keyword
https://read.qxmd.com/read/38532394/evaluating-the-association-between-duration-of-breastfeeding-and-fine-motor-development-among-children-aged-20-to-24-months-in-butajira-ethiopia-a-case-control-study
#21
JOURNAL ARTICLE
Rediate Shiferaw, Robel Yirgu, Yalemwork Getnet
BACKGROUND: A Suitable environment and proper child nutrition are paramount to a child's physical and mental development. Different environmental factors contribute to proper child development. Breast milk is an important source of nutrition during the early years of life and contains essential nutrients that are the building blocks for growth and development. OBJECTIVE: To assess the association between the duration of breastfeeding and fine motor development among children aged 20 to 24 months living in Butajira, southern Ethiopia...
March 27, 2024: BMC Pediatrics
https://read.qxmd.com/read/38532147/prediction-of-short-and-long-term-outcomes-using-pre-operative-ventricular-size-in-infants-with-post-hemorrhagic-ventricular-dilation
#22
JOURNAL ARTICLE
Molly Serebin, Jian Zhang, Ke Yan, Erwin Cabacungan, Tejaswini Deshmukh, Mohit Maheshwari, Andrew Foy, Susan Cohen
PURPOSE: Post-hemorrhagic ventricular dilation (PHVD) leads to developmental delays in premature infants, yet the optimal timing of neurosurgical interventions is unknown. Neuroimaging modalities have emerged to delineate injury and follow the progression of PHVD. Fronto-temporal horn ratio (FTHR) is used as a marker of ventricular dilation and can be a standardized tool to direct the timing of neurosurgical intervention. Our study determined a pre-operative FTHR measurement threshold to predict short- and long-term outcomes...
March 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38531968/prismatic-adaptation-coupled-with-cognitive-training-as-novel-treatment-for-developmental-dyslexia-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Giulia Conte, Lauro Quadrana, Lilian Zotti, Agnese Di Garbo, Massimiliano Oliveri
Despite intense and costly treatments, developmental dyslexia (DD) often persists into adulthood. Several brain skills unrelated to speech sound processing (i.e., phonology), including the spatial distribution of visual attention, are abnormal in DD and may represent possible treatment targets. This study explores the efficacy in DD of rightward prismatic adaptation (rPA), a visuomotor adaptation technique that enables visuo-attentive recalibration through shifts in the visual field induced by prismatic goggles...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531365/de-novo-missense-variants-in-exon-9-of-sephs1-cause-a-neurodevelopmental-condition-with-developmental-delay-poor-growth-hypotonia-and-dysmorphic-features
#24
JOURNAL ARTICLE
Sureni V Mullegama, Kaitlyn A Kiernan, Erin Torti, Ethan Pavlovsky, Nicholas Tilton, Austin Sekula, Hua Gao, Joseph T Alaimo, Kendra Engleman, Eric T Rush, Karli Blocker, Katrina M Dipple, Veronica M Fettig, Heather Hare, Ian Glass, Dorothy K Grange, Michael Griffin, Chanika Phornphutkul, Lauren Massingham, Lakshmi Mehta, Danny E Miller, Jenny Thies, J Lawrence Merritt, Eric Muller, Matthew Osmond, Sarah L Sawyer, Rachel Slaugh, Rachel E Hickey, Barry Wolf, Sanjeev Choudhary, Miljan Simonović, Yueqing Zhang, Timothy Blake Palculict, Aida Telegrafi, Deanna Alexis Carere, Ingrid M Wentzensen, Michelle M Morrow, Kristin G Monaghan, Jun Yang, Jane Juusola
Selenophosphate synthetase (SEPHS) plays an essential role in selenium metabolism. Two mammalian SEPHS paralogues, SEPHS1 and SEPHS2, share high sequence identity and structural homology with SEPHS. Here, we report nine individuals from eight families with developmental delay, growth and feeding problems, hypotonia, and dysmorphic features, all with heterozygous missense variants in SEPHS1. Eight of these individuals had a recurrent variant at amino acid position 371 of SEPHS1 (p.Arg371Trp, p.Arg371Gln, and p...
March 21, 2024: American Journal of Human Genetics
https://read.qxmd.com/read/38531261/developmental-programming-of-the-ovarian-reserve-in-livestock
#25
JOURNAL ARTICLE
Robert A Cushman, Vahid Akbarinejad, George A Perry, Clay A Lents
Mammalian females are born with a finite number of follicles in their ovaries that is referred to as the ovarian reserve. There is a large amount of variation between females in the number of antral follicles that they are born with, but this number is positively correlated to size of the ovarian reserve, has a strong repeatability within a female, and a moderate heritability. Although the heritability is moderate, numerous external factors including health, nutrition, ambient temperature, and litter size influence the size and function of the ovarian reserve throughout life...
