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Risk predictor

Mu-Rung Li, Hui-Ling Lai
No evidence exists in the literature concerning the prevalence of insomnia and its associated risk factors among prison inmates in Taiwan. The aim of the present study was to determine the prevalence and factors associated with insomnia among inmates in a large prison in Taiwan. A cross-sectional anonymous questionnaire survey was conducted at a prison. The participants were 1490 male inmates. Participants completed the self-reported Insomnia Severity Index-Chinese version questionnaire, and the sociodemographic and psychological distress questionnaires for the study...
February 18, 2019: Nursing & Health Sciences
Natalia Bustamante-Ara, Luis Villarroel, Fabio Paredes, Andrea Huidobro, Catterina Ferreccio
BACKGROUND: Aging presents an emerging health and social challenge. We report the prevalence of frailty, its association with chronic diseases and the risk of hospitalization or death within 29 months. METHODS: Cross-sectional and prospective study. From 2014 to 2017, we examined frailty in an agricultural population in Chile. We enrolled 619 individuals aged 60-74 years from the Maule Cohort. Measured frailty prevalence, based the presence of ≥3 of the five factors (unintentional weight loss, weakness, slowness, self-reported exhaustion, low physical activity)...
February 10, 2019: Archives of Gerontology and Geriatrics
Emily Aaronson, Naomi George, Kei Ouchi, Hui Zheng, Jason Bowman, Derek Monette, Juliet Jacobsen, Vicki Jackson
CONTEXT: Heart Failure (HF) is associated with symptom exacerbations and risk of mortality after an emergency department (ED) visit. While emergency physicians (EPs) treat symptoms of HF, often the opportunity to connect with palliative care is missed. The 'Surprise Question' (SQ), "would you be surprised if this patient died in the next 12 months?" is a simple tool to identify patients at risk for 12-month mortality. OBJECTIVES: To assess the accuracy of the SQ when used by EPs to assess patients with HF...
February 15, 2019: Journal of Pain and Symptom Management
Annika Vom Scheidt, Eric Flavio Grisolia Seifert, Carolin Pokrant, Klaus Püschel, Michael Amling, Björn Busse, Petar Milovanovic
BACKGROUND: Currently, bone densitometry fails to identify nearly half of those elderly patients at immediate fracture risk. To improve clinical assessment of vertebral fracture risk, we aimed to determine how the DXA-based 2D parameter Trabecular Bone Score (TBS) relates to subregional variability in 3D trabecular microstructure in young and elderly women compared to aBMD. METHODS: T12 vertebrae from 29 women (11 young: 32 ± 6 years, 18 aged: 71 ± 5 years) were DXA-scanned ex vivo in anterior-posterior (AP) and lateral projection providing vertebral aBMD and TBS...
February 15, 2019: Bone
Nauman A Khan, Rizwan A Khan, Adriano R Tonelli, Kristin B Highland, Neal F Chaisson, Miriam Jacob, Rahul Renapurkar, Raed A Dweik, Gustavo A Heresi
BACKGROUND: Pulmonary edema may complicate the use of pulmonary arterial hypertension (PAH) targeted therapies. We aimed to determine the proportion of patients who develop pulmonary edema after initiation of parenteral prostacyclin therapy, to identify its risk factors, and to assess its implications on hospital length of stay and mortality. METHODS: A retrospective cohort study of PAH patients at the initiation of parenteral prostacyclin between 1997 and 2015 enrolled in the Cleveland Clinic PAH registry...
February 15, 2019: Chest
Chethan M Puttarajappa, Amit D Tevar, Sundaram Hariharan, Saul J Silver, Prem Soman, Shelly Hendrick, Girish Mour, Christine M Wu
BACKGROUND: The Utility of coronary angiography in patients with diabetes mellitus undergoing kidney transplant evaluation is unclear. Predictors of critical angiography lesions in these patients will aid in appropriate use of angiography. METHODS: Single center study of 80 patients with ≥ 15 years of diabetes mellitus who underwent a screening coronary angiography despite a negative cardiac stress test. Risk factors for needing coronary intervention (CI) (percutaneous or bypass grafting) were analyzed...
February 18, 2019: Clinical Transplantation
G Peggy McFall, Kirstie L McDermott, Roger A Dixon
BACKGROUND: Non-demented cognitive aging trajectories are characterized by vast level and slope differences and a spectrum of outcomes, including dementia. OBJECTIVE: The goal of AD risk management (and its corollary, promoting healthy brain aging) is aided by two converging objectives: 1) classifying dynamic distributions of non-demented cognitive trajectories, and 2) identifying modifiable risk-elevating and risk-reducing factors that discriminate stable or normal trajectory patterns from declining or pre-impairment patterns...
