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mitochondria transplant

Zhao-Huan Lou, Rong-Man Xia, Xiao-Juan Li, Ru-Bin Cheng, Ke-Ding Shao, Guang-Ji Zhang
At present, lung cancer ranks second and first respectively in the incidence and the mortality among malignant tumors. It is urgent to find new effective anti-lung cancer drugs with less side effects and relatively defined mechanisms. Endoplasmic reticulum stress (ERS)-mediated apoptosis pathway is an effective way to promote tumor cell apoptosis; diterpenoid tanshinone (DT), an effective part separated from Salviae Miltiorrhizae Radix et Rhizoma, was found to have an anti-lung cancer effect in previous studies via ERS-induced PERK-EIF2α pathway...
December 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Amaneh Mohammadi Roushandeh, Yoshikazu Kuwahara, Mehryar Habibi Roudkenar
Mitochondria are attractive cellular organelles which are so interesting in both basic and clinical research, especially after it was found that they were arisen as a bacterial intruder in ancient cells. Interestingly, even now, they are the focus of many investigations and their function and relevance to health and disease have remained open questions. More recently, research on mitochondria have turned out their potential application in medicine as a novel therapeutic intervention. The importance of this issue is highlighted when we know that mitochondrial dysfunction can be observed in a variety of diseases such as cardiovascular diseases, neurodegenerative diseases, ischemia, diabetes, renal failure, skeletal muscles disorders, liver diseases, burns, aging, and cancer progression...
January 31, 2019: Cytotechnology
Richard S Legro
This introduction reviews the background of mitochondrial transplantation. Its goals are to provide both basic and clinical insights into mitochondria and reproduction. The articles will review the biology of mitochondria, mitochondrial DNA, mitochondrial dynamics, and mitochondrial stress (unfolded protein response), discuss novel imaging technology, fluorescent lifetime imaging microscopy to visualize mitochondria and their function in oocytes and early embryos, provide a critical and objective review of the data suggesting and refuting the possible use of mitochondrial DNA as well as other emerging technologies as a biomarker for embryo viability and finally to review the use of mitochondria as a rejuvenation tool in human in vitro fertilization...
February 2019: Fertility and Sterility
Jui-Chih Chang, Huei-Shin Chang, Yao-Chung Wu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ju Chang, Shou-Jen Kuo, Shou-Tung Chen, Chin-San Liu
BACKGROUND: The transfer of whole mitochondria that occurs during cell contact has been found to support cancer progression. However, the regulatory role of mitochondria alone is difficult to elucidate due to the complex microenvironment. Currently, mitochondrial transplantation is an available approach for restoring mitochondrial function in mitochondrial diseases but remains unclear in breast cancer. Herein, effects of mitochondrial transplantation via different approaches in breast cancer were investigated...
January 23, 2019: Journal of Experimental & Clinical Cancer Research: CR
Bin Zhou, Fangyi Wu, Jingxuan Han, Fei Qi, Ting Ni, Feng Qian
The encephalomyocarditis virus (EMCV) is a single-stranded RNA virus that induces sudden death, diabetes, myocarditis and nervous disorders in non-human primates. The rapid development of xenografts such as heart transplantation from pig to human raises the issue of EMCV safety in human cells. SFPQ, a proline and glutamine rich splicing factor that participates in diverse molecular functions including paraspeckle formation, microRNA synthesis and transcription regulation, is known to regulate host innate immune response to viruses...
January 18, 2019: Biochemical and Biophysical Research Communications
Rahel K Wyss, Natalia Méndez-Carmona, Maria-Nieves Sanz, Maria Arnold, Adrian Segiser, Georg M Fiedler, Thierry P Carrel, Siamak Djafarzadeh, Hendrik T Tevaearai Stahel, Sarah L Longnus
BACKGROUND: Cardioprotection and graft evaluation after ischemia-reperfusion (IR) are essential in facilitating heart transplantation with donation after circulatory death. Given the key role of mitochondria in IR, we aimed to investigate the tolerance of cardiac mitochondria to warm, global ischemia and to determine the predictive value of early reperfusion mitochondria-related parameters for post-ischemic cardiac recovery. METHODS: Isolated, working rat hearts underwent 0, 21, 24, 27, 30, or 33 minutes of warm, global ischemia, followed by 60 minutes of reperfusion...
December 21, 2018: Journal of Heart and Lung Transplantation
Kaiming Liu, Liang Guo, Zhijian Zhou, Mengxiong Pan, Chuanzhu Yan
Mesenchymal stem cells can be used as a novel treatment of ischemic stroke, but their therapeutic effect and mechanism of action require further evaluation. Mitochondrial dysfunction has core functions in ischemia-reperfusion stroke injury. Our recent research has demonstrated that mesenchymal stem cells can transfer their functional mitochondria to injured endothelial cells via tunneling nanotubes in vitro, resulting in the rescue of aerobic respiration and protection of endothelial cells from apoptosis. Therefore, we presume that the mechanisms of mitochondrial protection may be involved in stem cell-mediated rescue of injured cerebral microvasculature and recovery from ischemic stroke...