March 19, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38531017/clinical-characteristics-developmental-trajectory-and-caregiver-burden-of-patients-with-creatine-transporter-deficiency-slc6a8
#26
JOURNAL ARTICLE
Aurore Curie, Laurence Lion-François, Vassili Valayannopoulos, Nathalie Perreton, Marie Gavanon, Nathalie Touil, Amandine Brun-Laurisse, Fahra Gheurbi, Marion Buchy, Hulya Halep, David Cheillan, Catherine Mercier, Anaïs Brassier, Béatrice Desnous, Behrouz Kassai, Pascale De Lonlay, Vincent Des Portes
BACKGROUND AND OBJECTIVES: Creatine transporter deficiency (CTD) is a rare X-linked genetic disorder characterized by intellectual disability (ID). We evaluated the clinical characteristics and trajectory of patients with CTD and the impact of the disease on caregivers to identify relevant endpoints for future therapeutic trials. METHODS: As part of a French National Research Program, patients with CTD were included based on (1) a pathogenic SLC6A8 variant and (2) ID and/or autism spectrum disorder...
April 23, 2024: Neurology
https://read.qxmd.com/read/38530558/logistic-regression-and-other-statistical-tools-in-diagnostic-biomarker-studies
#27
JOURNAL ARTICLE
Dina Mohamed Ahmed Samir Elkahwagy, Caroline Joseph Kiriacos
A biomarker is a measured indicator of a variety of processes, and is often used as a clinical tool for the diagnosis of diseases. While the developmental process of biomarkers from lab to clinic is complex, initial exploratory stages often focus on characterizing the potential of biomarkers through utilizing various statistical methods that can be used to assess their discriminatory performance, establish an appropriate cut-off that transforms continuous data to apt binary responses of confirming or excluding a diagnosis, or establish a robust association when tested against confounders...
March 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38530427/plant-regeneration-capacity-in-seeds-of-three-species-of-miconia-melastomataceae-may-be-related-to-endogenous-polyamine-profiles
#28
JOURNAL ARTICLE
Juliana Klostermann Ziemmer, Tadeu Dos Reis de Oliveira, Claudete Santa-Catarina, Leila do Nascimento Vieira, Renato Goldenberg, Hugo Pacheco de Freitas Fraga
In plant tissue culture, differences in endogenous levels of species-specific plant growth regulators (PGRs) may explain differences in regenerative capacity. In the case of polyamines (PAs), their dynamics and distribution may vary between species, genotypes, tissues, and developmental pathways, such as sexual reproduction and apomixis. In this study, for the first time, we aimed to assess the impact of varying endogenous PAs levels in seeds from distinct reproductive modes in Miconia spp. (Melastomataceae), on their in vitro regenerative capacity...
March 26, 2024: Protoplasma
https://read.qxmd.com/read/38530142/single-nucleotide-polymorphisms-of-ankk1-ddr4-and-grin2b-genes-predict-behavior-in-a-prospective-cohort-of-mexican-children-and-adolescents
#29
JOURNAL ARTICLE
Barbara Moctezuma, Ángel Santiago, Ana Burguete-García, Jesus Martínez-Barnetche, Claudia Morales-Gómez, Carmen Hernandez-Chavez, Gabriela Gil, Karen E Peterson, Martha M Tellez-Rojo, Hector Lamadrid-Figueroa
Numerous studies have established associations between single nucleotide polymorphisms (SNPs) and various behavioral and neurodevelopmental conditions. This study explores the links between SNPs in candidate genes involved in central nervous system (CNS) physiology and their implications for the behavioral and emotional aspects in children and teenagers. A total of 590 participants, aged 7-15 years, from the Early Life Exposures In Mexico To Environmental Toxicants (ELEMENT) cohort study in Mexico City, underwent genotyping for at least one of 15 CNS gene-related SNPs at different timepoints...
March 26, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38529891/older-adults-decision-making-following-bad-advice
#30
JOURNAL ARTICLE
Tarren Leon, Gabrielle Weidemann, Phoebe E Bailey
There is minimal research investigating the influence of advice on decision-making in older age. The present study investigated the effect of different types of bad advice, relative to no advice, on young and older adults' decision-making in the Iowa Gambling Task (IGT). Fifty-four older adults and 59 young adults completed the IGT after receiving no advice, or advice to select from disadvantageous deck A (small, high-frequency losses), or disadvantageous deck B (larger, low-frequency losses). Corrugator EMG, memory and fluid intelligence were assessed...
