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Hemostatic powder TC-325

Felipe Iankelevich Baracat, Diogo Turiani Hourneaux de Moura, Vítor Ottoboni Brunaldi, Caio Vinicius Tranquillini, Renato Baracat, Paulo Sakai, Eduardo Guimarães Hourneaux de Moura
BACKGROUND AND AIMS: Despite advances in pharmacological and endoscopic management of non-variceal upper gastrointestinal bleeding (NVUGIB), mortality is still relevant. TC-325 (Hemospray-Cook Medical) is a mineral powder with adsorptive properties, designed for endoscopic hemostasis. There are still no comparative trials studying this new hemostatic modality. The objective of this research was to compare the use of TC-325 (associated with epinephrine injection) with the combined technique of endoscopic clipping and epinephrine injection for the treatment of patients with NVUGIB...
March 29, 2019: Surgical Endoscopy
Ariadna Iraís Ramírez-Polo, Jorge Casal-Sánchez, Angélica Hernández-Guerrero, Luz María Castro-Reyes, Melissa Yáñez-Cruz, Louis Francois De Giau-Triulzi, Javier Vinageras-Barroso, Félix Ignacio Téllez-Ávila
INTRODUCTION: Hemostatic powder (TC-325) is a new tool for treatment of gastrointestinal bleeding that allows the treatment of large surfaces with active bleeding. The aim was to describe the initial success of TC-325 for the control of GI bleeding. MATERIALS AND METHODS: We did a multicenter cohort study with patients admitted to the endoscopy service for GI bleeding. A format was generated to standardize the information obtained in each center. It was determined whether this treatment had been used as a single therapy or as a combination therapy...
February 28, 2019: Surgical Endoscopy
Lawrence Hookey, Alan Barkun, Richard Sultanian, Robert Bailey
BACKGROUND AND AIMS: Acute lower GI bleeding is a frequent cause of hospital admission. The objective of this study was to evaluate the safety and performance of a hemostatic powder (TC-325/Hemospray) in the treatment of nonvariceal lower GI bleeding. METHODS: Patients were enrolled into this prospective, multicenter, single-arm study at 4 tertiary care centers in Canada. Fifty patients with active lower GI bleeding of multiple different causes (52 bleeding sites) underwent topical endoscopic application of hemostatic powder...
April 2019: Gastrointestinal Endoscopy
Rapat Pittayanon, Rungsun Rerknimitr, Alan Barkun
BACKGROUND AND AIMS: Endoscopic hemostatic techniques remain poorly effective for GI tumor bleeding. We assessed Tc-325 (Hemospray, Cook Medical, Bloomington, Ind, USA) for this indication and determined possible predictors of decreased recurrent bleeding and improved 6-month survival in affected patients. METHODS: This retrospective study identified 99 patients with active malignant GI bleeding (primary or metastatic) treated with Tc-325. Eleven patients were excluded because of incomplete data...
April 2018: Gastrointestinal Endoscopy
Sami Haddara, Jeremie Jacques, Stéphane Lecleire, Julien Branche, Sarah Leblanc, Yann Le Baleur, Jocelyn Privat, Laurent Heyries, Philippe Bichard, Philippe Granval, Ulriikka Chaput, Stephane Koch, Jonathan Levy, Bruno Godart, Antoine Charachon, Jean-François Bourgaux, Elodie Metivier-Cesbron, Edouard Chabrun, Vincent Quentin, Bastien Perrot, Geoffroy Vanbiervliet, Emmanuel Coron
Background and study aims: The hemostatic powder TC-325 (Hemospray; Cook Medical, Winston-Salem, North Carolina, USA) has shown promising results in the treatment of upper gastrointestinal bleeding (UGIB) in expert centers in pilot studies. The aim of this study was to evaluate the feasibility and efficacy of TC-325 in a large prospective registry of use in routine practice. Patients and methods: The data of all patients treated with TC-325 were prospectively collected through a national registry. Outcomes were the immediate feasibility and efficacy of TC-325 application, as well as the rates of rebleeding at Day 8 and Day 30...
December 2016: Endoscopy
Alan N Barkun, Viviane Adam, Yidan Lu, Yen-I Chen, Myriam Martel
GOALS: We compared the cost-effectiveness of traditional recommended endoscopic hemostatic therapies and Hemospray alone or in combination when treating nonvariceal upper gastrointestinal bleeding (NVUGIB). BACKGROUND: Hemospray (TC-325) is a novel endoscopic hemostatic powder, achieving hemostasis through adherence to actively bleeding biological surfaces. STUDY: A decision tree of patients with NVUGIB assessed 4 possible treatment strategies: traditional therapy alone (T), Hemospray alone (H), traditional therapy completed by Hemospray if needed (T+H), or Hemospray completed by traditional therapy if needed (H+T)...
