keyword
https://read.qxmd.com/read/38522239/research-progress-on-sirtuins-sirts-family-modulators
#1
REVIEW
Mingkai Chen, Junfei Tan, Zihan Jin, Tingting Jiang, Jiabiao Wu, Xiaolong Yu
Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases that exert a crucial role in cellular signal transduction and various biological processes. The mammalian sirtuins family encompasses SIRT1 to SIRT7, exhibiting therapeutic potential in counteracting cellular aging, modulating metabolism, responding to oxidative stress, inhibiting tumors, and improving cellular microenvironment. These enzymes are intricately linked to the occurrence and treatment of diverse pathological conditions, including cancer, autoimmune diseases, and cardiovascular disorders...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38512537/sirt3-a-potential-target-of-different-types-of-osteoporosis
#2
REVIEW
Binjing Pan, Chongyang Chen, Yangting Zhao, Jing Cai, Songbo Fu, Jingfang Liu
Osteoporosis (OP) is a common age-related disease. OP is mainly a decrease in bone density and mass caused by the destruction of bone microstructure, which leads to an increase in bone fragility. SIRT3 is a mitochondrial deacetylase that plays critical roles in mitochondrial homeostasis, metabolic regulation, gene transcription, stress response, and gene stability. Studies have shown that the higher expression levels of SIRT3 are associated with decreased levels of oxidative stress in the body and may play important roles in the prevention of age-related diseases...
March 21, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38484732/the-sirtuin-associated-human-senescence-program-converges-on-the-activation-of-placenta-specific-gene-pappa
#3
JOURNAL ARTICLE
Shijia Bi, Xiaoyu Jiang, Qianzhao Ji, Zehua Wang, Jie Ren, Si Wang, Yang Yu, Ruoqi Wang, Zunpeng Liu, Junhang Liu, Jianli Hu, Guoqiang Sun, Zeming Wu, Zhiqing Diao, Jingyi Li, Liang Sun, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Guang-Hui Liu, Jing Qu
Sirtuins are pro-longevity genes with chromatin modulation potential, but how these properties are connected is not well understood. Here, we generated a panel of isogeneic human stem cell lines with SIRT1-SIRT7 knockouts and found that any sirtuin deficiency leads to accelerated cellular senescence. Through large-scale epigenomic analyses, we show how sirtuin deficiency alters genome organization and that genomic regions sensitive to sirtuin deficiency are preferentially enriched in active enhancers, thereby promoting interactions within topologically associated domains and the formation of de novo enhancer-promoter loops...
March 11, 2024: Developmental Cell
https://read.qxmd.com/read/38476973/sirt3-expression-predicts-overall-survival-and-neoadjuvant-chemosensitivity-in-triple-negative-breast-cancer
#4
JOURNAL ARTICLE
Lvwen Ning, Ni Xie
BACKGROUND: The Sirtuin (SIRT) family consists of seven evolutionary conserved NAD-dependent deacetylases that play important roles in various cancers, including breast cancer (BC). SIRTs expression has been reported to have prognostic value in BC, but these studies used limited sample size and yielded inconsistent conclusions. This study evaluated the association of SIRT3 and other SIRT family members with survival and neoadjuvant chemotherapy outcomes. METHODS: BC patients' data was obtained from the TCGA-BRCA, METABRIC and GEO databases, comprising 4336 samples...
2024: Cancer Management and Research
https://read.qxmd.com/read/38441777/long-term-intake-of-sulforaphene-alleviates-d-galactose-induced-skin-senescence-by-activating-ampk-sirt-1-pathway
#5
JOURNAL ARTICLE
Bo Zhang, Pengtao Liu, Huakang Sheng, Yongzhi Han, Qipeng Yuan
D-Galactose (D-gal) accumulation triggers the generation of oxygen free radicals, resulting in skin aging. Sulforaphene (SFE), an isothiocyanate compound derived from radish seeds, possesses diverse biological activities, including protective effects against inflammation and oxidative damage. This investigation delves into the antioxidant impact of SFE on age-related skin injury. In vivo experiments demonstrate that SFE treatment significantly improves the macro- and micro-morphology of dorsal skin. It effectively diminishes the elevation of oxidative stress biomarkers in mice skin tissue treated with D-gal, concurrently enhancing the activity of antioxidant enzymes...
