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spinal tuberculosis

Baharak Afshar, Jacqueline Carless, Anita Roche, Sooria Balasegaram, Charlotte Anderson
Recurrence of TB in an individual can occur due to relapse of the same strain or reinfection by a different strain. The contribution of reinfection and relapse to TB incidence, and the factors associated with each are unknown. We aimed to quantify and describe cases attributable to relapse or reinfection, and identify associated risk factors in order to reduce recurrence. We categorised recurrent TB cases from notifications in London (2002-2015) as relapse or reinfection using molecular (MIRU VNTR strain type) and epidemiological information (hierarchical approach using time since notification, site of disease and method of case finding)...
2019: PloS One
Yun Liang, Peng Liu, Li-Bo Jiang, Hou-Lei Wang, An-Nan Hu, Xiao-Gang Zhou, Xi-Lei Li, Hong Lin, Dong Wu, Jian Dong
OBJECTIVE: A retrospective study was designed to evaluate the effectiveness of CT-guided core needle biopsy in diagnosing spinal lesions through comparison with C-arm guidance. METHODS: From April 2013 to July 2017, a total of 188 patients, who suffered from spinal lesions or had malignant tumor history with a new spinal fracture, were included in this study. There were 96 men and 92 women, with an average of 57.1 years. A total of 238 core needle biopsies were performed...
February 14, 2019: Orthopaedic Surgery
E Uma Maheswari, R M Bhoopathy, K Bhanu, Heber Anandan
Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus. Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS). Materials and Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate...
January 2019: Journal of Neurosciences in Rural Practice
Xiaowei Yang, Runsheng Guo, Xin Lv, Qi Lai, Banglin Xie, Xiaozhen Jiang, Min Dai, Bin Zhang
RATIONALE: Spinal epidural abscess (SEA) is a rare condition that shows a high prevalence in immunocompromised patients. The clinical presentation of SEA includes the "classic triad" of pain, fever, and neurological dysfunction. However, these nonspecific features can lead to a high rate of misdiagnosis. SEA may lead to paralysis or even death; thus, prognosis of these patients remains unfavorable. PATIENT CONCERNS: We report a case of a multilevel (T6-T12) SEA in a 22-year-old woman...
February 2019: Medicine (Baltimore)
Zhigang Huang, Jing Liu, Ke Ma
The aim of this study was to compare clinical effect of posterior approach and anterior approach surgery for patients with thoracolumbar spinal tuberculosis. It was a descriptive, analytical study carried out at the Third People's Hospital of Shenzhen City, China, from March 2012 to March 2015. A total of 84 patients with thoracolumbar spinal tuberculosis were randomly divided into group A and group B, each group having 42 patients. Group A was treated with posterior approach surgery, while group B was treated with anterior approach surgery...
February 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Ahmed Ali, Omar Musbahi, Veronica L C White, Alexander Sheriff Montgomery
No abstract text is available yet for this article.
January 29, 2019: JBJS Reviews
Ajoy Prasad Shetty, Aju Bosco, Shanmuganathan Rajasekaran, Rishi Mugesh Kanna
STUDY DESIGN: Single-center retrospective cohort analysis. OBJECTIVES: To analyze the impact of loss of global lumbar lordosis (GLL) on functional outcomes in tuberculosis of the lumbar and lumbosacral spine and to define strategies to restore or preserve the physiological lumbar lordosis. SUMMARY OF BACKGROUND DATA: In tuberculosis of lumbosacral spine, loss of lumbar lordosis (LL) leads to altered lumbosacral biomechanics. All available studies have assessed treatment outcomes with respect to physical well-being, neurologic improvement, bone healing, and changes in radiologic parameters...
March 2019: Spine Deformity
Kenji Okazaki, Hirofumi Takamuku, Shiori Yonemoto, Yu Itahashi, Takashi Gakuhari, Minoru Yoneda, Jie Chen
The earliest evidence of human tuberculosis can be traced to at least the early dynastic periods, when full-scaled wet-rice agriculture began or entered its early developmental stages, in circum-China countries (Japan, Korea, and Thailand). Early studies indicated that the initial spread of tuberculosis coincided with the development of wet-rice agriculture. It has been proposed that the adaptation to agriculture changed human social/living environments, coincidentally favoring survival and spread of pathogenic Mycobacterial strains that cause tuberculosis...
