keyword
https://read.qxmd.com/read/37650725/diagnosis-and-practical-management-of-digoxin-toxicity-a-narrative-review-and-consensus
#21
REVIEW
Paul Andrews, Kurt Anseeuw, Dipak Kotecha, Frédéric Lapostolle, Ruben Thanacoody
There are currently no universally accepted guidelines for the management of digoxin toxicity. In the absence of clinical practice guidelines, a set of consensus recommendations for management of digoxin toxicity in the clinical setting were developed through a modified Delphi approach. The recommendations highlight the importance of early recognition of signs of potentially life-threatening toxicity that requires immediate treatment with digoxin-specific antibodies. The consensus identifies a straightforward approach to dosing immune antibody fragments according to the presence or absence of signs of life-threatening toxicity...
December 1, 2023: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://read.qxmd.com/read/37631076/reports-of-symptoms-associated-with-supraventricular-arrhythmias-as-a-serious-adverse-drug-reaction-in-the-spanish-pharmacovigilance-database
#22
JOURNAL ARTICLE
Javier Pueyo-Val, Ana Avedillo-Salas, Pablo Berdún-Viñegra, Olga María Pueyo-Val, Ana Fanlo-Villacampa, Cristina Navarro-Pemán, Francisco Javier Lanuza-Giménez, Ignatios Ioakeim-Skoufa, Jorge Vicente-Romero
This study aimed to determine the type of drugs reported as suspected of causing severe supraventricular arrhythmias from the Spanish Human Pharmacovigilance System database. A total of 1053 reports were analysed, of which 526 (50%) were on men and 516 (49%) were on women. The most affected age group was the over-65s, with 593 reports (56%). Of the 1613 drugs, those belonging to the cardiovascular system (ATC Group C) were the most numerous (414 reports, 26%), with digoxin being the most frequent drug (49 reports, 12%)...
August 15, 2023: Pharmaceuticals
https://read.qxmd.com/read/37628922/endogenous-digitalis-like-factors-as-a-key-molecule-in-the-pathophysiology-of-pregnancy-induced-hypertension-and-a-potential-therapeutic-target-in-preeclampsia
#23
REVIEW
Maciej W Socha, Jakub Chmielewski, Miłosz Pietrus, Mateusz Wartęga
Preeclampsia (PE), the most severe presentation of hypertensive disorders of pregnancy, is the major cause of morbidity and mortality linked to pregnancy, affecting both mother and fetus. Despite advances in prophylaxis and managing PE, delivery of the fetus remains the only causative treatment available. Focus on complex pathophysiology brought the potential for new treatment options, and more conservative options allowing reduction of feto-maternal complications and sequelae are being investigated. Endogenous digitalis-like factors, which have been linked to the pathogenesis of preeclampsia since the mid-1980s, have been shown to play a role in the pathogenesis of various cardiovascular diseases, including congestive heart failure and chronic renal disease...
August 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37623350/arrhythmias-in-patients-with-cardiac-amyloidosis-a-comprehensive-review-on-clinical-management-and-devices
#24
REVIEW
Alexandros Briasoulis, Christos Kourek, Adamantia Papamichail, Konstantinos Loritis, Dimitrios Bampatsias, Evangelos Repasos, Andrew Xanthopoulos, Elias Tsougos, Ioannis Paraskevaidis
Cardiac amyloidosis (CA) is a rare but potentially life-threatening disease in which misfolded proteins accumulate in the cardiac wall tissue. Heart rhythm disorders in CA, including supraventricular arrhythmias, conduction system disturbances, or ventricular arrhythmias, play a major role in CA morbidity and mortality, and thus require supplementary management. Among them, AF is the most frequent arrhythmia during CA hospitalizations and is associated with significantly higher mortality, while ventricular arrhythmias are also common and are usually associated with poor prognosis...
