keyword
https://read.qxmd.com/read/38539626/-akkermansia-muciniphila-is-beneficial-to-a-mouse-model-of-parkinson-s-disease-via-alleviated-neuroinflammation-and-promoted-neurogenesis-with-involvement-of-scfas
#1
JOURNAL ARTICLE
Chen-Meng Qiao, Wen-Yan Huang, Yu Zhou, Wei Quan, Gu-Yu Niu, Ting Li, Mei-Xuan Zhang, Jian Wu, Li-Ping Zhao, Wei-Jiang Zhao, Chun Cui, Yan-Qin Shen
Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson's disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to PD is unknown. To answer this question, the mice received MPTP intraperitoneally to construct a subacute model of PD and were then supplemented with Akk orally for 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, and neurogenesis were examined...
February 29, 2024: Brain Sciences
https://read.qxmd.com/read/38538756/causal-role-of-myeloid-cells-in-parkinson-s-disease-mendelian-randomization-study
#2
JOURNAL ARTICLE
Wei Quan, Yidan Qin, Jia Li, Lin Wang, Jia Song, Jing Xu, Jiajun Chen
BACKGROUND: Previous studies have observed elevated myeloid cells in the peripheral blood of patients with Parkinson's disease (PD), but the causal relationship between them remains to be elucidated. We investigated whether there is a causal relationship between different subtypes of peripheral blood myeloid cells and PD using Mendelian randomization (MR) combined with bioinformatics analysis. Exploring the etiology of PD from the perspective of genetics can remove confounding factors and provide a more reliable theoretical basis for elucidating the pathogenesis of PD...
March 27, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38534746/mitochondrial-dysfunction-a-key-player-in-brain-aging-and-diseases
#3
REVIEW
Sydney Bartman, Giuseppe Coppotelli, Jaime M Ross
Mitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegenerative diseases, although the underlying mechanisms are not entirely understood...
March 2, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38530880/glucosylceramide-accumulation-in-microglia-triggers-sting-dependent-neuroinflammation-and-neurodegeneration-in-mice
#4
JOURNAL ARTICLE
Rui Wang, Hongyang Sun, Yifan Cao, Zhixiong Zhang, Yajing Chen, Xiying Wang, Lele Liu, Jin Wu, Hao Xu, Dan Wu, Chenchen Mu, Zongbing Hao, Song Qin, Haigang Ren, Junhai Han, Ming Fang, Guanghui Wang
Mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo...
March 26, 2024: Science Signaling
https://read.qxmd.com/read/38526011/c9-functionalized-doxycycline-analogs-as-drug-candidates-to-prevent-pathological-%C3%AE-synuclein%C3%A2-aggregation-and-neuroinflammation-in-parkinson-s-disease-degeneration
#5
JOURNAL ARTICLE
Laurent Ferrié, Bruno Figadère, Clémence Rose, Rodrigo Hernán Tomas-Grau, Rosana Chehín, Brenda Zabala, Patrick Pierre Michel, Rita Raisman-Vozari, Jean-Michel Brunel
Doxycycline, a semi-synthetic tetracycline, is a widely used antibiotic for treating mild-to-moderate infections, including skin problems. However, its anti-inflammatory and antioxidant properties, combined with its ability to interfere with α-synuclein aggregation, make it an attractive candidate for repositioning in Parkinson's disease. Nevertheless, the antibiotic activity of doxycycline restricts its potential use for long-term treatment of Parkinsonian patients. In the search for non-antibiotic tetracyclines that could operate against Parkinson's disease pathomechanisms, eighteen novel doxycycline derivatives were designed...