January 16, 2019: International Journal of Paleopathology
I Procopie, E L Popescu, R M Pleșea, M Dorobanțu, R F Mureșan, C V Lupașcu-Ursulescu, I E Pleșea, D N Anușca
Osteoarticular tuberculosis (OATB) Aim: The authors made a clinical morphological assessment of tissue samples from patients admitted in Surgical Departments of the Emergency County Hospital of Craiova, Romania, between 1990 and 2015, proved as presenting tuberculous lesions of the spine in the Department of Pathology of the same Hospital. MATERIALS AND METHODS: The studied material consisted of bone, joint and sometimes muscle tissue fragments resulted from biopsies or surgical excisions from 7 cases coming out of 54 patients investigated in the above-mentioned period of time, where the established histological diagnosis was tuberculosis (TB)...
July 2018: Current Health Sciences Journal
Rui-Song Chen, Xin Liao, Mo-Liang Xiong, Feng-Rong Chen, Bo-Wen Wang, Jian-Ming Huang, Xiao-Lin Chen, Gang-Hui Yin, Hao-Yuan Liu, Da-di Jin
OBJECTIVES: Multilevel noncontiguous thoracic and lumbar spinal tuberculosis (MNST) is a relatively rare entity. The objective of this retrospective study was to investigate whether a technique involving a one-stage posterior debridement and decompression, combined with an intervertebral fusion and posterior instrumentation, is effective for treating MNST. METHODS: Thirteen patients, with an average age of 40.69 (18-67) years, who had MNST and were surgically treated in our department from January 2008 to October 2013, were reviewed...
December 26, 2018: Postgraduate Medicine
Justine Gibson, John Coucher, Chris Coulter, Geoffrey Eather
A healthy 31-year-old man presenting with back pain was found to have multiple spinal enhancing lesions on MRI. An incidental asymptomatic large pleural effusion was identified on investigations for the back pain and pleural and pulmonary tuberculosis (TB) was subsequently diagnosed. The radiographical features on MRI spine were not typical of spinal TB and a Ga68 DOTATATE Positron Emission Tomography (PET)/CT confirmed metastatic paraganglioma with multiple bone metastases. Although metastatic paraganglioma is rare, this case highlights that even in young patients dual pathology needs to be considered...
December 22, 2018: BMJ Case Reports
S Rajasekaran, Dilip Chand Raja Soundararajan, Ajoy Prasad Shetty, Rishi Mugesh Kanna
Study Design: Review article. Objectives: A review of literature on the epidemiology, diagnosis, and management of spinal tuberculosis (TB). Methods: A systematic computerized literature search was performed using Cochrane Database of Systematic Reviews, EMBASE, and PubMed. Studies published over the past 10 years were analyzed. The searches were performed using Medical Subject Headings terms, and the subheadings used were "spinal tuberculosis," "diagnosis," "epidemiology," "etiology," "management," "surgery," and "therapy...
December 2018: Global Spine Journal
Kripa Maharjan, Sudeep Adhikari, Buddha Basnyat
No abstract text is available yet for this article.
December 19, 2018: BMJ Case Reports
Sudeep Adhikari, Buddha Basnyat
We report a case of a 33-year-old woman from Nepal who presented to a hospital with paraplegia. She was found to have pulmonary tuberculosis (TB) with lumbar spine involvement, and bilateral psoas abscesses. She had no initial symptoms attributable to pulmonary involvement. Her delayed presentation to the hospital led to complication of TB spine, which compromised the life of this woman working as a labourer. Early diagnosis and treatment of extrapulmonary TB is essential. Awareness regarding symptoms of different forms of extrapulmonary TB and making diagnostic modalities such as CT scan, MRI or biopsy readily available through insurance schemes are some important measures to minimise the problem so that complications like paraplegia as in our patient with spinal TB can potentially be avoided...
