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Castells, Maria

Marcos Díaz-Gay, Sebastià Franch-Expósito, Coral Arnau-Collell, Solip Park, Fran Supek, Jenifer Muñoz, Laia Bonjoch, Anna Gratacós-Mulleras, Paula A Sánchez-Rojas, Clara Esteban-Jurado, Teresa Ocaña, Miriam Cuatrecasas, Maria Vila-Casadesús, Juan José Lozano, Genis Parra, Steve Laurie, Sergi Beltran, Epicolon Consortium, Antoni Castells, Luis Bujanda, Joaquín Cubiella, Francesc Balaguer, Sergi Castellví-Bel
Colorectal cancer (CRC) shows aggregation in some families but no alterations in the known hereditary CRC genes. We aimed to identify new candidate genes which are potentially involved in germline predisposition to familial CRC. An integrated analysis of germline and tumor whole-exome sequencing data was performed in 18 unrelated CRC families. Deleterious single nucleotide variants (SNV), short insertions and deletions (indels), copy number variants (CNVs) and loss of heterozygosity (LOH) were assessed as candidates for first germline or second somatic hits...
March 13, 2019: Cancers
Ibai Los-Arcos, Meritxell Royuela, María Teresa Martín-Gómez, Ana Alastruey-Izquierdo, Joana Sellarès, Manel Perelló, Lluís Castells, Cristina Dopazo, Joan Gavaldà, Oscar Len
Medicopsis romeroi is a melanized coelomycetous fungus, mainly found in tropical and subtropical regions and an uncommon cause of infection in solid organ transplant (SOT) recipients. We describe 2 cases of SOT recipients diagnosed with phaeohyphomycosis due to M. romeroi and provide a comprehensive literature review. These infections should be considered in patients native to tropical countries with a localized skin and soft tissue infection. Sequencing is needed for accurate identification of uncommon melanized fungi...
March 13, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Maria J Rodríguez-Lagunas, Filipa Vicente, Paula Pereira, Margarida Castell, Francisco J Pérez-Cano
Due to its polyphenol content, cocoa's potential health effects are attracting much attention, showing, among other things, cardioprotective, anti-inflammatory, anti-obesity, and neuroprotective actions. However, there is very limited information regarding the effect of cocoa on human immunity. This study aimed to establish the relationship between cocoa consumption and health status, focusing on physical activity habits and allergy prevalence in young people. For this, a sample of 270 university students was recruited to complete a food frequency questionnaire, the International Physical Activity Questionnaire (IPAQ), and a lifestyle and health status questionnaire...
February 23, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sofía D Castell, María F Harman, Gabriel Morón, Belkys A Maletto, María C Pistoresi-Palencia
It is well known that neutrophils are rapidly recruited to a site of injury or infection and perform a critical role in pathogen clearance and inflammation. However, they are also able to interact with and regulate innate and adaptive immune cells and some stimuli induce the migration of neutrophils to lymph nodes (LNs). Previously, we demonstrated that the immune complex (IC) generated by injecting OVA into the footpad of OVA/CFA immunized mice induced the migration of OVA+ neutrophils to draining LNs (dLNs)...
2019: Frontiers in Immunology
Carles Ariza, Francesca Sánchez-Martínez, Gemma Serral, Sara Valmayor, Olga Juárez, María Isabel Pasarín, Conxa Castell, Luis Rajmil, María José López
Background: Childhood obesity is becoming a serious problem, and prevention programs are needed. Objective: The purpose of this study was to evaluate, after 1 y, the effectiveness of a multicomponent, school-based obesity intervention program. Methods: This intervention, conducted in Barcelona, Spain, was a quasi-experimental obesity primary prevention intervention targeting schoolchildren aged 9-10 y. Participants were assigned to an intervention group (IG) (1464 students) or to a comparison group (CG) (1609 students)...
February 12, 2019: Journal of Nutrition
Steven Clayton, Elliot Cauble, Ambuj Kumar, Nirav Patil, Dennis Ledford, Narasaiah Kolliputi, Maria F Lopes-Virella, Donald Castell, Joel Richter
An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to achalasia or occurs with other diseases involving the esophagus. The primary aim of our study was to compare the differences in plasma immunological profiles (TNF- α receptor, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23) of patients with achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD)...
February 11, 2019: BMC Gastroenterology
Ma Assumpta Recasens, Eva Xicola-Coromina, Josep-Maria Manresa, Pierre Antoine Ullmo, Bjarne Bruun Jensen, Rosa Franco, Anna Suarez, Anna Nadal, Maria Vila, Isabel Recasens, M José Pérez, Conxa Castell, Esteve Llargués
BACKGROUND & AIMS: The prevalence of obesity and overweight among children is increasing, representing a new and pressing societal problem. Excess weight in childhood is an independent risk factor for adult obesity. Although school-based interventions are generally considered effective in the short term, few studies analyze their longterm impact. The aim of study was to assess if the effect of the intervention on body mass Index (BMI) immediately after the intervention remained eight years later (AVall Study)...
