Anna Szumera-Cieckiewicz, Daniela Massi, Angelo Cassisa, Mateusz Krzyzinski, Monika Dudzisz-Sledz, Przemyslaw Biecek, Piotr Rutkowski, Andrzej Marszalek, Mai P Hoang, Piotr Donizy
Histopathological evaluation of lymph nodes in Merkel cell carcinoma has become crucial in progression estimation and treatment modification. This study was undertaken to determine the most sensitive immunohistochemical panel for detecting MCC nodal metastases. We included 56 patients with 102 metastatic MCC lymph nodes, which were tested with seven antibodies: cytokeratin (CKAE1/AE3), CK20, chromogranin A, synaptophysin, INSM1, SATB2, and neurofilament (NF). Tissue microarrays (TMA) composed of 2-mm tissue cores from each nodal metastasis were constructed...
December 8, 2023: Virchows Archiv: An International Journal of Pathology