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JOURNAL ARTICLE
Natalia Picola Brau, Maria Fiol Riera, Begoña Etcheverry Giadrosich, Lluis Riera Canals, Edoardo Melilli, Núria Sabé Fernández, Manel Castells Esteve, Francesc Vigués Julià
BACKGROUND: Kidney transplantation is associated with a high risk of infectious complications due to immunosuppressive therapy. Although infections may be transmitted from donor to transplant recipient through contaminated preservation solution (PS), the clinical impact of this is not well-understood. METHODS: We retrospectively evaluated PS contamination rates in a series of 339 patients who underwent cadaveric renal transplant at our centre. All patients with a positive culture received targeted preemptive therapy (PET)...
December 9, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#22
JOURNAL ARTICLE
María Ríos-Barnés, Eneritz Velasco-Arnaiz, Clàudia Fortuny, Marta Benavides, Fernando Baquero-Artigao, Oihana Muga, Rut Del Valle, Marie Antoinette Frick, Xavier Bringué, Susana Herrero, Javier Vilas, Almudena Alonso-Ojembarrena, Laura Castells-Vilella, Pablo Rojo, Daniel Blázquez-Gamero, Cristina Esteva, Emilia Sánchez, Ana Alarcón, Antoni Noguera-Julian
BACKGROUND: We aimed to determine the prevalence and severity of glomerular and tubular renal dysfunction by means of urinalysis in infants and toddlers with congenital cytomegalovirus infection (cCMV) and their association with cCMV disease, viruria and antiviral treatment. METHODS: This cross-sectional study was done using the Spanish Registry of Congenital Cytomegalovirus Infection. First-morning urine samples were collected from January 2016 to December 2018 from patients <5 years old enrolled in Spanish Registry of Congenital Cytomegalovirus Infection...
March 1, 2024: Pediatric Infectious Disease Journal
#23
JOURNAL ARTICLE
Jacob A Stanosheck, M Elena Castell-Perez, Rosana G Moreira, Maria D King, Alejandro Castillo
We assessed the efficacy of oversampling techniques to enhance machine learning model performance in predicting Escherichia coli MG1655 presence in spinach wash water. Three oversampling methods were applied to balance two datasets, forming the basis for training random forest (RF), support vector machines (SVMs), and binomial logistic regression (BLR) models. Data underwent method-specific centering and standardization, with outliers replaced by feature-specific means in training datasets. Testing occurred without these preprocessing steps...
December 5, 2023: Journal of Food Science
#24
JOURNAL ARTICLE
Isaac Kuzmar, José Rafael Consuegra, Tiffany Rangel, Jorge Luis Barroso, Yoselys María Cuentas, Sofía Ibáñez, María Mercedes Rizo-Baeza, Ernesto Cortés-Castell
BACKGROUND: the development of specialised nutritional support techniques allows the maintenance of an adequate supply of nutrients in those patients in whom oral feeding is not possible or is insufficient in relation to their requirements, trying to improve the quality of life, especially in those with chronic diseases. METHODS: single-center clinical study carried out in a clinical-nutritional center consisting of a medically supervised nasogastric-duodenal tube feeding treatment for overweight, obesity and increased body fat percentage in patients requiring it by means of duodeno-enteral feeding, expecting losses of more than 10 %...
November 27, 2023: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#25
JOURNAL ARTICLE
Raquel Muñoz-Castells, Margherita Modesti, Jaime Moreno-García, María Rodríguez-Moreno, Alexandro Catini, Rosamaria Capuano, Corrado Di Natale, Andrea Bellincontro, Juan Moreno
BACKGROUND: The growing demand for rosé sparkling wine has led to an increase in its production. Traditional or Charmat wine-making influence the aromatic profiles in wine. Analysis such as gas chromatography makes an accurate assessment of wines based on volatile detection but is resource-intensive. On the other hand, electronic noses emerged as versatile tools, offering rapid, cost-effective discrimination of wines, and contributing insights into quality and production processes, because of its aptitude to perform a global aromatic pattern evaluation...