January 24, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Cristina Puzzarini, Maria Pilar de Lara-Castells, Maria J Ramos
No abstract text is available yet for this article.
February 1, 2019: Physical Chemistry Chemical Physics: PCCP
Marta Herreros-Villanueva, Saray Duran-Sanchon, Ana Carmen Martín, Rosa Pérez-Palacios, Elena Vila-Navarro, María Marcuello, Mireia Diaz-Centeno, Joaquín Cubiella, Maria Soledad Diez, Luis Bujanda, Angel Lanas, Rodrigo Jover, Vicent Hernández, Enrique Quintero, Juan José Lozano, Marta García-Cougil, Ibon Martínez-Arranz, Antoni Castells, Meritxell Gironella, Rocio Arroyo
OBJECTIVES: Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising diagnostic biomarkers for colorectal cancer (CRC) screening. In this study, we investigated the performance of a specific signature of miRNA in plasma samples to design a robust predictive model that can distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases...
January 2019: Clinical and Translational Gastroenterology
Manju Shri, Pradyumna Kumar Singh, Maria Kidwai, Neelam Gautam, Sonali Dubey, Giti Verma, Debasis Chakrabarty
Arsenic (As), classified as a "metalloid" element, is well known for its carcinogenicity and other toxic effects to humans. Arsenic exposure in plants results in the alteration of the physiochemical and biological properties and consequently, loss of crop yield. Being a staple food for half of the world's population, the consumption of As-contaminated rice grain by humans may pose serious health issues and risks for food security. In this study, we have described the principal understanding of the molecular basis of arsenic toxicity and accumulation in plant parts...
January 23, 2019: Metallomics: Integrated Biometal Science
Valéry Bocquet, Maria Ruiz-Castell, Carine de Beaufort, Jessica Barré, Nathalie de Rekeneire, Georges Michel, Richard P Donahue, Andrea Kuemmerle, Saverio Stranges
OBJECTIVE: The aim of this study was to determine the burden and risk factors of prediabetes and diabetes in the general adult population of Luxembourg. DESIGN: Cross-sectional survey between 2013 and 2015. SETTING: Data were collected as part of the European Health Examination Survey in Luxembourg (EHES-LUX). PARTICIPANTS: 1451 individuals were recruited in a random sample of the 25-64-year-old population of Luxembourg...
January 21, 2019: BMJ Open
Maria Del Mar Rigo-Adrover, Karen Knipping, Johan Garssen, Kees van Limpt, Jan Knol, Àngels Franch, Margarida Castell, Maria J Rodríguez-Lagunas, Francisco J Pérez-Cano
Several microbial modulatory concepts, such as certain probiotics and prebiotics, confer protection against gastrointestinal infections, among which is acute diarrhea caused by the rotavirus (RV). Other microbiota modulators, such as postbiotics, produced during fermentation, might also have the potential to counteract RV infection. In light of this, a fermented milk, made by using Bifidobacterium breve C50 (BbC50) and Streptococcus thermophilus 065 (St065) with a prebiotic mixture-short chain galactooligosaccharides/long chain fructooligosaccharides (scGOS/lcFOS 9:1)-with potential to impact the intestinal microbiota composition was tested...
January 18, 2019: Nutrients
Maria Del Mar Rigo-Adrover, Karen Knipping, Johan Garssen, Sandra Saldaña-Ruíz, Àngels Franch, Margarida Castell, Francisco J Pérez-Cano
Rotaviruses are the main cause of acute diarrhea among young children worldwide with an increased frequency of reinfection. Several life style factors, such as dietary components, may influence such processes by affecting the outcome of the first rotavirus infection and therefore having a beneficial impact on the anti-rotavirus immune responses during any subsequent reinfections. The aim of this research was to develop a double-infection model in rat that mimics real-life clinical scenarios and would be useful in testing whether nutritional compounds can modulate the rotavirus-associated disease and immune response...
January 10, 2019: Nutrients
Carolina Mangas-Sanjuan, Rodrigo Jover, Joaquín Cubiella, Mercè Marzo-Castillejo, Francesc Balaguer, Xavier Bessa, Luis Bujanda, Marco Bustamante, Antoni Castells, José Diaz-Tasende, Pilar Díez-Redondo, Maite Herráiz, Juan José Mascort-Roca, María Pellisé, Enrique Quintero
There is limited scientific evidence available to stratify the risk of developing metachronous colorectal cancer after resection of colonic polyps and to determine surveillance intervals and is mostly based on observational studies. However, while awaiting further evidence, the criteria of endoscopic follow-up needs to be unified in our setting. Therefore, the Spanish Association of Gastroenterology, the Spanish Society of Family and Community Medicine, the Spanish Society of Digestive Endoscopy, and the Colorectal Cancer Screening Group of the Spanish Society of Epidemiology, have written this consensus document, which is included in chapter 10 of the "Clinical Practice Guideline for Diagnosis and Prevention of Colorectal Cancer...
