keyword
https://read.qxmd.com/read/36556990/klatskin-tumor-a-survival-analysis-according-to-tumor-characteristics-and-inflammatory-ratios
#21
JOURNAL ARTICLE
Vlad-Ionuţ Nechita, Emil Moiş, Luminiţa Furcea, Mihaela-Ancuţa Nechita, Florin Graur
Background and Objectives : The aim was to evaluate the association of inflammatory biomarkers with resectability and overall survival in hilar cholangiocarcinoma. Materials and Methods : We conducted a retrospective cohort study over 72 consecutive surgical cases of Klatskin tumor over an 11-year period. The sample was divided into two groups: 42 surgical resection cases and 30 unresectable tumors. Values of inflammatory ratios were compared according to the resectability. Log-rank test, univariate, and multivariate Cox proportional hazards models were used to evaluate the overall survival...
December 5, 2022: Medicina
https://read.qxmd.com/read/36556261/liver-tumor-markers-halp-score-and-nlr-simple-cost-effective-easily-accessible-indexes-for-predicting-prognosis-in-icc-patients-after-surgery
#22
JOURNAL ARTICLE
Deyao Zhang, Huilan Zeng, Yangxun Pan, Yumo Zhao, Xin Wang, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Li Xu, Minshan Chen, Dandan Hu
INTRODUCTION: To investigate the prognostic significance of liver tumor markers, the hemoglobin, albumin, lymphocyte, and platelet (HALP) score; neutrophil-to-lymphocyte ratio (NLR); and platelet-to-lymphocyte ratio (PLR), for predicting the specific site of recurrence or metastasis after surgery in patients with intrahepatic cholangiocarcinoma (ICC). METHODS: In total, 162 patients with pathologically proven ICC who underwent curative surgery at Sun Yat-sen University Cancer Center between April 2016 and April 2020 were analyzed...
December 9, 2022: Journal of Personalized Medicine
https://read.qxmd.com/read/36387142/preoperative-peripheral-blood-inflammatory-markers-especially-the-fibrinogen-to-lymphocyte-ratio-and-novel-flr-n-score-predict-the-prognosis-of-patients-with-early-stage-resectable-extrahepatic-cholangiocarcinoma
#23
JOURNAL ARTICLE
Shijie Li, Xingli Zhang, Changjie Lou, Yuanlong Gu, Juan Zhao
BACKGROUND: Systemic inflammation is important in the development of extrahepatic cholangiocarcinoma (ECC). The aim of this study was to compare the prognostic power of preoperative peripheral blood inflammatory markers and the novel FLR-N score in patients with resectable ECC. METHODS: A total of 140 patients with resectable ECC and 140 healthy controls (HCs) were recruited for the study. The Mann-Whitney U test was used to evaluate the differences in inflammatory markers between groups...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36380668/-the-prognostic-value-of-preoperative-peripheral-blood-inflammatory-biomarkers-for-intrahepatic-cholangiocarcinoma-after-radical-resection
#24
JOURNAL ARTICLE
Q Li, R Zhang, J L Fu, J Zhang, J B Su, Z C Jin, C Chen, D Zhang, Z M Geng
Objective: To explore the value of preoperative peripheral blood inflammatory biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma (ICC) after radical resection. Methods: A total of 124 patients who underwent radical resection for ICC in the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2018 were retrospectively analyzed. Receiver operating characteristic (ROC) curve was conducted to determine the best cut-off values of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), systemic immune inflammatory index (SII), and systemic inflammatory response index (SIRI)...