March 25, 2024: ChemMedChem
https://read.qxmd.com/read/38515447/analyzing-the-bibliometrics-of-brain-gut-axis-and-parkinson-s-disease
#6
JOURNAL ARTICLE
Lingshan Chen, Jianfei Chen, Min Wu, Pingkang Yan, Xueping Zhou
BACKGROUND: Parkinson's disease (PD), characterized by the loss of dopaminergic neurons, is a progressive neurodegenerative disorder. Recent research has revealed a significant connection between gut microbiota and PD. To gain insight into research interests, disciplinary contexts, and potential future directions, a comprehensive bibliometric analysis was conducted on the brain-gut axis and PD literature published between 2014 and 2023. METHODS: Relevant literature records were gathered from the Web of Science Core Collection on August 11, 2023...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38514643/vdr-and-deubiquitination-control-neuronal-oxidative-stress-and-microglial-inflammation-in-parkinson-s-disease
#7
JOURNAL ARTICLE
Zihui Zheng, Miao Chen, Shengliang Feng, Huanhuan Zhao, Tiange Qu, Xudong Zhao, Qinli Ruan, Lei Li, Jun Guo
Close correlation between vitamin D (VitD) deficiency and Parkinson's Disease (PD) risk, VitD as an adjuvant treatment promising to improve PD progression. However, VitD excessive intake could induce hypercalcemia and renal damage. Therefore, upregulation of vitD receptor (VDR) is considered a compensatory strategy to overcome VitD insufficiency and alleviate PD symptoms. In this study, we discovered that VDR played antioxidative roles in dopaminergic neurons by decreasing reactive oxygen species (ROS) and maintaining mitochondrial membrane potential...
March 21, 2024: Cell Death Discovery
https://read.qxmd.com/read/38514017/interplay-of-mitochondria-associated-membrane-proteins-and-autophagy-implications-in-neurodegeneration
#8
REVIEW
Prakash G Kulkarni, Vaibhavi M Mohire, Pranjal P Waghmare, Tanushree Banerjee
Since the discovery of membrane contact sites between ER and mitochondria called mitochondria-associated membranes (MAMs), several pieces of evidence identified their role in the regulation of different cellular processes such as Ca2+ signalling, mitochondrial transport, and dynamics, ER stress, inflammation, glucose homeostasis, and autophagy. The integrity of these membranes was found to be essential for the maintenance of these cellular functions. Accumulating pieces of evidence suggest that MAMs serve as a platform for autophagosome formation...
March 19, 2024: Mitochondrion
https://read.qxmd.com/read/38513154/bv2-membrane-coated-pegylated-liposomes-delivered-hfgf21-to-cortical-and-hippocampal-microglia-for-alzheimer-s-disease-therapy
#9
JOURNAL ARTICLE
Heng-Cai Wang, Wei Yang, Ling Xu, Yong-Hui Han, Yi Lin, Cui-Tao Lu, Kwonseop Kim, Ying-Zheng Zhao, Xi-Chong Yu
Microglia-mediated inflammation is involved in the pathogenesis of Alzheimer's disease (AD), whereas hFGF21 has demonstrated the ability to regulate microglia activation in Parkinson's disease, indicating a potential therapeutic role in AD. However, challenges such as aggregation, rapid inactivation, and the blood-brain barrier hinder its effectiveness in treating AD. This study develops targeted delivery of hFGF21 to activated microglia using BV2 membrane-coated PEGylated liposomes (hFGF21@BCM-LIP), preserving the bioactivity of hFGF21...
March 21, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38511224/epigenetics-and-the-neurodegenerative-process
#10
REVIEW
Bartosz Słowikowski, Wojciech Owecki, Jan Jeske, Michał Jezierski, Michał Draguła, Ulyana Goutor, Paweł P Jagodziński, Wojciech Kozubski, Jolanta Dorszewska
Neurological diseases are multifactorial, genetic and environmental. Environmental factors such as diet, physical activity and emotional state are epigenetic factors. Environmental markers are responsible for epigenetic modifications. The effect of epigenetic changes is increased inflammation of the nervous system and neuronal damage. In recent years, it has been shown that epigenetic changes may cause an increased risk of neurological disorders but, currently, the relationship between epigenetic modifications and neurodegeneration remains unclear...