January 6, 2019: Gastroenterología y Hepatología
Konstantina Koutroumpa, Spyros Theodoridis, Ben H Warren, Ares Jiménez, Ferhat Celep, Musa Doğan, Maria M Romeiras, Arnoldo Santos-Guerra, Jóse María Fernández-Palacios, Juli Caujapé-Castells, Mónica Moura, Miguel Menezes de Sequeira, Elena Conti
Plumbaginaceae is characterized by a history of multiple taxonomic rearrangements and lacks a broad molecular phylogenetic framework. Limonium is the most species-rich genus of the family with ca . 600 species and cosmopolitan distribution. Its center of diversity is the Mediterranean region, where ca . 70% of all Limonium species are endemic. In this study, we sample 201 Limonium species covering all described infrageneric entities and spanning its wide geographic range, along with 64 species of other Plumbaginaceae genera, representing 23 out of 29 genera of the family...
December 2018: Ecology and Evolution
Erik J Timmermans, Elisa J de Koning, Natasja M van Schoor, Suzan van der Pas, Michael D Denkinger, Elaine M Dennison, Stefania Maggi, Nancy L Pedersen, Ángel Otero, Richard Peter, Cyrus Cooper, Paola Siviero, Maria Victoria Castell, Florian Herbolsheimer, Mark Edwards, Federica Limongi, Dorly J H Deeg, Laura A Schaap
BACKGROUND: This study examines the association of both pain severity and within-person pain variability with physical activity (PA) in older adults with osteoarthritis (OA). METHODS: Data from the European Project on OSteoArthritis were used. At baseline, clinical classification criteria of the American College of Rheumatology were used to diagnose OA in older adults (65-85 years). At baseline and 12-18 months follow-up, frequency and duration of participation in the activities walking, cycling, gardening, light and heavy household tasks, and sports activities were assessed with the Longitudinal Aging Study Amsterdam Physical Activity Questionnaire...
January 5, 2019: BMC Musculoskeletal Disorders
Margarita Posso, Javier Louro, Mar Sánchez, Marta Román, Carmen Vidal, María Sala, Marisa Baré, Xavier Castells
OBJECTIVES: To investigate how breast density affects screening performance indicators in a digital mammography context. METHODS: We assessed the effect of breast density over the screen-detected and interval cancers rates, false-positives, specificity, sensitivity, recall rate, positive predictive value of recall (PPV-1), and PPV of invasive tests (PPV-2). Radiologists classified breast density using the BIRADS System. We used generalized estimating equations to account for within-woman correlation by means of the robust Huber-White variance estimator...
January 2019: European Journal of Radiology
Victoria J Butler, Dominique A Salazar, David Soriano-Castell, Miguel Alves-Ferreira, Frank J A Dennissen, Mihir Vohra, Juan A Oses-Prieto, Kathy H Li, Austin L Wang, Beibei Jing, Biao Li, Alex Groisman, Edgar Gutierrez, Sean Mooney, Alma L Burlingame, Kaveh Ashrafi, Eva-Maria Mandelkow, Sandra E Encalada, Aimee W Kao
Mutations in the microtubule-associated protein tau (MAPT) underlie multiple neurodegenerative disorders, yet the pathophysiological mechanisms are unclear. A novel variant in MAPT resulting in an alanine to threonine substitution at position 152 (A152T tau) has recently been described as a significant risk factor for both frontotemporal lobar degeneration and Alzheimer's disease. Here we use complementary computational, biochemical, molecular, genetic and imaging approaches in Caenorhabditis elegans and mouse models to interrogate the effects of the A152T variant on tau function...
December 26, 2018: Human Molecular Genetics
Alexis Sentís, Cristina González, Maria Montero, Milagros Herranz, Carlota Hidalgo, Cristina Campà, Maria Sala, Francesc Macià, Marta Román, Albert Prats-Uribe, Juan Pablo Horcajada, Xavier Castells
Background: To determine the risk of hospital readmission and associated factors in patients with a positive sample for multidrug-resistant microorganisms (MRM) and to analyze whether there is a higher risk of hospital readmission with some of the more common MRM. Methods: Retrospective cohort study (2012-16) performed in a tertiary-care teaching hospital in Barcelona. Patients were divided into two groups, depending on the presence or absence of an MRM-positive sample during hospital admission...
December 24, 2018: European Journal of Public Health
Dritan Bejko, Maria Ruiz-Castell, Anna Schritz, Bjarne Laursen, Rupert Kisser, Wim Rogmans, Ronan A Lyons, Huib Valkenberg, Samantha Turner, Robert Bauer, Gabrielle Ellsaesser, Nathalie de Rekeneire
Background: Measuring the true incidence of injury or medically attended injury is challenging. Population surveys, despite problems with recall and selection bias, remain the only source of information for injury incidence calculation in many countries. Emergency department (ED) registry based data provide an alternative source.The aim of this study is to compare the yearly incidence of hospital treated Home and Leisure Injuries (HLI), and Road Traffic Injuries (RTI) estimated by survey-based and register-based methods and combine information from both sources in to a comprehensive injury burden pyramide...
2018: Archives of Public Health, Archives Belges de Santé Publique
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