keyword
https://read.qxmd.com/read/37935873/asmt-determines-gut-microbiota-and-increases-neurobehavioral-adaptability-to-exercise-in-female-mice
#21
JOURNAL ARTICLE
Weina Liu, Zhuochun Huang, Ye Zhang, Sen Zhang, Zhiming Cui, Wenbin Liu, Lingxia Li, Jie Xia, Yong Zou, Zhengtang Qi
N-acetylserotonin O-methyltransferase (ASMT) is responsible for melatonin biosynthesis. The Asmt gene is located on the X chromosome, and its genetic polymorphism is associated with depression in humans. However, the underlying mechanism remains unclear. Here, we use CRISPR/Cas9 to delete 20 bp of exon 2 of Asmt, and construct C57BL/6J mouse strain with Asmt frameshift mutation (Asmtft/ft ). We show that female Asmtft/ft mice exhibit anxiety- and depression-like behaviors, accompanied by an obvious structural remodeling of gut microbiota...
November 7, 2023: Communications Biology
https://read.qxmd.com/read/37918798/sleep-deprivation-impairs-intestinal-mucosal-barrier-by-activating-endoplasmic-reticulum-stress-in-goblet-cells
#22
JOURNAL ARTICLE
Gaoxiang Li, Mengru Gao, Shuangshuang Zhang, Tianliang Dai, Fei Wang, Jinke Geng, Jia Rao, Xuejia Qin, Jizhao Qian, Li Zuo, Meng Zhou, Lixin Liu, Hong Zhou
Sleep deficiency is frequently associated with intestinal inflammatory conditions and has been increasingly recognized as a public health concern worldwide. However, the effects of sleep deficiency on intestinal goblet cells (GCs), which play a major role in intestinal barrier formation, remain elusive. Herein, we determined the effects of sleep deprivation on intestinal GCs using a sleep-deprivation mouse model. Sleep deprivation impaired the intestinal mucosal barrier and decreased the expression of tight junction proteins...
October 31, 2023: American Journal of Pathology
https://read.qxmd.com/read/37898179/microbiota-derived-tryptophan-metabolism-impacts-on-health-aging-and-disease
#23
JOURNAL ARTICLE
Sonu Kumar Gupta, Sagar Vyavahare, Ian L Duchesne Blanes, Ford Berger, Carlos Isales, Sadanand Fulzele
The intricate interplay between gut microbiota and the host is pivotal in maintaining homeostasis and health. Dietary tryptophan (TRP) metabolism initiates a cascade of essential endogenous metabolites, including kynurenine, kynurenic acid, serotonin, and melatonin, as well as microbiota-derived Trp metabolites like tryptamine, indole propionic acid (IPA), and other indole derivatives. Notably, tryptamine and IPA, among the indole metabolites, exert crucial roles in modulating immune, metabolic, and neuronal responses at both local and distant sites...
October 26, 2023: Experimental Gerontology
https://read.qxmd.com/read/37885113/circadian-rhythms-and-sleep-disorders-associated-to-major-depressive-disorder-pathophysiology-and-therapeutic-opportunities
#24
JOURNAL ARTICLE
Luana M Manosso, Luciano A Duarte, Nicoly S Martinello, Gisiane B Mathia, Gislaine Z Réus
Major depressive disorder (MDD) is a complex mood disorder. While much progress has been made in understanding the pathophysiology of MDD, no single mechanism can explain all facets of this disorder. Several studies show that disturbances in biological rhythms can lead to the development of MDD. Indeed, insomnia or hypersomnia are symptoms included in the MDD diagnostic criteria. Clinical studies and meta-analyses showed a strong relationship between MDD and sleep disorders. Sleep disorder and MDD are associated with activation in the hypothalamicpituitary-adrenal (HPA) axis and inflammation...
October 25, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37865307/promising-new-pharmacological-targets-for-depression-the-search-for-efficacy
#25
REVIEW
Lucila Emiko Tsugiyama, Ruan Carlos Macedo Moraes, Yaslle Andrade Cavalcante Moraes, Jose Francis-Oliveira
Pharmacological treatment of major depressive disorder (MDD) still relies on the use of serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have been developed in recent years, but many fail in clinical trials. Several hypotheses have been proposed to explain MDD pathophysiology, indicating that physiological processes such as neuroplasticity, circadian rhythms, and metabolism are potential targets. Here, we review the current state of pharmacological treatments for MDD and their problems, as well as the preclinical and clinical evidence for an antidepressant effect of molecules that target non-serotonergic systems...
