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SNP diabetes

Wen-Wen Cheng, Qiang Zhu, Hong-Yu Zhang
We applied Mendelian randomization analyses to investigate the potential causality between blood minerals (calcium, magnesium, iron, copper, and zinc) and osteoporosis (OP), gout, rheumatoid arthritis (RA), type 2 diabetes (T2D), Alzheimer's disease (AD), bipolar disorder (BD), schizophrenia , Parkinson's disease and major depressive disorder. Single nucleotide polymorphisms (SNPs) that are independent ( r ² < 0.01) and are strongly related to minerals ( p < 5 × 10-8 ) are selected as instrumental variables...
February 12, 2019: Nutrients
Diego Alves Vieira, Luciana Rodrigues da Cunha, Cliviany Borges da Silva, Maria Thereza Bastos Almeida, Adriana Dias Gomes, César Lúcio Lopes de Faria, Rosângela Teixeira, Fernando Silva Neves, Gifone Aguiar Rocha, Fabrício Freire de Melo, Dulciene Maria de Magalhães Queiroz, Luciana Diniz Silva
PURPOSE: Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, - 819C/T, and - 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients...
February 7, 2019: Quality of Life Research
Małgorzata Tupikowska-Marzec, Katarzyna Kolačkov, Aleksandra Zdrojowy-Wełna, Natalia K Słoka, Jacek C Szepietowski, J Maj
Background: Psoriasis is often accompanied by obesity, hyperlipidemia, diabetes, and metabolic syndrome as risk factors of cardiovascular conditions and premature mortality. Objective: The study was aimed at investigating whether psoriatic patients, who carry risk allele of obesity-related FTO gene, are more predisposed to obesity and metabolic disturbances and whether it influences the severity of psoriasis. Methods: 197 patients with psoriasis, representing Lower Silesia region of Poland, underwent physical examination and anthropometric measurements...
2019: BioMed Research International
Linlin Li, Jinjin Wang, Zhiguang Ping, Yuqian Li, Chongjian Wang, Yuanyuan Shi, Wen Zhou, Lulu Zhang
BACKGROUND & AIMS: Type 2 diabetes (T2D) is a complex metabolic disease with numerous risk factors, including a growing number of genetic susceptibility variants. The TCF7L2 gene is closely associated with an increased risk of type 2 diabetes, but the association of TCF7L2 with weight-related traits in humans is unclear. The purpose of this study was to determine if TCF7L2 variants and body mass index/waist circumference (BMI/WC) act synergistically to influence the incidence of type 2 diabetes in a Chinese population...
January 24, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
M N Phasha, P Soma, E Pretorius, A Phulukdaree
The prevalence of type 2 diabetes mellitus (T2DM) has quadrupled within three decades since 1980 affecting 422 million adults in 2016. It remains one of the most common non-communicable chronic diseases and underlying risk factor for cardiovascular diseases worldwide. There are different underlying mechanisms that play a role in the development of pathologies associated with the disease such as hyperglycaemia, oxidative stress, obesity, inflammation and hypercoagulation. Each of which are interlinked. Hyperglycaemia, oxidative stress and obesity play a huge role in the activation of inflammation and coagulation...
January 29, 2019: Current Diabetes Reviews
Mari Cassol Ferreira, Maria Elizabeth Rossi da Silva, Rosa Tsuneshiro Fukui, Maria do Carmo Arruda-Marques, Salman Azhar, Rosa Ferreira Dos Santos
Background: Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and reduces blood glucose in type 2 diabetes mellitus (T2DM). TCF7L2 rs7903146 polymorphism has been associated with decreased insulin secretion, reduced GLP-1 action, and possible impaired peripheral insulin sensitivity. Objectives: To evaluate the postprandial pancreatic hormone response in patients with T2DM carriers of the TCF7L2 variant rs7903146 (CT/TT) compared with noncarriers of this variant (CC) after treatment with the GLP-1 agonist exenatide...
2019: Diabetology & Metabolic Syndrome
Bertha A Hidalgo, Tamar Sofer, Qibin Qi, Neil Schneiderman, Y-D Ida Chen, Robert C Kaplan, M Larissa Avilés-Santa, Kari E North, Donna K Arnett, Adam Szpiro, Jianwen Cai, Bing Yu, Eric Boerwinkle, George Papanicolaou, Cathy C Laurie, Jerome I Rotter, Adrienne M Stilp
Five sequence variants in SLC16A11 (rs117767867, rs13342692, rs13342232, rs75418188, and rs75493593), which occur in two non-reference haplotypes, were recently shown to be associated with diabetes in Mexicans from the SIGMA consortium. We aimed to determine whether these previous findings would replicate in the HCHS/SOL Mexican origin group and whether genotypic effects were similar in other HCHS/SOL groups. We analyzed these five variants in 2492 diabetes cases and 5236 controls from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), which includes U...
