keyword
Keywords Pseudomonas aeruginosa resista...

Pseudomonas aeruginosa resistant synergies

https://read.qxmd.com/read/38004699/determination-of-antimicrobial-resistance-and-the-impact-of-imipenem-cilastatin-synergy-with-tetracycline-in-pseudomonas-aeruginosa-isolates-from-sepsis
#21
JOURNAL ARTICLE
Telma de Sousa, Catarina Silva, Olimpia Alves, Eliana Costa, Gilberto Igrejas, Patricia Poeta, Michel Hébraud
Pseudomonas aeruginosa is among the most ubiquitous bacteria in the natural world, exhibiting metabolic and physiological versatility, which makes it highly adaptable. Imipenem + cilastatin and tetracycline are antibiotic combinations commonly used to treat infections caused by P. aeruginosa , including serious infections such as sepsis. In the context of bacterial infections, biofilm, formed by bacterial cells surrounded by extracellular substances forming a matrix, plays a pivotal role in the resistance of P...
November 2, 2023: Microorganisms
https://read.qxmd.com/read/38001937/synergistic-antimicrobial-effects-of-ibuprofen-combined-with-standard-of-care-antibiotics-against-cystic-fibrosis-pathogens
#22
JOURNAL ARTICLE
Qingquan Chen, Marleini Ilanga, Sabona B Simbassa, Bhagath Chirra, Kush N Shah, Carolyn L Cannon
Cystic fibrosis (CF) is a common life-shortening genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Lungs of CF patients are often colonized or infected with microorganisms requiring frequent courses of antibiotics. Antibiotic-resistant bacterial infections have been a growing concern in CF patients. Chronic bacterial infections and concomitant airway inflammation damage the lungs, ultimately leading to respiratory failure. Several clinical trials have demonstrated that high-dose ibuprofen reduces the rate of pulmonary function decline in CF patients...
October 30, 2023: Biomedicines
https://read.qxmd.com/read/37992909/fibrous-matrices-facilitate-pleurocidin-killing-of-wound-associated-bacterial-pathogens
#23
JOURNAL ARTICLE
Celia Ramos, Kairi Lorenz, Marta Putrinš, Charlotte K Hind, Andres Meos, Ivo Laidmäe, Tanel Tenson, J Mark Sutton, A James Mason, Karin Kogermann
Conventional wound infection treatments neither actively promote wound healing nor address the growing problem of antibacterial resistance. Antimicrobial peptides (AMPs) are natural defense molecules, released from host cells, which may be rapidly bactericidal, modulate host-immune responses, and/or act as endogenous mediators for wound healing. However, their routine clinical use has hitherto been hindered due to their instability in the wound environment. Here we describe an electrospun carrier system for topical application of pleurocidin, demonstrating sufficient AMP release from matrices to kill wound-associated pathogens including Acinetobacter baumannii and Pseudomonas aeruginosa...
November 20, 2023: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/37938982/investigating-the-role-of-metabolism-for-antibiotic-combination-therapies-in-pseudomonas-aeruginosa
#24
JOURNAL ARTICLE
Martina M Golden, Savannah J Post, Renata Rivera, William M Wuest
Antibacterial resistance poses a severe threat to public health; an anticipated 14-fold increase in multidrug-resistant (MDR) bacterial infections is expected to occur by 2050. Contrary to antibiotics, combination therapies are the standard of care for antiviral and anticancer treatments, as synergistic drug-drug interactions can decrease dosage and resistance development. In this study, we investigated combination treatments of a novel succinate dehydrogenase inhibitor (promysalin) with specific inhibitors of metabolism and efflux alongside a panel of clinically approved antibiotics in synergy studies...
November 8, 2023: ACS Infectious Diseases
https://read.qxmd.com/read/37917414/evaluated-gene-expressions-of-metallo-beta-lactamase-genes%C3%A2-gim-and-vim-spm-in-pseudomonas-aeruginosa-clinical-isolates
#25
JOURNAL ARTICLE
Marwa Ghalib Ali, Zahraa Abd Almoneim, Sawsan M Kareem
Pseudomonas aeruginosa is considered as one of the human health care problems, P. aeruginosa's carbapenem resistance emerges by several different mechanisms, some of which include carbapenems genes. P. aeruginosa's carbapenem resistance is a significant health concern, So this study aims to evaluate MBL gene expressions. The study was conducted at the Department of Microbiology, AL-Mahmoodia Hospital, over one year from January to December 2022. The samples were collected from patients with different clinical sources (Burn, Urine, Wound, Sputum, Ear, and Blood), from different ages while...
November 2, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37887219/complementary-activities-of-host-defence-peptides-and-antibiotics-in-combating-antimicrobial-resistant-bacteria
#26
REVIEW
Patrick R Lennard, Pieter S Hiemstra, Peter H Nibbering
Due to their ability to eliminate antimicrobial resistant (AMR) bacteria and to modulate the immune response, host defence peptides (HDPs) hold great promise for the clinical treatment of bacterial infections. Whereas monotherapy with HDPs is not likely to become an effective first-line treatment, combinations of such peptides with antibiotics can potentially provide a path to future therapies for AMR infections. Therefore, we critically reviewed the recent literature regarding the antibacterial activity of combinations of HDPs and antibiotics against AMR bacteria and the approaches taken in these studies...
