Julio Alvarez, Alain Coulombe, Olivier Cazorla, Mehmet Ugur, Jean-Michel Rauzier, Janos Magyar, Eve-Lyne Mathieu, Guylain Boulay, Rafael Souto, Patrice Bideaux, Guillermo Salazar, François Rassendren, Alain Lacampagne, Jérémy Fauconnier, Guy Vassort
Extracellular purines and pyrimidines have major effects on cardiac rhythm and contraction. ATP/UTP are released during various physiopathological conditions, such as ischemia, and despite degradation by ectonucleotidases, their interstitial concentrations can markedly increase, a fact that is clearly associated with arrhythmia. In the present whole cell patch-clamp analysis on ventricular cardiomyocytes isolated from various mammalian species, ATP and UTP elicited a sustained, nonselective cationic current, I(ATP)...
July 2008: American Journal of Physiology. Heart and Circulatory Physiology