Laetitia Velly, Steven Volant, Catherine Fitting, Daniel Aiham Ghazali, Florian Salipante, Julien Mayaux, Gentiane Monsel, Jean-Marc Cavaillon, Pierre Hausfater
OBJECTIVE: To define the best combination of biomarkers for the diagnosis of infection and sepsis in the emergency room. METHODS: In this prospective study, consecutive patients with a suspicion of infection in the emergency room were included. Eighteen different biomarkers measured in plasma, and twelve biomarkers measured on monocytes, neutrophils, B and T-lymphocytes were studied and the best combinations determined by a gradient tree boosting approach. RESULTS: Overall, 291 patients were included and analysed, 148 with bacterial infection, and 47 with viral infection...
April 2021: Journal of Infection