P H Goff, E T Huynh, K Lachance, N Harikrishnan, M Cook, S K Schaub, Y D Tseng, J J Liao, S Apisarnthanarax, K Wallner, P Nghiem, U Parvathaneni
PURPOSE/OBJECTIVE(S): Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high recurrence risk. Postoperative radiotherapy (PORT) improves the local recurrence rate (LRR) in early-stage MCC with risk factors per NCCN guidelines: primary tumor size > 1cm, head/neck (HN) location, immunosuppression, lymphovascular invasion (LVI), and positive/narrow surgical margins. Conventionally fractionated PORT (C-PORT, ∼50 Gy in 25 fractions) is often recommended for localized MCC with these risk factors; however, some institutions elect observation...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics