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Mubarak A AlAmri, Mark Jeeves, Youcef Mehellou
The binding of SPAK and OSR1 kinases to their upstream WNK kinases is mediated by the interaction of their highly conserved SPAK and OSR1 C-terminal domain (CTD) to RFx [V/I] peptide sequences from WNK kinases. A SPAK CTD knock-in mouse, where SPAK was unable to bind WNK kinases, exhibited low blood pressure. This highlighted the inhibition of SPAK and OSR1 kinases binding to their upstream WNK kinases as a plausible strategy in the discovery of new antihypertensive agents. To facilitate such endeavour, we herein report the optimisation and expression of isotopically labelled OSR1 CTD in E...
March 17, 2019: Biochemical and Biophysical Research Communications
Shaik Mohammed Asif, Sultan Mohammed Kaleem, Hussain Mohammed Al Mubarak, Mansoor Shariff, Nuchlakath Chalikkandy Sandeepa
Ameloblastomas with multiple histologic variants are rare odontogenic neoplasm of mandible and maxilla, and have high recurrence rates if improperly treated. They are histologically benign, slow growing, and invasive tumors. These tumors are asymptomatic in nature, unless they attain a large size to cause expansion and perforation of adjacent tissues, for which patient might seek treatment. Due to their aggressive nature and high recurrence rate, treatment remains a matter of debate. Complete excision of lesion with least morbidity would be the therapeutic challenge...
2019: SAGE Open Medical Case Reports
Fajer AlHamdan, Iman Qadhi, Sameera Shuaibi, Shaden Younes, Salman Al Sabah, Eliana Al Haddad
BACKGROUND AND OBJECTIVES: A global trend in female leadership roles in the medical profession is on the rise, and females have been taking up leadership roles in varying and increasing levels. This study aims to identify changes in trends in the medical field in terms of gender in the last decade in Kuwait. METHODS: A case study was conducted, in which data on leadership positions in Kuwait's government hospitals were obtained from hospital registries. Demographic data about female to male physicians was collected from statistics published by the Department of Manpower, Statistics and Planning of Kuwait's Ministry of Health...
March 15, 2019: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Tamima Al-Dughaishi, Mussab Mubarak Hamed Al-Jabri, Amjad Hamed Al-Haddabi, Vaidyanathan Gowri
Background: This study aimed to find out the patients preference towards the management of pregnancy loss to either Misoprostol or dilatation and evacuation or curettage (D&C) in two different study periods. Methods: Retrospective chart review study included a total of 411 patients. The first study period was January to December 2010 and the second study period was January to December 2014. All patients were managed in Sultan Qaboos University Hospital of Oman...
January 2019: Journal of Reproduction & Infertility
Amir Ali, Sher Mohammad, Mubarak Ali Khan, Naveed Iqbal Raja, Mohammad Arif, Atif Kamil, Zia-Ur-Rehman Mashwani
Elicited plant in vitro cultures are gaining more interest worldwide for their potential in the uniform production of industrially important secondary metabolites. In the present study, different ratios of silver nanoparticles (AgNPs) and plant growth regulators (PGRs) were supplemented to in vitro cultures for the sustainable production of biomass and antioxidant secondary metabolites through callus cultures of Caralluma tuberculata. Results indicated that various concentrations of AgNPs significantly affected the callus proliferation and substantially increased the callus biomass, when combined with PGRs in the MS (Murashige and Skoog) media...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Sher Mohammad, Mubarak Ali Khan, Amir Ali, Latif Khan, Muhammad Shahsawar Khan, Zia-Ur-Rehman Mashwani
Light is the most important physical factor in growth and development of plants. Light intensity is directly proportional to the growth and accumulation of natural antioxidants during in vitro cultures of various medicinal plants. The present research study was designed to determine the effect of different light intensities i.e. normal light (2000-2500 lx), diffused light (500-1000 lx) and complete dark (0 lx) on callus growth dynamics and production of natural antioxidants in olive cult. Arbosana. Highest callus induction frequency (50%) was observed in the stem explants pre-treated with silver nanoparticles suspension (AgNPs: 50 ppm) and cultured on MS media supplemented with combination of 6-Benzylaminopurine (BAP: 2 mg/l), Gibberellic acid (GA3 : 1...