December 19, 2018: BMJ Case Reports
Xin Hua Yin, Liang Yan, Ming Yang, Ke Zhang, Bao Rong He, Zhong Kai Liu, Ding Jun Hao
To investigate the clinical efficacy of surgical treatment for thoracic spinal tuberculosis with kyphosis deformity via posterolateral debridement, fusion, posterior instrumentation and local continuous chemotherapy. A total of 25 patients with thoracic tuberculosis received surgery by posterolateral decompression, fusion, posterior instrumentation, and postural drainage with local continuous chemotherapy between June 2009 and October 2011. The clinical outcomes was evaluated using statistical analysis about deformity correction, bone fusion, neurologic status, and the visual analog score (VAS) and erythrocyte sedimentation rate (ESR)...
December 2018: Medicine (Baltimore)
Yin Liu, Zheng Wang, Guang Yao, Yuying Lu, Zhongyang Hu, Huan Yao, Qinghua Zhang, Haixia Zhu, Zhi Song, Wei Wang, Ding Liu
OBJECTIVE: The aim of this study was to investigate the occurrence of paradoxical reaction (PR) in HIV-negative tuberculous meningitis (TBM) patients with spinal involvement, as well as its possible risk factors. METHODS: Fifty TBM patients with spinal involvement were studied retrospectively and divided into a PR group and a non-PR group according to the presence of PR. Their demographic, clinical, radiological, and laboratory data, and status at follow-up were collected and compared...
December 4, 2018: International Journal of Infectious Diseases: IJID
Kai Wang, Na Wang, Yuliang Wang, Yayi Xia, Feixue Song, Jingsheng Liu
BACKGROUND: To compare clinical and functional outcomes of anterior versus posterior debridement and spinal fixation for surgical treatment of thoracolumbar tuberculosis. METHODS: A computer-based online search of the Cochrane Library, PubMed, EMBase, Wanfang, VIP, and the CNKI database was performed. The methodological quality of included studies was evaluated, and data analyses were performed using RevMan 5.0 software (The Nordic Cochrane Centre, The Cochrane Collaboration Copenhagen, Denmark)...
December 6, 2018: Der Orthopäde
Huipeng Yin, Kun Wang, Yong Gao, Yukun Zhang, Wei Liu, Yu Song, Shuai Li, Shuhua Yang, Zengwu Shao, Cao Yang
BACKGROUND: Junction tuberculous spondylitis involves the stress transition zone of the spine and has a high risk of progression to kyphosis or paraplegia. Problems still exist with treatment for spinal junction tuberculosis. This study investigated the surgical approach and clinical outcomes of junction spinal tuberculosis. METHODS: From June 1998 to July 2014, 77 patients with tuberculous spondylitis were enrolled. All patients received 2-3 weeks of anti-tuberculous treatment preoperatively; treatment was prolonged for 2-3 months when active pulmonary tuberculosis was present...
December 6, 2018: Journal of Orthopaedic Surgery and Research
Yoshi Pratama Djaja, Phedy Phedy, Jamot Silitonga, Didik Librianto, Ifran Saleh
INTRODUCTION: Both gluteal abscess and sacral tuberculosis are rare entities in spinal tuberculosis cases. Even in endemic country, this atypical presentation may be the cause of delayed diagnosis and treatment. PRESENTATION OF CASE: A 51-year-old woman was admitted with painless massive lump on both of her thighs that have been enlarging for the past 6 months. She had a history of previous tuberculosis treatment. From the MRI examination submuscular gluteal abscess, which was an extension of the sacral tuberculosis, were found...
November 24, 2018: International Journal of Surgery Case Reports
Khaled Omran, Ahmed S Abdel-Fattah
BACKGROUND DATA: Complexity in ventral surgical exposure, presence of scapula and large para-scapular musculature during posterior surgery are the main obstacles in operative treatment of Upper Thoracic Spine Compressive Lesions (UTSCL) like trauma, tuberculosis and neoplasm. Recently, the advantages of combined ventro-dorsal surgery could be successfully gained using 1-stage posterior salvage technique with enough accessibility to all three spinal columns. PURPOSE: Retrospective evaluation of 35 patients with UTSCL treated by Posterior Extensive Circumferential Decompressive Reconstructive (PECDR) procedure...
December 3, 2018: World Neurosurgery
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