Jianling Bi, Emily Witt, Vanessa A Voltarelli, Vivian R Feig, Veena Venkatachalam, Hannah Boyce, Megan McGovern, Wade R Gutierrez, Jeffrey D Rytlewski, Kate R Bowman, Ashley C Rhodes, Austin N Cook, Benjamin N Muller, Matthew G Smith, Alexis Rebecca Ramos, Heena Panchal, Rebecca D Dodd, Michael D Henry, Adam Mailloux, Giovanni Traverso, Leo E Otterbein, James D Byrne
Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard-of-care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas-entrapping materials (GeMs) that are capable of tunable oxygen release are formulated...
February 2, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)