January 3, 2019: Microvascular Research
Yvonne de Vries, Alix P M Matton, Maarten W N Nijsten, Maureen J M Werner, Aad P van den Berg, Marieke T de Boer, Carlijn I Buis, Masato Fujiyoshi, Ruben H J de Kleine, Otto B van Leeuwen, Peter Meyer, Marius C van den Heuvel, Vincent E de Meijer, Robert J Porte
Ex situ dual hypothermic oxygenated machine perfusion (DHOPE) and normothermic machine perfusion (NMP) of donor livers may have a complementary effect when applied sequentially. While DHOPE resuscitates the mitochondria and increases hepatic ATP content, NMP enables hepatobiliary viability assessment prior to transplantation. In contrast to DHOPE, NMP requires a perfusion solution with an oxygen carrier, for which red blood cells (RBC) have been used in most series. RBC, however, have limitations and cannot be used cold...
December 26, 2018: American Journal of Transplantation
Kiyoshi Hayasaka, Chikahiko Numakura
Citrin deficiency is a recessively inherited metabolic disorder with age-dependent clinical manifestations. It causes neonatal intrahepatic cholestasis (NICCD) and adult-onset type II citrullinemia (CTLN2). Patients with NICCD present with intrahepatic cholestasis in the neonatal period and usually respond to the treatment with medium-chain triglyceride (MCT) supplement and lactose-restricted formula. In adulthood, CTLN2 develops in <10 % of the patients showing hyperammonemic encephalopathy. Patients with CTLN2 required liver transplantation for the most promising prognosis; however, they were successfully treated with MCT supplement with a low carbohydrate formula...
2018: Application of Clinical Genetics
Yuta Okuwa, Taku Toriumi, Hidenori Nakayama, Tatsuaki Ito, Keita Otake, Kenichi Kurita, Misako Nakashima, Masaki Honda
The effects of transplanted human dental pulp-derived cells (DPCs) on peripheral nerve regeneration were studied in a rat model of sciatic nerve crush injury. In one group, DPCs were transplanted into the compression site (cell transplantation group); the control group underwent no transplantation (crushed group). Sciatic nerve regeneration was determined based on the recovery of motor function and histological and immunohistochemical analyses. The cell transplantation group showed improved motor function compared with the crushed group using the CatWalk XT system, which corresponded to a higher ratio of tibialis to anterior muscle weight 14 days after surgery...
2018: Journal of Oral Science
Davide Scozzi, Mohsen Ibrahim, Fuyi Liao, Xue Lin, Hsi-Min Hsiao, Ramsey Hachem, Laneshia Tague, Alberto Ricci, Hrishikesh S Kulkarni, Howard J Huang, Seiichiro Sugimoto, Alexander S Krupnick, Daniel Kreisel, Andrew E Gelman
Primary graft dysfunction (PGD) is a major limitation to short and long-term lung transplant survival. Recent work has shown mitochondrial damage associated molecular patterns (Mt-DAMPs) can promote solid organ injury but whether they contribute to PGD severity remains unclear. We quantitated circulating plasma Mt-DNA in 62 patients, prior to lung transplant and shortly after ICU arrival. Although all recipients released Mt-DNA, high levels were associated with severe PGD development. In a mouse orthotopic lung transplant model of PGD we detected airway cell-free damaged mitochondria and Mt-DNA in the peripheral circulation...
December 23, 2018: American Journal of Transplantation
Kowsar Bavarsad, Maryam Matbou Riahi, Saeideh Saadat, George Barreto, Stephen L Atkin, Amirhossein Sahebkar
Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury...
December 15, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Rui Zheng, Xiaoliang Fang, Lei He, Yanjiao Shao, Nana Guo, Liren Wang, Mingyao Liu, Dali Li, Hongquan Geng
BACKGROUND: Primary hyperoxaluria type 1 (PH1) is an inherited disease caused by mutations in alanine-glyoxylate aminotransferase (AGXT). It is characterized by abnormal metabolism of glyoxylic acid in liver leading to endogenous oxalate overproduction and deposition of oxalate in multiple organs, mainly the kidney. Patients of PH1 often suffer from recurrent urinary tract stones, and finally renal failure. There is no effective treatment other than combined liver-kidney transplantation...
December 11, 2018: Current Molecular Medicine
Eleonora Russo, Eleonora Napoli, Cesar V Borlongan
Stroke is a debilitating disease that remains as a significant unmet need. Although our understanding of the disease pathology has advanced over the years, treatment options for stroke are limited. Recent studies have implicated the important role of healthy mitochondria in neuroprotection against stroke. Under the stroke pathological condition, transfer of healthy mitochondria is observed from astrocytes to ischemic neurons. However, without additional therapeutic intervention, such astrocyte-to-neuron transfer of mitochondria may not sufficiently afford a robust and stable therapeutic effect against the devastating primary insult and progressive neurodegeneration associated with stroke...