August 5, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37608699/impact-of-concomitant-cardiovascular-medications-on-overall-survival-in-patients-with-liver-cirrhosis
#25
JOURNAL ARTICLE
Moying Li, Timo Itzel, Nathally Espinosa Montagut, Thomas Falconer, Jimmy Daza, Jimyung Park, Jae Youn Cheong, Rae Woong Park, Isabella Wiest, Matthias Philip Ebert, George Hripcsak, Andreas Teufel
OBJECTIVES OF THE ARTICLE: Liver cirrhosis is the end-stage liver disease associated with poor prognosis and cardiovascular comorbidity could significantly impact mortality of cirrhotic patients. We conducted a large, retrospective study to investigate the survival impact of cardiovascular co-medications in patients with liver cirrhosis. MATERIALS AND METHODS: A study-specific R package was processed on the local databases of partner institutions within the Observational Health Data Sciences and Informatics consortium, namely Columbia University, New York City (NYC), USA and Ajou University School of Medicine (AUSOM), South Korea...
August 22, 2023: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/37576545/therapies-for-patients-with-coexisting-heart-failure-with-reduced-ejection-fraction-and-non-alcoholic-fatty-liver-disease
#26
REVIEW
Jose Arriola-Montenegro, Renato Beas, Renato Cerna-Viacava, Andres Chaponan-Lavalle, Karla Hernandez Randich, Diego Chambergo-Michilot, Herson Flores Sanga, Pornthira Mutirangura
Heart failure with reduced ejection fraction (HFrEF) and nonalcoholic fatty liver disease (NAFLD) are two common comorbidities that share similar pathophysiological mechanisms. There is a growing interest in the potential of targeted therapies to improve outcomes in patients with coexisting HFrEF and NAFLD. This manuscript reviews current and potential therapies for patients with coexisting HFrEF and NAFLD. Pharmacological therapies, including angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, mineralocorticoids receptor antagonist, and sodium-glucose cotransporter-2 inhibitors, have been shown to reduce fibrosis and fat deposits in the liver...
July 26, 2023: World Journal of Cardiology
https://read.qxmd.com/read/37575359/a-case-of-sudden-slow-heart-rate-in-a-patient-with-atrial-fibrillation-what-could-be-the-possible-cause
#27
JOURNAL ARTICLE
Jin Yi Goh, Carwen Siaw
General practitioners regularly encounter atrial fibrillation in their daily practice. A crucial cornerstone of its management includes prescribing anticoagulants and controlling the heart rate. Tachycardia or bradycardia often reflects an ongoing pathological process that should be addressed. Clues are frequently revealed through comprehensive history-taking, complete physical assessment and 12-lead electrocardiogram (ECG) interpretation at the bedside. Thus, early recognition of potential life-threatening arrhythmia in the outpatient setting will lead to appropriate clinical management...
2023: Malaysian Family Physician
https://read.qxmd.com/read/37512010/what-is-the-optimal-digoxin-level-challenging-case-of-fetal-atrial-flutter-treatment-in-a-monochorionic-diamniotic-twin
#28
Soo Jung Kim, Hee Do Jeon, So-Yeon Shim, Yi-Seul Kim, Mi-Hye Park, Kyung A Lee
Background : Atrial flutter is an infrequent yet potentially fatal arrhythmia. Digoxin is the preferred first-line treatment for fetal atrial flutter due to its efficacy and favorable safety profile. The optimal digoxin serum target level for neonatal atrial flutter management remains uncertain, with the standard target level ranging from 1.0 to 2.0 ng/mL due to potential toxicity concerns above this threshold. Case Presentation : We present a case of atrial flutter in a fetus within a monochorionic diamniotic (MCDA) twin pregnancy that was successfully managed using a higher-than-standard target level of digoxin...
