keyword
https://read.qxmd.com/read/38512763/breaking-the-barriers-the-role-of-gut-homeostasis-in-metabolic-associated-steatotic-liver-disease-masld
#1
REVIEW
Raquel Benedé-Ubieto, Francisco Javier Cubero, Yulia A Nevzorova
Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), a growing health concern. The complex progression of MASLD extends beyond the liver, driven by "gut-liver axis," where diet, genetics, and gut-liver interactions influence disease development. The pathophysiology of MASLD involves excessive liver fat accumulation, hepatocyte dysfunction, inflammation, and fibrosis, with subsequent risk of hepatocellular carcinoma (HCC)...
2024: Gut Microbes
https://read.qxmd.com/read/38493812/irisin-delays-the-onset-of-type-1-diabetes-in-nod-mice-by-enhancing-intestinal-barrier
#2
JOURNAL ARTICLE
Yujing Sun, Yilin Wang, Ziang Lin, Fuhua Zhang, Yan Zhang, Tongxin Ren, LiNa Wang, Qincheng Qiao, Mengyang Shen, Juncheng Wang, Youchen Song, Yu Sun, Peng Lin
Type 1 diabetes (T1D), a complex autoimmune disease, is intricately linked to the gut's epithelial barrier function. Emerging evidence emphasizes the role of irisin, an exercise-related hormone, in preserving intestinal integrity. This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed T1D patients and non-obese diabetic (NOD) mice, worsening with age and accompanied by islet inflammation. Using an LPS-induced colonic inflammation model, a dose-dependent impact of LPS on colon cells irisin expression, secretion, and barrier function was revealed...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38468112/urolithin-a-ameliorates-athletic-ability-and-intestinal-microbiota-in-sleep-deprivation-from-the-perspective-of-the-gut-muscle-axis
#3
JOURNAL ARTICLE
Hongkang Zhu, Haotian Zhao, He Qian, Chang Liu
SCOPE: Urolithin A (UA), a gut-microbiota-derived metabolite of ellagic acid, presents various benefits to intestinal microecology. The presence of "gut-muscle axis" regulating the onset and progression of exercise-related physical frailty and sarcopenia has been recently hypothesized. This study aims to explore the underlying mechanism of gut-muscle axis by which UA enhances muscle strength and fatigue resistance of sleep-deprived (SD) mice. METHODS AND RESULTS: UA is gavaged to C57BL/6 mice (50 mg kg-1  bw) before 48-h SD...
March 11, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38427981/safety-and-efficacy-of-a-probiotic-cocktail-containing-p-acidilatici-and-l-plantarum-for-gastrointestinal-discomfort-in-endurance-runners-randomized-double-blinded-crossover-clinical-trial
#4
JOURNAL ARTICLE
Sarah Lennon, Thomas Lackie, Adriana Miltko, Zoey Cameron Kearns, Maxime Paquette, Richard J Bloomer, Anyou Wang, Marie van der Merwe
Probiotics are increasingly used to treat conditions associated with gastrointestinal injury and permeability, including exercise-induced gastrointestinal discomfort. This study assessed safety and efficacy of a probiotic in altering the intestinal milieu and mitigating gastrointestinal symptoms in endurance runners. In a double blind, crossover study, sixteen runners were randomized to 4 weeks of daily supplementation with a probiotic cocktail containing P. acidilatici and L. plantarum or placebo. Fasting blood, and stool samples were collected for measurement of gut permeability markers, immune parameters, and microbiome analyses...
March 1, 2024: Applied Physiology Nutrition and Metabolism
https://read.qxmd.com/read/38386104/effects-of-bovine-whey-protein-on-exercise-induced-gut-permeability-in-healthy-adults-a-randomised-controlled-trial
#5
JOURNAL ARTICLE
Dulantha Ulluwishewa, Grayson Nicholls, Harold Henderson, Daniel Bernstein, Karl Fraser, Matthew P G Barnett, Matthew J Barnes
PURPOSE: Intestinal permeability is a critical component of gut barrier function. Barrier dysfunction can be triggered by certain stressors such as exercise, and if left unmanaged can lead to local and systemic disorders. The aim of this study was to investigate the effects of a specific whey protein fraction in alleviating exercise-induced gut permeability as assessed by recovery of lactulose/rhamnose (L/R) and lactulose/mannitol (L/M) urinary probes. METHODS: Eight males and eight females (aged 18-50) completed two arms of a double-blind, placebo-controlled, crossover study...
