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https://read.qxmd.com/read/30753324/dopamine-metabolism-of-the-nucleus-accumbens-and-fronto-striatal-connectivity-modulate-impulse-control
#1
Jochen Hammes, Hendrik Theis, Kathrin Giehl, Merle C Hoenig, Andrea Greuel, Marc Tittgemeyer, Lars Timmermann, Gereon R Fink, Alexander Drzezga, Carsten Eggers, Thilo van Eimeren
Impulsive-compulsive behaviours like pathological gambling or hypersexuality are a frequent side effect of dopamine replacement therapy in patients with Parkinson's disease. Multiple imaging studies suggest a significant reduction of presynaptic dopamine transporters in the nucleus accumbens to be a predisposing factor, reflecting either a reduction of mesolimbic projections or, alternatively, a lower presynaptic dopamine transporter expression per se. Here, we aimed to test the hypothesis of fewer mesolimbic projections as a risk factor by using dopamine synthesis capacity as a proxy of dopaminergic terminal density...
February 8, 2019: Brain: a Journal of Neurology
https://read.qxmd.com/read/30704084/same-same-but-different-a-clinical-characterization-of-men-with-hypersexual-disorder-in-the-sex-brain-study
#2
Jannis Engel, Maria Veit, Christopher Sinke, Ivo Heitland, Jonas Kneer, Thomas Hillemacher, Uwe Hartmann, Tillmann H C Kruger
Problems arising from hypersexual behavior are often seen in clinical settings. We aimed to extend the knowledge about the clinical characteristics of individuals with hypersexual disorder (HD). A group of people who fulfilled the proposed diagnostic criteria for HD (men with HD, n = 50) was compared to a group of healthy controls ( n = 40). We investigated differences in sociodemographic, neurodevelopmental, and family factors based on self-report questionnaires and clinical interviews. Men with HD reported elevated rates of sexual activity, paraphilias, consumption of child abusive images, and sexual coercive behavior compared to healthy controls...
January 30, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30687068/young-onset-dementia-with-lewy-bodies
#3
Yosuke Aiba, Ryuji Sakakibara, Tsuyoshi Ogata, Ayako Iimura, Keiichiro Terayama, Keiko Suzuki, Shuichi Katsuragawa, Yuuki Kato, Fuyuki Tateno, Hitoshi Terada, Tsutomu Inaoka, Tomoya Nakatsuka
Young-onset (< 65 years) dementia is a challenging clinical problem. A 61-year-old man visited our clinic because of a 2-year history of mild cognitive impairment of the executive disorder type. He was initially suspected of having young-onset Alzheimer's disease due to the lack of motor signs or hippocampal atrophy by conventional brain MRI. However, he proved to have anosmia, erectile dysfunction, hypersexuality, constipation, REM sleep behavior disorder, and emotional lability; imaging findings included positive brain perfusion SPECT, nigrosome MRI, DAT scan, and MIBG myocardial scintigraphy...
September 2018: Case Reports in Neurology
https://read.qxmd.com/read/30657020/a-validation-study-of-the-spanish-version-of-the-hypersexual-behavior-inventory-hbi-paper-and-pencil-versus-online-administration
#4
Rafael Ballester-Arnal, Jesús Castro-Calvo, Beatriz Gil-Julia, Cristina Giménez-García, María Dolores Gil-Llario
Hypersexuality is a problematic behavior characterized by the combination of an excessive sexual desire and the pathological inability to control it. This study presents the psychometric properties of the Spanish paper-and-pencil and online versions of the Hypersexual Behavior Inventory (HBI), one of the most popular scales to assess this issue. A total of 2,250 participants (1,070 men) completed a translated version of the HBI (1,450 in paper-and-pencil; 800 online). The exploratory factor analysis yielded three factors that explained 67...
