Sai-Nan Miao, Meng-Qi Chai, Xiang-Yu Liu, Cheng-Yu Wei, Cun-Cun Zhang, Ning-Ning Sun, Qing-Ze Fei, Lin-Lin Peng, Huan Qiu
BACKGROUND AND PURPOSE: In recent years, there has been extensive research on the role of exercise as an adjunctive therapy for cancer. However, the potential mechanisms underlying the anti-tumor therapy of exercise in lung cancer remain to be fully elucidated. As such, our study aims to confirm whether exercise-induced elevation of epinephrine can accelerate CD8+ T cell recruitment through modulation of chemokines and thus ultimately inhibit tumor progression. METHOD: C57BL/6 mice were subcutaneously inoculated with Lewis lung cancer cells (LLCs) to establish a subcutaneous tumor model...
April 15, 2024: BMC Cancer