March 5, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38440069/predictive-value-of-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-in-hcc-treated-with-sorafenib-and-radioembolization
#6
JOURNAL ARTICLE
Osman Öcal, Melanie Alexandra Kimm, Thi Phuong Thao Hoang, Maciej Pech, Elif Öcal, Najib Ben Khaled, Bruno Sangro, Jens Ricke, Max Seidensticker, Moritz Wildgruber
BACKGROUND & AIMS: Herein we used data derived from the SORAMIC trial to explore the predictive value of systemic inflammatory markers (neutrophil-to-lymphocyte ratio [NLR] and platelet-to-lymphocyte ratio [PLR]) in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib monotherapy or the combination of selective internal radiation therapy (SIRT)/sorafenib. METHODS: Patients randomized to sorafenib monotherapy or SIRT/sorafenib within the per-protocol population of the SORAMIC trial were evaluated in this exploratory post hoc analysis...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38429891/exploring-the-therapeutic-potential-of-quercetin-a-focus-on-its-sirtuin-mediated-benefits
#7
REVIEW
Anca Ungurianu, Anca Zanfirescu, Denisa Margină
As the global population ages, preventing lifestyle- and aging-related diseases is increasing, necessitating the search for safe and affordable therapeutic interventions. Among nutraceuticals, quercetin, a flavonoid ubiquitously present in various plants, has garnered considerable interest. This review aimed to collate and analyze existing literature on the therapeutic potentials of quercetin, especially its interactions with SIRTs and its clinical applicability based on its bioavailability and safety. This narrative review was based on a literature survey spanning from 2015 to 2023 using PUBMED...
March 1, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38396635/sirtuins-as-players-in-the-signal-transduction-of-citrus-flavonoids
#8
REVIEW
Giovanni Enrico Lombardo, Caterina Russo, Alessandro Maugeri, Michele Navarra
Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+ )-dependent class III histone deacetylases, which come into play in the regulation of epigenetic processes through the deacetylation of histones and other substrates. The human genome encodes for seven homologs (SIRT1-7), which are localized into the nucleus, cytoplasm, and mitochondria, with different enzymatic activities and regulatory mechanisms. Indeed, SIRTs are involved in different physio-pathological processes responsible for the onset of several human illnesses, such as cardiovascular and neurodegenerative diseases, obesity and diabetes, age-related disorders, and cancer...
February 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38385961/adapting-the-early-recognition-inventory-eriraos-to-estonian-a-validation-study
#9
JOURNAL ARTICLE
Kairit Sirts, Kätlin Anni, Roman Balõtšev, Siim Jakobsoo, Kirti-Ly Jaanson, Liina Haring
AIM: Validated assessment tools are needed to identify clinically high risk for psychosis. This study aimed to validate the early recognition inventory ERIraos, which consists of the ERIraos Checklist for risk screening and the ERIraos Symptom List for a more thorough risk assessment in the Estonian language to detect psychotic prodromal symptoms. METHODS: A prospective cohort study provided an opportunity to evaluate the characteristics of the ERIraos instrument in predicting the increased risk of a psychotic disorder in the future...
February 22, 2024: Early Intervention in Psychiatry
https://read.qxmd.com/read/38339337/anatomical-quantitative-volumetric-evaluation-of-liver-segments-in-hepatocellular-carcinoma-patients-treated-with-selective-internal-radiation-therapy-key-parameters-influencing-untreated-liver-hypertrophy
#10
JOURNAL ARTICLE
Raphaël Girardet, Jean-François Knebel, Clarisse Dromain, Naik Vietti Violi, Georgia Tsoumakidou, Nicolas Villard, Alban Denys, Nermin Halkic, Nicolas Demartines, Kosuke Kobayashi, Antonia Digklia, Niklaus Schaefer, John O Prior, Sarah Boughdad, Rafael Duran
Background : Factors affecting morphological changes in the liver following selective internal radiation therapy (SIRT) are unclear, and the available literature focuses on non-anatomical volumetric assessment techniques in a lobar treatment setting. This study aimed to investigate quantitative changes in the liver post-SIRT using an anatomical volumetric approach in hepatocellular carcinoma (HCC) patients with different levels of treatment selectivity and evaluate the parameters affecting those changes. This retrospective, single-institution, IRB-approved study included 88 HCC patients...