November 29, 2023: Journal of the Science of Food and Agriculture
#26
JOURNAL ARTICLE
Marta Soriano Hervás, Daniel Robles-Hernández, Anna Serra, Rosa Játiva-Porcar, Luis Gómez Quiles, Karina Maiocchi, Sara Llorca, María Teresa Climent, Antoni Llueca
Background : Cytoreductive surgery (CRS) is a complex procedure with a high incidence of perioperative complications. Elevated lactacidaemia levels have been associated with complications and perioperative morbidity and mortality. This study aims to analyse the intraoperative variables of patients undergoing CRS and their relationship with lactacidaemia levels. Methods : This retrospective, observational study included 51 patients with peritoneal carcinomatosis who underwent CRS between 2014 and 2016 at the Abdomino-Pelvic Oncological Surgery Reference Unit (URCOAP) of the General University Hospital of Castellón (HGUCS)...
October 26, 2023: Journal of Personalized Medicine
#27
JOURNAL ARTICLE
Jorge Gil-Albarova, María José Martínez-Morlanes, José Miguel Fernández, Pere Castell, Luis Gracia, José Antonio Puértolas
The biocompatible polymer polyetheretherketone (PEEK) is a suitable candidate to be part of potential all-polymer total joint replacements, provided its use is associated with better osseointegration, mechanical performance, and wear resistance. Seeking to meet the aforementioned requirements, respectively, we have manufactured a PEEK composite with different fillers: carbon fibers (CF), hydroxyapatite particles (HA) and graphene platelets (GNP). The mechanical outcomes of the composites with combinations of 0, 1...
November 17, 2023: Bioengineering
#28
JOURNAL ARTICLE
Kevin Ibeas, Christian Griñán-Ferré, Maria Del Mar Romero, David Sebastián, Marianela Bastías-Pérez, Roberto Gómez, M Carmen Soler-Vázquez, Sebastián Zagmutt, Mercè Pallás, Margarida Castell, Denise D Belsham, Paula Mera, Laura Herrero, Dolors Serra
Orexigenic neurons expressing agouti-related protein (AgRP) and neuropeptide Y in the arcuate nucleus (ARC) of the hypothalamus are activated in response to dynamic variations in the metabolic state, including exercise. We previously observed that carnitine palmitoyltransferase 1a (CPT1A), a rate-limiting enzyme of mitochondrial fatty acid oxidation, is a key factor in AgRP neurons, modulating whole-body energy balance and fluid homeostasis. However, the effect of CPT1A in AgRP neurons in aged mice and during exercise has not been explored yet...
November 22, 2023: Aging Cell
#29
JOURNAL ARTICLE
Sara Castel-Feced, Sara Malo, Isabel Aguilar-Palacio, Cristina Feja-Solana, José Antonio Casasnovas, Lina Maldonado, María José Rabanaque-Hernández
Assessment of the influence of cardiovascular risk factors (CVRF) on cardiovascular event (CVE) using machine learning algorithms offers some advantages over preexisting scoring systems, and better enables personalized medicine approaches to cardiovascular prevention. Using data from four different sources, we evaluated the outcomes of three machine learning algorithms for CVE prediction using different combinations of predictive variables and analysed the influence of different CVRF-related variables on CVE prediction when included in these algorithms...
2023: PloS One
#30
JOURNAL ARTICLE
Elizabeth I Pierpont, Anton M Bennett, Lisa Schoyer, Beth Stronach, April Anschutz, Sarah C Borrie, Benjamin Briggs, Emma Burkitt-Wright, Pau Castel, Ion C Cirstea, Fieke Draaisma, Michelle Ellis, Vanessa S Fear, Megan N Frone, Elisabetta Flex, Bruce D Gelb, Tamar Green, Karen W Gripp, Sattar Khoshkhoo, Mark W Kieran, Karolin Kleemann, Bonita P Klein-Tasman, Maria I Kontaridis, Paul Kruszka, Chiara Leoni, Clifford Z Liu, Nadia Merchant, Pilar L Magoulas, Christopher Moertel, Carlos E Prada, Katherine A Rauen, Renée Roelofs, Rodrigue Rossignol, Christine Sevilla, Gigi Sevilla, Ryan Sheedy, Elliot Stieglitz, Daochun Sun, Dagmar Tiemens, Forest White, Ellen Wingbermühle, Cordula Wolf, Martin Zenker, Gregor Andelfinger
Germline pathogenic variants in the RAS/mitogen-activated protein kinase (MAPK) signaling pathway are the molecular cause of RASopathies, a group of clinically overlapping genetic syndromes. RASopathies constitute a wide clinical spectrum characterized by distinct facial features, short stature, predisposition to cancer, and variable anomalies in nearly all the major body systems. With increasing global recognition of these conditions, the 8th International RASopathies Symposium spotlighted global perspectives on clinical care and research, including strategies for building international collaborations and developing diverse patient cohorts in anticipation of interventional trials...
