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Statins in gastroenterology

Elena Mosso, Valentina Boano, Mario Grassini, Edda Battaglia, Rinaldo Pellicano
Microscopic colitis (MC) is diagnosed in presence of microscopic alterations of colonic mucosa, in patients without macroscopic lesions who referred for chronic diarrhea. The two types of MC are lymphocytic colitis (LC) and collagenous colitis (CC), but it is unclear whether these are the different expression of one unique disease or if they are distinct conditions. Today, although MC represents a consistent health problem, being responsible for a large part of gastroenterological consultations for diarrhea, it remains often underestimated...
March 2019: Minerva Gastroenterologica e Dietologica
Jennifer C Price, Phyllis C Tien
Evidence is emerging that statins may reduce liver-related adverse outcomes in individuals with chronic liver disease. In this issue of the American Journal of Gastroenterology, Kamal et al. found in their meta-analysis that statin use was associated with a reduced risk of fibrosis progression, decompensated cirrhosis, and mortality. These encouraging findings suggest beneficial liver effects of statins. However, the overall quality of the evidence is low because 9 of the 10 studies included in the meta-analysis were observational...
October 2017: American Journal of Gastroenterology
Daisuke Asaoka, Akihito Nagahara, Mariko Hojo, Kenshi Matsumoto, Hiroya Ueyama, Kohei Matsumoto, Kentaro Izumi, Tsutomu Takeda, Hiroyuki Komori, Yoichi Akazawa, Yuji Shimada, Taro Osada, Sumio Watanabe
BACKGROUND: Because of a change in lifestyle, especially adoption of westernized eating habits, lifestyle-related diseases have become increasingly prevalent. The aim of this study was to investigate the association of medications for lifestyle-related diseases with reflux esophagitis (RE). METHODS: We conducted a hospital-based, cross-sectional retrospective study of consecutive outpatients who received an upper gastrointestinal endoscopy in our department from February 2008 to November 2014, which was performed by one specialist who was a member of the Japan Gastroenterological Endoscopy Society...
2016: Therapeutics and Clinical Risk Management
Hamed Khalili
In addition to cholesterol depletion, statins also significantly decrease systemic inflammation as measured by C-reactive protein. In this issue of American Journal of Gastroenterology, Ungaro et al. present their results on the associations between statin prescriptions and risk of Crohn's disease (CD) and ulcerative colitis (UC). Using a national medical claims and pharmacy database created by Symphony Health Solutions LLC (SHA), they show that any use of statin is protective against diagnosis of CD and UC...
October 2016: American Journal of Gastroenterology
A A Svistunov, M A Osadchuk, N V Kireeva
We present the analytical review of non-cardial effects of statins used in gastroenterology with the data illustrating their high antibacterial activity as exemplified by combined therapy of conditions associated with Helicobacter pylori infection. Special emphasis is laid on anti-inflammatory and oncoprotective mechanisms of statin action that are successfully made use of for the treatment of liver, pancreas, gallbladder, and biliary system diseases. Prophylactic aspects of statin application to overcome an addiction to fast food are discussed...
2016: Klinicheskaia Meditsina
Barbara Farrell, Corey Tsang, Lalitha Raman-Wilms, Hannah Irving, James Conklin, Kevin Pottie
Polypharmacy and inappropriate medication use among older adults contribute to adverse drug reactions, falls, cognitive impairment, noncompliance, hospitalization and mortality. While deprescribing - tapering, reducing or stopping a medication - is feasible and relatively safe, clinicians find it difficult to carry out. Deprescribing guidelines would facilitate this process. The aim of this paper is to identify and prioritize medication classes where evidence-based deprescribing guidelines would be of benefit to clinicians...
2015: PloS One
Rajesh Tota-Maharaj, Bhooshan Perera, Jeffrey Murray, Joann Petrini, Andrew M Keller
BACKGROUND: There is little data to support Troponin I (TNI) use in the management of noncardiac patients. We studied the use of TNI in patients on our gastroenterology service, to determine whether there was a change in management as a result of TNI testing. METHODOLOGY: Patients admitted from September 2011 to June 2012 to our gastroenterology service who had TNI performed were included. Data collected included symptoms, cardiovascular risk factors, medical treatment, and testing...
December 2014: Critical Pathways in Cardiology
Frank K Friedenberg, Mandeep Singh, Nina S George, Abhinav Sankineni, Swetang Shah
BACKGROUND: The American College of Gastroenterology recommends colorectal cancer (CRC) screening for average-risk black Americans ages 45-49. This is based on this group's younger age for the development of adenomas and CRC. Our purpose was to determine the yield of CRC screening in average-risk black Americans including those <age 50. We also aimed to identify whether there was a higher prevalence of proximal adenomas in black Americans. STUDY: This was a cross-sectional, retrospective study...
