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Takeshi Ogura, Takaaki Eguchi, Mio Amano, Tatushi Sano, Nobu Nishioka, Akira Miyano, Masahiro Tsujimae, Hirohisa Tanimura, Tadahiro Yamada, Yoshihiko Terashima, Akihiko Okada, Kazuhide Higuchi
BACKGROUND: Severe acute cholecystitis (AC) is defined by the association of organ dysfunction, including hematological dysfunction, with AC. Severe AC is often complicated by disseminated intravascular coagulation (DIC), the diagnostic criteria of which overlap with AC-associated hematological dysfunction. Since the diagnosis of DIC often delays definitive surgical management of severe AC, treatment of DIC in this setting is clinically important. Recombinant human soluble thrombomodulin (rTM) is a new agent that has proven clinically useful for treating DIC...
February 13, 2019: Thrombosis Research
Jian Lu, Jun Wu, Cui Zhang, Yuxuan Zhang, Yichen Lin, Yongming Luo
Information on ecological and health risks posed by antibiotics in coastal waters at continental or national scale is limited although antibiotics have continuously entered the natural environments due to extensive usage for human beings and animals. This study collected coastal water samples along nearly 18,000 km of coastline of China to investigate the distribution, possible sources, and potential ecological-health risks of antibiotics. Only 7 out of 13 target antibiotics were detected in coastal water samples...
December 10, 2018: Science of the Total Environment
Manzoor Khan, Jake Olivier
Regression to the mean (RTM) occurs when subjects having relatively high or low measurements are remeasured and found closer to the population mean. This phenomenon can potentially lead to an inaccurate conclusion in a pre-post study design. Expressions are available for quantifying RTM when the distribution of pre and post observations are bivariate normal and bivariate Poisson. However, situations exist where the response variables are the number of successes in a fixed number of trials and follow the bivariate binomial distribution...
February 11, 2019: Statistics in Medicine
Toshio Ichiki, Futoshi Kohda, Toshiki Hiramatsu, Reo Saiki, Atsushi Sakai, Masutaka Furue
OBJECTIVE: Rhabdophis tigrinus (Yamakagashi in Japanese) is a venomous non-front-fanged colubroid snake capable of inflicting envenoming with life-threatening defibrinating coagulopathy. However, because of the uncommon incidence of bites and tendency for late development of symptoms/signs, the early effects of the venom on the coagulation system are poorly known. CASE REPORT: We describe a boy bitten by a wild R. tigrinus and report his clinical course starting at 30 min after the bite...
January 28, 2019: Clinical Toxicology
Hiroyuki Miyawaki, Brendon O Watson, Kamran Diba
Neurons fire at highly variable intrinsic rates and recent evidence suggests that low- and high-firing rate neurons display different plasticity and dynamics. Furthermore, recent publications imply possibly differing rate-dependent effects in hippocampus versus neocortex, but those analyses were carried out separately and with potentially important differences. To more effectively synthesize these questions, we analyzed the firing rate dynamics of populations of neurons in both hippocampal CA1 and frontal cortex under one framework that avoids the pitfalls of previous analyses and accounts for regression to the mean (RTM)...
January 24, 2019: Scientific Reports
Jonathan Yinhao Huang, Farhan Majid, Mark Daku
BACKGROUND: Road traffic deaths are a substantial barrier to population health improvement in low-income and middle-income countries (LMICs). In South Africa, the road-traffic injury mortality (RTM) rate of 27 per 100 000 population is twice the global average, over 60% of which are alcohol-related. Recent US studies suggest the Uber ride-sharing service may reduce alcohol-related RTM, however RTM burden in the USA is relatively low and transport behaviours differ from LMICs. METHODS: Using certification data from all deaths occurring in South Africa in the years 2010-2014 (n=2 498 216), we investigated the relative change in weekly road traffic-related death counts between provinces which received Uber services (beginning in 2013) against those that did not using a difference-in-differences approach...
January 11, 2019: Journal of Epidemiology and Community Health
Sergei G Kruglik, Félix Royo, Jean-Michel Guigner, Laura Palomo, Olivier Seksek, Pierre-Yves Turpin, Irène Tatischeff, Juan M Falcón-Pérez
The technique of Raman tweezers microspectroscopy (RTM) for the global biomolecular content characterization of a single extracellular vesicle (EV) or a small number of EVs or other nanoscale bioparticles in an aqueous dispersion in the difficult-to-access size range of near 100 nm is described in detail. The particularities and potential of RTM are demonstrated using the examples of DOPC liposomes, exosomes from human urine and rat hepatocytes, and a mixed sample of the transfection reagent FuGENE in diluted DNA solution...
