Qin Wei, Xuan Xu, Long Chen, Tao Wang, Liang Xie, Fu-Chao Yu, Si-Fan Song, Zhi-Qiang Sheng, Jia-Yi Tong
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease that is characterized by chronic intermittent hypoxia (CIH), and its impact is related to age. This study aims to assess the age-related impact of CIH on cardiac function and to further explore the mechanism. After 8 wk of severe CIH exposure, the hearts of young mice showed slight physiological hypertrophy, decreased diastolic function, and collagen I accumulation but no obvious change in contractile function. However, the contractile function of the hearts of aged mice was severely decreased...
March 1, 2022: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology