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Keywords Vancomycin AND outcome AND Mor...

Vancomycin AND outcome AND Mortality

https://read.qxmd.com/read/38317197/role-of-multidrug-resistant-bacteria-in-weaning-from-invasive-mechanical-ventilation
#21
JOURNAL ARTICLE
Julia D Michels-Zetsche, Vicky Gassmann, Jasmin K Jasuja, Benjamin Neetz, Philipp Höger, Jan Meis, Simone Britsch, Urte Sommerwerck, Sebastian Fähndrich, Florian Bornitz, Michael M Müller, Felix J F Herth, Franziska C Trudzinski
BACKGROUND: Although multidrug-resistant bacteria (MDR) are common in patients undergoing prolonged weaning, there is little data on their impact on weaning and patient outcomes. METHODS: This is a retrospective analysis of consecutive patients who underwent prolonged weaning and were at a university weaning centre from January 2018 to December 2020. The influence of MDR colonisation and infection on weaning success (category 3a and 3b), successful prolonged weaning from invasive mechanical ventilation (IMV) with or without the need for non-invasive ventilation (NIV) compared with category 3c (weaning failure 3cI or death 3cII) was investigated...
February 5, 2024: Respiratory Research
https://read.qxmd.com/read/38313906/staphylococcus-hemolyticus-the-most-common-and-resistant-coagulase-negative-staphylococcus-species-causing-bacteremia-in-north-india
#22
JOURNAL ARTICLE
Anuragani Verma, Sanjay Kumar, Vimala Venkatesh, Parul Jain, RajKumar Kalyan, Himanshu Reddy
INTRODUCTION: Coagulase-negative Staphylococcus (CoNS) species are normal skin commensals but may also cause bacteremia. Therefore, isolating a CoNS species on blood culture often leads to a diagnostic dilemma about whether to consider the isolate as a true pathogen or not. This study was done to understand the distribution of various CoNS species in bloodstream infections, determine their antibiotic resistance patterns, and identify possible risk factors and patient outcomes in hospital settings...
January 2024: Curēus
https://read.qxmd.com/read/38309732/epidemiology-of-clostridioides-difficile-infection-at-a-tertiary-care-facility-in-saudi-arabia-results-of-prospective-surveillance
#23
MULTICENTER STUDY
Naoufel M Kaabia, Hanadi Al Basha, Dalal A Bukhari, Nabiha Bouafia, Aeshah N Al Qahtani, Ahmad M Alshahrani, Ismail M Aboushanab, Abdulrahman N Al Odayani
OBJECTIVES: To determine the incidence of Clostridioides difficile infection (CDI) and the frequency of known risk factors. METHODS: A prospective hospital-based surveillance for CDI, according to the Centers for Disease Control and Prevention criteria, was carried out from July 2019 to March 2022 for all inpatients aged more than one year in Prince Sultan Military Medical City, Riyadh, Saudi Arabia. RESULTS: A total of 139 cases of CDI were identified during the survey among 130 patients admitted in the hospital...
February 2024: Saudi Medical Journal
https://read.qxmd.com/read/38304681/tuberculous-meningitis-an-endemic-cause-of-intracranial-hypertension
#24
Miguel Costa, João Pedro Caria, João Bilardo Caiano, Alexandra Caeiro, Fernando Maltez
Tuberculous meningitis (TBM) presents a complex clinical scenario, often marked by delayed recognition and high mortality. Our case involves a 27-year-old woman from Nepal with no significant medical history, presented with a two-week history of fatigue, altered consciousness, dizziness, vomiting, fever, holocranial headache, and photophobia. Initial examination revealed signs consistent with meningitis, including fever, hypertensive state, prostration, bilateral exophthalmos, sixth cranial nerve paresis, and positive Kernig/Brudzinski signs...
January 2024: Curēus
https://read.qxmd.com/read/38297970/the-purine-biosynthesis-repressor-purr-contributes-to-vancomycin-susceptibility-of-methicillin-resistant-staphylococcus-aureus-in-experimental-endocarditis
#25
JOURNAL ARTICLE
Yan Q Xiong, Yi Li, Mariya I Goncheva, Ahmed M Elsayed, Fengli Zhu, Liang Li, Wessam Abdelhady, Ronald S Flannagan, Michael R Yeaman, Arnold S Bayer, David E Heinrichs
BACKGROUND: Staphylococcus aureus is the most common cause of life-threatening endovascular infections, including infective endocarditis (IE). These infections, especially when caused by methicillin-resistant strains (MRSA), feature limited therapeutic options and high morbidity and mortality rates. METHODS: Herein, we investigated the role of the purine biosynthesis repressor, PurR, in virulence factor expression and vancomycin (VAN) treatment outcomes in experimental IE due to MRSA...
