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Addictive disorders

Konstantinos Ioannidis, Roxanne Hook, Anna E Goudriaan, Simon Vlies, Naomi A Fineberg, Jon E Grant, Samuel R Chamberlain
BACKGROUND: Excessive use of the internet is increasingly recognised as a global public health concern. Individual studies have reported cognitive impairment in problematic internet use (PIU), but have suffered from various methodological limitations. Confirmation of cognitive deficits in PIU would support the neurobiological plausibility of this disorder.AimsTo conduct a rigorous meta-analysis of cognitive performance in PIU from case-control studies; and to assess the impact of study quality, the main type of online behaviour (for example gaming) and other parameters on the findings...
February 20, 2019: British Journal of Psychiatry: the Journal of Mental Science
Marisa Silbernagl, Rudolf Slamanig, Maike Stegemann, Michael Sterzer, Laura Mayer, Gabriele Fischer, Annemarie Unger
OBJECTIVE: Attention-deficit hyperactivity disorder (ADHD) often coincides with substance abuse and delinquency. A sample of opioid-maintained inmates was assessed for symptoms of ADHD, substance abuse history, types of offense, psychiatric comorbidities, and psychopharmacological treatment using a standardized battery of instruments. METHOD: Adult inmates (n = 133, mean age 35.7 years, 21.8% female) in opioid-maintenance therapy (OMT) were administered the Adult ADHD self-report scale, Wender Utah Rating Scale, Mini International Neuropsychiatric Interview, -European Addiction Severity Index...
February 18, 2019: European Addiction Research
Germa Catherina Maria Nass, Leon Willem van Rens, Boukje Arnolda Gerdina Dijkstra
BACKGROUND: Posttraumatic Stress Disorder (PTSD) is more common in patients with Substance Use Disorder (SUD) than in the general population. Although international guidelines recommend integrated treatment clinicians are still hesitant in offering integrated treatment and more concrete recommendations are needed. This study aims to contribute to a practice-based guideline through the exploration of practice-based decision criteria to determine the indication and treatment of SUD and PTSD...
February 19, 2019: Substance Abuse Treatment, Prevention, and Policy
Ryan Nicholson, Corey Mackenzie, Tracie O Afifi, Matthew Keough, Jitender Sareen
Substantial changes were made with the creation of the Substance Related and Addictive Disorders category in the fifth edition of the Diagnostic and Statistical Manual (DSM-5; APA in Diagnostic and statistical manual of mental disorders, 5th edn, American Psychiatric Publishing, Arlington, 2013a), including the addition of gambling disorder to the category and a reduction in the minimum threshold of diagnostic criteria required for a gambling disorder. As gambling shares many similarities with substance use disorders, it stands to reason that comorbidity rates of other psychiatric disorders would be similar among gambling and substance use disorders...
February 18, 2019: Journal of Gambling Studies
Jordan E Stevens, Douglas Steinley, Yoanna E McDowell, Cassandra L Boness, Timothy J Trull, Christopher S Martin, Kenneth J Sher
Psychiatric diagnostic systems, such as The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), use expert consensus to determine diagnostic criteria sets and rules (DCSRs), rather than exploiting empirical techniques to arrive at optimal solutions (OS). Our project utilizes complete enumeration (i.e., generating all possible subsets of item combinations A and B with all possible thresholds, T) to evaluate all possible DCSRs given a set of relevant diagnostic data. This method yields the entire population distribution of diagnostic classifications (i...
February 5, 2019: Addictive Behaviors
Jennifer McNeely, Andrea B Troxel, Hillary V Kunins, Donna Shelley, Joshua D Lee, Alexander Walley, Zoe M Weinstein, John Billings, Nichola J Davis, Roopa Kalyanaraman Marcello, Bruce R Schackman, Charles Barron, Luke Bergmann
BACKGROUND: Treatment for opioid use disorder (OUD) is highly effective, yet it remains dramatically underutilized. Individuals with OUD have disproportionately high rates of hospitalization and low rates of addiction treatment. Hospital-based addiction consult services offer a potential solution by using multidisciplinary teams to evaluate patients, initiate medication for addiction treatment (MAT) in the hospital, and connect patients to post-discharge care. We are studying the effectiveness of an addiction consult model [Consult for Addiction Treatment and Care in Hospitals (CATCH)] as a strategy for engaging patients with OUD in treatment as the program rolls out in the largest municipal hospital system in the US...
