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Chuan He

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https://read.qxmd.com/read/30739828/design-and-synthesis-of-aminothiazole-based-hepatitis-b-virus-hbv-capsid-inhibitors
#1
Ting Pan, Yanchao Ding, Liyang Wu, Liting Liang, Xin He, Qianwen Li, Chuan Bai, Hui Zhang
The capsid assembly is an essential step for Hepatitis B Virus (HBV) life cycle and is an important target for anti-HBV drug development. In this report, we identified a hit compound with aminothiazole structure by the high throughput screening (HTS) which inhibited the interaction of HBV capsid protein within the cells. The structure hopping and SAR studies of the hit compound afforded compound 79 with potent anti-HBV replication activity and good basic drug-like properties. The working mechanism studies showed that compound 79 could bind to the similar binding site of known HBV capsid inhibitor with heteroaryldihydropyrimidine (HAP) scaffold, through similar hydrophobic interactions but with a different hydrogen bond...
February 5, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30738449/-clinical-significance-of-tf-and-vegf-expressions-on-peripheral-cd14-positive-monocytes-in-patients-with-diffuse-large-b-cell-lymphoma
#2
Ya-Jun Jiang, Gui-Hua Zhu, Yao He, Xing-Xing Chai, Xiao-Yun Yang, Fan-Jing Meng, Wan-Chuan Zhuang
OBJECTIVE: To investigate the clinical significance of tissue factor (TF) and vascular endothelial growth factor (VEGF) expression on peripheral blood CD14 positive monocytes in patients with diffuse large B cell lymphoma (DLBCL). METHODS: The expressions of TF and VEGF on peripheral CD14+ monocytes in 41 patients with DLBCL (DLBCL group) before chemotherapy and after 4 chemotherapeutic courses, and in 20 healthy subjects (control group) were detected by flow cytometry respectively, meanwhile, the relationship of the expression of TF and VEGF with international prognostic indexes (IPI) and short-term effects were analysed...
February 2019: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/30737498/publisher-correction-n-6-methyladenosine-methyltransferase-zcchc4-mediates-ribosomal-rna-methylation
#3
Honghui Ma, Xiaoyun Wang, Jiabin Cai, Qing Dai, S Kundhavai Natchiar, Ruitu Lv, Kai Chen, Zhike Lu, Hao Chen, Yujiang Geno Shi, Fei Lan, Jia Fan, Bruno P Klaholz, Tao Pan, Yang Shi, Chuan He
In the version of this article originally published, the references were incorrectly re-ordered during production. The hyphen in "N6 -methyladenosine" in the title was also superscript. The errors have been corrected in the HTML and PDF versions of the paper.
February 8, 2019: Nature Chemical Biology
https://read.qxmd.com/read/30734555/a-ph-triggered-self-assembled-and-bioprintable-hybrid-hydrogel-scaffold-for-mesenchymal-stem-cell-based-bone-tissue-engineering
#4
Chen Zhao, Nader Taheri Qazvini, Monirosadat Sadati, Zongyue Zeng, Shifeng Huang, Ana Losada De La Lastra, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Zhengyu Dai, Yi Shen, Xi Wang, Wenping Luo, Bo Liu, Yan Lei, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Aravind Athiviraham, Michael J Lee, Jennifer M Wolf, Russell R Reid, Matthew Tirrell, Wei Huang, Juan J de Pablo, Tong-Chuan He
Effective bone tissue engineering can restore bone and skeletal functions that are impaired by traumas and/or certain medical conditions. Bone is a complex tissue and functions through orchestrated interactions between cells, biomechanical forces and biofactors. To identify ideal scaffold materials for effective mesenchymal stem cell (MSC)-based bone tissue regeneration, here we develop and characterize a composite nanoparticle hydrogel by combining carboxymethyl chitosan (CMCh) and amorphous calcium phosphate (ACP) (designated as CMCh-ACP hydrogel)...