March 26, 2024: British Journal of Developmental Psychology
https://read.qxmd.com/read/38529888/co-developmental-trajectories-of-suicidal-ideation-and-non-suicidal-self-injury-among-chinese-adolescents-transdiagnostic-predictors-and-association-with-suicide-attempts
#31
JOURNAL ARTICLE
Yunhong Shen, Danrui Chen, Jiaqi Guo, Yue Zheng, Jiajing Zhang, Shiting Zhan, Jianing You
INTRODUCTION: Adolescent suicidal ideation (SI) and non-suicidal self-injury (NSSI) are crucial public health issues, yet their co-developmental trajectories during early adolescence and their associations with predictors and outcomes are unclear. This study aimed to (a) identify heterogeneous co-developmental trajectories of SI and NSSI, (b) explore associations between transdiagnostic predictors and trajectories, and (c) assess suicide attempt risk across trajectories. METHODS: Four hundred fifty-three adolescents (Mage  = 12...
March 26, 2024: Suicide & Life-threatening Behavior
https://read.qxmd.com/read/38529405/superior-migration-ability-of-umbilical-cord-derived-mesenchymal-stromal-cells-mscs-toward-activated-lymphocytes-in-comparison-with-those-of-bone-marrow-and-adipose-derived-mscs
#32
JOURNAL ARTICLE
Akiko Hori, Atsuko Takahashi, Yuta Miharu, Satoru Yamaguchi, Masatoshi Sugita, Takeo Mukai, Fumitaka Nagamura, Tokiko Nagamura-Inoue
Introduction: Mesenchymal stromal cells (MSCs) are activated upon inflammation and/or tissue damage and migrate to suppress inflammation and repair tissues. Migration is the first important step for MSCs to become functional; however, the migration potency of umbilical cord-derived MSCs (UC-MSCs) remains poorly understood. Thus, we aimed to assess the migration potency of UC-MSCs in comparison with those of bone marrow-derived MSCs (BM-MSCs) and adipose tissue-derived MSCs (AD-MSCs) and investigate the influence of chemotactic factors on the migration of these cells...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38528903/medical-students-perceptions-on-preparedness-and-care-delivery-for-patients-with-autism-or-intellectual-disability
#33
JOURNAL ARTICLE
E Bitektine, M A Hintermayer, A Chen, A Ko, C Rodriguez
INTRODUCTION: To provide competent care to patients with autism spectrum disorder (ASD) or intellectual developmental disorder (IDD), healthcare professionals must recognize the needs of neurodivergent populations and adapt their clinical approach. We assessed the perceived preparedness of medical students to adapt care delivery for patients with ASD/IDD, as well as their perceptions on neurodiversity education. METHODS: We conducted a sequential explanatory mixed-methods study on undergraduate medical students at McGill University during the academic year 2020-2021...
February 2024: Canadian Medical Education Journal
https://read.qxmd.com/read/38528816/the-importance-of-decomposing-periodic-and-aperiodic-eeg-signals-for-assessment-of-brain-function-in-a-global-context
#34
JOURNAL ARTICLE
Teresa Del Bianco, Rianne Haartsen, Luke Mason, Virginia Carter Leno, Cilla Springer, Mandy Potter, Wendy Mackay, Petrusa Smit, Carlie Du Plessis, Lucy Brink, Mark H Johnson, Declan Murphy, Eva Loth, Hein Odendaal, Emily J H Jones
Measures of early neuro-cognitive development that are suitable for use in low-resource settings are needed to enable studies of the effects of early adversity on the developing brain in a global context. These measures should have high acquisition rates and good face and construct validity. Here, we investigated the feasibility of a naturalistic electroencephalography (EEG) paradigm in a low-resource context during childhood. Additionally, we examined the sensitivity of periodic and aperiodic EEG metrics to social and non-social stimuli...
May 2024: Developmental Psychobiology
https://read.qxmd.com/read/38528754/alcohol-use-and-moffitt-s-maturity-gap-thesis-for-adolescent-offending-an-evolutionary-perspective-and-analysis
#35
JOURNAL ARTICLE
Meghan L Royle, Eric J Connolly
While a wealth of research has focused on testing several arguments from Moffitt's developmental taxonomy of antisocial behavior-mainly the presence of life-course-persistent vs. adolescence-limited offending and predictors of each trajectory-much less attention has been devoted to examining how evolutionarily adaptive lifestyle factors common during adolescence may condition the relationship between the maturity gap and delinquent offending. One factor that may play a role during this period of development is alcohol use, as many adolescents begin to experiment with consuming alcohol in varying degrees in social settings to model adult-like behaviors...