October 19, 2023: Drug Discovery Today
https://read.qxmd.com/read/37846137/gut-microbiota-bile-acid-vitamin-d-axis-plays-an-important-role-in-determining-oocyte-quality-and-embryonic-development
#26
JOURNAL ARTICLE
Ang Li, Fei Li, Wei Song, Zi-Li Lei, Qian-Qian Sha, Shao-Yuan Liu, Chang-Yin Zhou, Xue Zhang, Xiao-Zhen Li, Heide Schatten, Teng Zhang, Qing-Yuan Sun, Xiang-Hong Ou
OBJECTIVE: To reveal whether gut microbiota and their metabolites are correlated with oocyte quality decline caused by circadian rhythm disruption, and to search possible approaches for improving oocyte quality. DESIGN: A mouse model exposed to continuous light was established. The oocyte quality, embryonic development, microbial metabolites and gut microbiota were analyzed. Intragastric administration of microbial metabolites was conducted to confirm the relationship between gut microbiota and oocyte quality and embryonic development...
October 2023: Clinical and Translational Medicine
https://read.qxmd.com/read/37833416/age-related-changes-in-the-gut-melatonin-levels-and-its-possible-role-in-the-regulation-of-feeding-and-digestibility-with-the-development-of-the-gut-from-fingerling-to-adult-stages-of-carp-catla-catla
#27
JOURNAL ARTICLE
Sona Sutradhar, Farha Yasmin, Arun Roy, Russel Sarkar, Sourav Mukherjee
The present study aims to understand the feeding-related age-bound changes in gut histoarchitecture and its response to gut melatonin (GM) titer regulating major digestive enzymes in carp, Catla catla. Therefore, gut samples were collected from different growth stages of carp, viz. (i) fingerling (FL), body weight (BW) ≥ 3 g to ≤ 20 g; (ii) advanced fingerling (AFL), BW > 20 g to ≤ 40 g; (iii) early juvenile (EJv), BW > 40 g to ≤ 70 g; (iv) juvenile (Jv), BW > 70 g to ≤ 200 g; (v) late juvenile (LJv), BW > 200 g to ≤ 300 g; (vi) preadult (PA), BW > 300 g to ≤ 500 g; (vii) subadult (SA), BW > 500 g to ≤ 1...
October 13, 2023: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://read.qxmd.com/read/37823531/role-of-bmal1-and-gut-microbiota-in-alzheimer-s-disease-and-parkinson-s-disease-pathophysiology-the-probable-effect-of-melatonin-on-their-association
#28
REVIEW
Mohammad Rafi Khezri, Ayda Esmaeili, Morteza Ghasemnejad-Berenji
In recent years, the role of new factors in the pathophysiology of neurodegenerative diseases has been investigated. Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases worldwide. Although pathological changes such as the accumulation of aggregated proteins in the brain and inflammatory responses are known as the main factors involved in the development of these diseases, new studies show the role of gut microbiota and circadian rhythm in the occurrence of these changes...
October 12, 2023: ACS Chemical Neuroscience
https://read.qxmd.com/read/37815021/feeding-during-the-resting-phase-causes-gastrointestinal-tract-dysfunction-and-desynchronization-of-metabolic-and-neuronal-rhythms-in-rats
#29
JOURNAL ARTICLE
Roberto C Salgado-Delgado, Ricardo Espinosa-Tanguma, Belkis Valdés Abadía, Oscar D Ramírez-Plascencia, Carolina Escobar, Nadia Saderi
BACKGROUND: Disrupted circadian rhythms may result from a misalignment between the environmental cycles (due to shift work, sleep restriction, feeding at an unusual time of day) and endogenous rhythms or by physiological aging. Among the numerous adverse effects, disrupted rhythms affect the brain-gut axis, contributing to the pathogenesis of several diseases in the gastrointestinal tract, for example, abdominal pain, constipation, gastric dyspepsia, inflammatory bowel disease, irritable bowel syndrome, and others...
