Nabham Rai, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Grégoire Manaud, Swathi Veeroju, Clemens Ruppert, Frédéric Perros, Hossein Ardeschir Ghofrani, Norbert Weissmann, Werner Seeger, Ralph T Schermuly, Tatyana Novoyatleva
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disease characterised by pro-proliferative and anti-apoptotic phenotype in vascular cells, leading to pulmonary vascular remodelling and right heart failure. Peptidyl-prolyl cis / trans isomerase, NIMA interacting 1 (Pin1), a highly conserved enzyme, which binds to and catalyses the isomerisation of specific phosphorylated Ser/Thr-Pro motifs, acts as a molecular switch in multiple coordinated cellular processes. We hypothesised that Pin1 plays a substantial role in PAH, and its inhibition with a natural organic compound, Juglone, would reverse experimental pulmonary hypertension...
August 2022: European Respiratory Journal