June 25, 2023: Medicina
https://read.qxmd.com/read/37491874/intrauterine-management-and-outcomes-of-persistent-fetal-atrial-flutter-a-case-report
#29
Runxuan Du, Fangna Wang, Yuewen Dong, Wei Chu, Lishuang Ma, Jian Gao
BACKGROUND: Fetal atrial flutter (AF), accounting for 30% of all fetal tachyarrhythmias, predominantly (over 80%) manifests as a 2:1 atrioventricular conduction. Swift referral and timely intervention become imperative in instances of severe persistent arrhythmia. CASE PRESENTATION: We discuss the case of a 32-year-old multiparous Chinese woman, at 30+2 weeks of gestation, wherein an ultrasonographic examination revealed persistent fetal AF (atrial rate ranging from 219 to 445 beats/min and ventricular rate from 219 to 228 beats/min, with a 2:1 or 1:1 down transmission) and minor ascites...
July 25, 2023: Birth Defects Research
https://read.qxmd.com/read/37457790/digoxin-for-the-management-of-unstable-paroxysmal-supraventricular-tachycardia-in-a-patient-who-refused-electrical-cardioversion-in-a-rural-hospital
#30
Belayneh Dessie Kassa, Mekbib Amede, Mollalign Wubante, Mebratu Libanos, Kumlachew Geta
BACKGROUND: The most frequent atrioventricular tachycardia in the emergency room is atrioventricular nodal reentrant tachycardia (AVNRT). The first treatment option for ending stable narrow QRS complex SVTs is vagal maneuvers and adenosine. When adenosine or vagal maneuvers fail to change a patient's rhythm to normal sinus rhythm, long-acting AV nodal-blocking medications, including nondihydropyridine calcium channel blockers (verapamil and diltiazem), flecainide, or beta-blockers, are employed...
2023: Case Reports in Emergency Medicine
https://read.qxmd.com/read/37397486/lanatoside-c-decelerates-proliferation-and-induces-apoptosis-through-inhibition-of-stat3-and-ros-mediated-mitochondrial-membrane-potential-transformation-in-cholangiocarcinoma
#31
JOURNAL ARTICLE
Chao Zhang, Hong-Ying Yang, Long Gao, Ming-Zhen Bai, Wen-Kang Fu, Chong-Fei Huang, Ning-Ning Mi, Hai-Dong Ma, Ya-Wen Lu, Ning-Zu Jiang, Liang Tian, Teng Cai, Yan-Yan Lin, Xing-Xing Zheng, Kun Gao, Jian-Jun Chen, Wen-Bo Meng
Introduction: The incidence of cholangiocarcinoma (CCA) has increased worldwide in recent years. Given the poor prognosis associated with the current management approach of CCA, new therapeutic agents are warranted to improve the prognosis of this patient population. Methods: In this study, we extracted five cardiac glycosides (CGs) from natural plants: digoxin, lanatoside A, lanatoside C, lanatoside B, and gitoxin. Follow-up experiments were performed to assess the effect of these five extracts on cholangiocarcinoma cells and compounds with the best efficacy were selected...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37321800/physical-and-psychological-impact-of-yoga-therapy-in-improving-heart-failure
#32
REVIEW
Sridevi Prabhu, Krishnananda Nayak, Annapoorna Kadiyali, Tom Devasia, Rekha Varadaraju, Manjoosha Moodukudru
Effective therapy for patients with chronic cardiac failure (CCF) entails significant lifestyle modifications as well as often complex pharmaceutical regimes to alleviate symptoms, which, however, do not actually cure many patients. The gradual loss of cardiac function is impeded but not halted by such complicated pharmacological therapy, which primarily includes angiotensin-converting enzyme inhibitors, beta-blockers and diuretics, and sometimes digoxin, aspirin, warfarin, and anti-arrhythmic agents. Patients may be advised to track their weight and modify their diuretic prescription accordingly to avoid fluid overload or dehydration as part of the treatment plan...
