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https://read.qxmd.com/read/30877976/prognostic-impact-of-src-cdkn1b-and-jak2-expression-in-metastatic-breast-cancer-patients-treated-with-trastuzumab
#1
Panagiota Economopoulou, Vassiliki Kotoula, Georgia-Angeliki Koliou, Kyriaki Papadopoulou, Christos Christodoulou, George Pentheroudakis, Georgios Lazaridis, Petroula Arapantoni-Dadioti, Angelos Koutras, Dimitris Bafaloukos, Pavlos Papakostas, Helen Patsea, Kitty Pavlakis, Dimitrios Pectasides, Athanasios Kotsakis, Evangelia Razis, Gerasimos Aravantinos, Epaminondas Samantas, Konstantine T Kalogeras, Theofanis Economopoulos, Amanta Psyrri, George Fountzilas
BACKGROUND: Src, CDKN1B, and JAK2 play a crucial role in the coordination of cell signaling pathways. In the present study, we aim to investigate the prognostic significance of these biomarkers in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab (T). METHODS: Formalin-fixed paraffin-embedded tumor tissue samples from 197 patients with HER2-positive MBC treated with T were retrospectively collected. All tissue samples were centrally assessed for ER, PgR, Ki67, HER2, and PTEN protein expression; EGFR gene amplification; PI3KCA mutational status; and tumor-infiltrating lympocytes density...
March 13, 2019: Translational Oncology
https://read.qxmd.com/read/30877479/the-2018-guidelines-for-the-diagnosis-and-treatment-of-osteoporosis-in-greece
#2
Polyzois Makras, Athanasios D Anastasilakis, George Antypas, Efstathios Chronopoulos, Evangelia G Kaskani, Aikaterini Matsouka, Dimos K Patrikos, Konstantinos D Stathopoulos, Symeon Tournis, George Trovas, Christos Kosmidis
We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting. PURPOSE: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011. METHODS: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece...
March 15, 2019: Archives of Osteoporosis
https://read.qxmd.com/read/30877075/outcomes-and-treatment-strategies-for-autoimmunity-and-hyperinflammation-in-patients-with-rag-deficiency
#3
Jocelyn R Farmer, Zsofia Foldvari, Boglarka Ujhazi, Suk See De Ravin, Karin Chen, Jack J H Bleesing, Catharina Schuetz, Waleed Al-Herz, Roshini Sarah Abraham, Avni Y Joshi, Beatriz T Costa-Carvalho, David Buchbinder, Claire Booth, Andreas Reiff, Polly J Ferguson, Asghar Aghamohammadi, Hassan Abolhassani, Jennifer M Puck, Mehdi Adeli, Caterina Cancrini, Paolo Palma, Alice Bertaina, Franco Locatelli, Gigliola Di Matteo, Raif S Geha, Maria G Kanariou, Evangelia Lycopoulou, Marianna Tzanoudaki, John W Sleasman, Suhag Parikh, Gloria Pinero, Bernard M Fischer, Ghassan Dbaibo, Ekrem Unal, Turkan Patiroglu, Musa Karakukcu, Khulood Khalifa Al-Saad, Meredith A Dilley, Sung-Yun Pai, Cullen M Dutmer, Erwin W Gelfand, Christoph B Geier, Martha M Eibl, Hermann M Wolf, Lauren A Henderson, Melissa M Hazen, Carmem Bonfim, Beata Wolska-Kuśnierz, Manish J Butte, Joseph D Hernandez, Sarah K Nicholas, Polina Stepensky, Shanmuganathan Chandrakasan, Maurizio Miano, Emma Westermann-Clark, Vera Goda, Gergely Kriván, Steven M Holland, Olajumoke Fadugba, Sarah E Henrickson, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Ayca Kiykim, Robbert Bredius, Birgit Hoeger, Kaan Boztug, Olga Pashchenko, Benedicte Neven, Despina Moshous, Jean-Pierre de Villartay, Ahmed Aziz Bousfiha, Harry R Hill, Luigi D Notarangelo, Jolan E Walter
BACKGROUND: While autoimmunity and hyperinflammation secondary to recombinase activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series. OBJECTIVE: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency. METHODS: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology...
March 12, 2019: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/30871083/antidiabetic-properties-of-naringenin-a-citrus-fruit-polyphenol
#4
REVIEW
Danja J Den Hartogh, Evangelia Tsiani
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and hyperglycemia and is associated with personal health and global economic burdens. Current strategies/approaches of insulin resistance and T2DM prevention and treatment are lacking in efficacy resulting in the need for new preventative and targeted therapies. In recent years, epidemiological studies have suggested that diets rich in vegetables and fruits are associated with health benefits including protection against insulin resistance and T2DM...
