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Human Milk Fortifiers Preterm Infants

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https://read.qxmd.com/read/30769937/reply-letter-to-the-editor-re-billeaud-et-al-nutrients-2018-10-690
#1
Claude Billeaud, Carole Boué-Vaysse, Leslie Couëdelo, Philippe Steenhout, Jonathan Jaeger, Cristina Cruz-Hernandez, Laurent Ameye, Jacques Rigo, Jean-Charles Picaud, Elie Saliba, Nicholas P Hays, Frédéric Destaillats
We thank Bernard and colleagues for their careful reading and interest in our article Effects on Fatty Acid Metabolism of a New Powdered Human Milk Fortifier Containing Medium-Chain Triacylglycerols and Docosahexaenoic Acid in Preterm Infants [...].
February 15, 2019: Nutrients
https://read.qxmd.com/read/30739567/effect-of-fortifiers-on-the-osmolality-of-preterm-human-milk
#2
Pitiporn Siripattanapipong, Buranee Yangthara, Sopapan Ngerncham
BACKGROUND: The nutritional content of preterm human milk (HM) can be increased by adding human milk fortifier (HMF). Premature formula (PF) has been used as an alternative to HMF due to the high cost of HMF in some countries. However, the osmolality of HM after fortification remains a matter of concern. AIM: To evaluate the osmolality of fortified preterm HM. METHODS: This was a cross-sectional study. HM was collected from 28 mothers of infants with a gestational age of <32 weeks or birthweight <1500 g...
February 11, 2019: Paediatrics and International Child Health
https://read.qxmd.com/read/30715911/effect-of-nutritional-intake-on-the-body-composition-of-hiv-exposed-and-hiv-unexposed-preterm-and-low-birth-weight-infants
#3
Klara McClunan, Daniel Gerhardus Nel, Muhammad Ali Dhansay, Evette van Niekerk
BACKGROUND: Human breast milk (HBM) is considered inadequate in meeting protein requirements, especially for very low birth weight (VLBW) infants, which could affect body composition. OBJECTIVES: The primary objective was to determine the effect of HBM on body composition of HIV-exposed and unexposed preterm VLBW and extremely low birth weight infants. The secondary objectives were to ascertain the effect breast milk fortification and days nil per os (NPO) have on body composition...
February 4, 2019: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://read.qxmd.com/read/30682200/macronutrient-variability-in-human-milk-from-donors-to-a-milk-bank-implications-for-feeding-preterm-infants
#4
Ashley John, Ruichen Sun, Lisa Maillart, Andrew Schaefer, Erin Hamilton Spence, Maryanne T Perrin
BACKGROUND AND OBJECTIVE: The composition of human milk varies widely and impacts the ability to meet nutrient requirements for preterm infants. The purpose of this study is to use a large dataset of milk composition from donors to a milk bank to: (1) describe the macronutrient variability in human milk and how it contributes to the ability to meet the protein and calorie targets for the preterm infant using fortification with commercially available multi-nutrient fortifiers; (2) assess how temporal versus subject effects explain macronutrient variability; (3) determine how macronutrient variability contributes to the nutrient distribution in pooled donor milk...
2019: PloS One
https://read.qxmd.com/read/30678256/impact-of-donor-milk-on-short-and-long-term-growth-of-very-low-birth-weight-infants
#5
Rebecca Hoban, Michael E Schoeny, Anita Esquerra-Zwiers, Tanyaporn K Kaenkumchorn, Gina Casini, Grace Tobin, Alan H Siegel, Kousiki Patra, Matthew Hamilton, Jennifer Wicks, Paula Meier, Aloka L Patel
Mother's own milk (MOM) reduces the risk of morbidities in very low birth weight (VLBW) infants. When MOM is unavailable, donor breastmilk (DM) is used, with unclear impact on short- and long-term growth. This retrospective analysis compared anthropometric data at six time points from birth to 20⁻24 months corrected age in VLBW infants who received MOM supplements of preterm formula ( n = 160) versus fortified DM ( n = 161) during neonatal intensive care unit (NICU) hospitalization. The cohort was 46% female; mean birth weight and gestational age (GA) were 998 g and 27...