November 15, 2023: American Journal of Medical Genetics. Part A
#31
JOURNAL ARTICLE
Sergio Villanueva-Saz, María Victoria Martínez, Sandra Alsina, Antonio Fernández, Álex Gómez, Maite Verde, Héctor Ruiz, Delia Lacasta, Alaa Aldin Alnassan, Michele Trotta, Andrés Yzuel, Diana Marteles
Dirofilaria repens is an endemic mosquito-borne pathogen widely spread throughout Europe and other non-Europen regions. Infection by D. repens has been reported in dogs, although little is known about the occurrence and epidemiological features of this nematode in cats. During the surgical procedure within the framework of a trap, neuter and release sterilization program, two female filarial nematodes with spontaneous movement were removed from the internal part of the spermatic cord from asymptomatic stray cat in Spain (Grao de Castellón, Castellon de la Plana, province of Spain)...
November 3, 2023: Veterinary Research Communications
#32
JOURNAL ARTICLE
Teodorikez-Wilfox Jimenez-Rodriguez, Leticia de Las Vecillas, Marina Labella, Donna-Marie Lynch, Kylie Marie Besz, Kathleen Marquis, Amparo Burgos, Victor Soriano Gomis, Inmaculada Lozano, Rosa Ana Montoyo Antón, Francisco Marco de la Calle, María Purificación González Delgado, Aurora Gutiérrez, Estefanía Montenegro, Fernando Rodríguez, Francisco Javier Fernández Sánchez, Mariana Castells
BACKGROUND: Drug hypersensitivity reactions (DHRs) to platinum-based drugs are heterogenous and restrict their access, and drug desensitization (DD) has provided a ground-breaking procedure for their re-introduction, although the response is heterogeneous. We aimed to identify the phenotypes, endotypes, and biomarkers of reactions to carboplatin and oxaliplatin and their response to DD. METHODS: Seventy-nine patients presenting with DHRs to oxaliplatin (N = 46) and carboplatin (N = 33) were evaluated at the Allergy Departments of two tertiary care hospitals in Spain...
November 2, 2023: Allergy
#33
JOURNAL ARTICLE
Inma Jarrín, Marta Rava, Jorge Del Romero Raposo, Antonio Rivero, Jorge Del Romero Guerrero, María De Lagarde, Javier Martínez Sanz, Gemma Navarro, David Dalmau, José Ramón Blanco, Ana Koerting, Javier Gomez Castell, Julia Del Amo
OBJECTIVE: To estimate life expectancy (LE) of people with HIV (PWH) and describe causes of death. DESIGN: ART-naïve adults from the CoRIS cohort starting ART in 2004-2019. METHODS: We calculated LE at age 40 for men and women according to their ART initiation period, and stratified by transmission category, CD4 count and AIDS diagnosis.We estimated LE in 10-year age bands using life tables constructed from mortality rates, estimated through Poisson models...
October 30, 2023: AIDS
#34
JOURNAL ARTICLE
Stavros I Dimitriadis, Alba Castells-Sánchez, Francesca Roig-Coll, Rosalía Dacosta-Aguayo, Noemí Lamonja-Vicente, Pere Torán-Monserrat, Alberto García-Molina, Gemma Monte-Rubio, Chelsea Stillman, Alexandre Perera-Lluna, Maria Mataró
Lifestyle interventions have positive neuroprotective effects in aging. However, there are still open questions about how changes in resting-state functional connectivity (rsFC) contribute to cognitive improvements. The Projecte Moviment is a 12-week randomized controlled trial of a multimodal data acquisition protocol that investigated the effects of aerobic exercise (AE), computerized cognitive training (CCT), and their combination (COMB). An initial list of 109 participants was recruited from which a total of 82 participants (62% female; age = 58...
October 23, 2023: GeroScience
#35
JOURNAL ARTICLE
Ishani Barai, Maria Mas Castells, Hannah Timlin
No abstract text is available yet for this article.
