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Serotonine Bone

Samar M Koura, Mohamed Salama, Mahmoud El-Hussiny, Mahmoud El-Sayed Awad Khalil, Ahmed Lotfy, Samia Ahmed Hassan, Seham Aly Gad Elhak, Mohamed A Sobh
Selective serotonin reuptake inhibitors are the most commonly prescribed antidepressants worldwide, which have been reported to exert potential detrimental effects on bone mineral density and increase the risk of developing fractures. The present study aimed to investigate the pathways underlying the negative effects of fluoxetine on bone using mesenchymal stem cells (MSCs) derived from rat adipose tissue as a source of osteoprogenitor cells. MSCs were harvested from adipose tissue using a collagenase enzyme digestion method and were allowed to differentiate into osteoprogenitor cells...
February 1, 2019: Molecular Medicine Reports
Farzaneh Mahikhan, Morteza Hashemian, Tania Dehesh, Elham Jafari, Mandana Jafari, Hamid Reza Rahimi
BACKGROUND: Serotonin 5-HT3 receptor antagonists such as ondansetron have been investigated to attenuate opioid withdrawal signs in studies. OBJECTIVE: Therefore, we designed a randomized double-blinded placebo-controlled trial to evaluate this effect in opioid-addicted patients who were admitted to orthopedic department for surgery due to bone fractures. METHOD: Male adults who were addicted to opioids, aged 18 to 79 years were enrolled (n=96) and randomized into two oral doses (4 & 8 mg) of ondansetron (n=32) and placebo (n=32)...
January 31, 2019: Current Clinical Pharmacology
Antônio Carlos Melo Lima Filho, Irismara Sousa Silva, Francisca Beatriz Melo Sousa, Luan Kelves Miranda de Souza, Bruno da Silva Gomes, Rodrigo Lopes Gomes Gonçalves, Diana Carvalho de Rezende, Francisco Valmor Macedo Cunha, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Jand Venes-Rolim Medeiros, Damião Pergentino de Sousa, Francisco de Assis Oliveira
BACKGROUND: It is well known that medicinal plants and their products are relevant candidates for the treatment of inflammatory conditions. Ethyl p-coumarate is a phenylpropanoid that has similar structure to others anti-inflammatory and antioxidant substances. However, these activities have never been tested. PURPOSE: The aim of this study was to investigate the effect of ethyl p-coumarate on inflammatory and oxidative stress parameters. STUDY DESIGN: This is an experimental study to evaluate the anti-inflammatory and antioxidant activities of ethyl p-coumarate in acute and chronic models of inflammation...
September 27, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Samantha R Weaver, Cynthia Xie, Julia F Charles, Laura L Hernandez
Selective Serotonin Reuptake Inhibitors (SSRIs) such as fluoxetine are widely prescribed to pregnant and breastfeeding women, yet the effects of peripartum SSRI exposure on neonatal bone are not known. In adult populations, SSRI use is associated with compromised bone health, and infants exposed to in utero SSRIs have a smaller head circumference and are shorter, suggesting possible effects on longitudinal growth. Yet no study to date has examined the effects of peripartum SSRIs on long bone growth or mass...
January 18, 2019: Scientific Reports
Nathaniel C Bloodworth, Cynthia R Clark, James D West, J Caleb Snider, Christa Gaskill, Sheila Shay, Christine Scott, Julie Bastarache, Santhi Gladson, Christy Moore, Reid D'Amico, Evan L Brittain, Harikrishna Tanjore, Timothy S Blackwell, Susan M Majka, W David Merryman
RATIONALE: Pulmonary arterial hypertension is a deadly disease of the pulmonary vasculature for which no disease-modifying therapies exist. Small-vessel stiffening and remodeling are fundamental pathological features of pulmonary arterial hypertension that occur early and drive further endovascular cell dysfunction. Bone marrow (BM)-derived proangiogenic cells (PACs), a specialized heterogeneous subpopulation of myeloid lineage cells, are thought to play an important role in pathogenesis...
December 7, 2018: Circulation Research
Georg Pongratz, Torsten Lowin, Philipp Sewerin, Frank Zaucke, Zsuzsa Jenei-Lanzl, Thomas Pauly, Benedikt Ostendorf, Matthias Schneider
OBJECTIVES: Tryptophan and its metabolites have been suggested to play a role in inflammatory processes. However, studies in rheumatoid arthritis (RA) are scarce, which prompted us to investigate two cohorts of RA patients to better understand the importance of tryptophan metabolism in this disease. METHODS: Tryptophan and its metabolites were characterised by ELISA in a cross-sectional cohort 1 (81 RA, 55 OA) and a longitudinal cohort 2 (25 RA, 3 visits over 6 months) to investigate discriminatory power between diseases and predicitive value for radiologic outcome, respectively...
