Firdose Lambey Nakwa, Letlhogonolo Sepeng, Alison van Kwawegen, Reenu Thomas, Karabo Seake, Tshiamo Mogajane, Nandi Ntuli, Claude Ondongo-Ezhet, Samantha Kesting, Dikeledi Maureen Kgwadi, Noela Holo Bertha Kamanga, Annaleen Coetser, Jeanne Van Rensburg, Michael S Pepper, Sithembiso C Velaphi
BACKGROUND: In randomized clinical trials, therapeutic hypothermia (TH) has been shown to reduce death and/or moderate-to-severe disability in neonates with hypoxic ischemic encephalopathy (HIE) in high-income countries, while this has not consistently been the case in low-and middle-income countries (LMICs). Many studies reporting on outcomes of neonates with HIE managed with TH are those conducted under controlled study conditions, and few reporting in settings where this intervention is offered as part of standard of care, especially from LMICs...
January 31, 2023: BMC Pediatrics