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Luis C Valencia, Giovanny F Pérez, Jordan Kaplan, Ricardo Fernández-Riera
BACKGROUND: Buccal fat pad excision is a procedure in which the fat pad is extracted in order to achieve a more youthful appearance. OBJECTIVES: To describe an alternative technique that utilizes hydrodissection as a means to extract the buccal fat pad. METHODS: This is a controlled, prospective, randomized clinical study with two groups. Group A (n=27) underwent buccal fat pad excision with hydrodissection, and 15 ml of a vasoconstricting anesthetic solution was injected into the buccal fat pad...
February 15, 2019: Aesthetic Surgery Journal
Trevor P Fidler, Alex Marti, Katelyn Gerth, Elizabeth A Middleton, Robert A Campbell, Matthew T Rondina, Andrew S Weyrich, E Dale Abel
Patients with type 1 diabetes mellitus (T1DM) have increased thrombosis and platelet activation. The mechanisms for platelet hyperactivation in diabetes are incompletely understood. T1DM is accompanied by hyperglycemia, dyslipidemia, and increased inflammation, in addition to an altered hormonal milieu. In vitro analysis of platelets revealed that normal glucose reduces platelet activation while hyperglycemic conditions increase platelet activation. We therefore hypothesized that hyperglycemia increases platelet glucose utilization, which increases platelet activation to promote thrombosis...
February 14, 2019: Diabetes
Camille Braun, Philippe Eigenmann
Food allergy reduces the quality of allergic children life because of a lethal risk. Current recommendations are favouring introduction of potentially allergenic foods according to usual, non-delayed, practices. In allergic children, intramuscular epinephrine is the key treatment of anaphylaxis. A self-injectable device must be prescribed in the presence of a severe reaction risk. Allergen avoidance is currently best to avoid an allergic reaction. Specific immunotherapy, essentially oral, is the only treatment for tolerance induction in allergic patients, and may be discussed to prevent severe reactions in the case of accidental ingestion...
February 13, 2019: Revue Médicale Suisse
Georges J M Maestroni
Hematopoiesis produce every day billions of blood cells and takes place in the bone marrow (BM) by the proliferation and differentiation of hematopoietic stem cells (HSC). HSC are found mainly adjacent to the BM vascular sinusoids where endothelial cells and mesenchimal stromal cells promote HSC maintenance by producing a variety of factors. Other cell types that regulate HSC niches include sympathetic nerves, non-myelinating Schwann cells and a variety of mature hematopoietic cells such as macrophages, neutrophils, and megakaryocytes...
February 14, 2019: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
(no author information available yet)
Cis-1,1,1,4,4,4-hexafluoro-2-butene (HFO-1336mzz-Z) is a clear, colorless liquid that finds uses as a foam-blowing agent, refrigerant, fire extinguishing agent, and solvent. HFO-1336mzz-Z is not an acute dermal or eye irritant and has very low acute toxicity via inhalation exposure (4-h lethal concentration (LC50 ) > 102,000 ppm). The no-observed adverse effect level (NOAEL) and lowest-observed adverse effect level (LOAEL) for cardiac sensitization (in epinephrine-challenged dogs) were 12,500 ppm and 25,000 ppm, respectively...
February 13, 2019: Toxicology and Industrial Health
Stoyan Dimitrov, Tanja Lange, Cécile Gouttefangeas, Anja T R Jensen, Michael Szczepanski, Jannik Lehnnolz, Surjo Soekadar, Hans-Georg Rammensee, Jan Born, Luciana Besedovsky
Efficient T cell responses require the firm adhesion of T cells to their targets, e.g., virus-infected cells, which depends on T cell receptor (TCR)-mediated activation of β2 -integrins. Gαs -coupled receptor agonists are known to have immunosuppressive effects, but their impact on TCR-mediated integrin activation is unknown. Using multimers of peptide major histocompatibility complex molecules (pMHC) and of ICAM-1-the ligand of β2 -integrins-we show that the Gαs -coupled receptor agonists isoproterenol, epinephrine, norepinephrine, prostaglandin (PG) E2 , PGD2 , and adenosine strongly inhibit integrin activation on human CMV- and EBV-specific CD8+ T cells in a dose-dependent manner...