February 11, 2019: Journal of Alzheimer's Disease: JAD
He-Bin Fan, Xiao-Ling Tong, Xin-Yu Qian, Zhi Li
BACKGROUND: Cirrhotic patients with hemorrhagic ascites have significant morbidity and mortality. This study aims to determine the relationship between D-dimer values and hemorrhagic ascites in cirrhotic patients and analyze its predictive value. METHODS: This retrospective study screened 572 consecutive cirrhotic patients with ascites and hemorrhagic ascites (defined as red blood cells (RBC) in ascitic fluid ≥ 10,000/µL) during a 72-month period. The overall patient survival rate was measured by Kaplan-Meier analysis method...
January 1, 2019: Clinical Laboratory
Sifeng Hu, Xiankun Yin, Guangyong Zhang, Fanmei Meng
Gastric adenocarcinoma is an important death-related cancer. To find factors related to survival and prognosis, and thus improve recovery prospects, a powerful signature is needed. DNA methylation plays an important role in gastric adenocarcinoma processes and development, and here we report on the search for a significant DNA methylation gene to aid with the earlier diagnosis of gastric adenocarcinoma patients. A Cox proportional risk regression analysis and random survival forest algorithm were used to analyze gastric adenocarcinoma patients' DNA methylation data from The Cancer Genome Atlas, a public database...
February 18, 2019: Journal of Cellular Biochemistry
Julie Anne L Gabat, Antonio L Faltado, Myrna B Sedurante, Michael L Tee
Objective: Studies on the association of obesity and sarcopenia are conflicting. Some studies showed that obesity is associated with muscle loss and frailty while others showed that lower body mass index (BMI) is associated with increased sarcopenia. To date, there is paucity of data on sarcopenia and obesity among Filipinos. This study aims to determine the association of obesity and sarcopenia among Filipinos. Methods: This is a cross sectional analytic study comparing sarcopenic versus nonsarcopenic in terms of obesity as measured by BMI and waist circumference (WC)...
September 2018: Osteoporosis and Sarcopenia
Ju-Yi Li, Zhong-Jing Wang, Ai-Ping Deng, Yu-Ming Li
Objectives: Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality. The aim of our study was to identify novel biomarkers of impaired wound healing in diabetic foot ulcers. Methods: 109 patients with neuropathic diabetic foot ulcers and 30 burn victims otherwise healthy participated. Antibody-coated glass slide arrays were used to determine the levels of 80 human cytokines in pooled plasma or pooled wound exudate of diabetic foot ulcers with rapidly healing (RH, n = 12) and matched nonhealing (NH, n = 12) patients...
2019: Journal of Diabetes Research
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Koji Suzuki, Taisuke Seki, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
Purpose: Osteoporosis is a common age-related disorder leading to increased bone fragility and risk of fracture. Early diagnosis of osteoporosis is a vital step in providing early therapeutic intervention. Serum cystatin C is a marker of early renal dysfunction, a predictor of cardiovascular and inflammatory diseases, and an inhibitor of the differentiation of osteoclast precursor cells. The purpose of this study was to evaluate the relationship between serum cystatin C and osteoporosis...
2019: BioMed Research International
Florent Tixier, Hyemin Um, Dalton Bermudez, Aditi Iyer, Aditya Apte, Maya S Graham, Kathryn S Nevel, Joseph O Deasy, Robert J Young, Harini Veeraraghavan
Background: Glioblastoma (GBM) is the most common malignant central nervous system tumor, and MGMT promoter hypermethylation in this tumor has been shown to be associated with better prognosis. We evaluated the capacity of radiomics features to add complementary information to MGMT status, to improve the ability to predict prognosis. Methods: 159 patients with untreated GBM were included in this study and divided into training and independent test sets. 286 radiomics features were extracted from the magnetic resonance images acquired prior to any treatments...
January 18, 2019: Oncotarget
Qiongyan Zhang, Lei Wang, Dan Huang, Midie Xu, Weiwei Weng, Shujuan Ni, Cong Tan, Weiqi Sheng
Background: Risk grade assessment determines therapy in patients with submucosal invasive colorectal carcinoma (CRC). However, treatment decisions are often difficult due to a lack of consensus on which risk factors should be considered. We aimed to identify predictive risk factors for lymph node metastasis (LNM) in a large cohort of submucosal invasive CRC patients from China. Patients and methods: Following collection of clinicopathological data and disease-free survival (DFS) rates from 290 patients who underwent radical intestinal resection with regional lymphadenectomy, we immunohistochemically assessed expression of DNA mismatch repair (MMR) proteins and p53...