February 19, 2019: Addiction Science & Clinical Practice
Reid H Phillips, Matthew Salzman, Rachel Haroz, Rachel Rafeq, Anthony J Mazzarelli, Alexis Pelletier-Bui
We present a case of elective naloxone-induced opioid withdrawal followed by buprenorphine rescue to initiate opioid use disorder treatment in the emergency department. This strategy may represent a safe alternative to prescribing buprenorphine for outpatient initiation, a method that puts the patient at risk for complications of unmonitored opioid withdrawal, including relapse. After confirmation that the naloxone-induced withdrawal was adequately treated with buprenorphine, the patient was discharged with prescribed buprenorphine to follow up in an addiction medicine clinic, where he was treated 2 days later...
February 14, 2019: Annals of Emergency Medicine
Naomi A Fineberg, Bernardo Dell'Osso, Umberto Albert, Giuseppe Maina, Daniel Geller, Lior Carmi, Nick Sireau, Susanne Walitza, Giacomo Grassi, Stefano Pallanti, Eric Hollander, Vlasios Brakoulias, Jose M Menchon, Donatella Marazziti, Konstantinos Ioannidis, Annemieke Apergis-Schoute, Dan J Stein, Danielle C Cath, Dick J Veltman, Michael Van Ameringen, Leonardo F Fontenelle, Roseli G Shavitt, Daniel Costa, Juliana B Diniz, Joseph Zohar
Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD...
February 14, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Thomas Schwitzer, Raymund Schwan, Karine Angioi-Duprez, Laurence Lalanne, Anne Giersch, Vincent Laprevote
Owing to the difficulty of obtaining direct access to the functioning brain, new approaches are needed for the indirect exploration of brain disorders in neuroscience research. Due to its embryonic origin, the retina is part of the central nervous system and is well suited to the investigation of neurological functions in psychiatric and addictive disorders. In this review, we focus on cannabis use, which is a crucial public health challenge, since cannabis is one of the most widely used addictive drugs in industrialized countries...
February 14, 2019: Neuroscience and Biobehavioral Reviews
Chuan-Yu Chen, I-An Wang, Shao-You Fang, Nicole Huang, Jen-Huoy Tsay, Su-Hui Chang
AIMS: The present study aims to investigate the utilization pattern of prenatal care and correlates for women with opioid use disorders (OUD) in Taiwan. METHOD: Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013...
February 13, 2019: International Journal on Drug Policy
Mayuri Shukla, Subhamita Maitra, Jean-François Hernandez, Piyarat Govitrapong, Bruno Vincent
Methamphetamine is a potent and highly addictive psychostimulant whose abuse has turned out to be a global health hazard. The multitudinous effects it exerts at the cellular level induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Strikingly, brain changes, tissue damage and neuropsychological symptoms due to Meth exposure compels and necessitates to link the probability of risk of developing premature Alzheimer's disease, a progressive neurodegenerative disorder characterized by amyloid plaques composed of amyloid-β peptides and clinical dementia...
February 13, 2019: Neuroscience Letters
Jérémie Richard, Alexa Martin-Storey, Erin Wilkie, Jeffrey L Derevensky, Thomas Paskus, Caroline E Temcheff
Gambling disorder has serious negative consequences for individual health and wellbeing, while being more prevalent among college student-athletes compared to the general college population. While previous research reports that sexual minority (i.e., gay, lesbian and bisexual) populations have higher rates of addictive behaviors such as alcohol and drug abuse, no previous research has explored risk for gambling disorder symptomatology by sexual identity status. The aim of the current study is to identify differences in the severity of gambling disorder symptomatology between sexual minority and heterosexual student-athletes...
February 15, 2019: Journal of Gambling Studies
Camilla L Nord, Seung-Goo Kim, Mette Buhl Callesen, Timo L Kvamme, Mads Jensen, Mads Uffe Pedersen, Kristine Rømer Thomsen, Valerie Voon
Impulsivity has been suggested as a neurocognitive endophenotype conferring risk across a number of neuropsychiatric conditions, including substance and behavioural addictions, eating disorders, and attention deficit/hyperactivity disorder. We used a paradigm with interspecies translation validity (the four-choice serial reaction time task, 4CSRTT) to assess 'waiting' impulsivity in a youth sample (N = 99, aged 16-26 years). We collected magnetization prepared two rapid acquisition gradient echo (MP2RAGE) scans, which enabled us to measure R1, the longitudinal relaxation rate, a parameter closely related to tissue myelin content, as well as quantify grey matter volume...