June 15, 2023: Tropical Doctor
https://read.qxmd.com/read/37305823/chemotherapy-induced-cardiotoxicity-a-new-perspective-on-the-role-of-digoxin-atg7-activators-resveratrol-and-herbal-drugs
#33
REVIEW
Hany Akeel Al-Hussaniy, Ali Hikmat Alburghaif, Zahraa Alkhafaje, Mohammed Abdul-Hassan Jabarah Al-Zobaidy, Hayder Mutair Alkuraishy, Gomaa Mostafa-Hedeab, Faizul Azam, Ali Mahmoud Al-Samydai, Zahraa Salam Al-Tameemi, Meena Akeel Naji
Cancer is a major public health problem, and chemotherapy plays a significant role in the management of neoplastic diseases. However, chemotherapy-induced cardiotoxicity is a serious side effect secondary to cardiac damage caused by antineoplastic's direct and indirect toxicity. Currently, there are no reliable and approved methods for preventing or treating chemotherapy-induced cardiotoxicity. Understanding the mechanisms of chemotherapy-induced cardiotoxicity may be vital to improving survival. The independent risk factors for developing cardiotoxicity must be considered to prevent myocardial damage without decreasing the therapeutic efficacy of cancer treatment...
April 2023: Journal of Medicine and Life
https://read.qxmd.com/read/37293556/incidence-and-predictors-of-implantable-cardioverter-defibrillator-therapies-after-generator-replacement-a-pooled-analysis-of-31-640-patients-data
#34
JOURNAL ARTICLE
Dibbendhu Khanra, Subha Manivannan, Anindya Mukherjee, Saurabh Deshpande, Anunay Gupta, Wasim Rashid, Ahmed Abdalla, Peysh Patel, Deepak Padmanabhan, Indranill Basu-Ray
Among primary prevention implantable cardioverter-defibrillator (ICD) recipients, 75% do not experience any appropriate ICD therapies during their lifetime, and nearly 25% have improvements in their left ventricular ejection fraction (LVEF) during the lifespan of their first generator. The practice guidelines concerning this subgroup's clinical need for generator replacement (GR) remain unclear. We conducted a proportional meta-analysis to determine the incidence and predictors of ICD therapies after GR and compared this to the immediate and long-term complications...
December 2022: Journal of Innovations in Cardiac Rhythm Management
https://read.qxmd.com/read/37292530/chronic-digoxin-toxicity-an-evaluation-of-digoxin-specific-antibodies-and-other-management-options
#35
Liam M Clifford, William Meere
Chronic digoxin toxicity comprises the bulk of digoxin poisonings and can be more difficult to manage than acute intoxications. A 60-year-old lady presented with severe chronic digoxin toxicity after ingesting digoxin 250mcg twice a day (BD) for two weeks. Due to hemodynamic instability on presentation, she was treated with digoxin-specific antibodies and admitted to the coronary care unit. This case of chronic digoxin toxicity did not respond to digoxin-specific antibodies and required intensive cardiac therapy with isoprenaline and intravenous electrolyte replacement, highlighting the complexities in the management of toxicity...
May 2023: Curēus
https://read.qxmd.com/read/37218193/entrapment-of-digoxin-klh-conjugate-in-alginate-chitosan-nanoparticles-a-new-antigen-delivery-system-for-production-of-anti-digoxin-antibodies
#36
JOURNAL ARTICLE
Nazli Kashani Javid, Nasser Mohammadpour Dounighi, Sepideh Arbabi Bidgoli
BACKGROUND: Nanoparticles have received more and more attention in the vaccine and drug delivery systems field due to their specific properties. In particular, alginate and chitosan have been known as the most promising nano-carries. Digoxin-specific antibodies effectively manage acute and chronic digitalis poisoning using sheep antiserum. OBJECTIVE: The present study aimed to develop alginate/chitosan nanoparticles as a carrier of Digoxin-KLH to promote the immune response by improving the hyper-immunization of animals...
