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Breast cancer immunosupression

Leonardo Pires Novais Dias, Ana Luiza Antunes Faria, Maissa Marçola Scandiuzzi, Claudia Luci dos Santos Inhaia, Jorge Yoshinori Shida, Luiz Henrique Gebrim
BACKGROUND: Dermatomyositis and polymyositis are both types of idiopathic inflammatory myositis characterized by inflammation and weakness of proximal skeletal muscles and skin rash. CASE: A 49-year-old Caucasian woman recently diagnosed with breast cancer classified as T1N2M0, stage IIIA, presenting skin rash associated with heliotrope and Gottron's papules. In addition, there was a progression to a severe reduction in proximal muscle strength with severe dysphagia...
April 1, 2015: World Journal of Surgical Oncology
Dukagjin Morina, Georgios Ntoulias, Homajoun Maslehaty, Martin Scholz, Athanasios K Petridis
The posterior reversible encephalopathy syndrome (PRES) is a well described entity of white matter pathology. PRES is triggered by numerous different factors such as acute elevated arterial hypertension, immunosupressive therapy, chemotherapy, etc. The case of a 67-year old woman is presented. The patient was treated for breast cancer 10 months ago and because of acute disorientation a magnetic resonance imaging (MRI) was performed. In the MRI biparieto-occipital hyperintense lesions were seen. Brain metastases were suspected...
March 27, 2014: Clinics and Practice
U Hille, P Soergel, L Makowski, T Dörk-Bousset, P Hillemanns
A common situation presented in any clinical facility is a woman with swelling and redness of the breast. Diagnosis upon suspicion is often mastitis or inflammatory breast cancer, which are popular and well-known diseases of the breast. However, there is one main differential diagnosis which has to be taken into consideration: lymphedema of the breast. Twenty patients with internal diseases presented in our Breast Care Unit over a 4-year period with breast-affecting lymphedema. The patients suffered from cardiac failure, nephrotic syndrome, liver failure, lymphadenopathy, and central vein occlusion...
June 2012: Lymphatic Research and Biology
Joanna P Wood, Andrew P Haynes, K L Cheung
BACKGROUND: Many cancers are known to be associated with paraneoplastic syndromes. These syndromes are usually treated by chemotherapy with or without immunosupression but they often respond poorly. There are no published reviews on response to endocrine treatment. CASE PRESENTATION: We report a case of a patient presenting with papillitis, myositis and sensory peripheral neuropathy 18 months before a diagnosis of metastatic oestrogen receptor positive breast cancer was confirmed...
2008: World Journal of Surgical Oncology
Md Zahidunnabi Dewan, Hiroshi Terunuma, Masahiro Takada, Yuetsu Tanaka, Hiroyuki Abe, Tetsutaro Sata, Masakazu Toi, Naoki Yamamoto
Natural killer (NK) cells play a central role in host defense against tumor and virus-infected cells. Direct role of NK cells in tumor growth and metastasis remains to be elucidated. We here demonstrated that NOD/SCID/gammac(null) (NOG) mice lacking T, B and NK cells inoculated with breast cancer cells were efficient in the formation of a large tumor and spontaneous organ-metastasis. In contrast, breast cancer cells produced a small tumor at inoculated site in T and B cell knock-out NOD/SCID mice with NK cells while completely failed to metastasize into various organs...
September 2007: Breast Cancer Research and Treatment
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