March 3, 2019: Journal of Photochemistry and Photobiology. B, Biology
Qing Zhao, Khetam Alhilali, Abdulaziz Alzahrani, Mubarak Almutairi, Juwaria Amjad, Hong Liu, Yonghu Sun, Lele Sun, Huimin Zhang, Xiaoli Meng, Andrew Gibson, Monday O Ogese, B Kevin Park, Jianjun Liu, David A Ostrov, Furen Zhang, Dean J Naisbitt
BACKGROUND: Research into drug hypersensitivity associated with expression of specific HLA alleles has focussed on the interaction between parent drug and the HLA with no attention given to reactive metabolites. For this reason, we have studied HLA-B*13:01-linked dapsone hypersensitivity to (1) explore whether the parent drug and/or nitroso metabolite activates T-cells and (2) determine whether HLA-B*13:01 is involved in the response. METHODS: PBMC from 6 patients were cultured with dapsone and nitroso dapsone and proliferative responses and IFN-γ release were measured...
March 7, 2019: Allergy
Sumreen Begum, Nazia Ahmed, Muhammed Mubarak, Syeda Mamoona Mateen, Nida Khalid, Syed Adibul Hasan Rizvi
Background and Objectives: In regenerative medicine, mesenchymal stem cells derived from adipose tissues (Ad-MSCs) are a very attractive target to treat many diseases. In relation to nephrology, the aim of the current study is to investigate the effects of Ad-MSCs for the amelioration of acute kidney injury and to explore the mechanism of renal parenchymal changes in response to allogeneic transplantation of Ad-MSCs. Methods and Results: The nephrotoxicity was induced by cisplatin (CP) in balb/c mice according to RIFLE Class and AKIN Stage 3...
February 28, 2019: International Journal of Stem Cells
Huma Ali, Mubarak Ali Khan, Waqas Khan Kayani, Erum Dilshad, Rehana Rani, Raham Sher Khan
Ajuga bracteosa an important medicinal herb, is getting endangered worldwide due to destructive harvesting by pharmaceutical industries in its different habitats. It is in dire need for protection and demands conservation and sustainable utilization. In the present study, effects of α-naphthalene acetic acid (NAA) under different spectral lights were estimated on the growth, secondary metabolism and biosynthesis of phenolic acids in adventitious roots (AR) cultures of A. bracteosa. Among the different spectral lights, highest AR induction frequency (88%) and formation of biomass (72 g/L FW and 22 g/L DW) were recorded in explants incubated in the presence of 1...
February 26, 2019: Journal of Photochemistry and Photobiology. B, Biology
Mohamed Eissa, Ayyub A Patel, Shehata Farag, Nashwa H Babiker, Malak S Al-Shahrani, Albatool M Al-Nahari, Ali M Al Sahmaa, Mubarak Al-Shraim
Hemoglobinopathies can disturb a patient's life style leading to community problems. Premarital screening is an important tool to control and minimize hemoglobinopathies. This study aimed to assess and improve the awareness and attitude of King Khalid University (KKU) [Abha, Kingdom of Saudi Arabia (KSA)] students in the Aseer Region, regarding hemoglobinopathies and the National Premarital Screening Programme (NPMS) in addition to screening for hemoglobin (Hb) variants of students who agreed to participate...
July 2018: Hemoglobin
Ahmed ElMinshawi, Salah Abdelfattah, Fahmy Mubarak
This article aims to present the outcomes of treating anterior mandibular fractures using Herbert's screw. A total of 10 patients were treated for fractures of anterior mandible by open reduction and internal fixation using the Herbert screw. The patients were collected starting from June 2016 to November 2017, at the Department of Craniomaxillofacial Surgery, Nasser Institute for Research and Treatment, Cairo, and Faculty of Dentistry, Ain Shams University, Cairo, Egypt. The follow-up plan was done to evaluate the postoperative clinical outcomes for malocclusion, neurosensory status, hardware failure, malunion/ nonunion, pain, and edema...
March 2019: Craniomaxillofacial Trauma & Reconstruction
Hussain Mubarak Al-Aamri, Heng Ku, Helen R Irving, Joseph Tucci, Terri Meehan-Andrews, Christopher Bradley
BACKGROUND: Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following exposure to daunorubicin and to investigate the effects of daunorubicin on the cell cycle and the protein kinases involved in specific checkpoints following DNA damage and recovery periods. METHODS: Three ALL cell lines CCRF-CEM and MOLT-4 derived from T lymphocytes and SUP-B15 derived from B lymphocytes were examined following 4 h treatment with daunorubicin chemotherapy and 4, 12 and 24 h recovery periods...
