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Acute kidney injury, chronic kidney disease

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https://read.qxmd.com/read/30784934/morin-has-protective-potential-against-er-stress-induced-apoptosis-in-renal-proximal-tubular-hk-2-cells
#1
Jung-Soon Mo, Dabin Choi, Yu-Ran Han, Nambin Kim, Han-Sol Jeong
ER stress is an early event of acute kidney injury and has been linked to accelerate the development of chronic kidney disease. Therefore, the compounds that can mimic ER stress inhibitor may confer regulatory effects on ER stress induced apoptosis. In this study, we investigated the protective effects of flavonoid morin against ER stress induced apoptosis in human renal proximal tubular HK-2 cells. Morin downregulated the expression of GRP78, central regulator of ER stress response, induced by ER stress inducer tunicamycin...
February 19, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30784660/executive-summary-for-the-2015-annual-data-report-of-the-china-kidney-disease-network-ck-net
#2
Fang Wang, Chao Yang, Jianyan Long, Xinju Zhao, Wen Tang, Dongliang Zhang, Kunhao Bai, Zaiming Su, Bixia Gao, Hong Chu, Jinwei Wang, Xiaoyu Sun, Song Wang, Li Zuo, Yue Wang, Feng Yu, Haibo Wang, Luxia Zhang, Ming-Hui Zhao
Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. One major output of CK-NET is to generate an Annual Data Report (ADR) providing resourceful information regarding kidney disease in China...
March 2019: Kidney International
https://read.qxmd.com/read/30784230/burden-access-and-disparities-in-kidney-disease
#3
Deidra C Crews, Aminu K Bello, Gamal Saadi
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
March 2019: Journal of Renal Care
https://read.qxmd.com/read/30783195/analysis-of-postmarketing-safety-data-for-proton-pump-inhibitors-reveals-increased-propensity-for-renal-injury-electrolyte-abnormalities-and-nephrolithiasis
#4
Tigran Makunts, Isaac V Cohen, Linda Awdishu, Ruben Abagyan
Proton pump inhibitors, PPIs, are widely prescribed and sold globally. Although initially intended for time-limited treatment of acute disorders, such as gastric ulcers and esophagitis, PPIs are now commonly used for prolonged durations and are considered safe for over the counter access. Recent studies have raised concern over associations between PPI use and acute kidney injury, chronic kidney disease, end-stage renal disease, and electrolyte abnormalities. The growing concern over potentially serious adverse drug reactions warrants an evaluation of post marketing surveillance data...
February 19, 2019: Scientific Reports
https://read.qxmd.com/read/30783033/burden-access-and-disparities-in-kidney-disease
#5
EDITORIAL
Deidra C Crews, Aminu K Bello, Gamal Saadi
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
February 18, 2019: Nephron
https://read.qxmd.com/read/30779194/proton-pump-inhibitors-and-risk-of-acute-and-chronic-kidney-disease-a-retrospective-cohort-study
#6
Emily Hart, Terry E Dunn, Steven Feuerstein, David M Jacobs
BACKGROUND: Proton pump inhibitors (PPIs) have been linked to acute kidney injury (AKI) and chronic kidney disease (CKD); however, current evidence has only been evaluated in a small number of studies with short follow-up periods. This study examined the association between PPI use and risk of incident AKI and CKD in a large, population-based health-maintenance organization (HMO) cohort. METHODS: Patients aged 18 years or older, without evidence of pre-existing renal disease, started on PPI therapy, and continuously enrolled for at least 12 months between July 1993 and September 2008 were identified in an HMO database...
February 18, 2019: Pharmacotherapy
https://read.qxmd.com/read/30778780/predictors-of-withdrawal-from-renal-replacement-therapy-among-patients-with-acute-kidney-injury-requiring-renal-replacement-therapy
#7
Katsuhito Ihara, Junichi Ishigami, Seiji Inoshita
BACKGROUND: Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear. METHODS: In this single-center retrospective cohort study, we examined the clinical records of AKI patients requiring RRT who were hospitalized in the ICU or general wards at our hospital from January 2010 to December 2013. A priori-determined covariates of age, sex, cardiovascular disease, chronic kidney disease (CKD), mean arterial pressure (MAP), sepsis, nephrotoxic agents, and hypoalbuminemia were assessed in Cox hazard models to estimate hazard ratio (HR)...