November 16, 2018: Clinical and Experimental Rheumatology
Amal M Mahfoz
Sensory contact model (SCM) permits the evolution of diverse psychopathological states by the repeated antagonistic interactions between male mice. Biphenyl dimethyl dicarboxylate (DDB) is used as a hepatoprotective agent. The present work aimed to study the possible effects of DDB on social behavior developed by SCM by studying its effects on the transformation process to aggressive and submissive behaviors. Besides, measuring behavioral changes using the open field test (OFT) and the elevated plus maze test (EPM), neurochemical parameters [serotonin (5HT), norepqinephrine (NE), and dopamine(DA)], and immunological changes (total leucocyte count, differential leucocytic count, and evaluation of bone marrow lymphocytes count and viability assessment)...
November 28, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Samantha R Weaver, Hannah P Fricke, Cynthia Xie, Robert J Aiello, Julia F Charles, Laura L Hernandez
Long-term effects of breastfeeding on maternal bone are not fully understood. Excessive maternal bone loss stimulated by serotonin signaling during lactation may increase bone fragility later in life. We hypothesized inhibiting non-neuronal serotonin activity by feeding a small molecule inhibitor of the rate-limiting enzyme in serotonin synthesis (tryptophan hydroxylase 1; TPH1) would preserve maternal bone post-weaning without affecting neonatal bone. Small molecule TPH1 inhibitor LP778902 (~100 mg/kg) or control chow was fed to C57BL/6 dams throughout pregnancy and lactation and blood collected on days 1 and 21 of lactation...
October 23, 2018: American Journal of Physiology. Endocrinology and Metabolism
Vivianne Chappuis, Gustavo Avila-Ortiz, Mauricio G Araújo, Alberto Monje
OBJECTIVES: The aim of this systematic review was to investigate the association between the intake of systemic medications that may affect bone metabolism and their subsequent impact on implant failures. MATERIAL AND METHODS: Electronic and manual literature searches were conducted. Implant failure (IF) was the primary outcome, while biological/mechanical and the causes/timing associated with IF were set as secondary outcomes. Meta-analyses for the binary outcome IF and odds ratio were performed to investigate the association with medications...
October 2018: Clinical Oral Implants Research
Ronald E Jung, Bilal Al-Nawas, Mauricio Araujo, Gustavo Avila-Ortiz, Stephen Barter, Nadine Brodala, Vivianne Chappuis, Bo Chen, Andre De Souza, Ricardo Faria Almeida, Stefan Fickl, Gary Finelle, Jeffrey Ganeles, Hadi Gholami, Christoph Hammerle, Simon Jensen, Asbjørn Jokstad, Hideaki Katsuyama, Johannes Kleinheinz, Chatchai Kunavisarut, Nikos Mardas, Alberto Monje, Panos Papaspyridakos, Michael Payer, Eik Schiegnitz, Ralf Smeets, Martina Stefanini, Christiaan Ten Bruggenkate, Konstantinos Vazouras, Hans-Peter Weber, Dieter Weingart, Péter Windisch
OBJECTIVES: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient-reported outcomes in implant dentistry. Focused questions on (a) short posterior dental implants (≤6 mm), (b) narrow diameter implants, (c) implant design (tapered compared to a non-tapered implant design), and (d) medication-related dental implant failures were addressed. MATERIALS AND METHODS: Four systematic reviews were prepared in advance of the Consensus Conference and were discussed among the participants of Group 1...
October 2018: Clinical Oral Implants Research
L Abu Nada, A Al Subaie, A Mansour, X Wu, M N Abdallah, H Al-Waeli, A Ersheidat, L S Stone, M Murshed, F Tamimi
AIM: Selective Serotonin Reuptake Inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. MATERIALS AND METHODS: On a total of 24 Sprague-Dawley rats, a custom-made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia...
October 5, 2018: Journal of Clinical Periodontology
Khac-Dung Nguyen, Bahador Bagheri, Haleh Bagheri
Drug-induced bone loss remains the major cause of vertebral and hip fractures and significantly associated to morbidity and mortality. This article will review the common drugs identified as the causes of bone loss and the risk factors and management in European countries. Areas covered: Beyond glucorticoid - the most cause of osteoporosis, many different drugs could cause harmful skeletal disorders. The antiepileptics, hormonal therapy, GnRH antagonists, aromatase inhibitors are well-known cause of bone loss...