February 8, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30732177/the-different-effects-of-adefovir-dipivoxil-and-telbivudine-on-the-prognosis-of-hepatitis-b-virus-related-hepatocellular-carcinoma-patients-after-curative-resection
#5
Linye He, Zijing Xia, Junyi Shen, Xiaoyun Zhang, Wei Peng, Chuan Li, Tianfu Wen
Numerous studies suggested that antiviral therapy could reduce the recurrence in hepatocellular carcinoma (HCC) patients after hepatectomy. The impact of nucleotide and nucleoside analogues on prognosis of chronic hepatitis B (CHB) related HCC remains to be explored. We aimed to investigate the role of the telbivudine and adefovir dipivoxil on the prognosis of CHB-related HCC patients after hepatectomy.One hundred eighty-eight CHB-related patients who received hepatectomy from February 2010 to February 2017 were divided into telbivudine (LdT) and adefovir dipivoxil (ADV) groups...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30717600/special-issue-on-regulating-the-central-dogma
#6
Chuan He
No abstract text is available yet for this article.
February 5, 2019: Biochemistry
https://read.qxmd.com/read/30716118/monotherapy-with-a-low-dose-lipopeptide-hiv-fusion-inhibitor-maintains-long-term-viral-suppression-in-rhesus-macaques
#7
Huihui Chong, Jing Xue, Yuanmei Zhu, Zhe Cong, Ting Chen, Qiang Wei, Chuan Qin, Yuxian He
Combination antiretroviral therapy (cART) dramatically improves survival of HIV-infected patients, but lifelong treatment can ultimately result in cumulative toxicities and drug resistance, thus necessitating the development of new drugs with significantly improved pharmaceutical profiles. We recently found that the fusion inhibitor T-20 (enfuvirtide)-based lipopeptides possess dramatically increased anti-HIV activity. Herein, a group of novel lipopeptides were designed with different lengths of fatty acids, identifying a stearic acid-modified lipopeptide (LP-80) with the most potent anti-HIV activity...
February 4, 2019: PLoS Pathogens
https://read.qxmd.com/read/30714628/fatty-acid-profiles-of-triacylglycerols-and-phospholipids-of-sea-cage-cultured-trachinotus-blochii-a-comparative-study-of-head-viscera-skin-bone-and-muscle
#8
Chen He, Jun Cao, Xin Jiang, Chunyan Wen, Xinpeng Bai, Chuan Li
Trachinotus blochii (golden pompano) is an economically important cultured marine fish that is rich in polyunsaturated fat. The fatty acid profiles of triacylglycerols and phospholipids of T. blochii tissues were analyzed. Lipid contents in tissues followed the order of viscera (28.27%) > skin (17.25%) ≈ bone (16.18%) ≈ head (15.12%) > muscle (7.38%). In triacylglycerols (TAG), saturated fatty acids (palmitic acid predominated) were preferentially esterified in the sn-2 position, and monounsaturated fatty acids (oleic acid predominated) were mainly distributed in the sn-1, 3 positions...
February 4, 2019: Journal of Food Science
https://read.qxmd.com/read/30712515/evolutionarily-significant-a-to-i-rna-editing-events-originated-through-g-to-a-mutations-in-primates
#9
Ni A An, Wanqiu Ding, Xin-Zhuang Yang, Jiguang Peng, Bin Z He, Qing Sunny Shen, Fujian Lu, Aibin He, Yong E Zhang, Bertrand Chin-Ming Tan, Jia-Yu Chen, Chuan-Yun Li
BACKGROUND: Recent studies have revealed thousands of A-to-I RNA editing events in primates, but the origination and general functions of these events are not well addressed. RESULTS: Here, we perform a comparative editome study in human and rhesus macaque and uncover a substantial proportion of macaque A-to-I editing sites that are genomically polymorphic in some animals or encoded as non-editable nucleotides in human. The occurrence of these recent gain and loss of RNA editing through DNA point mutation is significantly more prevalent than that expected for the nearby regions...
February 4, 2019: Genome Biology
https://read.qxmd.com/read/30705890/correlation-analysis-of-collagen-proportionate-area-in-budd-chiari-syndrome-a-preliminary-clinicopathological-study
#10
Fu-Liang He, Chuan Li, Fu-Quan Liu, Xing-Shun Qi
BACKGROUND: Collagen proportionate area (CPA) is an important index for assessing the severity of liver fibrosis. Budd-Chiari syndrome can frequently progress to liver fibrosis and cirrhosis. CPA might play an important role in the pathological progress of Budd-Chiari syndrome. AIM: To explore the role of CPA in predicting the outcomes of patients with Budd-Chiari syndrome. METHODS: Nine patients with Budd-Chiari syndrome undergoing transjugular intrahepatic portosystemic shunt (TIPS) were included...