March 12, 2019: Biomolecules
https://read.qxmd.com/read/30868169/health-related-quality-of-life-in-cutaneous-lymphomas-past-present-and-future
#5
Constanze Jonak, Stefanie Porkert, Simone Oerlemans, Evangelia Papadavid, Kevin Molloy, Eva Lehner-Baumgartner, Antonio Cozzio, Fabio Efficace, Julia Scarisbrick
Previous studies have reported that primary cutaneous lymphomas profoundly influence patients' health-related quality of life (HRQoL). However, assessment of this psycho-social concept is not common in routine patient care unless required within clinical trials. The aim of this review is to provide a comprehensive overview of HRQoL measures and outcomes in cutaneous lym-phomas in order to inform clinicians. Advanced-stage cutaneous lymphomas was found to be associated with worse HRQoL than early-stage disease...
March 14, 2019: Acta Dermato-venereologica
https://read.qxmd.com/read/30867554/clinical-scale-production-of-aspergillus-specific-t-cells-for-the-treatment-of-invasive-aspergillosis-in-the-immunocompromised-host
#6
Anastasia Papadopoulou, Maria Alvanou, Kiriakos Koukoulias, Evangelia Athanasiou, Andriana Lazaridou, Nikolaos Savvopoulos, Panayotis Kaloyannidis, Anthi-Marina Markantonatou, Timoleon-Achilleas Vyzantiadis, Minas Yiangou, Achilles Anagnostopoulos, Evangelia Yannaki
Invasive aspergillosis (IA) represents a leading cause of mortality in immunocompromised patients. Although adoptive immunotherapy with Aspergillus-specific T cells (Asp-STs) represents a promising therapeutic approach against IA, the complex and costly production limits its broader application. We generated Asp-STs from a single blood draw of healthy individuals or IA patients in only 10 days, by either Aspergillus fumigatus (AF) lysate or peptide stimulation of mononuclear cells. The cells were phenotypically and functionally characterized, and safety was assessed in xenografts...
March 13, 2019: Bone Marrow Transplantation
https://read.qxmd.com/read/30866666/right-ventricular-dysfunction-and-the-effect-of-defibrillator-implantation-in-patients-with-nonischemic-systolic-heart-failure
#7
Marie Bayer Elming, Sophia Hammer-Hansen, Inga Voges, Evangelia Nyktari, Anna Axelsson Raja, Jesper Hastrup Svendsen, Steen Pehrson, James Signorovitch, Lars Valeur Køber, Sanjay K Prasad, Jens Jakob Thune
Background Patients with nonischemic systolic heart failure are at an increased risk of sudden cardiac death, but more discriminating tools are needed to identify those patients likely to benefit from implantable cardioverter-defibrillator (ICD) implantation. Whether right ventricular (RV) ejection fraction (RVEF) can identify patients with nonischemic systolic heart failure more likely to benefit from ICD implantation is not yet known. Methods In this post hoc analysis of the DANISH trial (Danish Study to Assess the Efficacy of ICDs in Patients with Nonischemic Systolic Heart Failure on Mortality), patients with nonischemic systolic heart failure randomized to ICD or control underwent cardiovascular magnetic resonance...
March 2019: Circulation. Arrhythmia and Electrophysiology
https://read.qxmd.com/read/30866549/population-health-inequalities-across-and-within-european-metropolitan-areas-through-the-lens-of-the-euro-healthy-population-health-index
#8
Claudia Costa, Paula Santana, Sani Dimitroulopoulou, Bo Burstrom, Carme Borrell, Jürgen Schweikart, Dagmar Dzurova, Nicolás Zangarini, Klea Katsouyanni, Patrick Deboseree, Ângela Freitas, Christina Mitsakou, Evangelia Samoli, Sotiris Vardoulakis, Marc Marí Dell'Olmo, Mercè Gotsens, Michala Lustigova, Diana Corman, Giuseppe Costa
The different geographical contexts seen in European metropolitan areas are reflected in the uneven distribution of health risk factors for the population. Accumulating evidence on multiple health determinants point to the importance of individual, social, economic, physical and built environment features, which can be shaped by the local authorities. The complexity of measuring health, which at the same time underscores the level of intra-urban inequalities, calls for integrated and multidimensional approaches...