July 2018: Brain Circulation
Eleonora Russo, Hung Nguyen, Trenton Lippert, Julian Tuazon, Cesar V Borlongan, Eleonora Napoli
Stroke is a main cause of mortality and morbidity worldwide. Despite the increasing development of innovative treatments for stroke, most are unsuccessful in clinical trials. In recent years, an encouraging strategy for stroke therapy has been identified in stem cells transplantation. In particular, grafting cells and their secretion products are leading with functional recovery in stroke patients by promoting the growth and function of the neurovascular unit - a communication framework between neurons, their supply microvessels along with glial cells - underlying stroke pathology and recovery...
July 2018: Brain Circulation
Kamila Moskowitzova, Borami Shin, Kaifeng Liu, Giovanna Ramirez-Barbieri, Alvise Guariento, David Blitzer, Jerusha K Thedsanamoorthy, Rouan Yao, Erin R Snay, James A H Inkster, Arzoo Orfany, David Zurakowski, Douglas B Cowan, Alan B Packard, Gary A Visner, Pedro J Del Nido, James D McCully
BACKGROUND: Cold ischemia time (CIT) causes ischemia‒reperfusion injury to the mitochondria and detrimentally effects myocardial function and tissue viability. Mitochondrial transplantation replaces damaged mitochondria and enhances myocardial function and tissue viability. Herein we investigated the efficacy of mitochondrial transplantation in enhancing graft function and viability after prolonged CIT. METHODS: Heterotopic heart transplantation was performed in C57BL/6J mice...
September 28, 2018: Journal of Heart and Lung Transplantation
Makoto Kazama, Kazuhiro Yoshida, Sanae Ogiwara, Takashi Makiuchi, Hiroshi Tachibana
In mitochondria, compatibility of proteins encoded in mitochondrial DNA and nuclear DNA is essential for normal function of the organelle. Incompatibility between mitochondrial and nuclear DNA can lead to dysfunctional respiration, mitochondrial diseases and lethal problems, which suggests that the presence of heterologous mitochondria is unfavorable. In a previous study, we established a transplant method for DNA-lacking mitochondria (mitosomes) in the anaerobic protozoan Entamoeba histolytica. In this study, interspecies transplant of mitosomes from E...
October 17, 2018: Journal of Eukaryotic Microbiology
Armelle Paule, Domenico Frezza, Marvin Edeas
An imbalance of bacterial quantity and quality of gut microbiota has been linked to several pathologies. New strategies of microbiota manipulation have been developed such as fecal microbiota transplantation (FMT); the use of pre/probiotics; an appropriate diet; and phage therapy. The presence of bacteriophages has been largely underestimated and their presence is a relevant component for the microbiome equilibrium. As a promising treatment, phage therapy has been extensively used in Eastern Europe to reduce pathogenic bacteria and has arisen as a new method to modulate microbiota diversity...
October 5, 2018: Medical Sciences: Open Access Journal
Xiaotian Sun, Wenshuo Wang, Jing Dai, Jiechun Huang, Meng Shi, Xianglin Chu, Fangrui Wang, Changfa Guo, Chunsheng Wang, Liewen Pang, Yiqing Wang
Cardiac transplantation has been limited by the inability to long preserve donor hearts safely. Hydrogen sulfide (H2 S) has been recognized as an important gasotransmitter exerting potent cardioprotection from ischemia/reperfusion injury (I/R). Herein we investigated the cardioprotective effects of a novel long-term and slow-releasing H2 S system, namely DATS-MSN, in heart preservation solution using a heart transplantation models. The release of H2 S from DATS-MSN was slow and continuous in the University of Wisconsin solution (UW), correspondingly, DATS-MSN application demonstrated superior cardioprotective effects over the control and traditional H2 S donors after 6 h heart preservation and 1 h reperfusion, associated with greater allograft performance including left ventricular developed pressure (LVDP) and dP/dt max , reduced plasmic CK-MB and troponin I levels, inhibited myocardial inflammation, increased antioxidant enzyme activities, preserved mitochondria structure and function, and decreased cardiomyocyte apoptosis index...
September 11, 2018: Nitric Oxide: Biology and Chemistry
Zhanqin Zhang, Zhi Ma, Chaoying Yan, Kairui Pu, Meiyan Wu, Juan Bai, Yansong Li, Qiang Wang
The available evidence showed that mitochondrial transfer by releasing the extracellular vesicles containing mitochondria from astrocytes to neurons exerted a neuroprotective effect after stroke. Whether extracellular mitochondrial replenishment could rescue the tissues from cerebral ischemic injury still needs to be explored completely. It was hypothesized that the augmentation of mitochondrial damage after cerebral ischemia could be resolved by timely replenishment of exogenous mitochondria. A stroke model of middle cerebral artery occlusion (MCAO) was used in this study to verify this hypothesis...
January 1, 2019: Behavioural Brain Research
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