January 18, 2019: Journal of Sex & Marital Therapy
https://read.qxmd.com/read/30650522/online-porn-addiction-what-we-know-and-what-we-don-t-a-systematic-review
#5
REVIEW
Rubén de Alarcón, Javier I de la Iglesia, Nerea M Casado, Angel L Montejo
In the last few years, there has been a wave of articles related to behavioral addictions; some of them have a focus on online pornography addiction. However, despite all efforts, we are still unable to profile when engaging in this behavior becomes pathological. Common problems include: sample bias, the search for diagnostic instrumentals, opposing approximations to the matter, and the fact that this entity may be encompassed inside a greater pathology (i.e., sex addiction) that may present itself with very diverse symptomatology...
January 15, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30646355/prevalence-of-distress-associated-with-difficulty-controlling-sexual-urges-feelings-and-behaviors-in-the-united-states
#6
Janna A Dickenson, Neil Gleason, Eli Coleman, Michael H Miner
Importance: The veracity, nomenclature, and conceptualizations of sex addiction, out-of-control sexual behavior, hypersexual behavior, and impulsive or compulsive sexual behavior are widely debated. Despite such variation in conceptualization, all models concur on the prominent feature: failing to control one's sexual feelings and behaviors in a way that causes substantial distress and/or impairment in functioning. However, the prevalence of the issue in the United States is unknown. Objective: To assess the prevalence of distress and impairment associated with difficulty controlling sexual feelings, urges, and behaviors among a nationally representative sample in the United States...
November 2, 2018: JAMA network open
https://read.qxmd.com/read/30627932/the-relation-of-childhood-abuse-experiences-to-problematic-sexual-behaviors-in-male-youths-who-have-sexually-offended
#7
Kathryn A Davis, Raymond A Knight
Psychological abuse and sexual abuse, either alone or in combination, have been implicated as developmental antecedents of problematic sexual thoughts and behaviors in studies of sexually aggressive males (Jesperson, Lalumière, & Seto, 2009; Knight & Sims-Knight, 2011; Levenson & Grady, 2016; Seto & Lalumière, 2010). Recently, psychological abuse perpetrated by a male caregiver has emerged as strongly associated with subsequent hypersexuality in adult males who had sexually offended. In a study of 529 adult male sexual offenders, Kingston, Graham, and Knight (2017) found that male caregiver psychological abuse was the most prominent correlate of hypersexual thoughts and behaviors in adulthood, above and beyond the effects of other abuse types, such as physical abuse and sexual abuse...
January 9, 2019: Archives of Sexual Behavior
https://read.qxmd.com/read/30618473/a-case-of-hyper-sexuality-probably-associated-with-clozapine
#8
Sereen Rose Thomson, Navin Patil, Balaji Ommurugan, Rajesh Krishna Bhandary
Introduction: Schizophrenia treatment needs to cover several psychological interventions and pharmacological treatment for stabilizing the disease course and decreasing relapses. Sexual side effects are a major hindrance to patients and lead to decreased adherence to therapy and reduced quality of life. Recently, several studies outlined that sexual dysfunction is one of the most distressing side effects of antipsychotics and a major cause of a poor quality of life. We hereby report a case of hypersexuality probably associated with clozapine in a middle-aged woman with schizoaffective disorder...
June 20, 2018: Psychopharmacology Bulletin
https://read.qxmd.com/read/30590514/wait-and-you-shall-see-sexual-delay-discounting-in-hypersexual-parkinson-s-disease
#9
Romuald Girard, Ignacio Obeso, Stéphane Thobois, Seongmin A Park, Tiphaine Vidal, Emilie Favre, Miguel Ulla, Emmanuel Broussolle, Paul Krack, Franck Durif, Jean-Claude Dreher
Patients with Parkinson's disease may develop impulse control disorders under dopaminergic treatments. Impulse control disorders include a wide spectrum of behaviours, such as hypersexuality, pathological gambling or compulsive shopping. Yet, the neural systems engaged in specific impulse control disorders remain poorly characterized. Here, using model-based functional MRI, we aimed to determine the brain systems involved during delay-discounting of erotic rewards in hypersexual patients with Parkinson's disease (PD+HS), patients with Parkinson's disease without hypersexuality (PD - HS) and controls...