January 8, 2019: Nanoscale
Zeyu Sun, Jie Xiao, Lei Tao, Yuanping Wei, Shijie Wang, Hui Zhang, Shu Zhu, Muhuo Yu
To satisfy the light weight requirements of vehicles owing to the aggravation of environmental pollution, carbon-fiber (CF)-reinforced epoxy composites have been chosen as a substitute for traditional metal counterparts. Since the current processing methods such as resin transfer molding (RTM) and compression molding (CM) have many limitations, an integrated and optimal molding method needs to be developed. Herein, we prepared high-performance composites by an optimized molding method, namely compression resin transfer molding (CRTM), which combines the traditional RTM and CM selectively and comprehensively...
December 20, 2018: Materials
Yinghu Zhang, Jianbo He, Hongwei Wang, Shan Meng, Guangnan Xing, Yan Li, Shouping Yang, Jinming Zhao, Tuanjie Zhao, Junyi Gai
Soybean is one of the world's major vegetative oil sources, while oleic acid and linolenic acid content are the major quality traits of soybean oil. The restricted two-stage multi-locus genome-wide association analysis (RTM-GWAS), characterized with error and false-positive control, has provided a potential approach for a relatively thorough detection of whole-genome QTL-alleles. The Chinese soybean landrace population (CSLRP) composed of 366 accessions was tested under four environments to identify the QTL-allele constitution of seed oil, oleic acid and linolenic acid content (SOC, OAC, and LAC)...
2018: Frontiers in Plant Science
Zhi Geng, Shuaishuai Yang, Lianwang Zhang, Zhenzhen Huang, Qichao Pan, Jidi Li, Jianan Weng, Jianwen Bao, Zhengwei You, Yong He, Bo Zhu
Introducing fire-retardant additives or building blocks into resins is a widely adopted method used for improving the fire retardancy of epoxy composites. However, the increase in viscosity and the presence of insoluble additives accompanied by resin modification remain challenges for resin transfer molding (RTM) processing. We developed a robust approach for fabricating self-extinguishing RTM composites using unmodified and flammable resins. To avoid the effects on resin fluidity and processing, we loaded the flame retardant into tackifiers instead of resins...
December 15, 2018: Materials
Shosaku Nomura, Tomoki Ito, Yuta Katayama, Shuichi Ota, Kunio Hayashi, Shinya Fujita, Atsushi Satake, Kazuyoshi Ishii
BACKGROUND: Conditioning chemotherapies for hematopoietic stem cell transplantation (HSCT), especially those that include total body irradiation, can result in serious complications such as graft-versus-host disease (GVHD). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule with multiple immunoregulatory functions. METHODS: We measured interleukin (IL)-10, transforming growth factor (TGF)β1 , and soluble HLA-G (sHLA-G) in HSCT patients and examined the relationship between sHLA-G levels and acute GVHD (aGVHD)...
December 10, 2018: Transplant Immunology
Wayne X J Wei, Kenneth N K Fong, Raymond C K Chung, Hobby K Y Cheung, Eddie S L Chow
This study examined the effects of "Remind-to-Move" (RTM) via vibration cueing using wearable devices to increase the use of the affected upper limb and integrate upper limb activities undertaken at home in patients with subacute stroke after inpatient discharge. In a multi-centered randomized controlled trial, 84 eligible patients from four general hospitals who had had a first stroke in the last six months were randomly allocated to either an experimental, sham, or control group, stratified by arm function levels...
November 20, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
William G Breed, Hazirah Hassan, Macarena Gonzalez, Hanna J McLennan, Chris M Leigh, Lawrence R Heaney
The high diversity of native Philippine murid rodents includes an old endemic group, the chrotomyines, which are the sister group of the Australasian hydromyines. Herein we detail their interspecific diversity of relative testes mass (RTM) and sperm morphology. We find that in chrotomyines, as in the Australasian hydromyines, testes mass relative to body mass differs by an order of magnitude across the species and ranges from a large RTM in Soricomys and Chrotomys species to a small RTM in Apomys. Sperm morphology is associated with these findings, with individuals in species of Soricomys and Chrotomys producing relatively larger spermatozoa with a prominent apical hook and long tail, whereas, by contrast, the Apomys species have a sperm head that either has a very short or no apical hook and a shorter tail...