January 26, 2019: World Journal of Clinical Cases
https://read.qxmd.com/read/30703185/comparison-study-of-three-hydroxyapatite-based-bone-substitutes-in-a-calvarial-defect-model-in-rabbits
#11
Antian Xu, Chuan Zhou, Wenting Qi, Fuming He
PURPOSE: The aim of this study was to investigate the in vivo performance, including bone regeneration and biomaterial degradation, of three hydroxyapatite-based bone substitutes at surgically created defects in the cranium of rabbits. MATERIALS AND METHODS: A bovine-derived hydroxyapatite (BHA), a synthetic hydroxyapatite (SHA), and a nano-hydroxyapatite with collagen I (nHAC) composite were characterized and then placed in calvarial defects in rabbits. After surgery at 6 weeks and 12 weeks, the animals were sacrificed for further microcomputed tomography, histologic, and histomorphometric analyses...
January 31, 2019: International Journal of Oral & Maxillofacial Implants
https://read.qxmd.com/read/30699402/active-broadband-terahertz-wave-impedance-matching-based-on-optically-doped-graphene-silicon-heterojunction
#12
Wanyi Du, Yixuan Zhou, Zehan Yao, Yuanyuan Huang, Chuan He, Longhui Zhang, Yuhang He, Lipeng Zhu, Xinlong Xu
Broadband terahertz impedance matching is important for both spectral resolution improvement and terahertz anti-radar technology. Herein, graphene-silicon hybrid structure has been proposed for active broadband terahertz wave impedance matching with optical tunability. The main transmission pulse measured in the time domain indicates a modulation depth as high as 92.7 % totally from the graphene-silicon interface. The interface reflection from the graphene-silicon junction implies that an impedance matching condition can be actively achieved by optical doping...
January 30, 2019: Nanotechnology
https://read.qxmd.com/read/30698716/multi-ancestry-genome-wide-association-study-of-lipid-levels-incorporating-gene-alcohol-interactions
#13
Paul S de Vries, Michael R Brown, Amy R Bentley, Yun J Sung, Thomas W Winkler, Ioanna Ntalla, Karen Schwander, Aldi T Kraja, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jennifer E Huffman, Solomon K Musani, Changwei Li, Mary F Feitosa, Melissa A Richard, Raymond Noordam, Hugues Aschard, Traci M Bartz, Lawrence F Bielak, Xuan Deng, Rajkumar Dorajoo, Kurt K Lohman, Alisa K Manning, Tuomo Rankinen, Albert V Smith, Salman M Tajuddin, Evangelos Evangelou, Mariaelisa Graff, Maris Alver, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Ilaria Gandin, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E Harris, Fernando P Hartwig, Meian He, Andrea R V R Horimoto, Fang-Chi Hsu, Anne U Jackson, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Federica Laguzzi, Joseph H Lee, Jian'an Luan, Leo-Pekka Lyytikäinen, Nana Matoba, Ilja M Nolte, Maik Pietzner, Muhammad Riaz, M Abdullah Said, Robert A Scott, Tamar Sofer, Alena Stancáková, Fumihiko Takeuchi, Bamidele O Tayo, Peter J van der Most, Tibor V Varga, Yajuan Wang, Erin B Ware, Wanqing Wen, Lisa R Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Najaf Amin, Marzyeh Amini, Dan E Arking, Tin Aung, Christie Ballantyne, Eric Boerwinkle, Ulrich Broeckel, Archie Campbell, Mickaël Canouil, Sabanayagam Charumathi, Yii-Der Ida Chen, John M Connell, Ulf de Faire, Lisa de Las Fuentes, Renée de Mutsert, H Janaka de Silva, Jingzhong Ding, Anna F Dominiczak, Qing Duan, Charles B Eaton, Ruben N Eppinga, Jessica D Faul, Virginia Fisher, Terrence Forrester, Oscar H Franco, Yechiel Friedlander, Mohsen Ghanbari, Franco Giulianini, Hans J Grabe, Megan L Grove, C Charles Gu, Tamara