February 16, 2019: Clinical and Experimental Nephrology
https://read.qxmd.com/read/30774964/pharmacological-interventions-for-the-prevention-of-contrast-induced-acute-kidney-injury-in-high-risk-adult-patients-undergoing-coronary-angiography-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#8
Alexander J Sharp, Nishith Patel, Barney C Reeves, Gianni D Angelini, Francesca Fiorentino
Objective: Quantify the efficacy of strategies to prevent contrast-induced acute kidney injury (CI-AKI) in high-risk patients undergoing coronary angiography (CAG) with or without percutaneous coronary intervention (PCI). Background: CI-AKI remains a common problem. The renoprotective efficacy of existing pharmacological agents remains uncertain in high-risk populations. Methods: Systematic review and meta-analysis of randomised controlled trials (RCTs) to compare different strategies versus hydration in patients with chronic kidney disease (CKD) undergoing CAG±PCI...
2019: Open Heart
https://read.qxmd.com/read/30771017/diabetes-management-in-older-adults-with-chronic-kidney-disease
#9
REVIEW
Kristin K Clemens, Niamh O'Regan, Jinnie J Rhee
PURPOSE OF REVIEW: Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management. RECENT FINDINGS: Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities...
February 15, 2019: Current Diabetes Reports
https://read.qxmd.com/read/30769897/metabolomics-approaches-for-the-diagnosis-and-understanding-of-kidney-diseases
#10
REVIEW
Hayley Abbiss, Garth L Maker, Robert D Trengove
Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases...
February 14, 2019: Metabolites
https://read.qxmd.com/read/30768767/proteomics-for-clinical-assessment-of-kidney-disease
#11
Alberto Ortiz
Kidney disease is one of the fastest growing causes of death worldwide, disclosing an unmet clinical need for early diagnosis and optimized risk stratification that allows high risk patient selection for clinical trials and for more intensive nephroprotective interventions in the clinic. The current issue of PROTEOMICS - Clinical Applications contains four manuscripts that explore different aspects of clinical proteomics implementation in the context of acute kidney injury, chronic kidney disease and, more specifically, diabetic kidney disease, and kidney transplantation from a diagnostic and risk stratification point of view...
February 15, 2019: Proteomics. Clinical Applications
https://read.qxmd.com/read/30768191/association-of-nonsteroidal-anti-inflammatory-drug-prescriptions-with-kidney-disease-among-active-young-and-middle-aged-adults
#12
D Alan Nelson, Eric S Marks, Patricia A Deuster, Francis G O'Connor, Lianne M Kurina
Importance: Concern about the renal effects of nonsteroidand al anti-inflammatory drugs (NSAIDs) among young, healthy adults has been limited, but more attention may be warranted given the prevalent use of these agents. Objective: To test for associations between dispensed NSAIDs and incident acute kidney injury and chronic kidney disease while controlling for other risk factors. Design, Setting, and Participants: This retrospective, longitudinal cohort study used deidentified medical and administrative data on 764 228 active-duty US Army soldiers serving between January 1, 2011, and December 31, 2014...
February 1, 2019: JAMA network open
https://read.qxmd.com/read/30767290/urinary-neutrophil-gelatinase-associated-lipocalin-in-dogs-with-stable-or-progressive-kidney-disease
#13
Yoojin M Kim, David J Polzin, Aaron Rendahl, Jennifer L Granick
BACKGROUND: Active kidney injury may play a role in chronic kidney disease (CKD) progression in dogs. Neutrophil gelatinase-associated lipocalin (NGAL), a novel tubular kidney injury biomarker, may help differentiate progressive CKD from stable CKD in dogs. OBJECTIVES: To determine if urinary NGAL : creatinine ratio (UNCR) differentiates stable and progressive CKD in dogs. We hypothesized that UNCR would be higher in dogs with progressive CKD versus stable CKD...
February 14, 2019: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/30764800/serum-indoxyl-sulfate-is-associated-with-mortality-in-hospital-acquired-acute-kidney-injury-a-prospective-cohort-study
#14
Wenji Wang, Guihua Hao, Yu Pan, Shuai Ma, Tianye Yang, Peng Shi, Qiuyu Zhu, Yingxin Xie, Shaojun Ma, Qi Zhang, Hong Ruan, Feng Ding
BACKGROUND: Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound solute, and 90-day mortality in patients with acute kidney injury. METHODS: Adults with hospital-acquired AKI (HA-AKI) were enrolled in this prospective cohort study between 2014 and 2015, according to the KDIGO creatinine criteria. The primary end point was all-cause death during follow-up...
