dynamic brain connectivity

The brain mechanisms underlying the risk of cannabis use disorder (CUD) are poorly understood. Several studies have reported changes in functional connectivity (FC) in CUD, although none have focused on the study of time-varying patterns of FC. To fill this important gap of knowledge, 39 individuals at risk for CUD and 55 controls, stratified by their score on a self-screening questionnaire for cannabis-related problems (CUDIT-R), underwent resting-state functional magnetic resonance imaging. Dynamic functional connectivity (dFNC) was estimated using independent component analysis, sliding-time window correlations, cluster states and meta-state indices of global dynamics and were compared among groups...

Time-series data collected from a network of random variables are useful for identifying temporal pathways among the network nodes. Observed measurements may contain multiple sources of signals and noises, including Gaussian signals of interest and non-Gaussian noises, including artifacts, structured noise, and other unobserved factors (eg, genetic risk factors, disease susceptibility). Existing methods, including vector autoregression (VAR) and dynamic causal modeling do not account for unobserved non-Gaussian components...

BACKGROUND: Autism classification work on fNIRS data using dynamic graph networks. Explore the impact of the dynamic connection relationship between brain channels on ASD, and compare the brain channel connection diagrams of ASD and TD to explore potential factors that influence the development of autism. METHOD: Using dynamic graph construction to mine the dynamic relationships of fNIRS data, obtain spatio-temporal correlations through dynamic feature extraction, and improve the information extraction capabilities of the network through spatio-temporal graph pooling to achieve classification of ASD...

BACKGROUND: Juvenile myoclonic epilepsy (JME) is characterized by altered patterns of brain functional connectivity (FC). However, the nature and extent of alterations in the spatiotemporal characteristics of dynamic FC in JME patients remain elusive. Dynamic networks effectively encapsulate temporal variations in brain imaging data, offering insights into brain network abnormalities and contributing to our understanding of the seizure mechanisms and origins. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were procured from 37 JME patients and 37 healthy counterparts...

The relationship between skin diseases and mental illnesses has been extensively studied using cross-sectional epidemiological data. Typically, such data can only measure association (rather than causation) and include only a subset of the diseases we may be interested in. In this paper, we complement the evidence from such analyses by learning an overarching causal network model over twelve health conditions from the Google Search Trends Symptoms public data set. We learned the causal network model using a dynamic Bayesian network, which can represent both cyclic and acyclic causal relationships, is easy to interpret and accounts for the spatio-temporal trends in the data in a probabilistically rigorous way...

Video games are a valuable tool for studying the effects of training and neural plasticity on the brain. However, the underlying mechanisms related to plasticity-associated brain structural changes and their impact on brain dynamics are unknown. Here, we used a semi-empirical whole-brain model to study structural neural plasticity mechanisms linked to video game expertise. We hypothesized that video game expertise is associated with neural plasticity-mediated changes in structural connectivity that manifest at the meso‑scale level, resulting in a more segregated functional network topology...

BACKGROUND: Episodic memory (EM) deteriorates as a result of normal aging as well as Alzheimer's disease. The neural underpinnings of such age-related memory impairments in older individuals are not well-understood. Although previous research has unveiled the association between gray matter volume (GMV) and EM in the elderly population, such findings exhibit variances across distinct age cohorts. Consequently, an investigation into the dynamic evolution of this relationship with advancing age is imperative...

BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder that is predominantly known for its motor symptoms but is also accompanied by non-motor symptoms, including anxiety. OBJECTIVE: The underlying neurobiological substrates and brain network changes associated with comorbid anxiety in PD require further exploration. METHODS: An analysis of oscillation-specific nodal properties in patients with and without anxiety was conducted using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory...

Synaptic plasticity makes memristors particularly suitable for simulating the connection synapses between neurons that describe magnetic induction coupling. By applying a memristor to the synaptic coupling between two map-based neuron models, a memristor-coupled dual-neuron mapping (MCDN) model is proposed in this article. The MCDN model has a line fixed point set associated with the memristor initial state, which is always unstable for the model parameters and memristor initial state of interest. Complex spiking/bursting firing patterns and their transitions are disclosed using some dynamical analysis means...

Because cognitive competences emerge in evolution and development from the sensory-motor domain, we seek a neural process account for higher cognition in which all representations are necessarily grounded in perception and action. The challenge is to understand how hallmarks of higher cognition, productivity, systematicity, and compositionality, may emerge from such a bottom-up approach. To address this challenge, we present key ideas from Dynamic Field Theory which postulates that neural populations are organized by recurrent connectivity to create stable localist representations...