November 23, 2022: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/36324563/elevated-serum-neutrophil-lymphocyte-ratio-is-associated-with-worse-long-term-survival-in-patients-with-hbv-related-intrahepatic-cholangiocarcinoma-undergoing-resection
#25
JOURNAL ARTICLE
Jianwei Liu, Yong Xia, Feng Xue, Caixia Lu, Jie Wang, Chunyan Wang, Yeye Wu, Shilei Bai, Feng Shen, Kui Wang
Background: This study aimed to examine the influence of serum inflammatory marker levels on long-term outcomes after liver resection in patients with intrahepatic cholangiocarcinoma (ICC). Methods: Data from 1189 consecutive ICC patients who underwent liver resection were reviewed. The serum neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and prognostic nutritional index (PNI) were measured before surgery. Overall survival (OS) and tumour recurrence were analysed using the Kaplan-Meier method and compared using the log-rank test...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36238770/inflammation-based-scores-predict-responses-to-pd-1-inhibitor-treatment-in-intrahepatic-cholangiocarcinoma
#26
JOURNAL ARTICLE
Zhenyun Yang, Deyao Zhang, Huilan Zeng, Yizhen Fu, Zili Hu, Yangxun Pan, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Li Xu, Dandan Hu, Minshan Chen
Purpose: Inflammatory response is related to tumor progression and patient survival. We aimed to clarify the prognostic value of the inflammation-based scores in intrahepatic cholangiocarcinoma (ICC) patients receiving anti-PD1 therapy. Patients and Methods: A total of 73 patients who received anti-PD-1 therapy from February 2019 to February 2021 were included in the study. Representative inflammation-based prognostic scores, including C-reactive protein (CRP), the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-CRP ratio (LCR), lymphocyte-to-monocyte ratio (LMR), systemic immune inflammation index (SII), CRP-to-albumin ratio (CAR), prognostic nutritional index (PNI), Glasgow Prognostic Score (GPS), and prognostic index (PI), were assessed for prediction accuracy using Kaplan-Meier survival curves and time-dependent receiver operating characteristic (ROC)...
2022: Journal of Inflammation Research
https://read.qxmd.com/read/35954154/selective-internal-radiotherapy-changes-the-immune-profiles-of-extracellular-vesicles-and-their-immune-origin-in-patients-with-inoperable-cholangiocarcinoma
#27
JOURNAL ARTICLE
Florian Haag, Anjana Manikkam, Daniel Kraft, Caroline Bär, Vanessa Wilke, Aleksander J Nowak, Jessica Bertrand, Jazan Omari, Maciej Pech, Severin Gylstorff, Borna Relja
The incidence of cholangiocellular carcinoma (CCA) is rising worldwide. As there are no specific early symptoms or specific markers of CCA, it is often diagnosed in later inoperable stages. Accumulating evidence underlines the importance of radiation therapy in the induction of antitumor immunity. The surface protein composition on extracellular vesicles (EVs) relates to originating cells and thus may play a role in vesicle function. We assessed immune profiles of EVs and their immune origin in patients with inoperable CCA prior and after selective internal radiotherapy (SIRT)...
July 27, 2022: Cells
https://read.qxmd.com/read/35831998/prognostic-markers-including-immune-and-inflammatory-factors-predict-outcomes-in-patients-receiving-postoperative-radiation-therapy-for-cholangiocarcinoma
#28
JOURNAL ARTICLE
Yuki Mukai, Ryusei Matsuyama, Madoka Sugiura, Yasuhiro Yabushita, Risa Taniuchi, Yuki Homma, Kotaro Hashimoto, Kentaro Miyake, Yuya Tabuchi, Itaru Endo, Masaharu Hata
PURPOSE: This study aimed to analyze treatment outcomes and prognostic markers, including immune and inflammatory factors, of postoperative radiation therapy (RT) administered to patients with cholangiocarcinoma (CCA). METHODS: We retrospectively included 59 patients with CCA who underwent surgery and postoperative RT with curative intent from 2004 to 2019. Patients received external irradiation (50 Gy in 25 fractions) using three-dimensional RT. We analyzed prognostic factors of inflammation, such as pre-RT platelet count, hemoglobin, lymphocyte count ratio (LCR) of the leukocyte count, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR)...