December 22, 2018: Brain: a Journal of Neurology
https://read.qxmd.com/read/30574117/impulse-control-disorders-and-dopamine-related-creativity-pathogenesis-and-mechanism-short-review-and-hypothesis
#10
REVIEW
Pedro J Garcia-Ruiz
Impulse control disorder (ICD), including pathological gambling, hypersexuality, and compulsive shopping has been linked to antiparkinsonian medication, especially dopamine agonists. The mechanism of ICD is not completely clear, but it seems that ICD is the result of an activation of dopamine receptors, mostly D3 in the ventral striatum. Patients treated with dopamine agonists that have preferential affinity for D3 (including ropinirole and pramipexole) are much more prone to develop ICD. In addition, a genetic component is probably present, especially in young patients...
2018: Frontiers in Neurology
https://read.qxmd.com/read/30545378/-eat-and-you-will-be-eaten-a-qualitative-study-exploring-costs-and-benefits-of-age-disparate-sexual-relationships-in-tanzania-and-uganda-implications-for-girls-sexual-and-reproductive-health-interventions
#11
Joyce Wamoyi, Ana Maria Buller, Daniel Nyato, Nambusi Kyegombe, Rebecca Meiksin, Lori Heise
BACKGROUND: Age-disparate sex is associated with increased HIV risk among adolescent girls and young women (AGYW) in sub-Saharan Africa. However, little has been done to understand the dynamics of such relationships from the perspectives of either AGYW or older men, and the communities in which these relationships are embedded. This article explores the motivations and perceived benefits of such relationships for AGYW and older men, plus the social and sexual and reproductive health (SRH) consequences...
December 13, 2018: Reproductive Health
https://read.qxmd.com/read/30527057/response-and-rebuttal-to-editorial-comment-on-deviance-or-normalcy-the-relationship-between-paraphilic-thoughts-and-behaviors-hypersexuality-and-psychopathology-in-a-sample-of-university-students
#12
Giovanni Castellini, Alessandra H Rellini, Cristina Appignanesi, Irene Pinucci, Matteo Fattorini, Elisa Grano, Alessandra D Fisher, Emanuele Cassioli, Lorenzo Lelli, Mario Maggi, Valdo Ricca
No abstract text is available yet for this article.
December 2018: Journal of Sexual Medicine
https://read.qxmd.com/read/30527056/deviance-or-normalcy-the-relationship-between-paraphilic-thoughts-and-behaviors-hypersexuality-and-psychopathology-in-a-sample-of-university-students
#13
Eli Coleman, Janna Dickenson
No abstract text is available yet for this article.
December 2018: Journal of Sexual Medicine
https://read.qxmd.com/read/30480254/aripiprazole-for-the-treatment-of-inappropriate-sexual-behavior-case-report-of-an-alzheimer-s-disease-patient-known-as-heterosexual-with-recently-shifted-sexual-orientation-to-same-gender
#14
Sevda Sarikaya, Basar Sarikaya
Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome for healthcare professionals and caregivers as well as patients themselves. There is paucity of data in the literature for the management of these behaviors, but the limited available data suggest efficiency of some commonly used treatment modalities. Herein, we present a 74-year old Alzheimer's disease (AD) patient, known to be heterosexual throughout her past life, presenting with a recent display of same-sex inappropriate sexual behavior six years after the initial diagnosis of her disease...
June 29, 2018: JAD Reports
https://read.qxmd.com/read/30400048/psychological-effects-of-dopamine-agonist-treatment-in-patients-with-hyperprolactinemia-and-prolactin-secreting-adenomas
#15
Adriana G Ioachimescu, Maria Fleseriu, Andrew R Hoffman, T Brooks Vaughan Iii, Laurence Katznelson
BACKGROUND: Dopamine agonists (DAs) are the main treatment for patients with hyperprolactinemia and prolactinomas. Recently, an increasing number of reports emphasized DAs' psychological side effects, either de- novo or as exacerbations of prior psychiatric disease. METHODS: Review of prospective and retrospective studies (PubMed 1976- September 2018) evaluating the psychological profile of DAs-treated patients with hyperprolactinemia and prolactinomas. Case -series and case reports of psychiatric complications were also reviewed...
