Mingtong Ma, Yongjia Duan, Cheng Peng, You Wu, Xinning Zhang, Boran Chang, Fei Wang, Hua Yang, Ruijuan Zheng, Hongyu Cheng, Yuanna Cheng, Yifan He, Jingping Huang, Jinming Lei, Hanyu Ma, Liru Li, Jie Wang, Xiaochen Huang, Fen Tang, Jun Liu, Jinsong Li, Ruoyan Ying, Peng Wang, Wei Sha, Yawei Gao, Lin Wang, Baoxue Ge
Internal N6 -methyladenosine (m6 A) modifications are among the most abundant modifications of messenger RNA, playing a critical role in diverse biological and pathological processes. However, the functional role and regulatory mechanism of m6 A modifications in the immune response to Mycobacterium tuberculosis infection remains unknown. Here, we report that methyltransferase-like 14 (METTL14)-dependent m6 A methylation of NAPDH oxidase 2 (Nox2) mRNA was crucial for the host immune defense against M. tuberculosis infection and that M...
March 29, 2024: Cell Discovery