October 20, 2023: Orbit
#36
JOURNAL ARTICLE
Maria Mas-Castells, David H Verity, Geoffrey E Rose
AIM: To describe the features of orbital masses occurring as a late complication of hydrogel retinal explants. PATIENTS AND METHODS: Retrospective review of patients presenting with orbital masses at decades after retinal surgery. RESULTS: Two patients with huge orbital masses are described, their presenting 25 and 28 years after retinal detachment repair with expansile hydrogel explants. In one case, the preoperative diagnosis was pleomorphic adenoma, and the other-with extreme distortion of the globe-was considered to be lymphoma or chronic inflammation arising around prior retinal explants...
October 14, 2023: Eye
#37
JOURNAL ARTICLE
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A Fischer, Kyota Fujita, Amit L Deshmukh, Rachel J Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E Leib, Ran Chen, Hikari Tanaka, Amanda G Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R La Spada, Eric I Campos, Maurice A Curtis, François-Michel Boisvert, Richard L M Faull, Beverly L Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S Wold, Christopher E Pearson
Expansions of repeat DNA tracts cause >70 diseases, and ongoing expansions in brains exacerbate disease. During expansion mutations, single-stranded DNAs (ssDNAs) form slipped-DNAs. We find the ssDNA-binding complexes canonical replication protein A (RPA1, RPA2, and RPA3) and Alternative-RPA (RPA1, RPA3, and primate-specific RPA4) are upregulated in Huntington disease and spinocerebellar ataxia type 1 (SCA1) patient brains. Protein interactomes of RPA and Alt-RPA reveal unique and shared partners, including modifiers of CAG instability and disease presentation...
October 26, 2023: Cell
#38
MULTICENTER STUDY
María Gallardo-Gómez, Mar Rodríguez-Girondo, Núria Planell, Sebastian Moran, Luis Bujanda, Ane Etxart, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Manel Esteller, Joaquín Cubiella, David Gómez-Cabrero, Loretta De Chiara
BACKGROUND: Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. A blood test may improve both the adherence to screening and the selection to colonoscopy. In this study, we conducted a serum-based discovery and validation of cfDNA methylation biomarkers for CRC screening in a multicenter cohort of 433 serum samples including healthy controls, benign pathologies, advanced adenomas (AA), and CRC...
October 4, 2023: Clinical Epigenetics
#39
MULTICENTER STUDY
Réda Chebani, Florian Lombart, Guillaume Chaby, Ali Dadban, Sébastien Debarbieux, Manuelle-Anne Viguier, Saskia Ingen-Housz-Oro, Anne Pham-Ledard, Christophe R Bedane, Catherine Picard-Dahan, Clémence Berthin, Olivier Dereure, Maria-Polina Konstantinou, Marion Castel, Fabienne Jouen, Pascal Joly, Vannina Seta, Sophie Duvert-Lehembre, Christelle Le Roux, Gaëlle Quereux, Bruno Sassolas, Emilie Brenaut, Carole Sin, Marie-Aleth Richard, Frédéric Bérard, Delphine Giusti, Thibaut Belmondo, Thomas Gille, Frédéric Caux, Catherine Prost-Squarcioni, Sabine Grootenboer-Mignot, Marina Alexandre
BACKGROUND: Interest in the use of omalizumab to treat bullous pemphigoid (BP) in the event of resistance or contraindication to conventional therapies is currently based on limited evidence. OBJECTIVES: To assess the effectiveness and safety of omalizumab in BP and to identify predictive factors in response to treatment. METHODS: We conducted a French national multicentre retrospective study including patients with a confirmed diagnosis of BP treated with omalizumab after failure of one or several treatment lines...
January 23, 2024: British Journal of Dermatology
#40
JOURNAL ARTICLE
Maria Mas-Castells, David H Verity, Hannah Timlin, Geoffrey E Rose
A 60-year-old man was referred with 2 years of left conjunctivitis that persisted despite antibiotic and systemic corticosteroid therapy. The severity and extent of surface disease had increased slowly after prior dacryocystorhinostomy. Subsequent conjunctival biopsies demonstrated granulomas with patchy necrosis but no evidence of malignancy or organisms; systemic screening for sarcoidosis and tuberculosis was negative. A markedly thickened and inflamed left ocular surface was present on referral, with areas of conjunctival ischemia and patchy white slough on the tarsi...
January 2024: Ophthalmic Plastic and Reconstructive Surgery
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