January 22, 2019: Nutrients
https://read.qxmd.com/read/30646004/milk-curd-obstruction-in-human-milk-fed-preterm-infants
#6
Ann Carolin Longardt, Andrea Loui, Christoph Bührer, Monika Berns
BACKGROUND: Milk curd obstruction as a cause of intestinal obstruction has been known since 1959, but has nearly disappeared. However, in recent years it has experienced a revival in small premature infants. OBJECTIVE: The aim of this study was to evaluate the clinical characteristics of milk curd obstruction (lactobezoar) in preterm infants. METHODS: Data of preterm infants with milk curd obstruction cared for at a large tertiary neonatal intensive care unit between 2012 and 2016 were retrieved from the electronic registry and paper records...
January 15, 2019: Neonatology
https://read.qxmd.com/read/30638015/peptidomics-analysis-of-milk-protein-derived-peptides-released-over-time-in-the-preterm-infant-stomach
#7
Robert L Beverly, Mark A Underwood, David C Dallas
Over the course of milk digestion, native milk proteases and infant digestive proteases fragment intact proteins into peptides with potential bioactivity. This study investigated the release of peptides over three hours of gastric digestion in 14 preterm infant sample sets. The peptide content was extracted and analyzed from milk and gastric samples via Orbitrap tandem mass spectrometry. The relative ion intensity (abundance) and count of peptides in each sample were compared over time and between infants fed milk fortified with bovine milk fortifier and infants fed unfortified milk...
January 14, 2019: Journal of Proteome Research
https://read.qxmd.com/read/30544244/routine-versus-selective-fortification-of-human-milk-with-powdered-human-milk-fortifiers-in-very-low-birth-weight-vlbw-preterm-infants-a-retrospective-pre-post-cohort-study
#8
Gopal Agrawal, Sanjay Wazir, Surender Kumar, Bir Singh Yadav, Manish Balde
Objectives: The objective of this study was to show the effects of routine vs. selective fortification of human milk (HM) on short-term growth and metabolic parameters. Methods: Single-centre retrospective pre-post cohort study in India. Preterm infants ≤32 weeks' gestation and weighing ≤1500 g were included. Routine fortification: pre-fixed feed volume (100 ml/kg/day in our unit) at which fortification was done. Selective fortification: feed volume was gradually optimized till 180-200 ml/kg/day...
December 12, 2018: Journal of Tropical Pediatrics
https://read.qxmd.com/read/30486700/a-randomized-controlled-trial-comparing-the-effect-of-fortification-of-human-milk-with-an-infant-formula-powder-versus-unfortified-human-milk-on-the-growth-of-preterm-very-low-birth-weight-infants
#9
Vijay Gupta, Grace Rebekah, Yesudas Sudhakar, Sridhar Santhanam, Manish Kumar, Niranjan Thomas
OBJECTIVE: To optimize growth in very low birth weight (VLBW) infants, human milk fortification is standard of care in neonatal units of high income countries. However, commercial fortifiers may not be available or it may be too expensive in resource limited settings. As an alternative to using human milk fortifiers, we studied the effects of milk fortification with an infant formula on growth and biochemical parameters of very low birth weight (VLBW) infants Methods: We undertook a prospective, randomized controlled trial in the neonatal unit of a tertiary care hospital in south India...
November 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/30407223/human-milk-protein-vs-formula-protein-and-their-use-in-preterm-infants
#10
Maria L Gianni, Paola Roggero, Fabio Mosca
PURPOSE OF REVIEW: We review the current available evidence on the metabolic fate of human milk proteins and their potential clinical implications for growth and body composition development vs. those of formula proteins in preterm infants. RECENT FINDINGS: The decreased content of human milk protein in preterm mothers throughout lactation might contribute to the reduced growth reported in exclusively human milk-fed infants compared with that of formula-fed infants...
January 2019: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/30356677/the-effect-of-human-milk-on-modulating-the-quality-of-growth-in-preterm-infants
#11
Pasqua Piemontese, Nadia Liotto, Domenica Mallardi, Paola Roggero, Valeria Puricelli, Maria Lorella Giannì, Daniela Morniroli, Chiara Tabasso, Michela Perrone, Camilla Menis, Anna Orsi, Orsola Amato, Fabio Mosca
Introduction: Human milk is the optimal nutrition for preterm infants. When the mother's own milk is unavailable, donor human milk is recommended as an alternative for preterm infants. The association among early nutrition, body composition and the future risk of disease has recently attracted much interest. The aim of this study was to investigate the effect of human milk on the body composition of preterm infants. Materials and Methods: Very low birth weight infants (VLBW: birth weight <1,500 g) with a gestational age (GA) between 26 and 34 weeks were included...