July 13, 2022: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/35719959/prognostic-significance-of-nlr-plr-lmr-and-tumor-infiltrating-t-lymphocytes-in-patients-undergoing-surgical-resection-for-hilar-cholangiocarcinoma
#29
JOURNAL ARTICLE
Zhi-Qiang Lin, Chi Ma, Wen-Zhuo Cao, Zhen Ning, Guang Tan
Objective: This study evaluated the prognostic significance of preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and tumor-infiltrating lymphocytes (TILs), and whether these preoperative blood inflammatory indicators were associated with TILs in hilar cholangiocarcinoma (HCCA). Methods: A total of 76 patients with HCCA who underwent radical resection were included. Data on their clinicopathologic characteristics, perioperative features, and survival outcomes were analyzed...
2022: Frontiers in Oncology
https://read.qxmd.com/read/35692190/prognostic-utility-of-preoperative-inflammatory-markers-in-patients-with-intrahepatic-cholangiocarcinoma-after-hepatic-resection-a-systematic-review-and-meta-analysis
#30
JOURNAL ARTICLE
Hongxia Cui, Yarong Li, Su Li, Guangxuan Liu
BACKGROUND: The prognostic value of preoperative systemic inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), remains controversial in patients with intrahepatic cholangiocarcinoma (ICC). Therefore, this meta-analysis aimed to investigate the prognostic value of preoperative NLR, PLR, and LMR in patients with ICC who underwent hepatic resection. METHODS: We conducted a comprehensive search of four electronic databases...
June 12, 2022: Cancer Medicine
https://read.qxmd.com/read/35668355/utility-of-mean-platelet-volume-in-differentiating-intrahepatic-cholangiocarcinoma-from-hepatocellular-carcinoma
#31
JOURNAL ARTICLE
Xin Zhang, Wen-Juan Huang, Meng-Lin Zhang, Wen Wang, Ye Niu, Rui-Tao Wang, Zeng-Yao Liu
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are the most prevalent histologic types of primary liver cancer. HCC and ICC differ in treatment and prognosis, warranting an effective differential diagnosis between them. This study aimed to explore the clinical value of mean platelet volume (MPV) to discriminate between HCC and ICC. MATERIAL/METHODS: We performed a retrospective analysis of ICC and HCC patients who were from the Harbin Medical University Cancer Hospital, China...
June 6, 2022: BMC Gastroenterology
https://read.qxmd.com/read/35053599/the-value-of-platelet-to-lymphocyte-ratio-as-a-prognostic-marker-in-cholangiocarcinoma-a-systematic-review-and-meta-analysis
#32
REVIEW
Dong Liu, Zoltan Czigany, Lara R Heij, Stefan A W Bouwense, Ronald van Dam, Sven A Lang, Tom F Ulmer, Ulf P Neumann, Jan Bednarsch
The platelet-to-lymphocyte ratio (PLR), an inflammatory parameter, has shown prognostic value in several malignancies. The aim of this meta-analysis was to determine the impact of pretreatment PLR on the oncological outcome in patients with cholangiocarcinoma (CCA). A systematic literature search has been carried out in the PubMed and Google Scholar databases for pertinent papers published between January 2000 and August 2021. Within a random-effects model, the pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated to investigate the relationships among the PLR, overall survival (OS), and disease-free survival (DFS)...
January 16, 2022: Cancers
https://read.qxmd.com/read/35051946/prognostic-impact-of-inflammation-based-scores-for-extrahepatic-cholangiocarcinoma
#33
JOURNAL ARTICLE
Riki Asakura, Hiroaki Yanagimoto, Tetsuo Ajiki, Daisuke Tsugawa, Takuya Mizumoto, Shinichi So, Takeshi Urade, Yoshihide Nanno, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Kaori Kuramitsu, Tadahiro Goto, Sadaki Asari, Masahiro Kido, Hirochika Toyama, Takumi Fukumoto
INTRODUCTION: Although the relationship between systemic inflammatory responses and prognosis has been known in various cancers, it remains unclear which scores are most valuable for determining the prognosis of extrahepatic cholangiocarcinoma. We aimed to verify the usefulness of various inflammation-based scores as prognostic factors in patients with resected extrahepatic cholangiocarcinoma. METHODS: We analyzed consecutive patients undergoing surgical resection for extrahepatic cholangiocarcinoma at our institution between January 2000 and December 2019...