February 2012: Digestive Diseases and Sciences
O S Descamps, S Tenoutasse, X Stephenne, I Gies, V Beauloye, M-C Lebrethon, C De Beaufort, K De Waele, A Scheen, E Rietzschel, A Mangano, J P Panier, J Ducobu, M Langlois, J-L Balligand, P Legat, V Blaton, E Muls, L Van Gaal, E Sokal, R Rooman, Y Carpentier, G De Backer, F R Heller
UNLABELLED: Since heterozygous familial hypercholesterolemia (HeFH) is a disease that exposes the individual from birth onwards to severe hypercholesterolemia with the development of early cardiovascular disease, a clear consensus on the management of this disease in young patients is necessary. In Belgium, a panel of paediatricians, specialists in (adult) lipid management, general practitioners and representatives of the FH patient organization agreed on the following common recommendations...
October 2011: Atherosclerosis
L A Zvenigorodskaia, N G Samsonova, L I Efremov, E A Cherkashova, L B Lazebnik
The pathogenesis of atherosclerosis has been studied for over a hundred years, but so far no consensus on this issue doesn't exist. During this time, experts have gone from ideas of atherogenesis as a consequence of excess cholesterol in the diet to complex theories of the pathogenesis of atherosclerosis. Today generally accepted that one of the major risk factor for cardiovascular disease and atherosclerosis is dyslipidemia. When atherogenic dyslipidemia occur expressed disbiotic changes intestine and lead to endotoxemia, bacterial translocation and impaired liver function...
2011: Experimental & Clinical Gastroenterology
Elizabeth B Windgassen, Luciana Funtowicz, Tisha N Lunsford, Lucinda A Harris, Sharon L Mulvagh
The measurement of C-reactive protein (CRP) using both standard and high-sensitivity CRP (hs-CRP) assays is becoming common in clinical practice. This article addresses the causes of CRP elevation and the use of different CRP assays in internal medicine, including cardiology, gastroenterology, rheumatology, infectious diseases, and oncology. We focus on the recent medical literature on the use of hs-CRP in cardiovascular disease risk stratification and management, including updated screening guidelines on the use of hs-CRP, such as those issued in 2009 by the Canadian Cardiovascular Society...
January 2011: Postgraduate Medicine
A Ponnuswamy, R Manikandan, A Sabetpour, I M Keeping, J P Finnerty
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is increasing in incidence. One of the authors noted that many of his patients with IPF were taking statins, and suspected an association. A case-control study was undertaken to investigate the association of statins with interstitial lung disease. METHODS: The study population comprised patients attending the respiratory outpatients diagnosed with IPF between the beginning of 1999 and the beginning of July 2004, and 50 cases were identified...
April 2009: Respiratory Medicine
T Fuehner, T Welte, A Simon, J Gottlieb
Intestinal perforation after lung transplantation is common in elderly patients with diverticulitis. The distal intestinal obstruction syndrome (DIOS) is a current complication in patients with cystic fibrosis. Myelosuppressive drugs as in most immunosuppressive regimens can cause cytopenia. Thrombotic microangiopathy is often caused by immunosuppressive regimen with a calcineurin-inhibitor in combination with a proliferation signal-inhibitor. Although renal failure and neurological symptoms are often additional side effects of the immunosuppressive therapy there are no reliable data on CNI-free protocols...
April 2008: Deutsche Medizinische Wochenschrift
F López-Jiménez, M Brito, Y W Aude, P Scheinberg, M Kaplan, D A Dixon, N Schneiderman, J F Trejo, L H López-Salazar, E J Ramírez-Barba, R Kalil, C Ortiz, J Goyos, A Buenaño, S Kottiech, G A Lamas
More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes...
July 2000: Archives of Medical Research
M L Petroni, R P Jazrawi, P Pazzi, M Zuin, A Lanzini, M Fracchia, D Facchinetti, V Alvisi, R Ferraris, J M Bland, K W Heaton, M Podda, T C Northfield
OBJECTIVE: To assess risk factors for gallstone recurrence following non-surgical treatment. DESIGN: A prospective follow-up of a multicentre cohort of post-dissolution gallstone patients. SETTING: Six gastroenterology units in the UK and Italy. PARTICIPANTS: One hundred and sixty-three patients with confirmed gallstone dissolution following non-surgical therapy (bile acids or lithotripsy plus bile acids), followed up by ultrasound scan and clinical assessment at 6-monthly intervals for up to 6 years (median, 25 months; range, 6-70 months)...
June 2000: European Journal of Gastroenterology & Hepatology
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