2018: Frontiers in Pediatrics
https://read.qxmd.com/read/30320665/a-novel-donkey-milk-derived-human-milk-fortifier-in-feeding-preterm-infants-a-randomized-controlled-trial
#12
Enrico Bertino, Laura Cavallarin, Francesco Cresi, Paola Tonetto, Chiara Peila, Giulia Ansaldi, Melissa Raia, Alessia Varalda, Marzia Giribaldi, Amedeo Conti, Sara Antoniazzi, Guido E Moro, Elena Spada, Silvano Milani, Alessandra Coscia
OBJECTIVES: The purpose of the present randomized controlled clinical trial was to compare the use of donkey milk-derived fortifier (DF) with commercial bovine milk-derived fortifier (BF) in very preterm or very-low-birth-weight newborns, in terms of feeding tolerance. METHODS: This trial included 156 newborns born at <32 weeks of gestational age and/or with a birth weight ≤1500 g. Newborns were randomized 1:1 to receive enteral feeding with either a BF-arm, or a new, DF-arm for 21 days...
January 2019: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/30320413/tolerance-of-hydrolyzed-liquid-protein-fortified-human-milk-and-effect-on-growth-in-premature-infants
#13
Fauzia Shakeel, Melanie Newkirk, Taymeyah Altoubah, Denise Martinez, Ernest K Amankwah
BACKGROUND: We evaluated tolerance of hydrolyzed liquid protein (LP) supplement added to fortified human milk (HM) to optimize protein intake in preterm infants. METHODS: A prospective observational study of 31 subjects compared with 31 historic controls, receiving mothers own milk (MOM) and/or donor milk (DM) to assess LP tolerance, growth, and risk for morbidities was conducted. Milk was analyzed for nutrient content. Feeding intolerance, defined as cessation of feedings for ≥48 hours, abdominal distension and/or residuals, necrotizing enterocolitis (NEC), and metabolic acidosis were used to assess safety, while weight and head circumference (HC) were used to evaluate growth...
October 15, 2018: Nutrition in Clinical Practice
https://read.qxmd.com/read/30287775/evaluation-of-a-concentrated-preterm-formula-as-a-liquid-human-milk-fortifier-in-preterm-babies-at-increased-risk-of-feed-intolerance
#14
Anish Pillai, Susan Albersheim, Julie Matheson, Vikki Lalari, Sylvia Wei, Sheila M Innis, Rajavel Elango
There are concerns around safety and tolerance of powder human milk fortifiers to optimize nutrition in preterm infants. The purpose of this study was to evaluate the tolerance and safety of a concentrated preterm formula (CPF) as a liquid human milk fortifier (HMF) for premature infants at increased risk of feeding intolerance. We prospectively enrolled preterm infants over an 18-month period, for whom a clinical decision had been made to add CPF to human milk due to concerns regarding tolerance of powder HMF...
October 4, 2018: Nutrients
https://read.qxmd.com/read/30252854/human-milk-enriched-with-human-milk-lyophilisate-for-feeding-very-low-birth-weight-preterm-infants-a-preclinical-experimental-study-focusing-on-fatty-acid-profile
#15
Vanessa S Bomfim, Alceu A Jordão, Larissa G Alves, Francisco E Martinez, José Simon Camelo
BACKGROUND: Human milk, with essential nutrients and long chain polyunsaturated fatty acids (LC-PUFAs) such as the omega 3 and 6 fatty acids is important for development of the central nervous system and the retina in very low birth weight infants (<1,500 g). However, breast milk may not be sufficient to meet these needs. The possibility of supplementing breast milk with a lyophilisate of human milk was explored in this study. The objectives of this study were to determine the total lipid content and the lipid profile of the Human Milk on Baseline (HMB) and that of the Concentrates with the Human Milk + lyophilisate (with lyophilisate of milk in the immediate period (HMCI), at 3 months (HMC3m), and at 6 months (HMC6m) of storage)...