November 27, 2018: Reproduction, Fertility, and Development
Nozomi Morita, Kazunari Nakahara, Ryo Morita, Keigo Suetani, Yosuke Michikawa, Junya Sato, Kensuke Tsuji, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe, Nobuyuki Matsumoto, Chiaki Okuse, Michihiro Suzuki, Fumio Itoh
Objective The efficacy and safety of concomitant use of antithrombin (AT) with recombinant soluble human thrombomodulin (rTM) for acute cholangitis-induced disseminated intravascular coagulation (AC-induced DIC) remains unclear. This study was conducted to investigate the efficacy of AT combined with rTM as anticoagulant therapy for AC-induced DIC. Methods One hundred patients with AC-induced DIC received anticoagulant therapy using rTM from April 2010 to December 2017. Of the 83 patients treated with rTM immediately after the diagnosis of DIC, excluding those who had not undergone biliary drainage or who had malignancies or a serum AT III level >70%, 56 patients were studied...
November 19, 2018: Internal Medicine
Miyuki Ookura, Naoko Hosono, Toshiki Tasaki, Kana Oiwa, Kei Fujita, Kazuhiro Ito, Shin Lee, Yasufumi Matsuda, Mihoko Morita, Katsunori Tai, Eiju Negoro, Shinji Kishi, Hiromichi Iwasaki, Takanori Ueda, Takahiro Yamauchi
Disseminated intravascular coagulation (DIC) is a life-threatening condition that frequently occurs in patients with hematologic malignancies. Currently, recombinant human soluble thrombomodulin (rTM) is a therapeutic DIC drug that is manufactured and sold in Japan only. We evaluated the efficacy of rTM compared to that of gabexate mesilate (GM), which was previously used routinely for treating DIC in Japan, in patients with acute myeloid leukemia (AML). This retrospective study enrolled 43 AML patients, including 17 with acute promyelocytic leukemia (APL), that was complicated with DIC...
November 2018: Medicine (Baltimore)
Satoshi Takada, Tomoharu Miyashita, Yasuhiko Yamamoto, Shunsuke Kanou, Seiichi Munesue, Yoshinao Ohbatake, Shinichi Nakanuma, Koichi Okamoto, Seisho Sakai, Jun Kinoshita, Isamu Makino, Keishi Nakamura, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
BACKGROUND: Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease, is a form of drug-induced liver injury, the initial morphological changes associated with which occur in liver sinusoidal endothelial cells (LSECs). Recombinant human soluble thrombomodulin (rTM) is reported to have anti-inflammatory and cytoprotective effects. Therefore, we investigated the ability of rTM to protect endothelial cells and enhance their functions in a monocrotaline (MCT)-induced model of SOS...
November 2018: In Vivo
Takuhiro Yamaguchi, Yukio Kitajima, Yasuhiro Miyauchi, Kazutoshi Izawa, Masakazu Tanaka, Masatada Hirata, Yasunari Sadatsuki, Yoshihiro Ogawa
We aimed to investigate the incidence of bleeding-related adverse events (AEs) among patients with disseminated intravascular coagulation (DIC) receiving recombinant thrombomodulin (rTM) and those receiving other DIC treatments, the incidence by type of surgery, and the incidence when either blood transfusion or a hemostatic procedure was administered to treat DIC. In this cohort study, data were obtained from a large medical database (22 centers in Japan). The primary endpoint was the incidence rate of bleeding-related AEs by type of surgery...
2018: PloS One
Daniel Medenwald, Dirk Vordermark, Christian T Dietzel
Objectives: The aim of this study was to assess the association between the number of radiotherapy treatment machines (RTMs) in the population and incidence-adjusted cancer mortality. Methods: Data on cancer incidence and mortality were obtained from the GLOBOCAN project (only high-quality data, C3, or higher according to GLOBOCAN quality label), information on the number of RTMs from the Directory of Radiotherapy Centers database, and remaining data from the World Bank and World Health Organization database...
2018: Clinical Epidemiology
Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama, Yasuyuki Kakihana
Background: Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress. rTM mainly exerts its anticoagulant effects through an activated protein C (APC)-dependent mechanism, but the circulating APC levels after rTM treatment have not been clarified. This prospective observational study investigated plasma APC levels after rTM treatment...
2018: Thrombosis Journal
Joni Macdonald, Karen R Kilcoyne, Richard M Sharpe, Áine Kavanagh, Richard A Anderson, Pamela Brown, Lee B Smith, Anne Jørgensen, Rod T Mitchell
STUDY QUESTION: Does loss of DMRT1 in human fetal testis alter testicular development and result in testicular dysgenesis? SUMMARY ANSWER: DMRT1 repression in human fetal testis alters the expression of key testicular and ovarian determining genes, and leads to focal testicular dysgenesis. WHAT IS KNOWN ALREADY: Testicular dysgenesis syndrome (TDS) is associated with common testicular disorders in young men, but its etiology is unknown. DMRT1 has been shown to play a role in the regulation of sex differentiation in the vertebrate gonad...
November 1, 2018: Human Reproduction
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