keyword
https://read.qxmd.com/read/38515789/glitches-in-the-brain-the-dangerous-relationship-between-radiotherapy-and-brain-fog
#1
REVIEW
Noemi Marino, Martina Bedeschi, Melania Elettra Vaccari, Marco Cambiaghi, Anna Tesei
Up to approximately 70% of cancer survivors report persistent deficits in memory, attention, speed of information processing, multi-tasking, and mental health functioning, a series of symptoms known as "brain fog." The severity and duration of such effects can vary depending on age, cancer type, and treatment regimens. In particular, every year, hundreds of thousands of patients worldwide undergo radiotherapy (RT) for primary brain tumors and brain metastases originating from extracranial tumors. Besides its potential benefits in the control of tumor progression, recent studies indicate that RT reprograms the brain tumor microenvironment inducing increased activation of microglia and astrocytes and a consequent general condition of neuroinflammation that in case it becomes chronic could lead to a cognitive decline...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38329746/hyperbaric-oxygen-therapy-and-late-local-toxic-effects-in-patients-with-irradiated-breast-cancer-a-randomized-clinical-trial
#2
JOURNAL ARTICLE
Dieuwke R Mink van der Molen, Marilot C T Batenburg, Wiesje Maarse, Desiree H J G van den Bongard, Annemiek Doeksen, Marjoleine Y de Lange, Carmen C van der Pol, Daniel J Evers, Corine A Lansdorp, Jacco van der Laan, Peter M van de Ven, Femke van der Leij, Helena M Verkooijen
IMPORTANCE: Hyperbaric oxygen therapy (HBOT) is proposed as treatment for late local toxic effects after breast irradiation. Strong evidence of effectiveness is lacking. OBJECTIVE: To assess effectiveness of HBOT for late local toxic effects in women who received adjuvant radiotherapy for breast cancer. DESIGN, SETTING, AND PARTICIPANTS: This was a hospital-based, pragmatic, 2-arm, randomized clinical trial nested within the prospective UMBRELLA cohort following the trials within cohorts design in the Netherlands...
February 8, 2024: JAMA Oncology
https://read.qxmd.com/read/38299277/actinomyces-induced-osteomyelitis-of-the-mandible-a-rare-disease
#3
Caleb Nieves-Velez, Gilberto Rivera-Gonzalez, Suresh Antony
BACKGROUND: Actinomyces species are commensal oral cavity flora that can cause jaw osteomyelitis. Osteomyelitis of the jaw by Actinomyces is rare, and its presentation can be confused with many different pathologies. CASE PRESENTATION: This is the case of a 61-year-old female with breast cancer and on chemotherapy as well as non-invasive carcinoma of the tongue who initially presented to the dentist with white spots in the right mandible near the incisors associated with right mandible pain and swelling...
January 30, 2024: Infectious Disorders Drug Targets
https://read.qxmd.com/read/38279461/evaluation-of-use-of-hyperbaric-oxygen-in-suppression-of-hyper-proliferation-in-hypoxic-nsclc-cells
#4
JOURNAL ARTICLE
Jiun-Rung Chen, Haseeb Khan, Yigiter Umarzai, Abbaas Rajput, Tokalp Mamund
Hyperbaric oxygen therapy (HBO) is being researched as a potential adjuvant treatment for solid malignancies, such as NSCLC. It can reduce tumour hypoxia and has been found to slow tumour growth, stop dedifferentiation, and reduce apoptosis resistance in hypoxic NSCLC cells. Though HBO has shown promise in treating various cancers, more study is required to determine its precise mechanism of action in NSCLC. Analyze the effect of hyperbaric oxygen on the growth of hypoxic non-small cell lung cancer cells. We used the NSCLC cell lines A549 and H1299 to analyze aerobic glycolysis in vitro...
December 20, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/38137559/oral-surgery-and-osteoradionecrosis-in-patients-undergoing-head-and-neck-radiation-therapy-an-update-of-the-current-literature
#5
REVIEW
Giulia Corrao, Giovanni Carlo Mazzola, Niccolò Lombardi, Giulia Marvaso, Alberto Pispero, Elisa Baruzzi, Sem Decani, Marco Tarozzi, Luca Bergamaschi, Chiara Lorubbio, Ilaria Repetti, Anna Starzyńska, Daniela Alterio, Mohseen Ansarin, Roberto Orecchia, Fiorella D'Amore, Roberto Franchini, Andrea Nicali, Paolo Castellarin, Andrea Sardella, Giovanni Lodi, Elena Maria Varoni, Barbara Alicja Jereczek-Fossa
Osteoradionecrosis (ORN) is a serious long-term complication of head and neck radiotherapy (RT), which is often triggered by dental extractions. It results from avascular aseptic necrosis due to irradiated bone damage. ORN is challenging to treat and can lead to severe complications. Furthermore, ORN causes pain and distress, significantly reducing the patient's quality of life. There is currently no established preventive strategy. This narrative review aims to provide an update for the clinicians on the risk of ORN associated with oral surgery in head and neck RT patients, with a focus on the timing suitable for the oral surgery and possible ORN preventive treatments...