February 27, 2019: BMC Cancer
Muhammad Torequl Islam, Sajal Biswas, Rajat Bagchi, Roich Khan, Abul Bashar Ripon Khalipha, Razina Rouf, Shaikh Jamal Uddin, Jamil A Shilpi, Sanaa K Bardaweel, Dima A Sabbah, Mohammad S Mubarak
Ponicidin, an ent-kaurane diterpenoid derived from Rabdosia rubescens exhibits antitumor activities against several types of cancers. This review summarizes the botanical sources, biological activities, and biopharmaceutical profile of ponicidin. Additionally, a molecular docking study has been undertaken to correlate the interaction of this diterpenoid with biomacromolecules found in the literature. For this purpose, an up-to-date (till December 2018) literature survey was conducted using a number of databases such as PubMed, Science Direct, Web of Science, Scopus, the American Chemical Society, Clinicaltrials...
February 25, 2019: Biotechnology and Applied Biochemistry
Muhammad Imran, Abdur Rauf, Tareq Abu-Izneid, Muhammad Nadeem, Mohammad Ali Shariati, Imtiaz Ali Khan, Ali Imran, Ilkay Erdogan Orhan, Muhammad Rizwan, Muhammad Atif, Tanweer Aslam Gondal, Mohammad S Mubarak
Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-cancer compounds. Luteolin (3,4,5,7-tetrahydroxy flavone) is a flavonoid found in different plants such as vegetables, medicinal herbs, and fruits. It acts as an anticancer agent against various types of human malignancies such as lung, breast, glioblastoma, prostate, colon, and pancreatic cancers. It also blocks cancer development in vitro and in vivo by inhibition of proliferation of tumor cells, protection from carcinogenic stimuli, and activation of cell cycle arrest, and by inducing apoptosis through different signaling pathways...
February 21, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Syeda Maheen Batool, Fatima Mubarak, Syed Ather Enam
Background: Diffusion-weighted magnetic resonance has a well-defined role in differentiating between important intracranial lesions. Sometimes, the surgeon is faced with a dilemma of how to diagnose an infectious versus malignant lesion. Case Description: A 28-year-old male presented to the neurosurgery clinic with complaints of headache and left-sided weakness for 2 weeks. Neurological examination was intact. Magnetic resonance imaging (MRI) scan showed a large infiltrating heterogeneous mass involving the right parietal lobe...
2019: Surgical Neurology International
Lau Yien Jun, N M Mubarak, Lau Sie Yon, Chua Han Bing, Mohammad Khalid, Priyanka Jagadish, E C Abdullah
Surface modified Multi-walled carbon nanotubes (MWCNTs) Buckypaper/Polyvinyl Alcohol (BP/PVA) composite membrane was synthesized and utilized as support material for immobilization of Jicama peroxidase (JP). JP was successfully immobilized on the BP/PVA membrane via covalent bonding by using glutaraldehyde. The immobilization efficiency was optimized using response surface methodology (RSM) with the face-centered central composite design (FCCCD) model. The optimum enzyme immobilization efficiency was achieved at pH 6, with initial enzyme loading of 0...
February 18, 2019: Scientific Reports
Shazia Shad, Farina Hanif, Manzoor Ul Haq, Nasir H Luck, Tahir Aziz, Muhammad Mubarak
OBJECTIVES: Gastrointestinal complications are common in kidney transplant patients, with the most frequent being diarrhea (60%). Chronic diarrhea affects the patient's quality of life, causes fatigue and weight loss and malabsorption, increases the number of hospitalizations, increases serum creatinine levels, and causes alterations in immunosuppressive drug levels. Diarrhea is also associated with an increased risk of graft failure and death. In this study, we aimed to determine the frequencies of common infectious organisms causing chronic diarrhea in renal transplant patients...
January 2019: Experimental and Clinical Transplantation
Chun-Yin Chan, Mubarak I Umar, Chun Kit Kwok
Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.
February 6, 2019: Chemical Communications: Chem Comm
Mahdi M Kalayeh, Mubarak Shah
Batch Normalization (BN) is essential to effectively train state-of-the-art deep Convolutional Neural Networks (CNN). It normalizes the layer outputs during training using the statistics of each mini-batch. BN accelerates training procedure by allowing to safely utilize large learning rates and alleviates the need for careful initialization of the parameters. In this work, we study BN from the viewpoint of Fisher kernels that arise from generative probability models. We show that assuming samples within a mini-batch are from the same probability density function, then BN is identical to the Fisher vector of a Gaussian distribution...
January 28, 2019: IEEE Transactions on Pattern Analysis and Machine Intelligence
Ajaykumar C Morani, Ahmad Iyad Mubarak, Hrishabh R Bhosale, Nisha S Ramani, Steven G Waguespack, Anita Ying
No abstract text is available yet for this article.
January 31, 2019: Magnetic Resonance in Medical Sciences: MRMS
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