B Harris, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, James E Hixson, Barbara V Howard, M Arfan Ikram, David R Jacobs, Craig Johnson, Jost Bruno Jonas, Candace M Kammerer, Tomohiro Katsuya, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Heikki A Koistinen, Ivana Kolcic, Charles Kooperberg, Jose E Krieger, Steve B Kritchevsky, Michiaki Kubo, Johanna Kuusisto, Timo A Lakka, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Benjamin Lehne, Rozenn N Lemaitre, Yize Li, Jingjing Liang, Jianjun Liu, Kiang Liu, Marie Loh, Tin Louie, Reedik Mägi, Ani W Manichaikul, Colin A McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Karen L Mohlke, Thomas H Mosley, Kenneth J Mukamal, Mike A Nalls, Matthias Nauck, Christopher P Nelson, Nona Sotoodehnia, Jeff R O'Connell, Nicholette D Palmer, Raha Pazoki, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Ozren Polasek, Neil Poulter, Leslie J Raffel, Olli T Raitakari, Alex P Reiner, Treva K Rice, Stephen S Rich, Antonietta Robino, Jennifer G Robinson, Lynda M Rose, Igor Rudan, Carsten O Schmidt, Pamela J Schreiner, William R Scott, Peter Sever, Yuan Shi, Stephen Sidney, Mario Sims, Blair H Smith, Jennifer A Smith, Harold Snieder, John M Starr, Konstantin Strauch, Nicholas Tan, Kent D Taylor, Yik Ying Teo, Yih Chung Tham, André G Uitterlinden, Diana van Heemst, Dragana Vuckovic, Melanie Waldenberger, Lihua Wang, Yujie Wang, Zhe Wang, Wen Bin Wei, Christine Williams, Gregory Wilson, Mary K Wojczynski, Jie Yao, Bing Yu, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, John C Chambers, Ian J Deary, Tõnu Esko, Martin Farrall, Paul W Franks, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo L Horta, Yoichiro Kamatani, Norihiro Kato, Jaspal S Kooner, Markku Laakso, Karin Leander, Terho Lehtimäki, Patrik K E Magnusson, Brenda Penninx, Alexandre C Pereira, Rainer Rauramaa, Nilesh J Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E Wagenknecht, Ya Xing Wang, Nicholas J Wareham, Hugh Watkins, David R Weir, Ananda R Wickremasinghe, Wei Zheng, Paul Elliott, Kari E North, Claude Bouchard, Michele K Evans, Vilmundur Gudnason, Ching-Ti Liu, Yongmei Liu, Bruce M Psaty, Paul M Ridker, Rob M van Dam, Sharon L R Kardia, Xiaofeng Zhu, Charles N Rotimi, Dennis O Mook-Kanamori, Myriam Fornage, Tanika N Kelly, Ervin R Fox, Caroline Hayward, Cornelia M van Duijn, E Shyong Tai, Tien Yin Wong, Jingmin Liu, Jerome I Rotter, W James Gauderman, Michael A Province, Patricia B Munroe, Kenneth Rice, Daniel I Chasman, L Adrienne Cupples, Dabeeru C Rao, Alanna C Morrison
An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups...
January 29, 2019: American Journal of Epidemiology
https://read.qxmd.com/read/30683067/temporal-patterns-of-influenza-a-subtypes-and-b-lineages-across-age-in-a-subtropical-city-during-pre-pandemic-pandemic-and-post-pandemic-seasons
#14
Linlin Zhou, Huiping Yang, Yu Kuang, Tianshu Li, Jianan Xu, Shuang Li, Ting Huang, Chuan Wang, Wanyi Li, Mingyuan Li, Shusen He, Ming Pan
BACKGROUND: Seasonal patterns of influenza A subtypes and B lineages in tropical/subtropical regions across age have remained to be explored. The impact of the 2009 H1N1 pandemic on seasonal influenza activity have not been well understood. METHODS: Based on a national sentinel hospital-based influenza surveillance system, the epidemiology of influenza virus during 2006/07-2015/16 was characterized in the subtropical city, Chengdu. Chengdu is one of the most populous cities in southwestern China, where the first reported case of A/H1N1pdm09 in mainland China was identified...