2024: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
https://read.qxmd.com/read/38528603/building-a-maternal-and-child-cohort-amidst-lebanon-s-socioeconomic-collapse-preliminary-results-and-navigating-research-challenges
#36
JOURNAL ARTICLE
Rima Kaddoura, Martine Elbejjani, Hani Tamim, Ziyad R Mahfoud, Pascale Salameh, Fadi Mirza, Lama Charafeddine
The impact of conflict and crisis on maternal and child health underscores the need for reliable research in vulnerable populations. Lebanon, amidst ongoing economic collapse, political instability, and healthcare system strain, offers a case study for exploring these impacts, particularly on preterm babies and their development. This study aims to assess the feasibility of establishing a prospective cohort of mothers and their full-term and preterm babies in Lebanon, examining the association between social determinants, preterm birth, and developmental outcomes amidst the nation's multifaceted crises...
March 26, 2024: Population Health Metrics
https://read.qxmd.com/read/38528452/design-and-usability-evaluation-of-a-mobile-application-for-self-care-among-iranian-adolescents
#37
JOURNAL ARTICLE
Razieh Rezaee, Mohtasham Ghaffari, Reza Rabiei, Amir Kavousi, Sakineh Rakhshanderou
BACKGROUND: Mobile phones can be an ideal platform to engage adolescents to maintain, improve, and promote self-care. Therefore, the current study aims to design and evaluate the usability of a mobile application for self-care in adolescents with a user-centered approach. METHODS: The current applied developmental study was done in four steps. The first step, polling and examining opinions was conducted through in-depth semi-structured interviews, with the aim of user-centered mobile application design with the involvement of 30 participants...
March 25, 2024: BMC Public Health
https://read.qxmd.com/read/38528201/pervasive-environmental-chemicals-impair-oligodendrocyte-development
#38
JOURNAL ARTICLE
Erin F Cohn, Benjamin L L Clayton, Mayur Madhavan, Kristin A Lee, Sara Yacoub, Yuriy Fedorov, Marissa A Scavuzzo, Katie Paul Friedman, Timothy J Shafer, Paul J Tesar
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as their development extends from gestation into adulthood. However, few environmental chemicals have been assessed for potential risks to oligodendrocytes. Here, using a high-throughput developmental screen in cultured cells, we identified environmental chemicals in two classes that disrupt oligodendrocyte development through distinct mechanisms. Quaternary compounds, ubiquitous in disinfecting agents and personal care products, were potently and selectively cytotoxic to developing oligodendrocytes, whereas organophosphate flame retardants, commonly found in household items such as furniture and electronics, prematurely arrested oligodendrocyte maturation...
March 25, 2024: Nature Neuroscience
https://read.qxmd.com/read/38527349/quality-of-life-after-lower-leg-reconstruction-with-the-latissimus-dorsi-free-flap-in-pediatric-patients
#39
JOURNAL ARTICLE
Atenas Bustamante, Abraham Zavala, Martin Iglesias, Ray Tornero, Lucero Machaca, Wieslawa De Pawlikowski
BACKGROUND: The latissimus dorsi free flap is a widely used reconstructive technique for complex lower leg defects in the pediatric population due to its reliability and anatomical features. However, the impact of this technique on the postoperative quality of life in children and adolescents, who require appropriate lower extremity function during their developmental period, remains to be analyzed. METHODS: Patients who underwent microsurgical lower leg reconstruction using the latissimus dorsi flap were analyzed retrospectively...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38526542/using-longitudinal-twitter-data-for-digital-epidemiology-of-childhood-health-outcomes-an-annotated-data-set-and-deep-neural-network-classifiers
#40
JOURNAL ARTICLE
Ari Z Klein, José Agustín Gutiérrez Gómez, Lisa D Levine, Graciela Gonzalez-Hernandez
We manually annotated 9734 tweets that were posted by users who reported their pregnancy on Twitter, and used them to train, evaluate, and deploy deep neural network classifiers (F1 -score=0.93) to detect tweets that report having a child with attention-deficit/hyperactivity disorder (678 users), autism spectrum disorders (1744 users), delayed speech (902 users), or asthma (1255 users), demonstrating the potential of Twitter as a complementary resource for assessing associations between pregnancy exposures and childhood health outcomes on a large scale...
March 25, 2024: Journal of Medical Internet Research
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