February 22, 2024: European Journal of Applied Physiology
https://read.qxmd.com/read/37930804/too-hot-to-handle-unveiling-gut-permeability-during-exertional-heat-stress
#6
JOURNAL ARTICLE
Vito A Pipitone, Daniel L Scurto, Fasih A Rahman
No abstract text is available yet for this article.
November 6, 2023: Journal of Physiology
https://read.qxmd.com/read/37885441/combined-probiotics-with-vitamin-d-3-supplementation-improved-aerobic-performance-and-gut-microbiome-composition-in-mixed-martial-arts-athletes
#7
JOURNAL ARTICLE
Katarzyna Przewłócka, Marcin Folwarski, Mariusz Kaczmarczyk, Karolina Skonieczna-Żydecka, Joanna Palma, Zofia Kinga Bytowska, Sylwester Kujach, Jan Jacek Kaczor
INTRODUCTION: Mixed Martial Arts (MMA) is characterized as an interval sport in which the training program focuses on enhancing both aerobic and anaerobic capacities. Therefore, strategies targeting the intestinal microbiome may be beneficial for MMA athletes. Moreover, vitamin D supplementation may amplify the positive effects of certain bacterial strains. We previously demonstrated that the combined of probiotics and vitamin D3 supplementation improved the lactate utilization ratio, total work, and average power achieved during anaerobic tests in MMA...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37839038/what-if-gastrointestinal-complications-in-endurance-athletes-were-gut-injuries-in-response-to-a-high-consumption-of-ultra-processed-foods-please-take-care-of-your-bugs-if-you-want-to-improve-endurance-performance-a-narrative-review
#8
REVIEW
Jesús Álvarez-Herms, A González-Benito, F Corbi, A Odriozola
To improve performance and recovery faster, athletes are advised to eat more often than usual and consume higher doses of simple carbohydrates, during and after exercise. Sports energetic supplements contain food additives, such as artificial sweeteners, emulsifiers, acidity regulators, preservatives, and salts, which could be harmful to the gut microbiota and impair the intestinal barrier function. The intestinal barrier plays a critical function in bidirectionally regulation of the selective transfer of nutrients, water, and electrolytes, while preventing at the same time, the entrance of harmful substances (selective permeability)...
October 15, 2023: European Journal of Applied Physiology
https://read.qxmd.com/read/37836487/dark-chocolate-intake-positively-modulates-gut-permeability-in-elite-football-athletes-a-randomized-controlled-study
#9
JOURNAL ARTICLE
Cristina Nocella, Elena Cavarretta, Chiara Fossati, Fabio Pigozzi, Federico Quaranta, Mariangela Peruzzi, Fabrizio De Grandis, Vincenzo Costa, Carwyn Sharp, Massimo Manara, Antonia Nigro, Vittoria Cammisotto, Valentina Castellani, Vittorio Picchio, Sebastiano Sciarretta, Giacomo Frati, Simona Bartimoccia, Alessandra D'Amico, Roberto Carnevale
Gut barrier disruption can lead to enhanced intestinal permeability, which allows endotoxins, pathogens, and other proinflammatory substances to move through the intestinal barrier into circulation. Intense exercise over a prolonged period increases intestinal permeability, which can be further worsened by the increased production of reactive oxygen species (ROS) and pro-inflammatory cytokines. The aim of this study was to assess the degree of intestinal permeability in elite football players and to exploit the effect of cocoa polyphenols on intestinal permeability induced by intensive physical exercise...
September 28, 2023: Nutrients
https://read.qxmd.com/read/37667506/antidepressant-properties-of-voluntary-exercise-mediated-by-gut-microbiota
#10
JOURNAL ARTICLE
Chihiro Watanabe, Eri Oyanagi, Takafumi Aoki, Hiroki Hamada, Masato Kawashima, Takashi Yamagata, Michel J Kremenik, Hiromi Yano
Although regular exercise has been reported to prevent depression, it has not been clarified whether the gut microbiota is involved in the factors that prevent depression through exercise. We investigated the effects of voluntary exercise on the gut microbiota and the prevention of depression-like behaviors using mice. C57BL/6 J male mice were subjected to 10 weeks of sedentary control or wheel running, then they were subjected to social defeat stress (SDS). Exercise attenuated that sucrose drinking was decreased by SDS treatment...