October 2018: Expert Opinion on Drug Safety
Hui-Hui Xiao, Tung-Ting Sham, Chi-On Chan, Meng-Heng Li, Xi Chen, Qing-Chang Wu, Daniel Kam-Wah Mok, Xin-Sheng Yao, Man-Sau Wong
The lignan-rich fraction (SWR) of Sambucus Williamsii Ramulus, a folk herbal medicine in China for treatment of bone diseases, has previously reported to exert protective effects on bone without exerting uterotrophic effects in ovariectomized (OVX) mice. The aim of the present study was to identify the potential metabolites and the associated metabolic pathways that contribute to the beneficial effects of SWR on bone in vivo . Aged female Sprague Dawley rats (9 months old) were either sham-operated or ovariectomized for 12 weeks, before receiving treatment for another 12 weeks with the following treatment groups ( n = 12 each): vehicle (Sham), vehicle (OVX), Premarin (130 μg/kg) or low (57 mg/kg), medium (114 mg/kg), and high (228 mg/kg) doses of SWR...
2018: Frontiers in Pharmacology
Jian Zhang, Yanqin Lu, Yanzhou Wang, Xiuzhi Ren, Jinxiang Han
Intestinal microbial flora, known as the second gene pool of the human body, play an important role in immune function, nutrient uptake, and various activities of host cells, as well as in human disease. Intestinal microorganisms are involved in a variety of mechanisms that affect bone health. Gut microbes are closely related to genetic variation, and gene regulation plays an important part in the development of bone-related diseases such as osteoporosis. Intestinal microorganisms can disrupt the balance between bone formation and resorption by indirectly stimulating or inhibiting osteoblasts and osteoclasts...
August 2018: Intractable & Rare Diseases Research
Kristian H Mikkelsen, Tina Vilsbøll, Jens J Holst, Bolette Hartmann, Filip K Knop, Morten Frost
BACKGROUND: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown...
September 4, 2018: BMC Endocrine Disorders
R Nicole Howie, Samuel Herberg, Emily Durham, Zachary Grey, Grace Bennfors, Mohammed Elsalanty, Amanda C LaRue, William D Hill, James J Cray
Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors (SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients' ability to heal after sustaining trauma...
September 3, 2018: International Journal of Oral Science
Vanessa de J R De-Paula, Andrea S Forlenza, Orestes V Forlenza
Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as glucose and bone metabolism, inflammation and immune response, peripheral (enteric) and central neurotransmission. For that reason, recent studies proposed that abnormalities in gut microbiota may play a role in systemic and central nervous system (CNS) conditions...
October 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Anne Baudry, Benoit Schneider, Jean-Marie Launay, Odile Kellermann
Genetic and pharmacological studies provided evidence that serotonin (5-HT) is an important signaling molecule for the development and the maintenance of mineralized tissues. However, how 5-HT takes part to the homeostasis of teeth and bone remains elusive. In the dental field, a major breakthrough comes from the identification of 5-HT but also dopamine (DA) as "damage" signals necessary for stem cell-based tooth repair. Pulpal stem cells express the overall functions of 5-HT and DA neurons including a definite set of functional 5-HT/DA receptors that render cells responsive for circulating bioamines...
August 2, 2018: Biochimie
Deepa, Karishma Mujawar, Komal Dhillon, Premraj Jadhav, Indrani Das, Youginder K Singla
AIM: Dental implants are the preferred treatment modality in the present edentulous era. Selective serotonin reuptake inhibitors (SSRIs) have detrimental effect on bone density. The present study was conducted to determine the effect of SSRIs on the success rate of dental implants. MATERIALS AND METHODS: The present study was conducted on 352 patients of both genders with 680 dental implants. History of depression and SSRI medication was retrieved. Patients were divided into two groups...
July 1, 2018: Journal of Contemporary Dental Practice
Craig K Docherty, Katie Yates Harvey, Kirsty M Mair, Sinead Griffin, Nina Denver, Margaret R MacLean
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by increased pulmonary vascular resistance and pulmonary artery remodelling as result of increased vascular tone and vascular cell proliferation, respectively. Eventually, this leads to right heart failure. Heritable PAH is caused by a mutation in the bone morphogenetic protein receptor-II (BMPR-II). Female susceptibility to PAH has been known for some time, and most recent figures show a female-to-male ratio of 4:1. Variations in the female sex hormone estrogen and estrogen metabolism modify FPAH risk, and penetrance of the disease in BMPR-II mutation carriers is increased in females...
2018: Advances in Experimental Medicine and Biology
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