January 30, 2024: Cancers
https://read.qxmd.com/read/38338233/the-impact-of-8-weeks-of-combined-physical-exercise-training-on-sirt3-and-mtor-in-lymphocytes-and-on-lipid-peroxidation
#11
JOURNAL ARTICLE
Jorge Pinto Soares, Ricardo Cardoso, Vanessa Almeida, Ana Fátima Pereira, Amélia M Silva, Maria Paula Mota
The sirtuins (SIRT) protein family and the mechanistic/mammalian target of rapamycin (mTOR) are intracellular molecules that have been involved in the regulation of several biological processes, as well as in various aging-related processes. This pilot study, in small scale, aimed to analyze the effects of an 8-week physical exercise program on SIRT3 and mTOR levels in lymphocytes, as well as on lipid peroxidation in middle aged and older men. A total of 9 participants aged between 56 and 73 years were enrolled in an 8-week physical exercise program comprising cardiovascular and high-intensity interval training...
January 30, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38331805/astragalus-polysaccharides-attenuate-rat-aortic-endothelial-senescence-via-regulation-of-the-sirt-1-p53-signaling-pathway
#12
JOURNAL ARTICLE
Xinyu Miao, Lingjun Rong, Bo Fu, Shaoyuan Cui, Zhaoyan Gu, Fan Hu, Yanhui Lu, Shuangtong Yan, Banruo Sun, Wenli Jiang, Yuting Zhang, Yanping Gong, Chunlin Li
BACKGROUND: Astragalus polysaccharides (APS) have been verified to have antioxidative and antiaging activities in the mouse liver and brain. However, the effect of APS on aortic endothelial senescence in old rats and its underlying mechanism are currently unclear. Here, we aimed to elucidate the effects of APS on rat aortic endothelial oxidative stress and senescence in vitro and in vivo and investigate the potential molecular targets. METHODS: Twenty-month-old natural aging male rats were treated with APS (200 mg/kg, 400 mg/kg, 800 mg/kg daily) for 3 months...
February 8, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38321168/sirtuins-in-kidney-health-and-disease
#13
REVIEW
Luca Perico, Giuseppe Remuzzi, Ariela Benigni
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including mitochondrial metabolism, oxidative stress, autophagy, DNA repair and inflammation...
February 6, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38305254/genetic-insights-into-bladder-cancer-the-impact-of-sirt1-gene-polymorphism
#14
JOURNAL ARTICLE
Emre Bostanci, Duygu Kirkik, Sevgi Kalkanli Tas, Ugur Uyeturk
Bladder cancer (BC) has shown a significant global health concern with distinct pathological, genetic, and epigenetic characteristics. Its prevalence is influenced by various risk factors, including age, gender, and genetic predisposition. This study investigates the association between BC and the Sirtuin 1 (SIRT1) gene polymorphism rs369274325 in the Turkish population. Genomic DNA was isolated from peripheral blood samples and genotyping of rs369274325 polymorphism in SIRT 1 was investigated in 200 individuals (in 100 Turkish bladder cancer patients and 100 healthy individuals as the control group...
February 2, 2024: Nucleosides, Nucleotides & Nucleic Acids
https://read.qxmd.com/read/38285083/mind-the-gap-unraveling-the-intricate-dance-between-alzheimer-s-disease-and-related-dementias-and-bone-health
#15
REVIEW
Sonali J Karnik, Tyler J Margetts, Hannah S Wang, Alexandru Movila, Adrian L Oblak, Jill C Fehrenbacher, Melissa A Kacena, Lilian I Plotkin
PURPOSE OF REVIEW: This review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis is on "inflammaging"-a low-level inflammation common to both, and its implications in an aging population. RECENT FINDINGS: Aging intensifies both ADRD and bone deterioration. Notably, ADRD patients have a heightened fracture risk, impacting morbidity and mortality, though it is uncertain if fractures worsen ADRD...
January 29, 2024: Current Osteoporosis Reports
https://read.qxmd.com/read/38265402/endothelial-cell-aging-and-autophagy-dysregulation
#16
JOURNAL ARTICLE
Basheer Abdullah Marzoog
Entropy is a natural process that affects all living cells, including senescence, an irreversible physiological process that impairs cell homeostasis. Age is a significant factor in disease development, and the pathogenesis of endothelial cell aging is multifactorial. Autophagy dysfunction accelerates endothelial cell aging and cell death, while autophagy preserves endothelial cell youthfulness through intracellular homeostasis and gene expression regulation. Sirt, mTORC1, and AMPK are youthfulness genes that induce autophagy by inhibiting mTOR and upregulating FIP200/Atg13/ULK1...