January 29, 2019: Scientific Reports
Ebony Liu, Georgia Kaidonis, Mark C Gillies, Sotoodeh Abhary, Rohan W Essex, John H Chang, Bishwanath Pal, Mark Daniell, Stewart Lake, Jolly Gilhotra, Nikolai Petrovsky, Alex W Hewitt, Alicia Jenkins, Ecosse L Lamoureux, Jonathan M Gleadle, Kathryn P Burdon, Jamie E Craig
Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep...
January 24, 2019: Scientific Reports
Julien Vouillarmet, Audrey Josset-Lamaugarny, Paul Michon, Jean Louis Saumet, Audrey Koitka-Weber, Samir Henni, Berengere Fromy, Dominique Sigaudo-Roussel
Diabetic foot ulcer (DFU) is a problem worldwide and prevention is crucial. We hypothesized that the inability of the skin to respond to pressure is involved in DFU pathogenesis and could be an important predictive factor to take into account.We included 29 patients with DFU and 30 patients with type 2 diabetes without DFU. Neuropathy and skin blood flow at rest were assessed in response to acetylcholine, sodium nitroprusside, local heating (42°C), and to non-noxious locally applied pressure. Results were compared to those obtained from 10 healthy age-matched control subjects...
January 24, 2019: Diabetes
Julia Romanowska, Anagha Joshi
Advances in sequencing technologies have enabled the exploration of the genetic basis for several clinical disorders by allowing identification of causal mutations in rare genetic diseases. Sequencing technology has also facilitated genome-wide association studies to gather single nucleotide polymorphisms in common diseases including cancer and diabetes. Sequencing has therefore become common in the clinic for both prognostics and diagnostics. The success in follow-up steps, i.e., mapping mutations to causal genes and therapeutic targets to further the development of novel therapies, has nevertheless been very limited...
January 23, 2019: Genes
Mina Mozafarizadeh, Mohsen Mohammadi, Soha Sadeghi, Morteza Hadizadeh, Tayebe Talebzade, Massoud Houshmand
Objectives: Obesity is a significant risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. Obesity usually results from a combination of causes and contributing factors, including genetics and lifestyle choices. Many studies have shown an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated ( FTO ) and the melanocortin-4 receptor ( MC4R ) genes with body mass index (BMI). Therefore, recognizing the main genes and their relevant genetic variants will aid prediction of obesity risk...
January 2019: Oman Medical Journal
Andrea Vereczkei, Omar Abdul-Rahman, Zsuzsa Halmai, Geza Nagy, Anna Szekely, Aniko Somogyi, Gabor Faludi, Zsofia Nemoda
INTRODUCTION: The activation of the ATP-gated P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7) produces microglial activation, a process which has been demonstrated in depression, bipolar disorder, and schizophrenia. Emerging data over the last years highlighted the importance of P2X7 cation channel as a potential drug target for these central nervous system disorders. The Gln460Arg (rs2230912) polymorphism of the P2RX7 gene has been widely studied in mood disorders, however the results are still controversial...
January 18, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Suna Onengut-Gumuscu, Wei-Min Chen, Catherine C Robertson, Jessica K Bonnie, Emily Farber, Zhennan Zhu, Jorge R Oksenberg, Steven R Brant, S Louis Bridges, Jeffrey C Edberg, Robert P Kimberly, Peter K Gregersen, Marian J Rewers, Andrea K Steck, Mary H Black, Dana Dabelea, Catherine Pihoker, Mark A Atkinson, Lynne E Wagenknecht, Jasmin Divers, Ronny A Bell, Henry A Erlich, Patrick Concannon, Stephen S Rich
OBJECTIVE: Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those with other forms of diabetes and are starting to be used for population screening; however, most studies were conducted in European-ancestry populations. This study identifies novel genetic variants associated with type 1 diabetes risk in African-ancestry participants and develops an African-specific GRS. RESEARCH DESIGN AND METHODS: We generated single nucleotide polymorphism (SNP) data with the ImmunoChip on 1,021 African-ancestry participants with type 1 diabetes and 2,928 control participants...
January 18, 2019: Diabetes Care
Seth A Sharp, Stephen S Rich, Andrew R Wood, Samuel E Jones, Robin N Beaumont, James W Harrison, Darius A Schneider, Jonathan M Locke, Jess Tyrrell, Michael N Weedon, William A Hagopian, Richard A Oram
OBJECTIVE: Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have not captured all known information at non-HLA loci or, particularly, at HLA risk loci. We aimed to more completely incorporate HLA alleles, their interactions, and recently discovered non-HLA loci into an improved T1D GRS (termed the "T1D GRS2") to better discriminate diabetes subtypes and to predict T1D in newborn screening studies. RESEARCH DESIGN AND METHODS: In 6,481 case and 9,247 control subjects from the Type 1 Diabetes Genetics Consortium, we analyzed variants associated with T1D both in the HLA region and across the genome...