December 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/37807406/gut-microbiome-and-circadian-interactions-with-platelets-across-human-diseases-including-alzheimer-s-disease-amyotrophic-lateral-sclerosis-and-cancer
#30
JOURNAL ARTICLE
George Anderson
Platelets have traditionally been investigated for their role in clot formation in the course of cardiovascular diseases and strokes. However, recent work indicates platelets to be an integral aspect of wider systemic processes, with relevance to the pathophysiology of a host of diverse medical conditions, including neurodegenerative disorders and cancer. This article reviews platelet function and interactions with the gut microbiome and circadian systems, highlighting the role of the platelet mitochondrial melatonergic pathway in determining platelet activation, fluxes and plasticity...
October 2, 2023: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/37796746/protective-and-therapeutic-potential-of-melatonin-against-intestinal-diseases-updated-review-of-current-data-based-on-molecular-mechanisms
#31
REVIEW
Saeed Mehrzadi, Mohammad Sheibani, Fereshteh Koosha, Nazila Alinaghian, Mohammad Hossein Pourhanifeh, Seid Amir Pasha Tabaeian, Russel J Reiter, Azam Hosseinzadeh
INTRODUCTION: Intestinal diseases, a leading global cause of mortality and morbidity, carry a substantial socioeconomic burden. The small and large intestines play pivotal roles in gastrointestinal physiology and food digestion. Pathological conditions, such as gut dysbiosis, inflammation, cancer, therapy-related complications, ulcers, and ischemia, necessitate the urgent exploration of safe and effective complementary therapeutic strategies for optimal intestinal health. AREAS COVERED: this article evaluates the potential therapeutic effects of melatonin, a molecule with a wide range of physiological actions, on intestinal diseases including inflammatory bowel disease, irritable bowel syndrome, colon cancer, gastric/duodenal ulcers and other intestinal disorders...
October 5, 2023: Expert Review of Gastroenterology & Hepatology
https://read.qxmd.com/read/37711458/circadian-rhythms-in-colonic-function
#32
REVIEW
Timothy J Hibberd, Stewart Ramsay, Phaedra Spencer-Merris, Phil G Dinning, Vladimir P Zagorodnyuk, Nick J Spencer
A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed "peripheral clocks." Peripheral clocks are subject to entrainment by a multitude of factors, many of which are directly or indirectly controlled by the light-entrainable clock located in the suprachiasmatic nucleus of the hypothalamus. Peripheral clocks occur in the gastrointestinal tract, notably the epithelia whose functions include regulation of absorption, permeability, and secretion of hormones; and in the myenteric plexus, which is the intrinsic neural network principally responsible for the coordination of muscular activity in the gut...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37691830/melatonin-a-natural-antioxidant-therapy-in-spinal-cord-injury
#33
REVIEW
Lei Xie, Hang Wu, Xiaohong Huang, Tengbo Yu
Spinal cord injury (SCI) is a sudden onset of disruption to the spinal neural tissue, leading to loss of motor control and sensory function of the body. Oxidative stress is considered a hallmark in SCI followed by a series of events, including inflammation and cellular apoptosis. Melatonin was originally discovered as a hormone produced by the pineal gland. The subcellular localization of melatonin has been identified in mitochondria, exhibiting specific onsite protection to excess mitochondrial reactive oxygen species and working as an antioxidant in diseases...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37659335/melatonin-attenuates-chronic-intermittent-hypoxia-induced-intestinal-barrier-dysfunction-in-mice
#34
JOURNAL ARTICLE
Xinyi Li, Fan Wang, Zhenfei Gao, Weijun Huang, Xiaoman Zhang, Feng Liu, Hongliang Yi, Jian Guan, Xiaolin Wu, Huajun Xu, Shankai Yin
BACKGROUND AND PURPOSE: Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Increasing evidence suggests therapeutic effects of melatonin on systemic inflammation and gut microbiota remodelling. However, whether and how melatonin alleviates CIH-induced intestinal barrier dysfunction remains unclear. EXPERIMENTAL APPROACH: C57BL/6 J mice and Caco-2 cell line were treated. We evaluated gut barrier function spectrophotometrically using fluorescein isothiocyanate (FITC)-labelled dextran...
August 23, 2023: Microbiological Research
https://read.qxmd.com/read/37649458/the-mammalian-gastro-intestinal-tract-is-a-not-a-major-extra-pineal-source-of-melatonin-in-mammals
#35
REVIEW
David J Kennaway
In 1992, a paper reported that the melatonin content of the rat duodenum was 24 000 ± 2000 pg/g tissue (range: 4000-100 000 pg/g) while the pineal melatonin content was 580 000 ± 36 000 pg/g. The data has been used for the last 30 years to infer that the gut produces 400 hundred times more melatonin than the pineal gland and that it is the source of plasma melatonin during the daytime. No-one has ever challenged the statement...