February 12, 2019: Journal of Experimental Medicine
Peter V Bui, Nathan L Haas, Nicholas W C Herrman, Matthew Macias, Victoria Hoch, William Schaeffer, Christopher Wallace
BACKGROUND: Brugada pattern on electrocardiography (ECG) can manifest as type 1 (coved pattern) and type 2 (saddleback pattern). Brugada syndrome represents an ECG with Brugada pattern in a patient with symptoms or clinical factors, including syncope, cardiac arrest, ventricular dysrhythmias, and family history. Brugada syndrome is caused by a genetic channelopathy, but the Brugada pattern may be drug-induced. Epinephrine-induced Brugada pattern has not been reported previously. CASE REPORT: A 63-year-old man developed anaphylaxis secondary to a bee sting, had a transient loss of consciousness, and self-administered intramuscular epinephrine...
February 9, 2019: Journal of Emergency Medicine
Reyhaneh Nosrati, Steve Lin, Rohit Mohindra, Andrew Ramadeen, Vladislav Toronov, Paul Dorian
OBJECTIVES: Epinephrine is routinely administered to sudden cardiac arrest patients during resuscitation, but the neurologic effects on patients treated with epinephrine are not well understood. This study aims to assess the cerebral oxygenation and metabolism during ventricular fibrillation cardiac arrest, cardiopulmonary resuscitation, and epinephrine administration. DESIGN: To investigate the effects of equal dosages of IV epinephrine administrated following sudden cardiac arrest as a continuous infusion or successive boluses during cardiopulmonary resuscitation, we monitored cerebral oxygenation and metabolism using hyperspectral near-infrared spectroscopy...
February 8, 2019: Critical Care Medicine
Ala'a F Eftaiha, Farah M Mustafa, Fatima Alsoubani, Khaleel I Assaf, Abdussalam K Qaroush
Bio-renewables are emerging as potential materials for CO2 sorption. Epinephrine is employed as a green scrubbing agent for CO2 capturing through the formation of a metal carbamate as proved by 1H, 13C and 1H-15N NMR and ex situ ATR-FTIR spectroscopy, as well as supported by quantum-chemical calculations.
February 12, 2019: Chemical Communications: Chem Comm
Dana A Dominguez, Sora Ely, Cynthia Bach, Tina Lee, Jeffrey B Velotta
Background: Postsurgical pain control can have a significant impact on patient outcomes and hospital-associated costs. We sought to evaluate the effect of intercostal nerve blocks using liposomal bupivacaine on length of stay (LOS) in patients undergoing video-assisted thoracoscopic surgery (VATS). Methods: We retrospectively reviewed outcomes in 80 patients undergoing VATS wedge resection, VATS lobectomy, or minimally-invasive esophagectomy (MIE). Patients received either liposomal bupivacaine (n=40) or standard-release bupivacaine with epinephrine (n=40) via intercostal nerve block...
December 2018: Journal of Thoracic Disease
Antonio Córdoba-Fernández, Jesús González-Benítez, Adrián Lobo-Martín
PURPOSE: The study was conducted to investigate the onset time and safety profile of four different local anesthetic solutions. DESIGN: Randomized controlled clinical trial study. METHODS: One hundred twelve healthy volunteers were assigned to receive digital block on their second toe. Individuals were randomly assigned to one of the following groups: lidocaine 2%, lidocaine 2% with epinephrine, bupivacaine 0.5%, or bupivacaine 0.5% with epinephrine...
February 7, 2019: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
Maria Melchert, Christine Aurich, Jörg Aurich, Camille Gautier, Christina Nagel
Mares usually give birth when they perceive their environment as safe and therefore disturbance at foaling may inhibit labor. In this study, foaling mares were transferred to an unfamiliar environment at rupture of the allantochorion (stress, n = 6) or were left undisturbed (control, n = 5). The progress of foaling, heart rate, heart rate variability (HRV) and plasma catecholamine, oxytocin and cortisol concentration were determined. In stressed mares, time from rupture of the allantochorion to appearance of the fetal feet (5...
February 4, 2019: Theriogenology
Sean McGregor, Alyssa Miceli, Karthik Krishnamurthy
BACKGROUND: Sclerotherapy is used to treat varicosities and telangiectases. Glycerin is a sclerosing agent that has been used off-label for years with a favorable adverse effect profile. However, the treatment of facial telangiectases with sclerotherapy is controversial given the potential for necrosis and embolization in relation to the complex vascular anatomy of the face. OBJECTIVE: To determine the safety and efficacy of glycerin sclerotherapy for the treatment of facial telangiectases...
