, Parisa Samadi, Parisa Sarvarian, Sajjad Vakili-Samiani, Abbas Ali Hosein Pour Feizi, Mohammad Sadegh Soltani-Zangbar, Adel Baghersalimi, Bahram Darbandi, Aliakbar Movassaghpour, Mehdi Talebi, Roza Motavalli, Amir Mehdizadeh, Abdolhassan Kazemi, Mehdi Yousefi
Exosomes derived from solid tumour cells are involved in immune suppression, angiogenesis and metastasis; however, the role of leukaemia-derived exosomes has less been investigated. Hence, changes in immune response-related genes and human T cells apoptosis co-incubated with exosomes isolated from patients' pre-B cell acute lymphoblastic leukaemia were evaluated in this in vitro study. Vein blood sample was obtained from each newly diagnosed acute lymphoblastic leukaemia (ALL) patient prior any therapy. ALL serum exosomes were isolated by ultrafiltration and characterized using Western blotting and transmission electron microscopy...
July 13, 2022: Journal of Cellular and Molecular Medicine