2022: Digestive Surgery
https://read.qxmd.com/read/34880159/elevated-serum-ca19-9-indicates-severe-liver-inflammation-and-worse-survival-after-curative-resection-in-hepatitis-b-related-hepatocellular-carcinoma
#34
JOURNAL ARTICLE
Wei Zhang, Yingying Wang, Xiang Dong, Bo Yang, Hongyuan Zhou, Lu Chen, Zewu Zhang, Qin Zhang, Guangtai Cao, Zhiqiang Han, Huikai Li, Yunlong Cui, Qiang Wu, Ti Zhang, Tianqiang Song, Qiang Li
We explored the prognostic value of preoperative CA19-9 in α-fetoprotein (AFP)-positive and -negative HCC with hepatitis B virus (HBV) background (HBV-HCC), and explored the underlying mechanism. Recurrence-free survival (RFS) and overall survival (OS) were assessed in HBV-HCC patients who underwent curative resection (Cohort 1). Immunohistochemical staining of CA19-9 in HCC and liver parenchyma were quantified in another cohort of 216 patients with resected HCC (Cohort 2). Immunohistochemical staining of CA19-9 and serum CA19-9 level was also compared between patients with HCC and intrahepatic cholangiocarcinoma (ICC) (Cohort 3)...
January 23, 2022: Bioscience Trends
https://read.qxmd.com/read/34790724/a-multidimensional-nomogram-combining-imaging-features-and-clinical-factors-to-predict-the-invasiveness-and-metastasis-of-combined-hepatocellular-cholangiocarcinoma
#35
JOURNAL ARTICLE
Yi Wang, Chang-Wu Zhou, Gui-Qi Zhu, Na Li, Xian-Ling Qian, Huan-Huan Chong, Chun Yang, Meng-Su Zeng
BACKGROUND: Combined hepatocellular cholangiocarcinoma (CHCC-CCA) is a rare type of primary liver cancer having aggressive behavior. Few studies have investigated the prognostic factors of CHCC-CCA. Therefore, this study aimed to establish a nomogram to evaluate the risk of microvascular invasion (MVI) and the presence of satellite nodules and lymph node metastasis (LNM), which are associated with prognosis. METHODS: One hundred and seventy-one patients pathologically diagnosed with CHCC-CCA were divided into a training set (n=116) and validation set (n=55)...
October 2021: Annals of Translational Medicine
https://read.qxmd.com/read/34778691/fgfr-inhibitor-toxicity-and-efficacy-in-cholangiocarcinoma-multicenter-single-institution-cohort-experience
#36
MULTICENTER STUDY
Jennifer J Gile, Fang-Shu Ou, Amit Mahipal, Joseph J Larson, Kabir Mody, Zhaohui Jin, Joleen Hubbard, Thorvardur Halfdanarson, Steven R Alberts, Aminah Jatoi, Robert R McWilliams, Wen Wee Ma, Sumera Ilyas, Rory Smoot, Lewis Roberts, Gregory Gores, Mitesh Borad, Tanios S Bekaii-Saab, Nguyen H Tran
Cholangiocarcinomas (CCA) are a group of heterogeneous tumors arising from the biliary epithelia. Significant sequencing efforts have provided further insights into the molecular mechanisms of this disease including fibroblast growth factor receptor ( FGFR ) alterations, which occurs in approximately 15%-20% of intrahepatic CCAs. Herein, we describe the FGFR inhibitor (FGFRi)-associated treatment toxicity and cancer-specific outcomes from a multicenter single-institution cohort. METHODS: This is a retrospective study of patients with CCA and known FGFR alterations treated with FGFRi...