September 4, 2023: Bioscience, Biotechnology, and Biochemistry
https://read.qxmd.com/read/37476875/resveratrol-attenuated-high-intensity-exercise-training-induced-inflammation-and-ferroptosis-via-nrf2-fth1-gpx4-pathway-in-intestine-of-mice
#11
JOURNAL ARTICLE
Zhe Xu, Xiaonan Sun, Bin Ding, Ming Zi, Yan Ma
BACKGROUND: Moderate exercise has beneficial effects for human health and is helpful for the protection against several diseases. However, high intensity exercise training caused gastrointestinal syndrome. Resveratrol, a plant extract, plays a vital role in protecting various organs. However, whether resveratrol protected mice against high intensity exercise training-induced intestinal damage remains unclear. In this study, our objective was to investigate the protective effects and mechanism of resveratrol in high intensity exercise training-treated mice...
April 2023: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/37274680/walking-200%C3%A2-min-per-day-keeps-the-bariatric-surgeon-away
#12
JOURNAL ARTICLE
Daniel H Pfaff, Gernot Poschet, Rüdiger Hell, Julia Szendrödi, Aurelio A Teleman
Exercise and increased physical activity are vital components of the standard treatment guidelines for many chronic diseases such as diabetes, obesity and cardiovascular disease. Although strenuous exercise cannot be recommended to people with numerous chronic conditions, walking is something most people can perform. In comparison to high-intensity training, the metabolic consequences of low-intensity walking have been less well studied. We present here a feasibility study of a subject who performed an exercise intervention of low-intensity, non-fatiguing walking on a deskmill/treadmill for 200 min daily, approximately the average time a German spends watching television per day...
June 2023: Heliyon
https://read.qxmd.com/read/37217446/amino-acid-solution-mitigates-hypothermia-response-and-intestinal-damage-following-exertional-heat-stroke-in-male-mice
#13
JOURNAL ARTICLE
Michelle A King, Astrid Grosche, Shauna M Ward, Jermaine A Ward, Anusree Sasidharan, Thomas A Mayer, Mark L Plamper, Xiaodong Xu, Matthew D Ward, Thomas L Clanton, Sadasivan Vidyasagar
Increased gut permeability is implicated in the initiation and extent of the cytokine inflammatory response associated with exertional heat stroke (EHS). The primary objective of this study was to determine if a five amino acid oral rehydration solution (5AAS), specifically designed for the protection of the gastrointestinal lining, would prolong time to EHS, maintain gut function and dampen the systemic inflammatory response (SIR) measured during EHS recovery. Male C57/BL6J mice instrumented with radiotelemetry were gavaged with 150 μL of 5AAS or H2 O, and ≈12 h later were either exposed to an EHS protocol where mice exercised in a 37...
May 2023: Physiological Reports
https://read.qxmd.com/read/37174325/effects-of-probiotic-supplementation-on-exercise-and-the-underlying-mechanisms
#14
REVIEW
Li Zhang, Ruhao Zhang, Lu Li
Long-term, high-intensity exercise can trigger stress response pathways in multiple organs, including the heart and lungs, gastrointestinal tract, skeletal muscle, and neuroendocrine system, thus affecting their material and energy metabolism, immunity, oxidative stress, and endocrine function, and reducing exercise function. As a natural, safe, and convenient nutritional supplement, probiotics have been a hot research topic in the field of biomedical health in recent years. Numerous studies have shown that probiotic supplementation improves the health of the body through the gut-brain axis and the gut-muscle axis, and probiotic supplementation may also improve the stress response and motor function of the body...
April 25, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/37080945/the-muscle-gut-brain-axis-and-psychiatric-illness
#15
REVIEW
Mary Scriven, Angela McSweeney, Therese O'Carroll, Sabrina Morkl, Mary I Butler
The microbiota-gut-brain axis (MGBA) has been the subject of much research over the past decade, offering an exciting new paradigm for the treatment of psychiatric disorders. In this review, the MGBA is extended to include skeletal muscle and the potential role of an expanded "muscle-gut-brain axis" (MuGBA) in conditions such as anxiety and depression is discussed. There is evidence, from both preclinical and human studies, of bidirectional links between the gut microbiome and skeletal muscle function and structure...