December 18, 2023: Biomedicines
https://read.qxmd.com/read/38111247/results-of-acute-cerebral-infarction-treatment-with-hyperbaric-oxygen-therapy-2020-2022
#6
JOURNAL ARTICLE
Nam Bao Nguyen, Ha Hai Nguyen Thi, Hong Le Thi, Son Truong Nguyen, Tam Van Nguyen
BACKGROUND: Cerebral stroke is the third leading cause of death after cardiovascular disease, cancer and the leading cause of disability for patients. Hyperbaric oxygen is a non-drug treatment that has the potential to improve brain function for patients with ischaemic stroke. The objective of this study was to evaluate the results of treatment of acute cerebral infarction with hyperbaric oxygen therapy (HBOT). MATERIALS AND METHODS: This was a case-control study...
2023: International Maritime Health
https://read.qxmd.com/read/38076538/cellular-senescence-in-brain-aging-and-cognitive-decline
#7
REVIEW
Areez Shafqat, Saifullah Khan, Mohamed H Omer, Mahnoor Niaz, Ibrahem Albalkhi, Khaled AlKattan, Ahmed Yaqinuddin, Tamara Tchkonia, James L Kirkland, Shahrukh K Hashmi
Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, the impact of senescence on brain aging and cognitive decline in the absence of neurodegeneration remains uncertain. Moreover, patient populations like cancer survivors, traumatic brain injury survivors, obese individuals, obstructive sleep apnea patients, and chronic kidney disease patients can suffer age-related brain changes like cognitive decline prematurely, suggesting that they may suffer accelerated senescence in the brain...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38072393/nanotechnology-mediated-photodynamic-therapy-focus-on-overcoming-tumor-hypoxia
#8
REVIEW
Kave Moloudi, Heidi Abrahamse, Blassan P George
The oxygen level in the tumor is a critical marker that determines response to different treatments. Cancerous cells can adapt to hypoxia and low pH conditions within the tumor microenvironment (TME) to regulate tumor metabolism, proliferation, and promote tumor metastasis as well as angiogenesis, consequently leading to treatment failure and recurrence. In recent years, widespread attempts have been made to overcome tumor hypoxia through different methods, such as hyperbaric oxygen therapy (HBOT), hyperthermia, O2 carriers, artificial hemoglobin, oxygen generator hydrogels, and peroxide materials...
December 10, 2023: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://read.qxmd.com/read/37981845/two-cases-of-intractable-radiation-induced-hemorrhagic-cystitis-treated-with-transcatheter-embolization
#9
Masahiro Nitta, Moeko Tazawa, Jun Naruse, Kazuma Takeda, Kazuya Oda, Takato Uchida, Tatsuo Kano, Tatsuya Umemoto, Nobuyuki Nakajima, Masanori Hasegawa, Sunao Shoji, Akira Miyajima
Radiation-induced hemorrhagic cystitis is a late complication of radiotherapy, and in rare cases, refractory. Refractory bleeding may not be resolved by transurethral electrocoagulation (TUEC) or hyperbaric oxygen (HBO) therapy and requires transcatheter arterial embolization (TAE) or urinary diversion. Here, we report two cases of radiation-induced hemorrhagic cystitis successfully treated with TAE. Case 1 was a 61-yearold man who underwent total prostatectomy for prostate cancer followed by salvage radiation therapy...
December 20, 2023: Tokai Journal of Experimental and Clinical Medicine
https://read.qxmd.com/read/37900689/effects-of-hyperbaric-oxygen-therapy-for-clostridioides-difficile-associated-colitis-a-retrospective-study
#10
JOURNAL ARTICLE
Daisuke Muroya, Shinya Nadayoshi, Koito Yamada, Yutaro Kai, Naoki Masuda, Takamichi Nishida, Masayuki Shimokobe, Toru Hisaka
OBJECTIVES: Clostridioides difficile (CD) is an anaerobic spore-forming Gram-positive rod that is a major cause of antibiotic-associated diarrhea. Hyperbaric oxygen therapy (HBO) is a well-established treatment for Clostridium perfringens, but there are no reports that have examined the efficacy of HBO against CD, which is also an anaerobic bacterium. METHODS: In this study, we retrospectively examined whether HBO therapy affects the prognosis following CD infections (CDI)...