January 17, 2019: Diabetes Care
Birsen Aydemir, F Behice Serinkan Cinemre, Hakan Cinemre, Abdullah Tüten, M Aytaç Yüksel, Nevin Yılmaz, Barıs Kaya, Nermin Akdemir, Elif Erdogan, Rıza Madazlı
The aim of this study was to investigate the role of PON1Q192R and L55M single nucleotide polymorphisms(SNPs) and its association with the maternal levels of lipid parameters in gestational diabetes mellitus(GDM) and preeclampsia(PE). Ninety-nine pregnant with GDM, 97 pregnant with PE and 98 healthy pregnant were included in the study. No statistically significant difference was observed in the alleles or in the genotypes frequencies of SNPs between groups. In GDM patients, total cholesterol was higher in MM genotype of L55M gene (p < ...
January 18, 2019: Gynecological Endocrinology
América L Miranda-Lora, Mario Molina-Díaz, Miguel Cruz, Rocío Sánchez-Urbina, Nancy L Martínez-Rodríguez, Briceida López-Martínez, Miguel Klünder-Klünder
BACKGROUND AND OBJECTIVE: Genetics play a very strong role in the development of pediatric-onset type 2 diabetes (T2D); however, little information exists about specific common single nucleotide polymorphisms (SNPs) associated with T2D in this age group. The aim of the study was to analyze the association and parental transmission of 64 obesity-related SNPs with pediatric-onset T2D in Mexican families. METHODS: A total of 57 pedigrees containing 171 probands with pediatric-onset T2D and 119 unrelated controls older than 18 years were included...
January 16, 2019: Pediatric Diabetes
Daniela Kempe-Teufel, Fausto Machicao, Jürgen Machann, Anja Böhm, Fritz Schick, Andreas Fritsche, Norbert Stefan, Martin Hrabe de Angelis, Hans-Ulrich Häring, Harald Staiger
Context: Primary dysregulation of adipose tissue lipolysis due to genetic variation and independent of insulin resistance could explain unhealthy body fat distribution and its metabolic consequences. Objective: To analyze common single nucleotide polymorphisms (SNPs) in 48 lipolysis-, but not insulin-signaling-related genes, to form polygenic risk scores of lipolysis-associated SNPs and to investigate their effects on body fat distribution, glycemia, insulin sensitivity, insulin secretion and proinsulin conversion...
January 10, 2019: Journal of Clinical Endocrinology and Metabolism
Dianjianyi Sun, Tao Zhou, Yoriko Heianza, Xiang Li, Mengyu Fan, Vivian Fonseca, Lu Qi
RATIONALE: In observational studies, type 2 diabetes (T2D) has been associated with an increased risk of hypertension (HTN), and vice versa; however, the causality between these conditions remains to be determined. OBJECTIVE: This population-based prospective cohort study sought to investigate the bidirectional causal relations of T2D with HTN, systolic and diastolic blood pressure (SBP and DBP) using Mendelian randomization (MR) analysis. METHODS AND RESULTS: After exclusion of participants free of a history of heart failure, cardiovascular disease, cardiac procedures, and non T2D diabetes, a total of 318,664 unrelated individuals with qualified genotyping data of European descent aged 37-73 from UK Biobank were included...
January 16, 2019: Circulation Research
Imran Ali Khan, Parveen Jahan, Qurratulain Hasan, Pragna Rao
BACKGROUND: Meta-analysis is useful for combining the results of different studies statistically to confirm genuine associations in genetics. Based on earlier reports, we aimed to investigate the association between type 2 diabetes mellitus (T2DM) genetic variants identified in a previous meta-analysis in gestational diabetes mellitus (GDM) in an Indian woman. MATERIAL AND METHODS: In this study, 137 pregnant women with GDM and 150 pregnant women were selected on the basis of their serum glucose levels...
January 2019: Diabetes & Metabolic Syndrome
Ushma J Shah, Weijia Xie, Allan Flyvbjerg, John J Nolan, Kurt Højlund, Mark Walker, Caroline L Relton, Hannah R Elliott
AIMS: Epigenetic mechanisms regulate gene expression and may influence the pathogenesis of type 2 diabetes through the loss of insulin sensitivity. The aims of this study were to measure variation in DNA methylation at the type 2 diabetes locus KCNQ1 and assess its relationship with metabolic measures and with genotype. METHODS: DNA methylation from whole blood DNA was quantified using pyrosequencing at 5 CpG sites at the KCNQ1 locus in 510 individuals without diabetes from the 'Relationship between Insulin Sensitivity and Cardiovascular disease' (RISC) cohort...
January 11, 2019: Diabetes Research and Clinical Practice
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