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Mauricio La Rosa, Victoria Jauk, George R Saade, Kim Boggess, Sherri Longo, Erin A S Clark, Sean Esplin, Kirsten Cleary, Ronald Wapner, Kellet Letson, Michelle Y Owens, Sean Blackwell, Jeff M Szychowski, William Andrews, Alan T Tita
OBJECTIVE:  Hospital readmissions are increasingly tracked and assessed for value-based compensation. Our objective was to determine the incidence and risk factors associated with post-cesarean delivery (CD) readmissions or unexpected visits, defined as unexpected office or emergency room visits. STUDY DESIGN:  This is a secondary analysis of a multicenter randomized controlled trial of adjunctive azithromycin prophylaxis for CD performed in laboring patients with viable pregnancies...
March 15, 2019: American Journal of Perinatology
Ronald Ayoub, Yugyung Lee
Given the close relationship between protein structure and function, protein structure searches have long played an established role in bioinformatics. Despite their maturity, existing protein structure searches either use simplifying assumptions or compromise between fast response times and quality of results. These limitations can prevent the easy and efficient exploration of relationships between protein structures, which is the norm in other areas of inquiry. To address these limitations we have developed RUPEE, a fast and accurate purely geometric structure search combining techniques from information retrieval and big data with a novel approach to encoding sequences of torsion angles...
2019: PloS One
Kelly L Zuromski, Samantha L Bernecker, Peter M Gutierrez, Thomas E Joiner, Andrew J King, Howard Liu, James A Naifeh, Matthew K Nock, Nancy A Sampson, Alan M Zaslavsky, Murray B Stein, Robert J Ursano, Ronald C Kessler
Importance: The Department of Veterans Affairs recently began requiring annual suicide ideation (SI) screening of all patients and additional structured questions for patients reporting SI. Related changes are under consideration at the Department of Defense. These changes will presumably lead to higher SI detection, which will require hiring additional clinical staff and/or developing a clinical decision support system to focus in-depth suicide risk assessments on patients considered high risk...
March 1, 2019: JAMA Network Open
Qi Zhang, Sang Beom Lee, Xu Chen, Morgan Stevenson, Jing Pan, Donghai Xiong, Yu Zhou, Mark Miller, Ronald A Lubet, Yian Wang, Shama Mirza, Ming You
Bexarotene has exhibited inhibitory effects in preclinical models of lung, mammary gland tumorigenesis and in phase I/II trials of non-small cell lung cancer. The major side effects of bexarotene when administered orally were hypertriglyceridemia and hypercholesterolemia. In our previous study we demonstrated that aerosolized bexarotene through nasal inhalation exhibited potent chemopreventive activity in a lung adenoma preclinical model without the hypertriglyceridemia. To facilitate its future clinical translation, we modified the formula of the aerosolized bexarotene with a clinically relevant solvent system...
March 15, 2019: Nano Letters
Edoardo Picetti, Ronald V Maier, Sandra Rossi, Andrew W Kirkpatrick, Walter L Biffl, Philip F Stahel, Ernest E Moore, Yoram Kluger, Gian Luca Baiocchi, Luca Ansaloni, Vanni Agnoletti, Fausto Catena
Background: Traumatic brain injury (TBI) is a global health problem. Extracranial hemorrhagic lesions needing emergency surgery adversely affect the outcome of TBI. We conducted an international survey regarding the acute phase management practices in TBI polytrauma patients. Methods: A questionnaire was available on the World Society of Emergency Surgery website between December 2017 and February 2018. The main endpoints were the evaluation of (1) intracranial pressure (ICP) monitoring during extracranial emergency surgery (EES), (2) hemodynamic management without ICP monitoring during EES, (3) coagulation management, and (4) utilization of simultaneous multisystem surgery (SMS)...
2019: World Journal of Emergency Surgery: WJES
Femke M Hormann, Alex Q Hoogkamer, H Berna Beverloo, Aurélie Boeree, Ilse Dingjan, Moniek M Wattel, Ronald W Stam, Gabriele Escherich, Rob Pieters, Monique L den Boer, Judith M Boer
No abstract text is available yet for this article.
March 14, 2019: Haematologica
Mary Sano, Carolyn W Zhu, Jeffrey Kaye, James C Mundt, Tamara L Hayes, Steven Ferris, Ronald G Thomas, Chung-Kai Sun, Yanxin Jiang, Michael C Donohue, Lon S Schneider, Susan Egelko, Paul S Aisen, Howard H Feldman
INTRODUCTION: There is an unmet need for effective methods for conducting dementia prevention trials. METHODS: Home-based assessment study compared feasibility and efficiency, ability to capture change over time using in-home instruments, and ability to predict cognitive conversion using predefined triggers in a randomized clinical trial in (1) mail-in questionnaire/live telephone interviews, (2) automated telephone/interactive voice recognition, and (3) internet-based computer Kiosk technologies...