March 7, 2019: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30850364/serum-proteomic-signatures-of-male-breast-cancer
#9
Eleni Zografos, Athanasios K Anagnostopoulos, Aggeliki Papadopoulou, Evangelia Legaki, Flora Zagouri, Evangelos Marinos, George T Tsangaris, Maria Gazouli
BACKGROUND: To date, the elucidation of serum protein alterations in male breast cancer (MBC) has not been extensively studied, due to the rarity of the disease. MATERIALS AND METHODS: In the present work, two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) were employed to detect differences in serum protein expression between patients with MBC and healthy controls. RESULTS: A panel of differentially expressed serum proteins was identified, including proteins involved in the regulation of the cell cycle [e...
March 2019: Cancer Genomics & Proteomics
https://read.qxmd.com/read/30846472/effects-of-exercise-and-airway-clearance-pep-on-mucus-clearance-in-cystic-fibrosis-a-randomised-cross-over-trial
#10
Tiffany J Dwyer, Evangelia Daviskas, Rahizan Zainuldin, Jordan Verschuer, Stefan Eberl, Peter T P Bye, Jennifer A Alison
Exercise improves mucus clearance in people without lung disease and those with chronic bronchitis. No study has investigated exercise alone for mucus clearance in cystic fibrosis (CF). The aim was to compare treadmill exercise to resting breathing and airway clearance with Positive Expiratory Pressure (PEP) therapy, on mucus clearance in adults with CF.Fourteen adults with mild to severe CF lung disease (FEV1 31-113% predicted) completed a three-day randomised, controlled, cross-over trial. Interventions were 20 min of: resting breathing (control); treadmill exercise at 60% of the participant's peak oxygen consumption; and PEP therapy (including huffing and coughing)...
March 7, 2019: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://read.qxmd.com/read/30843003/more-advantages-in-detecting-bone-and-soft-tissue-metastases-from-prostate-cancer-using-18-f-psma-pet-ct
#11
EDITORIAL
Nikoletta K Pianou, Petros Z Stavrou, Evangelia Vlontzou, Phivi Rondogianni, Demetrios N Exarhos, Ioannis E Datseris
Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Imaging of BM is important not only for localization and characterization, but also to evaluate their size and number, as well as to follow-up the disease during and after therapy. Bone metastases formation is triggered by cancer initiating cells in the bone marrow and is facilitated by the release of several growth factors...
March 5, 2019: Hellenic Journal of Nuclear Medicine
https://read.qxmd.com/read/30838128/kindler-syndrome-a-rare-case-report-from-greece
#12
Maria Gkaitatzi, Evangelia Kalloniati, Cristina Has, Dimitra Kiritsi, Theofanis Spiliopoulos, Sophia Georgiou
Kindler syndrome is a rare autosomal recessive inherited disease characterized by infantile acral bullae, progressive poikiloderma, cutaneous atrophy, photosensitivity and various forms of mucosal involvement. In this paper, we report a case of a 49-year-old Greek Caucasian male aiming to emphasize the importance of genetic analysis as a gold standard of diagnosis.
February 2019: Oxford Medical Case Reports
https://read.qxmd.com/read/30838025/developing-biotel-a-semi-automated-spreadsheet-for-estimating-telomere-length-and-biological-age
#13
Aristidis Tsatsakis, Dimitrios Tsoukalas, Persefoni Fragkiadaki, Elena Vakonaki, Manolis Tzatzarakis, Evangelia Sarandi, Dragana Nikitovic, Gerasimos Tsilimidos, Athanasios K Alegakis
Introduction: Telomere length (TL) is causally related to aging and several age-related diseases. Specifically, the abundance of short telomeres and the rate of telomere shortening are strong determinants of cell homeostasis. Thus, tools for analyzing and manipulating TL data can vastly improve research focused on aging. Aim: In this study, we developed a semi-automated worksheet, BIOTEL, to generate individual and group TL statistics and provide a crude estimation of biological age. Results: Data from the Telomere Length Database Project (TLDP) were implemented to the spreadsheet to produce TL statistics...
2019: Frontiers in Genetics
https://read.qxmd.com/read/30837596/the-genetic-vulnerability-to-cisplatin-ototoxicity-a-systematic-review
#14
Evangelia Tserga, Tara Nandwani, Niklas K Edvall, Jan Bulla, Poulam Patel, Barbara Canlon, Christopher R Cederroth, David M Baguley
Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of genetics upon the risk of developing hearing loss. We searched Embase, Medline, ASSIA, Pubmed, Scopus, and Web of Science, for studies documenting the genetic risk of ototoxicity in patients with cancer treated with cisplatin. Titles/abstracts and full texts were reviewed for inclusion...