2023: Journal of the Anus, Rectum and Colon
https://read.qxmd.com/read/37886967/hyperbaric-oxygen-therapy-adjuvant-chemotherapy-and-radiotherapy-through-inhibiting-stemness-in-glioblastoma
#11
JOURNAL ARTICLE
Chun-Man Yuen, Hung-Pei Tsai, Tzu-Ting Tseng, Yu-Lung Tseng, Ann-Shung Lieu, Aij-Lie Kwan, Alice Y W Chang
Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumor in adults. Despite the advances in GBM treatment, outcomes remain poor, with a 2-year survival rate of less than 5%. Hyperbaric oxygen (HBO) therapy is an intermittent, high-concentration, short-term oxygen therapy used to increase cellular oxygen content. In this study, we evaluated the effects of HBO therapy, alone or combined with other treatment modalities, on GBM in vitro and in vivo. In the in vitro analysis, we used a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to assess the effects of HBO therapy alone, a colony formation assay to analyze the effects of HBO therapy combined with radiotherapy and with temozolomide (TMZ), and a neurosphere assay to assess GBM stemness...
October 12, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37860845/effect-and-molecular-mechanism-of-sulforaphane-alleviates-brain-damage-caused-by-acute-carbon-monoxide-poisoning-network-pharmacology-analysis-molecular-docking-and-experimental-evidence
#12
JOURNAL ARTICLE
Ao-Chun Yue, Xu-Dong Zhou, Hui-Ping Song, Xu-Han Liu, Ming-Jun Bi, Wei Han, Qin Li
Sulforaphane (SFN) has attracted much attention due to its ability on antioxidant, anti-inflammatory, and anti-apoptotic properties, while its functional targets and underlying mechanism of action on brain injury caused by acute carbon monoxide poisoning (ACOP) have not been fully elucidated. Herein, we used a systematic network pharmacology approach to explore the mechanism of SFN in the treatment of brain damage after ACOP. In this study, the results of network pharmacology demonstrated that there were a total of 81 effective target genes of SFN and 36 drug-disease targets, which were strongly in connection with autophagy-animal signaling pathway, drug metabolism, and transcription disorders in cancer...
October 20, 2023: Environmental Toxicology
https://read.qxmd.com/read/37850770/clinical-and-epidemiological-features-and-therapeutic-options-of-avascular-necrosis-in-patients-with-sickle-cell-disease-scd-a-cross-sectional-study
#13
JOURNAL ARTICLE
Awni Alshurafa, Ashraf T Soliman, Vincenzo De Sanctis, Omar Ismail, Mohammad Abu-Tineh, Mohammad Khair Eddin Hemadneh, Farah Rahat Rashid, Khadra Yassin, Hana Qasim, Abdulqadir Jeprel Nashwan, Mohamed A Yassin
BACKGROUND: Avascular necrosis (AVN) is a debilitating complication in sickle cell disease (SCD) patients, and its management is usually challenging. This study aims to evaluate the clinical and epidemiological features and therapeutic options of AVN in sickle cell patients in Qatar. PATIENTS AND METHODS: A cross-sectional study was conducted on a 49 SCD patients who were diagnosed with AVN and attended the hematology clinic at the National Center for Cancer care & research, Hamad Medical Corporation, Qatar between Jan-2011 to Jan2021...
October 17, 2023: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/37823059/hyperbaric-oxygen-therapy-as-a-complementary-treatment-in-neuroblastoma-a-narrative-review
#14
REVIEW
Diogo Alpuim Costa, J Guilherme Gonçalves-Nobre, Mafalda Sampaio-Alves, Nuno Guerra, Joana Arana Ribeiro, Carla Espiney Amaro
Neuroblastoma is the most frequently diagnosed cancer during the first year of life. This neoplasm originates from neural crest cells derived from the sympathetic nervous system, adrenal medulla, or paraspinal ganglia. The clinical presentation can vary from an asymptomatic mass to symptoms resulting from local invasion and/or spread of distant disease spread. The natural history of neuroblastoma is highly variable, ranging from relatively indolent biological behavior to a high-risk clinical phenotype with a dismal prognosis...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37790761/advances-in-hyperbaric-oxygen-to-promote-immunotherapy-through-modulation-of-the-tumor-microenvironment
#15
REVIEW
Pei Wang, Xiao-Yan Wang, Chang-Feng Man, Dan-Dan Gong, Yu Fan
Hyperbaric oxygen therapy is a relatively safe treatment method that has been used for a long time in the clinic. It has been proven that it can enhance the sensitivity of radiotherapy and photodynamic therapy for cancer. However, there are few studies on hyperbaric oxygen and immunotherapy. In this article, we summarize that hyperbaric oxygen therapy regulates the tumor microenvironment through various pathways such as improving tumor hypoxia, targeting hypoxia-inducing factors, and generating reactive oxygen species...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37786195/hyperbaric-oxygen-therapy-plus-hypofractionated-stereotactic-radiotherapy-in-recurrent-glioblastoma
