Laura Prieto-García, Laura Vicente-Vicente, Víctor Blanco-Gozalo, Omar Hidalgo-Thomas, María C García-Macías, Armin Kurtz, Anita T Layton, Ana B Sanz, Ana I Morales, Carlos Martínez-Salgado, Miguel Pericacho, Sandra M Sancho-Martínez, Francisco J López-Hernández
Simultaneous administration of certain antihypertensive (renin-angiotensin system inhibitors and diuretics) and nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a renal toxicity syndrome known as "triple whammy" acute kidney injury (TW-AKI), yet poorly characterized at the pathophysiological level, as no specific experimental model exists on which to conduct preclinical research. Herein, we generated and characterized a rat model of TW-AKI (0.7 mg/kg/day trandolapril +400 mg/kg/day ibuprofen +20 mg/kg/day furosemide)...
November 2020: Laboratory Investigation; a Journal of Technical Methods and Pathology