January 23, 2024: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://read.qxmd.com/read/38242495/the-role-of-sirtuin-2-in-liver-an-extensive-and-complex-biological-process
#17
REVIEW
Shan Li, Liang Guo
Liver disease has become one of the main causes of health issue worldwide. Sirtuin (Sirt) 2 is a nicotinamide adenine dinucleotide (NAD+ )-dependent deacetylase, and is expressed in multiple organs including liver, which plays important and complex roles by interacting with various substrates. Physiologically, Sirt2 can improve metabolic homeostasis. Pathologically, Sirt2 can alleviate inflammation, endoplasmic reticulum (ER) stress, promote liver regeneration, maintain iron homeostasis, aggravate fibrogenesis and regulate oxidative stress in liver...
January 17, 2024: Life Sciences
https://read.qxmd.com/read/38195017/heterogeneous-nuclear-ribonucleoprotein-f-deficiency-in-mouse-podocyte-promotes-podocytopathy-mediated-by-methyltransferase-like-14-nuclear-translocation-resulting-in-sirtuin-1-gene-inhibition
#18
JOURNAL ARTICLE
Min-Chun Liao, Chao-Sheng Lo, Yu-Chao Pang, Wen-Xia Yang, Ke Su, Xin-Ping Zhao, Kana N Miyata, Junzheng Peng, Julie R Ingelfinger, John S D Chan, Shao-Ling Zhang
Heterogeneous nuclear ribonucleoprotein F (HnRNP F) is a key regulator for nucleic acid metabolism; however, whether HnRNP F expression is important in maintaining podocyte integrity is unclear. Nephroseq analysis from a registry of human kidney biopsies was performed. Age- and sex-matched podocyte-specific HnRNP F knockout (HnRNP FPOD KO) mice and control (HnRNP Ffl/fl ) were studied. Podocytopathy was induced in male mice (more susceptible) either by adriamycin (ADR)- or low-dose streptozotocin treatment for 2 or 8 weeks...
January 7, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/38142421/comparison-of-absorbed-doses-to-the-tumoral-and-non-tumoral-liver-in-hcc-patients-undergoing-99m-tc-maa-and-90-y-microspheres-radioembolization
#19
JOURNAL ARTICLE
Nut Noipinit, Chanan Sukprakun, Punnarai Siricharoen, Kitiwat Khamwan
PURPOSE: This study aimed to determine the absorbed doses in the tumoral-liver and non-tumoral liver of hepatocellular carcinoma (HCC) patients undergoing radioembolization with Yttrium-90 (90 Y) resin microspheres, and compared with those derived from 99m Tc-MAA using the partition model. METHODS: A total of 42 HCC patients (28 males and 14 females, mean age 65 ± 11.51 years) who received 45 treatment sessions with 90 Y-microspheres between 2016 and 2021 were included...
December 24, 2023: Annals of Nuclear Medicine
https://read.qxmd.com/read/38132368/safety-and-efficacy-of-concurrent-atezolizumab-bevacizumab-or-nivolumab-combination-therapy-with-yttrium-90-radioembolization-of-advanced-unresectable-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Alexander Villalobos, Howard Hussein Dabbous, Olivia Little, Olumide Babajide Gbolahan, Mehmet Akce, Meghan Allegra Lilly, Zachary Bercu, Nima Kokabi
To evaluate the safety and efficacy of combining yttrium-90 radioembolization (Y90-RE) with immune checkpoint inhibitor therapy, consecutive advanced unresectable hepatocellular carcinoma (HCC) patients treated between 2016 and 2022 with atezolizumab/bevacizumab or nivolumab within three-months pre- and post-Y90-RE were retrospectively evaluated. Tumor response and treatment-related clinical/laboratory adverse events (AE) were assessed at 1 and 6 months, as well as differences in clinical and laboratory variables and median overall survival (OS) from initial treatment (whether it was Y90-RE or systemic therapy) between the two cohorts...
November 25, 2023: Current Oncology
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