#16
JOURNAL ARTICLE
D Arpa, E Parisi, G Ghigi, F Foca, L Fabbri, P Cenni, P Longobardi, M Celli, L Tontini, E Neri, M Pieri, S Cima, S Micheletti, R N Abousiam, V Tonelli, E Amadori, A Tesei, A Romeo
PURPOSE/OBJECTIVE(S): Hypoxia is thought to play a role in tumor development, angiogenesis and growth, and resistance to chemotherapy, antiangiogenic therapy and radiotherapy (RT) in a large number of human cancers. Brain tumors, especially highly aggressive GBM with its necrotic tissue, are more likely to be affected by hypoxia. The median partial pressure of oxygen (PO2) of high-grade gliomas in patients under anesthesia was approximately 5-7 mmHg, with a significant proportion of PO2 values <2...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37785686/risk-factors-and-clinical-features-of-fistula-after-concurrent-chemoradiation-and-brachytherapy-for-locally-advanced-cervical-cancer
#17
JOURNAL ARTICLE
N Ali, K Sykes Martin, R Tobillo, A McCook, J Switchenko, J W Shelton, A B Patel, P R Patel, T Y Eng, J S Remick
PURPOSE/OBJECTIVE(S): The standard treatment for locally advanced cervical cancer (LACC) is concurrent chemoradiation and brachytherapy (CRT-B). Fistula formation is a serious complication of treatment; however, risk factors and clinical outcomes are not well described. We sought to identify the incidence, risk factors and prognosis of radiation-induced fistula in women who underwent CRT-B for LACC. MATERIALS/METHODS: A single institution retrospective review of patients treated with CRT-B for LACC from July 2013 to August 2022 across 3 centers was performed...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784429/initial-report-of-boswellia-serrata-for-management-of-cerebral-radiation-necrosis-after-stereotactic-radiosurgery-for-brain-metastases
#18
JOURNAL ARTICLE
R Upadhyay, A N Elguindy, S Sengupta, K Wang, S Beyer, E M Thomas, R Raval, J D Palmer
PURPOSE/OBJECTIVE(S): Radiation necrosis (RN) is a concerning late toxicity after radiation therapy (RT) for brain metastases. Oral corticosteroids are the mainstay of management; however, they are not optimal for long-term use given multiple side effects and drug interactions, particularly with the emergence of immunotherapy for several cancers. Boswellia serrata (BS) is an over-the-counter supplement used for its anti-inflammatory properties and has been recently shown to reduce cerebral edema after brain RT...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37714622/a-patient-with-a-history-of-tonsillar-cancer-presents-for-evaluation-of-exposed-alveolar-bone-in-the-mouth
#19
REVIEW
Takako I Tanaka, Rabie Shanti
Osteoradionecrosis (ORN) is a rare but serious late complication of head and neck radiation therapy. The mandible, proximity of the primary tumor to the jawbones, radiation dose, poor oral hygiene, and smoking history are risk factors of ORN. ORN manifests as a chronic infection with exposed jawbone, which typically occurs in the first 3 years after radiotherapy; however, the risk for ORN development occurring in the patients who have undergone head and neck radiation therapy may be indefinite. Surgery has an important role in the management of cases of ORN, ranging from sequestrectomy, debridement, and extensive extirpative procedures with reconstructive surgery...
October 2023: Dental Clinics of North America
https://read.qxmd.com/read/37711669/the-benefits-and-harms-of-pharmacological-treatment-for-postradiation-pelvic-pain-a-systematic-review-by-the-european-association-of-urology-chronic-pelvic-pain-panel-with-recommendations-for-clinical-practice
#20
REVIEW
Valentin Zumstein, Brian A Parsons, Saeed Dabestani, Andrew P Baranowski, Victoria Tidman, Bary Berghmans, Jan Borovicka, Angela M Cottrell, Paolo Dinis-Oliveira, Sohier Elneil, John Hughes, Bert E J Messelink, Pedro Abreu-Mendes, Benjamin Sacks, Yuhong Yuan, Daniel S Engeler
CONTEXT: Radiotherapy of the pelvis is a widely used method for the treatment of malignancies, and local complications including pain following pelvic radiation therapy are acknowledged complications. OBJECTIVE: The primary objective is to assess the clinical effectiveness and safety of pharmacological therapies on postradiation pelvic pain. EVIDENCE ACQUISITION: A systematic review of the use of different pharmacological treatments in the management of post-radiation pelvic pain was conducted (PROSPERO-ID: CRD42021249026)...
October 2023: European urology open science
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