January 31, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38258968/comparison-of-morbidity-and-mortality-after-bloodstream-infection-with-vancomycin-resistant-versus-susceptible-enterococcus-faecium-a-nationwide-cohort-study-in-denmark-2010-2019
#26
JOURNAL ARTICLE
Peter Bager, Jonas Kähler, Mikael Andersson, Barbara Juliane Holzknecht, Sanne Grønvall Kjær Hansen, Kristian Schønning, Karen Leth Nielsen, Kristoffer Koch, Mette Pinholt, Marianne Voldstedlund, Anders Rhod Larsen, Brian Kristensen, Kåre Mølbak, Ute Wolff Sönksen, Sissel Skovgaard, Robert Skov, Anette M Hammerum
(unstructured)The emergence of bloodstream infections (BSI) caused by vancomycin-resistant Enterococci (VRE) has caused concern. Nonetheless, it remains unclear whether these types are associated with an excess risk of severe outcomes when compared with infections caused by vancomycin-susceptible Enterococci (VSE). This cohort study included hospitalised patients in Denmark with Enterococcus faecium positive blood cultures collected between 2010 and 2019 identified in the Danish Microbiology Database. We estimated the 30-day hazard ratio (HR) of death or discharge among VRE compared to VSE patients adjusted for age, sex, and comorbidity...
January 23, 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38251409/vancomycin-auc-based-dosing-practices-in-a-non-teaching-community-hospital-and-associated-outcomes-a-one-year-survey-of-uniform-targets-for-infections-with-or-without-mrsa
#27
JOURNAL ARTICLE
Iftekharul Islam
BACKGROUND: Intravenous (IV) vancomycin area under the curve (AUC)-based dosing is used uniformly for Gram-positive organisms in non-teaching community hospitals. However, evidence for using vancomycin AUC-based dosing for non-methicillin-resistant Staphylococcus aureus ( non-MRSA ) and less serious infections is limited in the literature. A gap in the literature also exists with respect to comparisons between the outcomes that can be derived using the regimens suggested by Bayesian programs and target doses of the AUC of 400-499 and 500-600...
January 17, 2024: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/38250624/partial-oral-versus-full-intravenous-antibiotic-treatment-of-endocarditis-in-people-who-inject-drugs-a-systematic-review
#28
JOURNAL ARTICLE
Amy Brown, Hallie L Jefferson, Peter Daley, William Dt Kent, Duncan Webster, Corey Adams
BACKGROUND: Prolonged intravenous (IV) antibiotic therapy may not be optimal for people who inject drugs (PWID) with infective endocarditis (IE) due to unique social and medical needs. The role of partial IV antibiotic therapy with continued oral (PO) antibiotic therapy is unclear. METHODS: A systematic review was performed using EMBASE and MEDLINE databases. Included studies compared PO to IV antibiotic treatment for IE in PWID. RESULTS: Four studies met eligibility...
January 2024: Journal of the Association of Medical Microbiology and Infectious Disease Canada, Journal officiel de l’Association pour la microbiologie médicale et l’infectiologie Canada
https://read.qxmd.com/read/38250202/model-informed-precision-dosing-improves-outcomes-in-patients-receiving-vancomycin-for-gram-positive-infections
#29
JOURNAL ARTICLE
Nicole M Hall, Matthew L Brown, W Seth Edwards, Robert A Oster, Will Cordell, Joshua Stripling
BACKGROUND: Consensus guidelines for dosing and monitoring of vancomycin recommend collection of 2 serum concentrations to estimate an area under the curve/minimum inhibitory concentration ratio (AUC/MIC). Use of Bayesian software for AUC estimation and model-informed precision dosing (MIPD) enables pre-steady state therapeutic drug monitoring using a single serum concentration; however, data supporting this approach are limited. METHODS: Adult patients with culture-proven gram-positive infections treated with vancomycin ≥72 hours receiving either trough-guided or AUC-guided therapy were included in this retrospective study...
January 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38247610/improving-clostridioides-difficile-infectious-disease-treatment-response-via-adherence-to-clinical-practice-guidelines
#30
JOURNAL ARTICLE
Dalia Adukauskienė, Rytis Mickus, Asta Dambrauskienė, Tomas Vanagas, Agnė Adukauskaitė
Clostridioides difficile ( C. difficile ) is a predominant nosocomial infection, and guidelines for improving diagnosis and treatment were published in 2017. We conducted a single-center, retrospective 10-year cohort study of patients with primary C. difficile infectious disease (CDID) at the largest referral Lithuanian university hospital, aiming to evaluate the clinical and laboratory characteristics of CDID and their association with the outcomes, as well as implication of concordance with current Clinical Practice Guidelines...