January 25, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30675909/increased-parp1-dna-binding-due-to-autoparylation-inhibition-of-parp1-on-dna-rather-than-parp1-dna-trapping-is-correlated-with-parp1-inhibitor-s-cytotoxicity
#15
Hua-Dong Chen, Chuan-Huizi Chen, Yu-Ting Wang, Ne Guo, Yu-Nan Tian, Xia-Juan Huan, Shan-Shan Song, Jin-Xue He, Ze-Hong Miao
PARP1 inhibitors (PARPis) are used clinically during cancer therapy and are thought to exert their cytotoxicity through PARP1 polymerase inhibition and PARP1-DNA trapping. Here, we showed no significant correlation between PARP1-DNA trapping and cytotoxicity induced by PARPis. We complemented PARP1-knockout sublines with wild-type PARP1 and 11 mutants with different point mutations that affect the polymerase activity. When examining the PARPi talazoparib, the induced cytotoxicity was highly significantly correlated with cellular PARP1 polymerase activity, but not with its PARP1-DNA trapping or polymerase inhibition...
January 24, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30675883/an-excellent-example-illustrating-the-fluorescence-sensing-property-of-cobalt-organic-frameworks
#16
Chuan-Lei Zhang, Zi-Teng Liu, Heng Xu, He-Gen Zheng, Jing Ma, Jing Zhao
A novel luminescent cobalt-organic framework was assembled and employed as a chemosensor for the detection of metal ions via fluorescence enhancement and quenching. The sensing mechanism was based on the exposed pyridyl and carboxyl functional sites in the MOF structure, which interacted with metal ions via Lewis acid-base interactions and electrostatic interactions.
January 24, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/30675869/-effect-of-probiotic-supplementation-during-pregnancy-and-infancy-in-preventing-atopic-dermatitis-in-children-a-meta-analysis
#17
Dao-Gen Yin, Zhen He, Xue-Yan Duan, Fei-Xiang Fan, Xiao-Bing Liao, Qing-Chuan Wang
OBJECTIVE: To systematically review the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children. METHODS: RevMan5.3 was used to perform a Meta analysis of randomized controlled trials on the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children published between January 2008 and May 2018 across the world. A subgroup analysis was conducted according to the type of probiotics for intervention, follow-up time, time of probiotic supplementation, and study areas...
January 2019: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/30672266/-systematic-review-and-analysis-on-the-appropriate-diseases-in-clinical-treatment-with-fu-s-subcutaneous-needling-therapy
#18
Wen Jia, Lin Luo, Li-Yun He, Chuan Wang, Bao-Yan Liu, Jia Liu, Zhong-Hua Fu, Hong-Jiao Li
The clinical research articles relevant with Fu 's subcutaneous needling therapy (FSN) were retrieved from CNKI, WANFANG, CBM and PubMed databases till January 2018 since the establishment of database. According to the general international criteria of disease classification, the diseases involved in the articles were classified and summarized. In terms of the clinical application and research of FSN, the questions were extracted and commented through expert's consultation. As a result, 412 articles were included...
January 12, 2019: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/30670697/multi-ancestry-study-of-blood-lipid-levels-identifies-four-loci-interacting-with-physical-activity
#19
Tuomas O Kilpeläinen, Amy R Bentley, Raymond Noordam, Yun Ju Sung, Karen Schwander, Thomas W Winkler, Hermina Jakupović, Daniel I Chasman, Alisa Manning, Ioanna Ntalla, Hugues Aschard, Michael R Brown, Lisa de Las Fuentes, Nora Franceschini, Xiuqing Guo, Dina Vojinovic, Stella Aslibekyan, Mary F Feitosa, Minjung Kho, Solomon K Musani, Melissa Richard, Heming Wang, Zhe Wang, Traci M Bartz, Lawrence F Bielak, Archie Campbell, Rajkumar Dorajoo, Virginia Fisher, Fernando P Hartwig, Andrea R V R Horimoto, Changwei Li, Kurt K Lohman, Jonathan Marten, Xueling Sim, Albert V Smith, Salman M Tajuddin, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Mariaelisa Graff, Sarah E Harris, Meian He, Fang-Chi Hsu, Anne U Jackson, Jing Hua Zhao, Aldi T Kraja, Brigitte