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Carbepenem use antimicrobial resistance

Richa Sinha, Sphurti Kamath, Suchitra M Shenoy
PURPOSE: Escherichia coli are the most frequent cause of gram negative bloodstream infection. This study was done to evaluate the association of risk factors, antimicrobial susceptibility pattern and detection of TEM, SHV and CTX M genes in the extended spectrum beta lactamase (ESBL) producing E.coli. MATERIALS AND METHODS: 11,133 blood samples were processed in BacT/Alert bottles. Bacteria grown were identified and antibiotic susceptibility patterns were studied using VITEK2 system...
2016: Infectious Disorders Drug Targets
Jaspal Kaurthe
Multidrug-resistant typhoid fever (MDRTF) is a major public health problem in developing countries and is an emerging problem in the developed world. Because of the difficulties in preventing typhoid by public health measures or immunization in developing countries, great reliance is placed on antimicrobial chemotherapy. The treatment should commence as soon as the clinical diagnosis is made rather than after the results of antimicrobial susceptibility tests but the existence of MDRTF poses a serious clinical dilemma in the selection of empiric antimicrobial therapy...
March 2013: Journal of Clinical and Diagnostic Research: JCDR
Meher Rizvi, Fatima Khan, Indu Shukla, Abida Malik, Shaheen
BACKGROUND: Urinary tract infections (UTI) are one of the most common medical complications of pregnancy. The emergence of drug resistance and particularly the Extended-spectrum beta-lactamase production by Escherichia coli and methicillin resistance in Staphylococci, limits the choice of antimicrobials. MATERIALS AND METHODS: Patients in different stages of pregnancy with or without symptoms of urinary tract infection attending the antenatal clinic of obstetrics and gynaecology were screened for significant bacteriuria, by standard loop method on 5% sheep blood agar and teepol lactose agar...
July 2011: Journal of Laboratory Physicians
Chen Liang-Yu, Shu-Chen Kuo, Chun-Yu Liu, Bin-Syun Luo, Ling-Ju Huang, Yi-Tzu Lee, Chien-Pei Chen, Te-Li Chen, Chang-Phone Fung
BACKGROUND: To determine whether the susceptibilities and the trends of nonsusceptibility of imipenem, meropenem, sulbactam, and colistin differed among Acinetobacter baumannii, Acinetobacter genomic species 3 (AGS 3), and Acinetobacter genomic species 13TU (AGS 13TU) over 11 years. METHODS: A total of 1,039 nonduplicate blood isolates of A baumannii complex from bacteremic patients between 1997 and 2007 were collected at Taipei Veterans General Hospital and were identified to the species level using a multiplex polymerase chain reaction method and sequence analysis of 16S-23S intergenic spacer...
October 2011: Journal of Microbiology Immunology and Infection
Sanae Yoshida, Tetsufumi Koga, Masayo Kakuta, Intetsu Kobayashi, Kaoru Matsuzaki, Eriko Urabe, Kaoru Omika, Miyuki Hasegawa, Yumie Sato
The antimicrobial activity of various antibiotics against clinical bacterial isolates recovered from patients with infectious diseases at the medical facilities in the Kanto region between March and September 2006 was evaluated. A total of 1030 clinical isolates were available for susceptibility tests: 420 aerobic Gram-positive organisms, 520 aerobic Gram-negative organisms, 30 anaerobic Gram-positive organisms and 60 anaerobic Gram-negative pathogens. Antimicrobial susceptibility data for Streptococcus pneumoniae and Haemophilus influenzae isolates from pediatric and adult patients were analyzed separately...
February 2008: Japanese Journal of Antibiotics
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