March 11, 2019: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Chelsea Chandler, Tianshi Liu, Ronald Buckanovich, Lan G Coffman
Cancer-associated fibrosis is a critical component of the tumor microenvironment (TME) which significantly impacts cancer behavior. However, there is significant controversy regarding fibrosis as a predominantly tumor promoting or tumor suppressing factor. Cells essential to the generation of tissue fibrosis such as fibroblasts and mesenchymal stem cells (MSCs) have dual phenotypes dependent upon their independence or association with cancer cells. Cancer-associated fibroblasts and cancer-associated MSCs have unique molecular profiles which facilitate cancer cell cross talk, influence extracellular matrix deposition, and direct the immune system to generate a protumorigenic environment...
February 21, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
Jacob P Brunner, Ronald G Amedee
No abstract text is available yet for this article.
March 2019: American Journal of Rhinology & Allergy
Rowan Saloner, Robert K Heaton, Laura M Campbell, Anna Chen, Donald Franklin, Ronald J Ellis, Ann C Collier, Christina Marra, David B Clifford, Benjamin Gelman, Ned Sacktor, Susan Morgello, J Allen Mccutchan, Scott Letendre, Igor Grant, Christine Fennema-Notestine
OBJECTIVE: The influence of confounding neurocognitive comorbidities in persons living with HIV (PLWH) on neuroimaging has not been systematically evaluated. We determined associations between comorbidity burden and brain integrity and examined the moderating effect of age on these relationships. DESIGN: Observational, cross-sectional substudy of the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) cohort. METHODS: 288 PLWH (mean age=44...
March 11, 2019: AIDS
Joseph DiNorcia, Sander S Florman, Brandy Haydel, Parissa Tabrizian, Richard M Ruiz, Goran B Klintmalm, Srinath Senguttuvan, David D Lee, C Burcin Taner, Elizabeth C Verna, Karim J Halazun, Maarouf Hoteit, Matthew H Levine, William C Chapman, Neeta Vachharajani, Federico Aucejo, Mindie H Nguyen, Marc L Melcher, Amit D Tevar, Abhinav Humar, Constance Mobley, Mark Ghobrial, Trevor L Nydam, Beth Amundsen, James F Markmann, Jennifer Berumen, Alan W Hemming, Alan N Langnas, Carol A Carney, Debra L Sudan, Johnny C Hong, Joohyun Kim, Michael A Zimmerman, Abbas Rana, Michael L Kueht, Christopher M Jones, Thomas M Fishbein, Daniela Markovic, Ronald W Busuttil, Vatche G Agopian
MINI: In a large, multicenter study of patients undergoing liver transplantation for hepatocellular carcinoma, complete pathologic response (cPR) to pretransplant locoregional therapy (LRT) portended significantly superior overall and recurrence-free survival. Multivariable predictors of cPR included age, sex, liver disease diagnosis, MELD, AFP, NLR, radiographic Milan status, and number of LRT treatments. OBJECTIVE: The aim of the study was to determine the rate, predictors, and impact of complete pathologic response (cPR) to pretransplant locoregional therapy (LRT) in a large, multicenter cohort of hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT)...
March 5, 2019: Annals of Surgery
Nabin K Mishra, Ravneet Kaur, Reda Kasmi, Jason R Hagerty, Robert LeAnder, Ronald J Stanley, Randy H Moss, William V Stoecker
PURPOSE: We present a classifier for automatically selecting a lesion border for dermoscopy skin lesion images, to aid in computer-aided diagnosis of melanoma. Variation in photographic technique of dermoscopy images makes segmentation of skin lesions a difficult problem. No single algorithm provides an acceptable lesion border to allow further processing of skin lesions. METHODS: We present a random forests border classifier model to select a lesion border from 12 segmentation algorithm borders, graded on a "good-enough" border basis...
March 14, 2019: Skin Research and Technology
Luke A Allen, Sjoerd B Vos, Rajesh Kumar, Jennifer A Ogren, Rebecca K Harper, Gavin P Winston, Simona Balestrini, Britta Wandschneider, Catherine A Scott, Sebsatien Ourselin, John S Duncan, Samden D Lhatoo, Ronald M Harper, Beate Diehl
OBJECTIVE: The processes underlying sudden unexpected death in epilepsy (SUDEP) remain elusive, but centrally mediated cardiovascular or respiratory collapse is suspected. Volume changes in brain areas mediating recovery from extreme cardiorespiratory challenges may indicate failure mechanisms and allow prospective identification of SUDEP risk. METHODS: We retrospectively imaged SUDEP cases (n = 25), patients comparable for age, sex, epilepsy syndrome, localization, and disease duration who were high-risk (n = 25) or low-risk (n = 23), and age- and sex-matched healthy controls (n = 25) with identical high-resolution T1-weighted scans...