Kühnel, Federica Laguzzi, Leo-Pekka Lyytikäinen, Ilja M Nolte, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Rico Rueedi, Heather M Stringham, Fumihiko Takeuchi, Peter J van der Most, Tibor V Varga, Niek Verweij, Erin B Ware, Wanqing Wen, Xiaoyin Li, Lisa R Yanek, Najaf Amin, Donna K Arnett, Eric Boerwinkle, Marco Brumat, Brian Cade, Mickaël Canouil, Yii-Der Ida Chen, Maria Pina Concas, John Connell, Renée de Mutsert, H Janaka de Silva, Paul S de Vries, Ayşe Demirkan, Jingzhong Ding, Charles B Eaton, Jessica D Faul, Yechiel Friedlander, Kelley P Gabriel, Mohsen Ghanbari, Franco Giulianini, Chi Charles Gu, Dongfeng Gu, Tamara B Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Steven C Hunt, M Arfan Ikram, Jost B Jonas, Woon-Puay Koh, Pirjo Komulainen, Jose E Krieger, Stephen B Kritchevsky, Zoltán Kutalik, Johanna Kuusisto, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Karin Leander, Rozenn N Lemaitre, Cora E Lewis, Jingjing Liang, Jianjun Liu, Reedik Mägi, Ani Manichaikul, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Karen L Mohlke, Thomas H Mosley, Alison D Murray, Mike A Nalls, Ei-Ei Khaing Nang, Christopher P Nelson, Sotoodehnia Nona, Jill M Norris, Chiamaka Vivian Nwuba, Jeff O'Connell, Nicholette D Palmer, George J Papanicolau, Raha Pazoki, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Ozren Polasek, David J Porteous, Alaitz Poveda, Olli T Raitakari, Stephen S Rich, Neil Risch, Jennifer G Robinson, Lynda M Rose, Igor Rudan, Pamela J Schreiner, Robert A Scott, Stephen S Sidney, Mario Sims, Jennifer A Smith, Harold Snieder, Tamar Sofer, John M Starr, Barbara Sternfeld, Konstantin Strauch, Hua Tang, Kent D Taylor, Michael Y Tsai, Jaakko Tuomilehto, André G Uitterlinden, M Yldau van der Ende, Diana van Heemst, Trudy Voortman, Melanie Waldenberger, Patrik Wennberg, Gregory Wilson, Yong-Bing Xiang, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, Ulf de Faire, Ian J Deary, Paul Elliott, Tõnu Esko, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Norihiro Kato, Markku Laakso, Timo A Lakka, Terho Lehtimäki, Patrik K E Magnusson, Albertine J Oldehinkel, Brenda W J H Penninx, Nilesh J Samani, Xiao-Ou Shu, Pim van der Harst, Jana V Van Vliet-Ostaptchouk, Peter Vollenweider, Lynne E Wagenknecht, Ya X Wang, Nicholas J Wareham, David R Weir, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Michele K Evans, Paul W Franks, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Tanika N Kelly, Yongmei Liu, Kari E North, Alexandre C Pereira, Paul M Ridker, E Shyong Tai, Rob M van Dam, Ervin R Fox, Sharon L R Kardia, Ching-Ti Liu, Dennis O Mook-Kanamori, Michael A Province, Susan Redline, Cornelia M van Duijn, Jerome I Rotter, Charles B Kooperberg, W James Gauderman, Bruce M Psaty, Kenneth Rice, Patricia B Munroe, Myriam Fornage, L Adrienne Cupples, Charles N Rotimi, Alanna C Morrison, Dabeeru C Rao, Ruth J F Loos
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus...
January 22, 2019: Nature Communications
https://read.qxmd.com/read/30670693/spin-current-generation-and-relaxation-in-a-quenched-spin-orbit-coupled-bose-einstein-condensate
#20
Chuan-Hsun Li, Chunlei Qu, Robert J Niffenegger, Su-Ju Wang, Mingyuan He, David B Blasing, Abraham J Olson, Chris H Greene, Yuli Lyanda-Geller, Qi Zhou, Chuanwei Zhang, Yong P Chen
Understanding the effects of spin-orbit coupling (SOC) and many-body interactions on spin transport is important in condensed matter physics and spintronics. This topic has been intensively studied for spin carriers such as electrons but barely explored for charge-neutral bosonic quasiparticles (including their condensates), which hold promises for coherent spin transport over macroscopic distances. Here, we explore the effects of synthetic SOC (induced by optical Raman coupling) and atomic interactions on the spin transport in an atomic Bose-Einstein condensate (BEC), where the spin-dipole mode (SDM, actuated by quenching the Raman coupling) of two interacting spin components constitutes an alternating spin current...
January 22, 2019: Nature Communications
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