March 5, 2019: Scientific Reports
https://read.qxmd.com/read/30825178/matrigel-plug-assay-for-in-vivo-evaluation-of-angiogenesis
#15
Pinelopi Kastana, Fatema Tuz Zahra, Despoina Ntenekou, Stamatiki Katraki-Pavlou, Dimitris Beis, Michail S Lionakis, Constantinos Μ Mikelis, Evangelia Papadimitriou
Matrigel is extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma in C57BL/6 mice, a tumor rich in extracellular matrix (ECM) proteins. It consists mainly of laminin (approximately 60%), collagen IV (approximately 30%), and nidogen-1/entactin (approximately 8%), while it also contains heparan sulfate proteoglycans, such as perlecan, other ECM proteins, as well as growth factors bound to the ECM. Matrigel mimics the physiological cell matrix and is the most commonly used matrix substrate to study in vitro and in vivo angiogenesis...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30825177/in-vitro-spheroid-sprouting-assay-of-angiogenesis
#16
Fatema Tuz Zahra, Efrossini Choleva, Md Sanaullah Sajib, Evangelia Papadimitriou, Constantinos Μ Mikelis
Angiogenesis is a well-coordinated physiological process that leads to new blood vessel formation. Physiologically, angiogenesis is more prominent during development and wound healing and its dysregulation drives or is related to several diseases, including cancer. The endothelial cells are the main regulators of the angiogenic process, and thus the angiogenic outcome is assessed based on the effect on endothelial cell functions. Several in vitro and in vivo techniques have been developed to assess the effect of various factors on angiogenesis...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30821196/first-report-of-a-coincidental-discovery-of-hb-shimonoseki-%C3%AE-54-e3-gln%C3%A2-arg-hba2-c-164a-g-or-hba1-in-a-greek-family
#17
Stamatia Theodoridou, Evangelia Delaki, Evangelia Skatharoudi, Olga Karakasidou, Timoleon-Achilleas Vyzantiadis, Theodoros Theodoridis, Panagiota Chalkia
The rare Hb Shimonoseki [α54(E3)Gln→Arg, HBA2: c.164A > G (or HBA1)] has been reported in Western Japan. Hb Shimonoseki seems to be an innocuous variant and few published data are available. Heterozygous carriers have no clinical or hematological findings. The abnormal hemoglobin (Hb) was detected by high performance liquid chromatography (HPLC) and classic electrophoresis or capillary electrophoresis (CE), but confirmation of the variant is based on molecular studies. This is the first description of Hb Shimonoseki heterozygosity in a Greek family...
July 2018: Hemoglobin
https://read.qxmd.com/read/30820252/%C3%AE-78-year-old-female-who-presents-with-a-non-resolving-pneumonia-what-is-your-diagnosis
#18
Evangelia Panagiotidou, Serafeim-Chrysovalantis Kotoulas, Maria Kilmpasani, Nikoleta Pastelli, Sofia Akritidou, Evangelos Chatzopoulos, Vasilis Bikos, Vasilios Bagalas, Katalin Fekete-Passa, Ioannis Stanopoulos, Athanasia Pataka
Non-resolving pneumonia with a mass-like radiological appearance raises clinical suspicion of many causes, with malignancy the most prominent. Infectious causes should be investigated thoroughly as they carry a better prognosis. http://ow.ly/QEPL30mLIk4.
December 2018: Breathe
https://read.qxmd.com/read/30809527/network-meta-analysis-of-metabolic-effects-of-olive-oil-in-humans-shows-the-importance-of-olive-oil-consumption-with-moderate-polyphenol-levels-as-part-of-the-mediterranean-diet
#19
Evangelia Tsartsou, Nikolaos Proutsos, Elias Castanas, Marilena Kampa
The beneficial role of olive oil consumption is nowadays widely recognized. However, it is not clear whether its health effects are due to the presence of monounsaturated lipids and/or to the antioxidant fraction of microconstituents present in olive oil. The aim of the present study was to analyze the exact role of olive oil in the modification of metabolic factors (glucose and circulating lipids) and explore the role of its antioxidant polyphenols. In the present work, we have performed a network meta-analysis of 30 human intervention studies, considering direct and indirect interactions and impact of each constituent...
2019: Frontiers in Nutrition
https://read.qxmd.com/read/30806588/lexical-competition-on-demand
#20
Gary M Oppenheim, Evangelia Balatsou
No abstract text is available yet for this article.
February 26, 2019: Cognitive Neuropsychology
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