May 22, 2023: Pharmaceutical Nanotechnology
https://read.qxmd.com/read/37182910/management-and-clinical-outcomes-of-cardiogenic-shock-in-king-abdulaziz-university-hospital-a-retrospective-study
#37
JOURNAL ARTICLE
Hamza L Fida, Mohammed A Qutub, Alaa S Algazzar, Abdulrahman S AlDharrab, Terad A Alnajjar, Anas M A Andijani, Ahmad M Taiyeb
OBJECTIVES: To assess frequencies of various management approaches in cardiogenic shock (CS) and their clinical outcomes. Cardiogenic shock is a state of organ hypoperfusion and hypoxia caused by cardiac failure. METHODS: In this retrospective record review, we assessed the presentations, vital signs, laboratory readings, and treatments for 188 consecutive CS inpatients from 2010-2021. Patients were labeled as "ischemic CS" or "non-ischemic CS" based on the occurrence of myocardial infarction as the precipitating cause, and "post-operative CS" if they had undergone cardiac surgery...
May 2023: Saudi Medical Journal
https://read.qxmd.com/read/37181974/a-retrospective-study-on-drug-and-dietary-patterns-in-patients-with-severe-rheumatic-valvular-heart-disease-in-eastern-india
#38
JOURNAL ARTICLE
Debasish Das, Satyapriya Mohanty, Satyabrata Guru, Anindya Banerjee, Abhinav Kumar, Pranjit Deb, Humshika Samantray
Background India has a high prevalence of rheumatic valvular heart diseases. Empirical treatment in rheumatic heart disease curtails morbidity and mortality. Less is known about the drug and dietary management of severe rheumatic heart disease at the pretertiary care level, which forms the building stone in the management of rheumatic heart disease. The present study was carried out to evaluate the drug and dietary patterns of patients with severe rheumatic valvular heart disease at a pretertiary care level, which is the backbone of the management of rheumatic heart disease...
April 2023: Curēus
https://read.qxmd.com/read/37162075/clinical-features-and-management-of-patients-assessed-by-cardiology-teleconsultation-in-the-brazilian-region-with-the-highest-number-of-isolated-cities
#39
JOURNAL ARTICLE
Tarso Augusto Duenhas Accorsi, Renato Paladino Nemoto, Jairo Tavares Nunes, Antônio Fernando Barros de Azevedo Filho, Flavio Tocci Moreira, Karen Francine Kohler, Karine de Amicis Lima, Bruna Dayanne Reges Amaral, Renata Albaladejo Morbeck, Carlos Henrique Sartorato Pedrotti
BACKGROUND: Cardiovascular diseases are the leading cause of adult mortality. Geographically remote and low-income Brazilian regions lack specialized consultations. The telemedicine management of this population by cardiologists is not fully known. OBJECTIVES: To analyze cardiology teleconsultation in the Brazilian region with the highest number of isolated cities. METHODS: From February 2020 to October 2021, patients from the North Region of Brazil evaluated by local general practitioners were referred for cardiological evaluation by telemedicine...
April 2023: Arquivos Brasileiros de Cardiologia
https://read.qxmd.com/read/37138852/an-updated-pharmacological-insight-into-calotropin-as-a-potential-therapeutic-agent-in-cancer
#40
REVIEW
Jovana Rajkovic, Radmila Novakovic, Jelica Grujic-Milanovic, Alibek Ydyrys, Nurzhanat Ablaikhanova, Daniela Calina, Javad Sharifi-Rad, Basem Al-Omari
Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, Calotropis gigantea, and Asclepias currasavica that belong to the Asclepiadaceae family. All of these plants are recognised as medical traditional plants used in Asian countries. Calotropin is identified as a highly potent cardenolide that has a similar chemical structure to cardiac glycosides (such as digoxin and digitoxin). During the last few years, cytotoxic and antitumor effects of cardenolides glycosides have been reported more frequently...
2023: Frontiers in Pharmacology
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