January 4, 2024: Antibiotics
https://read.qxmd.com/read/38223860/impact-of-limiting-vancomycin-loading-doses-in-patients-with-methicillin-resistant-staphylococcus-aureus-infections-after-hospital-protocol-revision
#31
JOURNAL ARTICLE
Alec R Raley, Matthew L Brown, Morgan Frawley, Robert A Oster, William Seth Edwards
Background: Vancomycin loading doses are commonly used to quickly attain target serum concentrations; however, data supporting their effect on clinical patient outcomes is limited. In April 2020, our institution revised our pharmacist-driven vancomycin dosing protocol to reserve loading doses for hemodynamically unstable patients with suspected serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Prior to the protocol update, all patients treated with vancomycin at our institution received a weight-based loading dose...
February 2024: Hospital Pharmacy
https://read.qxmd.com/read/38186930/prevalence-risk-factors-and-outcomes-of-acute-kidney-injury-in-a-pediatric-cardiac-intensive-care-unit-a-cross-sectional-study
#32
JOURNAL ARTICLE
Zahra Esmaeili, Fahimeh Asgarian, Ehsan Aghaei Moghadam, Amirali Khosravi, Behdad Gharib
BACKGROUND AND AIMS: Acute kidney injury (AKI) is a common complication in pediatric cardiac intensive care unit (CICU). This study aims to identify the prevalence, risk factors, and outcomes of AKI in pediatrics admitted to a CICU unit of a tertiary hospital. METHODS: We retrospectively gathered the data of 253 randomly selected patients admitted to the CICU unit from March 2018 to March 2022. Data were collected from EHRs. We used the Kidney Disease Improving Global Outcomes (KDIGO) criteria for identifying AKI in patients...
January 2024: Health Science Reports
https://read.qxmd.com/read/38166695/clinical-application-of-vancomycin-tdm-in-ventilated-patients-with-gastrointestinal-cancer-a-propensity-matched-analysis
#33
JOURNAL ARTICLE
Xiaowu Zhang, Yulin Wu, Donghao Wang
BACKGROUND: Therapeutic drug monitoring (TDM) of vancomycin is widely recommended for clinical treatment. Due to the complexity of 24-h area under the curve (AUC) guided vancomycin monitoring in clinical practice, the vancomycin trough level remains the most common and practical method. The purpose of this study was designed to investigate the differences in the safety and efficacies of vancomycin TDM based on the two different monitoring methods, and further explore the clinical application of trough-guided vancomycin monitoring in patients with gastrointestinal cancer requiring mechanical ventilation...
January 2, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38165875/a-prospective-observational-study-of-estimating-drug-related-problems-and-clinical-outcomes-in-subtypes-of-stroke-patients
#34
JOURNAL ARTICLE
Muhammad Ali, Muhammad Harris Shoaib, Shagufta Nesar, Muhammad Jamal, Sabiha Gul, Saira Shahnaz, Shoaib Nawaz, Quratulain Khan, Javaria Imran
BACKGROUND: Stroke is a neurological disease and a leading cause of mortality worldwide. Strokes mainly consist of two types: hemorrhage and ischemia. Stroke patients are being administered multiple drug therapy and are at risk of drug-related problems. AIM: To estimate drug-related problems (DRPs) and clinical end outcomes in hospitalized stroke patients. METHODS: Current study was a multicenter, cross-sectional prospective observational study including 250 stroke patients admitted to tertiary care hospitals in Karachi, Pakistan...
2024: PloS One
https://read.qxmd.com/read/38156206/association-of-vancomycin-induced-acute-kidney-injury-with-trough-versus-auc-monitoring-in-patients-receiving-extended-durations-of-therapy
#35
JOURNAL ARTICLE
C Tyler Pitcock, Aric Schadler, David S Burgess, Donna R Burgess, Sarah E Cotner, Jeremy Van Hoose, Eric R Gregory, Katie L Wallace
OBJECTIVE: Vancomycin therapy is associated with an increased risk of acute kidney injury (AKI). Previous studies suggest that area under the curve (AUC) monitoring reduces the risk of AKI, but literature is lacking to support this in patients receiving longer durations of vancomycin therapy. DESIGN: Retrospective cohort study. METHOD: Patients ≥18 years old, admitted between August 2015 and July 2017 or October 2017 and September 2019, and received at least 14 days of intravenous (IV) vancomycin therapy were included in the study...