2021: JCO Precision Oncology
https://read.qxmd.com/read/34674423/-prognostic-value-of-preoperative-peripheral-blood-neutrophil-to-lymphocyte-ratio-and-%C3%AE-glutamyl-transpeptidase-to-platelet-ratio-index-in-patients-with-hepatitis-b-virus-related-intrahepatic-cholangiocarcinoma-after-radical-resection
#37
JOURNAL ARTICLE
Q Li, R Zhang, J L Fu, J Zhang, J B Su, Z C Jin, C Chen, D Zhang, Z M Geng
Objective: To explore the value of preoperative neutrophil-to-lymphocyte ratio (NLR) and γ-glutamyl transpeptidase-to-platelet ratio index (GPRI) for predicting the prognosis of patients with HBV-related intrahepatic cholangiocarcinoma (ICC) after radical resection. Methods: The data of 79 patients who underwent radical resection for HBV-related ICC in the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2018 were retrospectively analyzed...
October 19, 2021: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/34549037/circulating-micrornas-as-biomarkers-in-bile-derived-exosomes-of-cholangiocarcinoma
#38
JOURNAL ARTICLE
Jin-Yi Han, Keun Soo Ahn, Yong Hoon Kim, Tae-Seok Kim, Won-Ki Baek, Seong-Il Suh, Koo Jeong Kang
PURPOSE: In this pilot study, using next-generation sequencing and integrated messenger RNA (mRNA) sequencing, we investigated circulating microRNA (miRNA) expression profiling from bile-derived exosomes to identify dysregulated miRNA signatures and oncogenic pathways and determine their effects on targeted mRNAs in cholangiocarcinoma (CCA). Moreover, we explored the possibility that genetic analysis using bile-derived exosomes may replace gene analysis using tissue. METHODS: Bile was collected from a patient with perihilar CCA before curative resection...
September 2021: Annals of Surgical Treatment and Research
https://read.qxmd.com/read/34430525/a-combined-cox-and-logistic-model-provides-accurate-predictive-performance-in-estimation-of-time-dependent-probabilities-for-recurrence-of-intrahepatic-cholangiocarcinoma-after-resection
#39
JOURNAL ARTICLE
Seogsong Jeong, Guijuan Luo, Qiang Gao, Jing Chen, Xiaolong Liu, Liangqing Dong, Yongjie Zhang, Feng Shen, Qingbao Cheng, Chengjun Sui, Jingfeng Liu, Hongyang Wang, Qiang Xia, Lei Chen
BACKGROUND: Intrahepatic cholangiocarcinoma has heterogeneous outcomes after resection. There remains a need for broadly applicable recurrence-specific tool offering precise evaluation on curativeness of resection. METHODS: A four hospital-based clinical cohort involving 1,655 patients with intrahepatic cholangiocarcinoma who received surgical resection were studied. Cox and logistic models were networked into one system containing risk categories with distinctive probabilities of recurrence...
August 2021: Hepatobiliary Surgery and Nutrition
https://read.qxmd.com/read/34408489/the-prognostic-value-of-systemic-inflammation-response-index-in-cholangiocarcinoma-patients
#40
JOURNAL ARTICLE
Bao Jin, Wenmo Hu, Si Su, Haifeng Xu, Xin Lu, Xinting Sang, Huayu Yang, Yilei Mao, Shunda Du
PURPOSE: We determined the prognostic value of the systemic inflammation response index (SIRI) in patients with cholangiocarcinoma after surgery and constructed a survival prediction model based on SIRI. PATIENTS AND METHODS: We recruited 328 patients with histopathologically confirmed cholangiocarcinoma from 2003 to 2017 and performed Kaplan-Meier survival and Cox analyses to analyze the prognostic value of the SIRI and identify other significant factors. A nomogram involving SIRI and other clinicopathological factors was established based on the training cohort...
2021: Cancer Management and Research
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