March 21, 2024: Epigenomics
https://read.qxmd.com/read/38510465/air-pollution-and-neurological-diseases-current-state-highlights
#11
REVIEW
Raymond Roy, Amedeo D'Angiulli
This paper delves into the increasingly recognized yet complex relationship between air pollution and Neurological Diseases. Although the detrimental effects of air pollution on respiratory and cardiovascular health are well-documented, its impact on neurological and cognitive disorders is an emerging area of concern. In this mini review, we explore the intricate mechanisms by which various air pollutants, such as particulate matter, nitrogen oxides, and polycyclic aromatic hydrocarbons, contribute to neurological pathologies...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38509320/revolutionizing-brain-interventions-the-multifaceted-potential-of-histotripsy
#12
REVIEW
Yash Verma, Arosh S Perera Molligoda Arachchige
Histotripsy, a non-thermal ultrasound technique, holds significant promise in various applications within the realm of brain interventions. While its use for treating brain tumors is somewhat limited, focused ultrasound technology has been extensively investigated for a wide range of purposes within the brain, including disrupting the blood-brain barrier, supporting immunotherapy, addressing conditions like essential tremor, Parkinson's disease, Alzheimer's disease, epilepsy, and neuropathic pain. Research findings indicate that histotripsy can reduce tumor cells with fewer pulses, minimizing the risk of bleeding and cellular injury...
March 21, 2024: Neurosurgical Review
https://read.qxmd.com/read/38507892/the-role-of-peripheral-inflammation-related-biomarkers-in-distinguishing-parkinson-s-disease
#13
JOURNAL ARTICLE
Zhuo Zhang, Yue Wang, Jin Wang, Ying Cai, Peipei Liu, Shoufeng Liu, Jialing Wu, Xin Xie
BACKGROUND: Peripheral inflammation plays a significant role in Parkinson's disease (PD). Conflicting studies on whether inflammatory indicators in blood could serve as biomarkers to distinguish PD. OBJECTIVE: Include a wider range of biomarkers and control confounding factors to comprehensively evaluate the value of peripheral inflammation-related indicators. METHODS: A total of 80 PD patients were recruited and 80 one-to-one matched healthy controls (HCs)...
March 16, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38507813/targeting-neuroinflammation-by-pharmacologic-downregulation-of-inflammatory-pathways-is-neuroprotective-in-protein-misfolding-disorders
#14
JOURNAL ARTICLE
Sydney J Risen, Sean W Boland, Sadhana Sharma, Grace M Weisman, Payton M Shirley, Amanda S Latham, Arielle J D Hay, Vincenzo S Gilberto, Amelia D Hines, Stephen Brindley, Jared M Brown, Stephanie McGrath, Anushree Chatterjee, Prashant Nagpal, Julie A Moreno
Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category of progressive diseases includes, but is not limited to, Alzheimer's disease, Parkinson's disease, and prion diseases. Shared pathogenesis involves the accumulation of misfolded proteins, chronic neuroinflammation, and synaptic dysfunction, ultimately leading to irreversible neuronal loss, measurable cognitive deficits, and death. Presently, there are few to no effective treatments to halt the advancement of neurodegenerative diseases...
March 20, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38505993/the-complement-system-in-neurodegenerative-diseases
#15
JOURNAL ARTICLE
Jacqui Nimmo, Robert A J Byrne, Nikoleta Daskoulidou, Lewis M Watkins, Sarah M Carpanini, Wioleta M Zelek, B Paul Morgan
Complement is an important component of innate immune defence against pathogens and crucial for efficient immune complex disposal. These core protective activities are dependent in large part on properly regulated complement-mediated inflammation. Dysregulated complement activation, often driven by persistence of activating triggers, is a cause of pathological inflammation in numerous diseases, including neurological diseases. Increasingly, this has become apparent not only in well-recognized neuroinflammatory diseases like multiple sclerosis but also in neurodegenerative and neuropsychiatric diseases where inflammation was previously either ignored or dismissed as a secondary event...