April 20, 2023: Advanced biology
https://read.qxmd.com/read/37061651/the-effect-of-gut-training-and-feeding-challenge-on-markers-of-gastrointestinal-status-in-response-to-endurance-exercise-a-systematic-literature-review
#16
Isabel G Martinez, Alice S Mika, Jessica R Biesiekierski, Ricardo J S Costa
BACKGROUND: Nutrition during exercise is vital in sustaining prolonged activity and enhancing athletic performance; however, exercise-induced gastrointestinal syndrome (EIGS) and exercise-associated gastrointestinal symptoms (Ex-GIS) are common issues among endurance athletes. Despite this, there has been no systematic assessment of existing trials that examine the impact of repetitive exposure of the gastrointestinal tract to nutrients before and/or during exercise on gastrointestinal integrity, function, and/or symptoms...
June 2023: Sports Medicine
https://read.qxmd.com/read/36994745/gut-microbiota-and-hypertension-association-mechanisms-and-treatment
#17
REVIEW
Zhihua Yang, Qingchun Wang, Yangxi Liu, Lin Wang, Zhao Ge, Zhenzhen Li, Shaoling Feng, Chongming Wu
OBJECTIVES: Hypertension is one of the most important risk factors for cardio-cerebral vascular diseases, which brings a heavy economic burden to society and becomes a major public health problem. At present, the pathogenesis of hypertension is unclear. Increasing evidence has proven that the pathogenesis of hypertension is closely related to the dysbiosis of gut microbiota. We briefly reviewed relevant literature on gut microbiota and hypertension to summarize the relationship between gut microbiota and hypertension, linked the antihypertension effects of drugs with their modulation on gut microbiota, and discussed the potential mechanisms of various gut microbes and their active metabolites to alleviate hypertension, thus providing new research ideas for the development of antihypertension drugs...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/36899808/dietary-fermentation-product-of-aspergillus-oryzae-prevents-increases-in-gastrointestinal-permeability-leaky-gut-in-horses-undergoing-combined-transport-and-exercise
#18
JOURNAL ARTICLE
Melissa McGilloway, Shannon Manley, Alyssa Aho, Keisha N Heeringa, Lynsey Whitacre, Yanping Lou, E James Squires, Wendy Pearson
Equine leaky gut syndrome is characterized by gastrointestinal hyperpermeability and may be associated with adverse health effects in horses. The purpose was to evaluate the effects of a prebiotic Aspergillus oryzae product (SUPP) on stress-induced gastrointestinal hyperpermeability. Eight horses received a diet containing SUPP (0.02 g/kg BW) or an unsupplemented diet (CO) (n = 4 per group) for 28 days. On Days 0 and 28, horses were intubated with an indigestible marker of gastrointestinal permeability (iohexol)...
March 6, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/36869551/effects-of-prebiotics-on-intestinal-physiology-neuropsychological-function-and-exercise-capacity-of-mice-with-sleep-deprivation
#19
JOURNAL ARTICLE
Yi Chung, Jia-Ling Wu, Wen-Ching Huang
People suffered from insufficient or disrupted sleep due to night shifts, work pressure, and irregular lifestyles. Sleep deprivation caused by inadequate quantity or quality of sleep has been associated with not only increased risk of metabolic diseases, gut dysbiosis, and emotional disorders but also decreased work and exercise performance. In this study, we used the modified multiple platform method (MMPM) to induce pathological and psychological characteristics of sleep deprivation with C57BL/6J male mice, and investigated whether supplementing a prebiotics mixture of short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) (9:1 ratio) could improve the impacts of sleep deprivation on intestinal physiology, neuropsychological function, inflammation, circadian rhythm, and exercise capacity...
March 2023: Food Research International
https://read.qxmd.com/read/36822132/dysbiosis-and-leaky-gut-in-hyper-inflated-copd-patients-have-smoking-and-exercise-training-any-role
#20
JOURNAL ARTICLE
Laura Comini, Evasio Pasini, Roberto Porta, Adriana Olivares, Cristian Testa, Simonetta Scalvini, Michele Vitacca
BACKGROUND: To characterize the leaky gut syndrome in a cohort of COPD patients with lung hyperinflation according to their clinical history (i.e. hyperinflation severity, chronic respiratory failure [CRF] presence, GOLD stage, prescribed therapy, smoking history) and with or without recent exercise training activity. METHODS: At the ambulatory visit, we evaluated selected COPD patients with lung hyperinflation [residual volume (RV)≥110% pred, TLC≤120% pred)] in clinical stability, identifying them as those who have attended a recent program of exercise training and those who were waiting for it...
January 9, 2023: Respiratory medicine and research
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