Synchronization is a key feature of the brain dynamics and is necessary for information transmission across brain regions and in higher brain functions like cognition, learning and memory. Experimental findings demonstrated that in cortical microcircuits there are multiple synapses between pairs of connected neurons. Synchronization of neurons in the presence of multiple synaptic connections may be relevant for optimal learning and memory, however, its effect on the dynamics of the neurons is not adequately studied...

Representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how the brain maintains these representations is given by continuous bump attractor networks (CBANs) in a broad range of brain functions across different areas, such as spatial navigation in hippocampal/entorhinal circuits and working memory in prefrontal cortex. Through recurrent connections, a CBAN maintains a persistent activity bump, whose peak location can vary along a neural space, corresponding to different values of a continuous variable...

Metacognition includes the ability to refer to one's own cognitive states, such as confidence, and adaptively control behavior based on this information. This ability is thought to allow us to predictably control our behavior without external feedback, for example, even before we take action. Many studies have suggested that metacognition requires a brain-wide network of multiple brain regions. However, the modulation of effective connectivity within this network during metacognitive tasks remains unclear. This study focused on medial prefrontal regions, which have recently been suggested to be particularly involved in metacognition...

Covert speech (CS) refers to speaking internally to oneself without producing any sound or movement. CS is involved in multiple cognitive functions and disorders. Reconstructing CS content by brain-computer interface (BCI) is also an emerging technique. However, it is still controversial whether CS is a truncated neural process of overt speech (OS) or involves independent patterns. Here, we performed a word-speaking experiment with simultaneous EEG-fMRI. It involved 32 participants, who generated words both overtly and covertly...

Research into ascending sensory pathways and cortical networks has generated detailed models of perception. These same cortical regions are strongly connected to subcortical structures, such as the basal ganglia (BG), which have been conceptualized as playing key roles in reinforcement learning and action selection. However, because the BG amasses experiential evidence from higher and lower levels of cortical hierarchies, as well as higher-order thalamus, it is well positioned to dynamically influence perception...

This present study identified an optimal model representing the relationship between orthography and phonology in Chinese handwritten production using dynamic causal modeling, and further explored how this model was modulated by word frequency and syllable frequency. Each model contained five volumes of interest in the left hemisphere (inferior frontal gyrus [IFG], middle frontal gyrus [MFG], angular gyrus [AG], supramarginal gyrus, and superior frontal gyrus), with the IFG as the driven input area. Results showed the superiority of a model in which both the MFG and the AG connected with the IFG, supporting the orthography autonomy hypothesis...

INTRODUCTION: The blood oxygen level-dependent (BOLD) signal derived from functional neuroimaging is commonly used in brain network analysis and dementia diagnosis. Missing the BOLD signal may lead to bad performance and misinterpretation of findings when analyzing neurological disease. Few studies have focused on the restoration of brain functional time-series data. METHODS: In this paper, a novel U -shaped convolutional transformer GAN (UCT-GAN) model is proposed to restore the missing brain functional time-series data...

BACKGROUND: Neuroimaging studies have revealed abnormal functional interaction during the processing of emotional faces in patients with major depressive disorder (MDD), thereby enhancing our comprehension of the pathophysiology of MDD. However, it is unclear whether there is abnormal directional interaction among face-processing systems in patients with MDD. METHODS: A group of patients with MDD and a healthy control group underwent a face-matching task during functional magnetic resonance imaging...

Major Depressive Disorder (MDD) is a debilitating, complex mental condition with unclear mechanisms hindering diagnostic progress. Research links MDD to abnormal brain connectivity using functional magnetic resonance imaging (fMRI). Yet, existing fMRI-based MDD models suffer from limitations, including neglecting dynamic network traits, lacking interpretability, and struggling with small datasets. We present DSFGNN, a novel graph neural network framework addressing these issues for improved MDD diagnosis. DSFGNN employs a graph isomorphism encoder to model static and dynamic brain networks, achieving effective fusion of temporal and spatial information through a spatiotemporal attention mechanism, thereby enhancing interpretability...

This article presents a novel method for learning time-varying dynamic Bayesian networks. The proposed method breaks down the dynamic Bayesian network learning problem into a sequence of regression inference problems and tackles each problem using the Markov neighborhood regression technique. Notably, the method demonstrates scalability concerning data dimensionality, accommodates time-varying network structure, and naturally handles multi-subject data. The proposed method exhibits consistency and offers superior performance compared to existing methods in terms of estimation accuracy and computational efficiency, as supported by extensive numerical experiments...