February 6, 2019: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Bruna Romana-Souza, Andréa Monte-Alto-Costa
OBJECTIVE: Chronic stress-induced oxidative damage and protease synthesis cause a loss of extracellular matrix components promoting human skin aging. The administration of antioxidant compounds, such as those observed in olive oil, may attenuate stress-induced aging signs in human skin. Thus, the aim of this study was to investigate the effect of olive oil administration in ex vivo stressed human skin. METHODS: Explants of human skin were treated with high levels of epinephrine (as observed in stressed patients) and olive oil in medium for 13 days...
February 10, 2019: International Journal of Cosmetic Science
Julianna Jung, Julie Rice, Sharon Bord
No abstract text is available yet for this article.
December 2018: Annals of Translational Medicine
Yun Young Yim, Katherine M Betke, W Hayes McDonald, Ralf Gilsbach, Yunjia Chen, Karren Hyde, Qin Wang, Lutz Hein, Heidi Hamm
G proteins are major transducers of signals from G-protein coupled receptors (GPCRs). They are made up of α, β, and γ subunits, with 16 Gα, 5 Gβ and 12 Gγ subunits. Though much is known about the specificity of Gα subunits, the specificity of Gβγs activated by a given GPCR and that activate each effector in vivo is not known. Here, we examined the in vivo Gβγ specificity of presynaptic α2a -adrenergic receptors (α2a ARs) in both adrenergic (auto-α2a ARs) and non-adrenergic neurons (hetero-α2a ARs) for the first time...
February 8, 2019: Scientific Reports
Matthew Greenhawt, Ruchi S Gupta, J Allen Meadows, Michael Pistiner, Jonathan M Spergel, Carlos A Camargo, F Estelle R Simons, Philip L Lieberman
Infant anaphylaxis is an emerging risk, with food allergy the most common cause. Although the presentation of anaphylaxis involves the same systems as in older children and adults, there are real-world challenges to identifying symptoms of an allergic emergency in nonverbal children, as well as implementing optimal treatment. Recognition of anaphylaxis in infants can be challenging because allergic symptoms and certain normal infant behaviors may overlap. Intramuscular epinephrine is the treatment of choice for infants, as it is for older children and adults, and an epinephrine autoinjector approved by the Food and Drug Administration is now available for infants weighing between 7...
February 5, 2019: Journal of Allergy and Clinical Immunology in Practice
Takuya Iseki, Sachiyuki Tsukada, Motohiro Wakui, Kenji Kurosaka, Shinichi Yoshiya
BACKGROUND: Although intraoperative periarticular multi-drug injection has been used for postoperative pain control after total knee arthroplasty (TKA), the injection has the inherent shortcoming of limited acting time. This randomized controlled trial was performed to assess whether adding percutaneous periarticular multi-drug injection at the day following TKA would improve the postoperative pain relief. METHODS: A total of 43 participants were randomly assigned to receive additional periarticular injection at 08:30, postoperative day 1 or no additional injection...
February 8, 2019: BMC Musculoskeletal Disorders
Jorge Felipe Argenta Model, Jordana Tres Dos Santos, Roselis Silveira Martins Da Silva, Anapaula Sommer Vinagre
Although widely known for their involvement in the control of carbohydrate and lipid metabolism of vertebrates, the participation of catecholamines (CAs) in the metabolism of invertebrates is less understood. This study was designed to identify the physiological role of Epinephrine (E) in the intermediary metabolism of the burrowing crab Neohelice granulata and how E regulates the metabolism in crabs fed with a high-carbohydrate (HC) or a high-protein (HP) diet. To answer these questions, we evaluated in vivo the effects of E injections on glucose and triglycerides in the hemolymph and tissue glycogen levels of crabs fed with HC or HP diet...
February 5, 2019: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Josefine Bunke, Rafi Sheikh, Nina Reistad, Malin Malmsjö
BACKGROUND: The aim of this study was to investigate the possibility of using extended-wavelength diffuse reflectance spectroscopy (EW-DRS) to measure tissue response related to blood perfusion. The study was performed on a model that we have previously found to be useful for studying techniques for perfusion monitoring following the injection of epinephrine in a local anesthetic in the human forearm. METHODS: Nine healthy subjects were included in the study. Spectroscopy was performed with an EW-DRS system using a combination of two spectrometers to resolve light in the visible (350 nm to 1100 nm) and the near-infrared regions (900 nm to 1700 nm)...
February 2, 2019: Microvascular Research
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