October 1, 2018: European Journal of Endocrinology
https://read.qxmd.com/read/30363420/the-role-of-sex-therapy-in-the-management-of-patients-with-parkinson-s-disease
#16
REVIEW
Gila Bronner, Amos D Korczyn
Background: Patients with Parkinson disease (PD) and their partners report deterioration in their sexual life. Sexual dysfunction (SD), an important and often ignored aspect, is common in PD. Motor and nonmotor symptoms are involved in limiting pleasure and disturbing function. Sexual dissatisfaction is more common in men that in women. Frequently, both patients and partners have SD associated with PD, and both need suitable treatment. These issues need to be evaluated by neurologists or PD nurses and by specialized sex therapists...
January 2018: Movement Disorders Clinical Practice
https://read.qxmd.com/read/30324793/management-of-endocrine-disease-impulse-control-disorders-in-patients-with-hyperpolactinemia-treated-with-dopamine-agonists-how-much-should-we-worry
#17
REVIEW
Maya Barake, Anne Klibanski, Nicholas A Tritos
Dopamine agonists (DAs) represent a cornerstone in the management of patients with hyperprolactinemia and have an important role in the treatment of neurologic disorders, including Parkinson's disease and restless legs syndrome. A growing body of evidence has identified impulse control disorders (ICDs) as possible adverse effects of DA therapy. A variety of ICDs may occur in patients treated with DA, including compulsive shopping, pathologic gambling, stealing, hypersexuality and punding (repetitive performance of tasks, such as collecting, sorting, disassembling and assembling objects)...
December 1, 2018: European Journal of Endocrinology
https://read.qxmd.com/read/30319466/altered-prefrontal-and-inferior-parietal-activity-during-a-stroop-task-in-individuals-with-problematic-hypersexual-behavior
#18
Ji-Woo Seok, Jin-Hun Sohn
Accumulating evidence suggests a relationship between problematic hypersexual behavior (PHB) and diminished executive control. Clinical studies have demonstrated that individuals with PHB exhibit high levels of impulsivity; however, relatively little is known regarding the neural mechanisms underlying impaired executive control in PHB. This study investigated the neural correlates of executive control in individuals with PHB and healthy controls using event-related functional magnetic resonance imaging (fMRI)...
2018: Frontiers in Psychiatry
https://read.qxmd.com/read/30317200/sleeping-beauty-syndrome-presenting-with-insomnia
#19
Sara Hussain, Khulood Al Jarman, Sahar Hussain
A young man previously diagnosed with Kleine-Levin syndrome (KLS) presented with abnormal behaviour over the last 8 days. This included decreased sleeping hours and appetite, hypersexuality, aggressiveness and visual hallucinations. All blood tests and investigations in the emergency department yielded normal results. A preliminary diagnosis of a KLS episode with psychosis was made and the patient was started on a regimen of aripiprazole 10 mg once daily along with lorazepam 2 mg intravenously in two divided doses in the event of agitation or insomnia...
October 12, 2018: BMJ Case Reports
https://read.qxmd.com/read/30229520/understanding-the-latent-structure-of-hypersexuality-a-taxometric-investigation
#20
Drew A Kingston, Glenn D Walters, Mark E Olver, Enya Levaque, Megan Sawatsky, Martin L Lalumière
We examined the latent structure and taxonicity of hypersexuality in large university and community samples of male and female respondents. Participants completed the Hypersexual Behavior Inventory (HBI) and Sexual Compulsivity Scale (SCS), each as part of larger anonymous online surveys of sexual behavior. Exploratory factor analyses (EFA) were performed in part to prepare the data for taxometric analysis and also to identify the putative dimensions underpinning each measure. Three latent dimensions were identified from each of the Sexual Compulsivity Scale (dyscontrol, consequences, and preoccupation) and Hypersexual Behavior Inventory (coping, dyscontrol, and consequences)...
September 18, 2018: Archives of Sexual Behavior
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