January 2018: Journal of Clinical Gastroenterology
Alan Barkun
No abstract text is available yet for this article.
July 2015: Gastroenterology & Hepatology
Yen-I Chen, Alan N Barkun
Topical hemostatic agents and powders are an emerging modality in the endoscopic management of upper and lower gastrointestinal bleeding. This systematic review demonstrates the effectiveness and safety of these agents with special emphasis on TC-325 and Ankaferd Blood Stopper. The unique noncontact/nontraumatic application, ability to cover large areas of bleed, and ease of use make these hemostatic agents an attractive option in certain clinical situations, such as massive bleeding with poor visualization, salvage therapy, and diffuse bleeding from luminal malignancies...
July 2015: Gastrointestinal Endoscopy Clinics of North America
Yen-I Chen, Alan Barkun, Sabrina Nolan
BACKGROUND AND STUDY AIMS: TC-325 is a novel endoscopic hemostatic powder. Our aim was to describe a single-center experience with the use of TC-325 in the upper and lower gastrointestinal tract, while for the first time attempting to determine how long the powder remains on a lesion. PATIENTS AND METHODS: The charts of consecutive patients receiving TC-325 therapy between July 2011 and July 2013 were reviewed retrospectively. Primary endpoints included immediate hemostasis and early rebleeding (≤ 72 hours)...
February 2015: Endoscopy
Enzo Masci, Monica Arena, Elisabetta Morandi, Paolo Viaggi, Benedetto Mangiavillano
INTRODUCTION AND OBJECTIVES: Acute gastrointestinal (GI) bleeding can lead from mild to immediately life-threatening clinical conditions. Upper GI bleeding (UGIB) is associated with a mortality of 6-10%. Spurting and oozing bleeding are associated with major risk of failure. Hemospray™ (TC-325), a new hemostatic powder, may be useful in these cases. Aim of this study is to review the efficacy of traditional endoscopic treatment in Forrest 1a-1b ulcers and to investigate the usefulness of Hemospray in these patients...
November 2014: Scandinavian Journal of Gastroenterology
Marco Bustamante-Balén, Gema Plumé
Acute gastrointestinal bleeding (AGIB) is a prevalent condition with significant influence on healthcare costs. Endoscopy is essential for the management of AGIB with a pivotal role in diagnosis, risk stratification and management. Recently, hemostatic powders have been added to our endoscopic armamentarium to treat gastrointestinal (GI) bleeding. These substances are intended to control active bleeding by delivering a powdered product over the bleeding site that forms a solid matrix with a tamponade function...
August 15, 2014: World Journal of Gastrointestinal Pathophysiology
Mostafa Ibrahim, Ahmed El-Mikkawy, Ibrahim Mostafa, Jacques Devière
BACKGROUND: Current standard of care of acute variceal bleeding (AVB) combines hemodynamic stabilization, antibiotic prophylaxis, pharmacological agents, and endoscopic treatment. The latter may be challenging in an emergency setting with active bleeding that interferes with visualization. OBJECTIVE: To assess the effectiveness of a pre-established delivery protocol of a hemostatic powder to control AVB originating from the esophagus or the gastroesophageal junction...
November 2013: Gastrointestinal Endoscopy
Yen-I Chen, Alan N Barkun, Constantine Soulellis, Serge Mayrand, Peter Ghali
No abstract text is available yet for this article.
June 2012: Gastrointestinal Endoscopy
S A Giday, Y Kim, D M Krishnamurty, R Ducharme, D B Liang, E J Shin, X Dray, D Hutcheon, K Moskowitz, G Donatelli, D Rueben, M I Canto, P I Okolo, A N Kalloo
BACKGROUND AND STUDY AIM: Endoscopic therapy of brisk upper gastrointestinal bleeding remains challenging. A proprietary nanopowder (TC-325) has been proven to be effective in high pressure bleeding from external wounds. The efficacy and safety of TC-325 were assessed in a survival gastrointestinal bleeding animal model. METHOD: 10 animals were randomized to treatment or sham. All animals received intravenous antibiotics, H2-blockers and heparin (activated clotting time 2 × normal)...
April 2011: Endoscopy
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