Celia Ramos, Kairi Lorenz, Marta Putrinš, Charlotte K Hind, Andres Meos, Ivo Laidmäe, Tanel Tenson, J Mark Sutton, A James Mason, Karin Kogermann
Conventional wound infection treatments neither actively promote wound healing nor address the growing problem of antibacterial resistance. Antimicrobial peptides (AMPs) are natural defense molecules, released from host cells, which may be rapidly bactericidal, modulate host-immune responses, and/or act as endogenous mediators for wound healing. However, their routine clinical use has hitherto been hindered due to their instability in the wound environment. Here we describe an electrospun carrier system for topical application of pleurocidin, demonstrating sufficient AMP release from matrices to kill wound-associated pathogens including Acinetobacter baumannii and Pseudomonas aeruginosa...
November 20, 2023: European Journal of Pharmaceutical Sciences