February 14, 2019: BMC Nephrology
https://read.qxmd.com/read/30762739/the-effects-of-perioperative-intravenous-fluid-administration-strategy-on-renal-outcomes-in-patients-undergoing-cardiovascular-surgery-an-observational-study
#15
Eun-Ho Lee, Sung-Cheol Yun, Ye-Ji Lim, Jun-Young Jo, Dae-Kee Choi, In-Cheol Choi
We assessed whether perioperative fluid management with balanced solutions and a limited volume of hydroxyethyl starch (renal-protective fluid management [RPF] strategy) could improve renal outcomes after cardiovascular surgery.For this retrospective observational study, we evaluated 2613 patients who underwent cardiovascular surgery from January 1, 2010 to December 31, 2013. The control group were given intravenous fluids with saline-based solutions and unlimited volumes of hydroxyethyl starch solutions and the RPF group were given intravenous fluids with RPF...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30758679/burden-access-and-disparities-in-kidney-disease
#16
EDITORIAL
Deidra C Crews, Aminu K Bello, Gamal Saadi
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
February 13, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30756319/clinical-electroencephalographic-features-and-prognostic-factors-of-cefepime-induced-neurotoxicity-a-retrospective-study
#17
Han-Tao Li, Chih-Hong Lee, Tony Wu, Mei-Yun Cheng, Wei-En Johnny Tseng, Chun-Wei Chang, Hsiang-Yao Hsieh, Hsing-I Chiang, Chih-Yin Lin, Bao-Luen Chang, Wey-Ran Lin, Siew-Na Lim
BACKGROUND: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures. METHODS: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed...
February 12, 2019: Neurocritical Care
https://read.qxmd.com/read/30746731/the-renaissance-of-cholemic-nephropathy-a-likely-underestimated-cause-of-renal-dysfunction-in-liver-disease
#18
EDITORIAL
Mattias Mandorfer, Manfred Hecking
In this issue of Hepatology, Bräsen and Mederacke et al (1) present an analysis of all kidney biopsies performed at the gastroenterology and hepatology department at Hannover Medical School over a 16-year period. The authors identified 79 patients with both liver disease and impaired renal function, 57% of whom had acute kidney injury (AKI) or AKI overlapping chronic kidney disease (CKD), while 43% had CKD, as defined by the recently updated European clinical practice guidelines. Interestingly, 8 patients were diagnosed with cholemic nephropathy (CN), who all presented as AKI...
February 11, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30743275/predicting-cardiac-surgery-associated-acute-kidney-injury-using-a-combination-of-clinical-risk-scores-and-urinary-biomarkers
#19
Philippe Grieshaber, Sina Möller, Borros Arneth, Peter Roth, Bernd Niemann, Harald Renz, Andreas Böning
BACKGROUND:  Prediction, early diagnosis, and therapy of cardiac surgery-associated acute kidney injury (CSA-AKI) are challenging. We prospectively tested a staged approach to identify patients at high risk for CSA-AKI combining clinical risk stratification and early postoperative quantification of urinary biomarkers for AKI. METHODS:  All patients, excluding those on chronic hemodialysis, undergoing scheduled surgery with cardiopulmonary bypass between August 2015 and July 2016 were included...
February 11, 2019: Thoracic and Cardiovascular Surgeon
https://read.qxmd.com/read/30741743/the-impact-of-preinfarct-angina-on-the-incidence-of-acute-kidney-injury-in-patients-with-myocardial-infarction-interaction-with-pre-existent-chronic-kidney-disease
#20
Raquel B Santos, Inês Silveira, Maria Trêpa, Bruno Brochado, Rui Magalhães, Patrícia Rodrigues, Maria J Sousa, André Luz, João Silveira, Aníbal Albuquerque, Severo Torres, Adelino F Leite-Moreira, Henrique Carvalho
AIM: Remote ischemic conditioning may reduce acute kidney injury (AKI) in patients undergoing a coronary intervention. As preinfarct angina (PIA) might act as a preconditioning stimulus in patients with ST-elevation myocardial infarction (STEMI), we aimed to study whether PIA reduces AKI in accordance to pre-existing chronic kidney disease. PATIENTS AND METHODS: We conducted a retrospective study including 891 consecutive STEMI patients who underwent primary coronary intervention from January 2008 to March 2016...
February 7, 2019: Coronary Artery Disease
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