2018: PloS One
https://read.qxmd.com/read/30237896/the-fortification-method-relying-on-assumed-human-milk-composition-overestimates-the-actual-energy-and-macronutrient-intakes-in-very-preterm-infants
#16
Israel Macedo, Luis Pereira-da-Silva, Manuela Cardoso
Background: To achieve recommended nutrient intakes in preterm infants, the target fortification method of human milk (HM) was proposed as an alternative to standard fortification method. We aimed to compare assumed energy and macronutrient intakes based on standard fortified HM with actual intakes relying on measured composition of human milk (HM), in a cohort of HM-fed very preterm infants. Methods: This study is a secondary retrospective analysis, in which assumed energy and macronutrient contents of daily pools of own mother's milk (OMM) from 33 mothers and donated HM (DHM) delivered to infants were compared with the measured values using a mid-infrared HM analyzer...
2018: Maternal Health, Neonatology and Perinatology
https://read.qxmd.com/read/30234121/best-practices-for-handling-and-administration-of-expressed-human-milk-and-donor-human-milk-for-hospitalized-preterm-infants
#17
REVIEW
Caroline Steele
The importance of human milk for the preterm infant is well established (1-3). However, the feeding of human milk to preterm infants is typically much more complicated than the mere act of breastfeeding (3, 4). The limited oral feeding skills of many preterm infants often results in human milk being administered via an enteral feeding tube (4). In addition, fortification is commonly required to promote optimal growth and development-particularly in the smallest of preterm infants (2, 4, 5). Consequently, a mother's own milk must be pumped, labeled, transported to the hospital, stored, tracked for appropriate expiration dates and times, thawed (if previously frozen), fortified, and administered to the infant with care taken at each step of the process to avoid microbial contamination, misadministration (the wrong milk for the wrong patient), fortification errors, and waste (1-5)...
2018: Frontiers in Nutrition
https://read.qxmd.com/read/30195561/improved-outcomes-in-preterm-infants-fed-a-nonacidified-liquid-human-milk-fortifier-a-prospective-randomized-clinical-trial
#18
Richard J Schanler, Sharon L Groh-Wargo, Bridget Barrett-Reis, Robert D White, Kaashif A Ahmad, Jeffery Oliver, Geraldine Baggs, Larry Williams, David Adamkin
OBJECTIVE: To compare growth, feeding tolerance, and clinical and biochemical evaluations in human milk-fed preterm infants randomized to receive either an acidified or a nonacidified liquid human milk fortifier. STUDY DESIGN: This prospective, controlled, parallel, multicenter growth and tolerance study included 164 preterm infants (≤32 weeks of gestation, birth weight 700-1500 g) who were randomized to acidified or nonacidified liquid human milk fortifier from study day 1, the first day of fortification, through study day 29 or until hospital discharge...
November 2018: Journal of Pediatrics
https://read.qxmd.com/read/30194887/improved-lung-function-at-age-6-in-children-born-very-preterm-and-fed-extra-protein-post-discharge
#19
Line Hedegaard Toftlund, Lone Agertoft, Susanne Halken, Gitte Zachariassen
BACKGROUND: In very preterm-born children alveolar maturation is challenged and lung function is often compromised during childhood. So far, very few studies have focused on type of early nutrition and lung function in children born preterm. METHODS: This study is a six years follow-up of 281 very preterm-born infants (VPI) with a gestational age (GA) < 32+0 weeks. Infants breastfed at discharge from hospital were randomized to unfortified (UHM) or fortified (FHM) mother's (human) milk, whereas those not breastfed received a preterm formula (PF)...
September 8, 2018: Pediatric Allergy and Immunology
https://read.qxmd.com/read/30149743/late-onset-hyponatremia-in-preterm-newborns-is-the-sodium-content-of-human-milk-fortifier-insufficient
#20
İsmail Kursad Gokçe, Serife Suna Oguz
INTRODUCTION: In this study, we aimed to define the incidence and time to detection of late onset hyponatremia (LOH) as well as factors affecting its development in preterm newborns. We also aimed to determine the daily sodium requirement of these patients. METHODS: We studied a total of 145 very low birth weight infants with a full or nearly full enteral diet and followed them up until discharge. We recorded demographic and clinic characteristics. We measured serum sodium (SNa) levels at least once a week after the second week...
September 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
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