March 20, 2024: Clinical Science (1979-)
https://read.qxmd.com/read/38501767/resveratrol-prevents-cognitive-deficits-induced-by-sleep-deprivation-via-modulating-sirtuin-1-associated-pathways-in-the-hippocampus
#16
JOURNAL ARTICLE
Yue-Ming Zhang, Ru-Meng Wei, Jing-Ya Zhang, Shuang Liu, Kai-Xuan Zhang, Xiao-Yi Kong, Yi-Jun Ge, Xue-Yan Li, Gui-Hai Chen
Accumulating evidence confirms that sleep insufficiency is a high risk factor for cognitive impairment, which involves inflammation and synaptic dysfunction. Resveratrol, an agonist of the Sirt1, has demonstrated anti-inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation-induced cognitive deficits and its underlying molecular mechanisms are unclear. In the present study, thirty-two male C57BL/6 J mice were randomly divided into a Control+DMSO group, Control+Resveratrol group, SD+DMSO group, and SD+Resveratrol group...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38501544/sodium-butyrate-activates-the-k-atp-channels-to-regulate-the-mechanism-of-parkinson-s-disease-microglia-model-inflammation
#17
JOURNAL ARTICLE
Ye Xu, Laofu Wen, Yunyi Tang, Zhenqiang Zhao, Miaojing Xu, Tan Wang, Zhibin Chen
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. Microglia-mediated neuroinflammation has emerged as an involving mechanism at the initiation and development of PD. Activation of adenosine triphosphate (ATP)-sensitive potassium (KATP ) channels can protect dopaminergic neurons from damage. Sodium butyrate (NaB) shows anti-inflammatory and neuroprotective effects in some animal models of brain injury and regulates the KATP channels in islet β cells. In this study, we aimed to verify the anti-inflammatory effect of NaB on PD and further explored potential molecular mechanisms...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38501412/-resveratrol-protects-dopaminergic-neurons-in-a-mouse-model-of-parkinson-s-disease-by-regulating-the-gut-brain-axis-via-inhibiting-the-tlr4-signaling-pathway
#18
JOURNAL ARTICLE
J Gui, X Sun, S Wen, X Liu, B Qin, M Sang
OBJECTIVE: To investigate the protective effect of resveratrol on intestinal barrier in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse models and its mechanism for regulating TLR4/MyD88/NF-κB signaling to protect dopaminergic neurons. METHODS: Fifty-two C57BL/6J mice were randomized into control group ( n = 12), MPTP group ( n =14), MPTP + resveratrol (30 mg/kg) group ( n =13), and MPTP + resveratrol (90 mg/kg) group ( n =13), and mouse models were established by intraperitoneal MPTP (30 mg/kg) injection for 7 days in the latter 3 groups...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38501016/global-biomarker-trends-in-parkinson-s-disease-research-a-bibliometric-analysis
#19
REVIEW
Xingxin Wang, Tiantian Dong, Xuhao Li, Wenyan Yu, Zhixia Jia, Yuanxiang Liu, Jiguo Yang
As the second most common neurodegenerative disease globally, Parkinson's disease (PD) affects millions of people worldwide. In recent years, the scientific publications related to PD biomarker research have exploded, reflecting the growing interest in unraveling the complex pathophysiology of PD. In this study, we aim to use various bibliometric tools to identify key scientific concepts, detect emerging trends, and analyze the global trends and development of PD biomarker research.The research encompasses various stages of biomarker development, including exploration, identification, and multi-modal research...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38499742/the-effects-of-cholesterol-and-statins-on-parkinson-s-neuropathology-a-narrative-review
#20
REVIEW
Hayder M Al-Kuraishy, Esraa H Fahad, Salah Al-Windy, Suzy A El-Sherbeni, Walaa A Negm, Gaber El-Saber Batiha
Parkinson disease (PD) is chronic and progressive neurodegenerative disease of the brain characterized by motor symptoms including tremors, rigidity, postural instability, and bradykinesia. PD neuropathology is due to the progressive degeneration of dopaminergic neurons in the substantia nigra and accumulation of Lewy bodies in the survival neurons. The brain contains a largest amount of cholesterol which is mainly synthesized from astrocytes and glial cells. Cholesterol is intricate in the pathogenesis of PD and may be beneficial or deleterious...
March 18, 2024: Inflammopharmacology
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