February 15, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Gene-Jack Wang, Corinde E Wiers, Elena Shumay, Dardo Tomasi, Kai Yuan, Christopher T Wong, Jean Logan, Joanna S Fowler, Nora D Volkow
The response to drugs of abuse is affected by expectation, which is modulated in part by dopamine (DA), which encodes for a reward prediction error. Here we assessed the effect of expectation on methylphenidate (MP)-induced striatal DA changes in 23 participants with an active cocaine use disorder (CUD) and 23 healthy controls (HC) using [11 C]raclopride and PET both after placebo (PL) and after MP (0.5 mg/kg, i.v.). Brain dopamine D2 and D3 receptor availability (D2R: non-displaceable binding potential (BPND )) was measured under four conditions in randomized order: (1) expecting PL/receiving PL, (2) expecting PL/receiving MP, (3) expecting MP/receiving PL, and (4) expecting MP/receiving MP...
February 15, 2019: Translational Psychiatry
Susan Salmond, Virginia Allread
The United States is in the midst of a nationwide public health emergency: an epidemic of opioid misuse and abuse that has been called the deadliest drug crisis in American history. This article reviews the current status of the opioid epidemic, the trends over the last 30-40 years that may have contributed to the epidemic, and a population health approach to addressing the epidemic. The epidemic is conceptualized from a population health perspective-an upstream and midstream perspective focusing on prevention and a downstream perspective targeting access to evidence-based interventions and maximizing health whether using or abstaining...
February 13, 2019: Orthopaedic Nursing
Marilyn Cyr, Gregory Z Tau, Martine Fontaine, Frances R Levin, Rachel Marsh
OBJECTIVE: Disturbances in self-regulatory control are involved in the initiation and maintenance of addiction, including cannabis use disorder (CUD). In adults, chronic cannabis use is associated with disturbances in fronto-striatal circuits during tasks that require the engagement of self-regulatory control, including the resolution of cognitive conflict. Understudied are the behavioral and neural correlates of these processes earlier in the course of cannabis use, disentangled from effects of long-term use...
October 30, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Mahmood Dhahir Al-Mendalawi
No abstract text is available yet for this article.
November 2018: Indian Journal of Endocrinology and Metabolism
Erin C Smith, Frederick M Burkle
IntroductionIn the years following the September 11, 2001 terrorist attacks in New York City (New York USA), otherwise known as 9/11, first responders began experiencing a range of health and psychosocial impacts. Publications documenting these largely focus on firefighters. This research explores paramedic and emergency medical technician (EMT) reflections on the long-term impact of responding to the 9/11 terrorist attacks. METHODS: Qualitative methods were used to conduct interviews with 54 paramedics and EMTs on the 15-year anniversary of 9/11...
February 2019: Prehospital and Disaster Medicine
Daniel C Ranson, Samir S Ayoub, Olivia Corcoran, Stefano O Casalotti
When exposed to ethanol, Drosophila melanogaster display a variety of addiction-like behaviours similar to those observed in mammals. Sensitivity to ethanol can be quantified by measuring the time at which 50% of the flies are sedated by ethanol exposure (ST50); an increase of ST50 following multiple ethanol exposures is widely interpreted as development of tolerance to ethanol. Sensitivity and tolerance to ethanol were measured after administration of the gamma-aminobutyric acid receptor B (GABAB ) agonist (SKF 97541) and antagonist (CGP 54626), when compared with flies treated with ethanol alone...
February 13, 2019: Addiction Biology
Ana Domi, Serena Stopponi, Esi Domi, Roberto Ciccocioppo, Nazzareno Cannella
Recent animal models of alcohol use disorder (AUD) are centered in capturing individual vulnerability differences in disease progression. Here, we used genetically selected Marchigian Sardinian alcohol-preferring (msP) and Wistars rats to apply a multidimensional model of AUD adapted from a previously described DSM-IV/DSM-5 multisymptomatic cocaine addiction model. As proof of concept, we hypothesized that msP rats, genetically selected for excessive drinking, would be more prone to develop dependence-like behavior compared to Wistars...
2019: Frontiers in Behavioral Neuroscience
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