August 31, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37611884/melatonin-reduced-colon-inflammation-but-had-no-effect-on-energy-metabolism-in-ageing-mongolian-gerbils-meriones-unguiculatus
#36
JOURNAL ARTICLE
Wen-Ting Gao, Jin-Xiu Liu, De-Hua Wang, Hai-Ji Sun, Xue-Ying Zhang
In photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process. The beneficial effects of MT in delaying the progress of ageing have been reported in laboratory mice and rats. However, little is known about MT in wild mammals. In the current study, we investigated energy metabolism, microbial community structure and colon homeostasis in ageing Mongolian gerbils (Meriones unguiculatus) through exogenous supplementation of MT to test the hypothesis that MT has beneficial effects on gut homeostasis in ageing gerbils...
August 21, 2023: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://read.qxmd.com/read/37583483/gut-microbiota-crosstalk-mechanisms-are-key-in-pulmonary-hypertension-the-involvement-of-melatonin-is-instrumental-too
#37
REVIEW
Steve Jacobs, Carmen Payne, Sara Shaboodien, Thato Kgatla, Amy Pretorius, Chrisstoffel Jumaar, Olakunle Sanni, Ghazwan Butrous, Gerald Maarman
The microbiota refers to a plethora of microorganisms with a gene pool of approximately three million, which inhabits the human gastrointestinal tract or gut. The latter, not only promotes the transport of nutrients, ions, and fluids from the lumen to the internal environment but is linked with the development of diseases including coronary artery disease, heart failure, and lung diseases. The exact mechanism of how the microbiota achieves crosstalk between itself and distant organs/tissues is not clear, but factors released to other organs may play a role, like inflammatory and genetic factors, and now we highlight melatonin as a novel mediator of the gut-lung crosstalk...
July 2023: Pulmonary Circulation
https://read.qxmd.com/read/37549451/targeting-microbiota-to-alleviate-the-harm-caused-by-sleep-deprivation
#38
REVIEW
Hongyu Chen, Chen Wang, Junying Bai, Jiajia Song, Linli Bu, Ming Liang, Huayi Suo
Sleep deprivation has become a common health hazard, affecting 37-58% of the population and promoting the occurrence and development of many diseases. To date, effective treatment strategies are still elusive. Accumulating evidence indicates that modulating the intestinal microbiota harbors significant potential for alleviating the deleterious impacts of sleep deprivation. This paper first reviews the effects of sleep deprivation on gastrointestinal diseases, metabolic diseases, and neuropsychiatric diseases, discussing its specific mechanisms of influence...
October 2023: Microbiological Research
https://read.qxmd.com/read/37527604/melatonin-promotes-gut-anti-oxidative-status-in-perinatal-rat-by-remodeling-the-gut-microbiome
#39
JOURNAL ARTICLE
Xudong Yi, Rui Cai, Weike Shaoyong, Guoyan Wang, Wenyong Yan, Zhaozhao He, Ri Li, Mingkun Chao, Tiantian Zhao, Lu Deng, Gongshe Yang, Weijun Pang
Gut health is important for nutrition absorption, reproduction, and lactation in perinatal and early weaned mammals. Although melatonin functions in maintaining circadian rhythms and preventing obesity, neurodegenerative diseases, and viral infections, its impact on the gut microbiome and its function in mediating gut health through gut microbiota remain largely unexplored. In the present study, the microbiome of rats was monitoring after fecal microbiota transplantation (FMT) and foster care (FC). The results showed that FMT and FC increased intestinal villus height/crypt depth in perinatal rats...
July 28, 2023: Redox Biology
https://read.qxmd.com/read/37492901/the-role-of-gnrh-in-tibetan-male-sheep-and-goat-reproduction
#40
REVIEW
Wangsheng Zhao, Michael Adjei, Zhenzhen Zhang, Zhenjie Yuan, Zhuoma Cisang, Tianzeng Song
The hypothalamic-pituitary-gonadal (HPG) axis connects the hypothalamus, pituitary gland, and gonads. The regulation of reproductive processes includes integrating various factors from structural functions and environmental conditions in the HPG axis, with the outcome indication of these processes being the pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. These factors include feed consumption and nutritional condition, sex steroids, season/photoperiod, pheromones, age, and stress...
July 26, 2023: Reproduction in Domestic Animals
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