March 14, 2019: Epilepsia
Jennifer A Chase, Melissa L Partyka, Ronald F Bond, Edward R Atwill
Field trials were conducted in July-August and October 2012 to quantify the inactivation rate of Escherichia coli O157:H7 when mixed with fecal slurry and applied to romaine lettuce leaves. Lettuce was grown under commercial conditions in Salinas Valley, California. One-half milliliter of rabbit, chicken, or pig fecal slurry, containing an average of 4.05 × 107 CFU E. coli O157:H7 (C0 ), was inoculated onto the upper (adaxial) surface of a lower leaf on 288 heads of lettuce per trial immediately following a 2...
2019: PeerJ
Wendy Bernhard, Ayman El-Sayed, Kris Barreto, Carolina Gonzalez, Humphrey Fonge, Clarence Ronald Geyer
Epidermal growth factor receptor (EGFR) is a transmembrane cell surface receptor that is frequently overexpressed and/or mutated in many cancers. Therapies targeting EGFR have poor outcomes due to the lack of reliable diagnostic tests to monitor EGFR. Current in vitro EGFR diagnostic methods are invasive, requiring biopsies, which limits tumor sampling and availability. EGFR molecular imaging provides non-invasive whole-body images capable of detecting primary tumors and metastases, which can be used to diagnose and monitor response to therapy...
2019: Theranostics
TianDuo Wang, Yuanxin Chen, John A Ronald
Early and accurate detection of cancer is essential to optimising patient outcomes. Of particular importance to prostate cancer is the ability to determine the aggressiveness of a primary tumour, which allows for effective management of patient care. In this work, we propose using gene vectors called tumour-activatable minicircles which deliver an exogenously encoded reporter gene into cancer cells, forcing them to produce a unique and sensitive biomarker. These minicircles express a blood reporter protein called secreted embryonic alkaline phosphatase mediated by the tumour-specific survivin promoter, which exhibits activity graded to prostate cancer aggressiveness...
March 13, 2019: Gene Therapy
Oliver Xiaoou Dong, Pamela C Ronald
No abstract text is available yet for this article.
March 13, 2019: Plant Physiology
Ahmed Kandeil, Mokhtar Gomaa, Mahmoud Shehata, Ahmed El-Taweel, Ahmed E Kayed, Awatef Abiadh, Jamel Jrijer, Yassmin Moatasim, Omnia Kutkat, Ola Bagato, Sara Mahmoud, Ahmed Mostafa, Rabeh El-Shesheny, Ranawaka Apm Perera, Ronald Lw Ko, Nagla Hassan, Basma Elsokary, Lotfi Allal, Ahmed Saad, Heba Sobhy, Pamela P McKenzie, Richard J Webby, Malik Peiris, Mohamed A Ali, Ghazi Kayali
Dromedary camels are natural host of the Middle East respiratory syndrome coronavirus (MERS-CoV). However, there are limited studies of MERS-CoV infection of other domestic mammals exposed to infected dromedaries. We expanded our surveillance among camels in Egypt, Tunisia, and Senegal to include other domestic mammalian species in contact with infected camels. A total of 820 sera and 823 nasal swabs from cattle, sheep, goats, donkeys, buffaloes, mules, and horses were collected. Swabs were tested using RT-PCR and virus RNA-positive samples were genetically sequenced and phylogenetically analysed...
2019: Emerging Microbes & Infections
Tomoya Kitani, Sang-Ging Ong, Chi Keung Lam, June-Wha Rhee, Joe Z Zhang, Angelos Oikonomopoulos, Ning Ma, Lei Tian, Jaecheol Lee, Melinda L Telli, Ronald M Witteles, Arun Sharma, Nazish Sayed, Joseph C Wu
BACKGROUND: Molecular targeted chemotherapies have been shown to significantly improve cancer patient outcomes, but often cause cardiovascular side effects that limit their use and impair patients' quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a distinct cardiotoxic clinical phenotype compared to cardiotoxicity induced by conventional chemotherapies. METHODS: We employed the human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) platform to determine the underlying cellular mechanisms in trastuzumab-induced cardiac dysfunction...
March 14, 2019: Circulation
Frank Kiwanuka, Mesomeeh Imanipour, Sanaz Akhavan Rad, Ronald Masaba, Yisak Hagos Alemayehu
BACKGROUND: Admission to Intensive Care Units (ICU) exposures family members to a new environment, advanced monitoring systems and aggressive treatments. This is coupled with the critical condition of the patient being admitted in ICU. In such times of stress and crisis, families have varying experiences as they navigate the ICU journey. These happen more or less in chronological phases. AIM: This review sought to describe the experiences of family members of patients admitted in adult ICUs...
March 13, 2019: Scandinavian Journal of Caring Sciences
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