2019: Cancer Management and Research
Ah Reum Khang, Hye Won Lee, Dongwon Yi, Yang Ho Kang, Seok Man Son
Purpose: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and it is the hepatic manifestation of metabolic syndrome (MetS). We aimed to estimate the prevalence of NAFLD defined by the fatty liver index (FLI), in order to investigate the association between FLI and metabolic disorders and to determine the cutoff value of FLI to screen for MetS. Subjects and methods: This study utilized a national representative sample of Korean adults (the Korean National Health and Nutrition Examination Surveys) which was conducted in 2010-2011...
2019: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Mohamed A Mekky, Hani I Sayed, Mohamed O Abdelmalek, Medhat A Saleh, Osman A Osman, Heba A Osman, Khairy H Morsy, Helal F Hetta
Background: Occult hepatitis C virus (HCV) infection (OCI) is characterized by the detection of HCV-RNA in non-serum reservoirs, such as peripheral blood mononuclear cells (PBMCs) and/or hepatocytes with undetectable HCV-RNA or antibodies in the serum. In this study, we tried to evaluate the prevalence and possible predictors of OCI in patients who achieved sustained virologic response (SVR) post sofosbuvir/daclatasvir (SOF/DCV) therapy. Patients and methods: A cross-sectional multicenter study was designed to enroll 1,280 HCV-infected patients who received SOF (400 mg) plus DCV (60 mg) once daily ± ribavirin regimen for 12 weeks and achieved SVR 12 weeks post treatment...
2019: Infection and Drug Resistance
Isabelle E Bauer, Robert Suchting, Tamsyn E Van Rheenen, Mon-Ju Wu, Benson Mwangi, Danielle Spiker, Giovana B Zunta-Soares, Jair C Soares
BACKGROUND AND AIMS: Cognitive impairments are primary hallmarks symptoms of bipolar disorder (BD). Whether these deficits are markers of vulnerability or symptoms of the disease is still unclear. This study used a component-wise gradient (CGB) machine learning algorithm to identify cognitive measures that could accurately differentiate pediatric BD, unaffected offspring of BD parents, and healthy controls. METHODS: 59 healthy controls (HC; 11.19 ± 3.15 yo; 30 girls), 119 children and adolescents with BD (13...
February 18, 2019: Cognitive Neuropsychiatry
Zhichao Wang, Chi Liu, Hong Fang
Major advances in coronary interventional techniques and pharmacotherapy as well as the use of drug-eluting stents (DESs) have considerably reduced the risk of in-stent restenosis (ISR). However, ISR remains a major clinical challenge. Inflammation and platelet activation are important processes that underlie the pathophysiology of ISR. Parameters related to blood cells, entailing both cell count and morphology, are useful markers of the inflammatory response and platelet activation in clinical practice. Recent studies have highlighted several new combined or derived parameters related to blood cells that independently predict ISR after DES implantation...
February 17, 2019: Angiology
Nobutaka Ikeda, Shuji Kubota, Toru Okazaki, Raisuke Iijima, Hidehiko Hara, Yukio Hiroi, Masato Nakamura
OBJECTIVES: The aims of this study were to (1) evaluate risk factors of complications of balloon pulmonary angioplasty (BPA) and (2) assess the mechanism of the complications. BACKGROUND: BPA represents a promising treatment option in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). However, the complication ratio differs across reports, and the causes remain controversial. METHODS: All complications found by angiography and non-contrasted computerized tomography (CT) immediately after BPA were recorded...
February 17, 2019: Catheterization and Cardiovascular Interventions
Jan Biegus, Robert Zymliński, Mateusz Sokolski, John Todd, Gad Cotter, Marco Metra, Ewa A Jankowska, Waldemar Banasiak, Piotr Ponikowski
AIMS: The clinical significance of the measurement of urine sodium concentration (UNa+ ) in response to loop diuretic administration in patients with acute heart failure (AHF) is still unsettled. We studied the association of serial measurements of spot UNa+ during the first 48 h of AHF treatment with the indices of decongestion, renal function, and prognosis. METHODS AND RESULTS: We enrolled 111 AHF patients, all of whom received intravenous furosemide on admission...
February 17, 2019: European Journal of Heart Failure
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