2023: Antimicrob Steward Healthc Epidemiol
https://read.qxmd.com/read/38146377/the-emergence-of-multidrug-resistant-gram-positive-bloodstream-infections-in-india-a-single-center-prospective-cohort-study
#36
JOURNAL ARTICLE
Nakka Vihari, Gopal Krishana Bohra, Ram Ratan Yadev, Deepak Kumar, Durga Shankar Meena, Vibhor Tak, Ankur Sharma, Vijaylaxmi Nag, Mahendra Kumar Garg
INTRODUCTION: Gram-positive bloodstream infections (BSIs) are an emerging health concern, especially in resource-limited settings. There is a paucity of data regarding the antimicrobial resistance (AMR) pattern of Gram-positive BSIs. The rise in multidrug-resistant infections further convoluted antibiotic selection. We aimed to assess the incidence, clinical and microbiological profile, antimicrobial resistance (AMR) and outcome in Gram-positive BSIs. METHODS: This was a single-center prospective study conducted at a tertiary care hospital in Western India...
September 2023: Germs
https://read.qxmd.com/read/38129468/intestinal-dysbiosis-as-an-intraoperative-predictor-of-septic-complications-evidence-from-human-surgical-cohorts-and-preclinical-models-of-peritoneal-sepsis
#37
JOURNAL ARTICLE
Daniel Spari, Simone N Zwicky, Bahtiyar Yilmaz, Lilian Salm, Daniel Candinas, Guido Beldi
Major surgery exposes the intestinal microbiota to inflammatory and antibiotic stressors, which alter the microbiota composition of the intestinal lumen and fecal contents. However, it is not sufficiently understood, if such dysbiosis develops already during surgery and if alterations in microbiota may be the cause of surgical complications. End-of-surgery composition of the microbiota in the rectum was assessed in 41 patients undergoing either rectal or duodenopancreatic resection and was compared to baseline before surgery using 16S-rRNA sequencing...
December 21, 2023: Scientific Reports
https://read.qxmd.com/read/38106359/prediction-of-acute-kidney-injury-in-intracerebral-hemorrhage-patients-using-machine-learning
#38
JOURNAL ARTICLE
Suhua She, Yulong Shen, Kun Luo, Xiaohai Zhang, Changjun Luo
BACKGROUND: Acute kidney injury (AKI) is prevalent in patients with intracerebral hemorrhage (ICH) and is associated with mortality. This study aimed to verify the predictive accuracy of different machine learning algorithms for AKI in patients with ICH using a large dataset. METHODS: A total of 1366 ICH patients received treatments between 2001 and 2012 from the Medical Information Mart for Intensive Care-III (MIMIC-III) database were identified based on the ICD-9 code: 431...
2023: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38100733/elizabethkingia-meningoseptica-outbreak-in-nicu-an-observational-study-on-a-debilitating-neuroinfection-in-neonates
#39
JOURNAL ARTICLE
Manish Swami, Praneetha Mude, Shrutiprajna Kar, Sushree Sarathi, Ashoka Mohapatra, Usha Devi, Pankaj K Mohanty, Tapas K Som, Behera Bijayini, Tanushree Sahoo
BACKGROUND: Elizabethkingia meningoseptica is an emerging nosocomial pathogen implicated in neonatal sepsis with high mortality and morbidities. However, there is very limited data regarding the characteristics as well as outcomes following this infection, particularly in developing countries. METHODS: We conducted a retrospective observational study of all infants with culture-positive Elizabethkingia sepsis as part of an outbreak, to study their clinical and epidemiological characteristics, as well as their antimicrobial susceptibility patterns, using a structured proforma from the neonatal intensive care unit database...
January 1, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38094526/a-comparison-of-the-efficacy-of-treatment-with-fidaxomicin-versus-vancomycin-in-clostridioides-difficile-infection
#40
JOURNAL ARTICLE
Beatriz Diaz-Pollan, Sergio Carrasco Molina, Cristina Marcelo, Alejandro de Gea Grela, Patricia Martínez-Martín, María Jiménez-González, Francisco Moreno Ramos, Marta Mora-Rillo
Background Clostridioides difficile infection (CDI) is a major cause of diarrhea in hospitalized adult patients. This study aims to evaluate the clinical characteristics, clinical cure, recurrence and mortality in patients with CDI treated with either fidaxomicin or vancomycin. Methods A retrospective case-control study was conducted on patients with CDI treated with either fidaxomicin or vancomycin at a hospital from January 2019 to March 2022. Results We assessed 140 patients with CDI episodes, 70 patients treated with fidaxomicin and 70 with vancomycin...
November 2023: Curēus
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