October 6, 2023: Antibiotics
https://read.qxmd.com/read/37855639/phage-antibiotic-combinations-against-multidrug-resistant-pseudomonas-aeruginosa-in-in-vitro-static-and-dynamic-biofilm-models
#27
JOURNAL ARTICLE
Dana J Holger, Amer El Ghali, Natasha Bhutani, Katherine L Lev, Kyle Stamper, Razieh Kebriaei, Ashlan J Kunz Coyne, Taylor Morrisette, Rahi Shah, Jose Alexander, Susan M Lehman, Laura J Rojas, Steven H Marshall, Robert A Bonomo, Michael J Rybak
Biofilm-producing Pseudomonas aeruginosa infections pose a severe threat to public health and are responsible for high morbidity and mortality. Phage-antibiotic combinations (PACs) are a promising strategy for combatting multidrug-resistant (MDR), extensively drug-resistant (XDR), and difficult-to-treat P. aeruginosa infections. Ten MDR/XDR P. aeruginosa strains and five P . aeruginosa -specific phages were genetically characterized and evaluated based upon their antibiotic susceptibilities and phage sensitivities...
October 19, 2023: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/37843410/bacterial-synergies-and-antagonisms-affecting-pseudomonas-aeruginosa-virulence-in-the-human-lung-skin-and-intestine
#28
REVIEW
Izel Ungor, Yiorgos Apidianakis
Pseudomonas aeruginosa requires a significant breach in the host defense to cause an infection. While its virulence factors are well studied, its tropism cannot be explained only by studying its interaction with the host. Why are P. aeruginosa infections so rare in the intestine compared with the lung and skin? There is not enough evidence to claim specificity in virulence factors deployed by P. aeruginosa in each anatomical site, and host physiology differences between the lung and the intestine cannot easily explain the observed differences in virulence...
October 16, 2023: Future Microbiology
https://read.qxmd.com/read/37839896/in-vitro-synergy-of-the-combination-of-sulbactam-durlobactam-and-cefepime-at-clinically-relevant-concentrations-against-a-baumannii-p-aeruginosa-and-enterobacterales
#29
JOURNAL ARTICLE
Aliaa Fouad, David P Nicolau, Christian M Gill
BACKGROUND: Sulbactam-durlobactam is a potent combination active against Acinetobacter baumannii; however, it lacks activity against other nosocomial pathogens. Cefepime is a common first-line therapy for hospital/ventilator-associated pneumonia caused by Gram-negative pathogens including Pseudomonas aeruginosa and Enterobacterales. With increasing resistance to cefepime, and the significant proportion of polymicrobial nosocomial infections, effective therapy for infections caused by Acinetobacter baumannii, P...
December 1, 2023: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/37824354/characterization-of-carbapenemase-producing-gram-negative-bacilli-first-report-of-blandm-1-in-enterobacter-cloacae
#30
JOURNAL ARTICLE
Manel Debabza, Raoudha Dziri, Abdelbasset Mechai, Amel Bouguessa, Naouel Klibi, Hadda Imene Ouzari
INTRODUCTION: The spread of multidrug-resistant bacteria, particularly carbapenem-resistant Gram-negative bacilli (CR-GNB), has become a serious challenge for clinicians due to limited therapeutic options. The aim of the study was to investigate the prevalence of carbapenemase production among clinical isolates recovered from 352 samples collected in Tebessa hospital, Algeria. METHODOLOGY: Bacterial isolates were identified by 16S RNA gene sequencing and susceptibility to antibiotics was determined by disk diffusion method...
September 30, 2023: Journal of Infection in Developing Countries
https://read.qxmd.com/read/37776535/antibacterial-and-toxic-activity-of-geopropolis-extracts-from-melipona-subnitida-ducke-1910-hymenoptera-apidae-and-scaptotrigona-depilis-moure-1942-hymenoptera-apidae
#31
JOURNAL ARTICLE
Danilo Costa Dos Santos, Nair Silva Macedo, Zildene de Sousa Silveira, Raimundo Luiz Silva Pereira, Isaac Moura Araújo, Ana Carolina Justino Araújo, Sheila Alves Gonçalves, Marcos da Silveira Regueira Neto, Valdir de Queiroz Balbino, Airton Torres de Carvalho, Bruno Oliveira de Veras, Francisco Assis Bezerra da Cunha, Henrique Coutinho, Samuel Vieira Brito
Bacteria are associated with many infections that affect humans and present antibiotic resistance mechanisms, causing problems in health organisations and increased mortality rates. Therefore, it is necessary to find new antibacterial agents that can act in the treatment of these microorganisms. Geopropolis is a natural product made by stingless bees, formed by a mixture of plant resins, salivary secretions, wax and soil particles, presenting a diverse chemical composition. Thus, this study aimed to evaluate antibacterial activity, antibiotic modulation and the toxicity of geopropolis extract from the stingless bees, Melipona subnitida (Ducke, 1910) and Scaptotrigona depilis (Moure, 1942) against standard and multi-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacteria...
September 30, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/37760673/detection-and-phylogenetic-analysis-of-extended-spectrum-%C3%AE-lactamase-esbl-genetic-determinants-in-gram-negative-fecal-microbiota-of-wild-birds-and-chicken-originated-at-trimmu-barrage
#32
JOURNAL ARTICLE
Muhammad Adnan Saeed, Aman Ullah Khan, Syed Ehtisham-Ul-Haque, Usman Waheed, Muhammad Fiaz Qamar, Aziz Ur Rehman, Amar Nasir, Muhammad Arfan Zaman, Muhammad Kashif, Jean-Paul Gonzalez, Hosny El-Adawy
Extended-spectrum β-lactamases (ESBL) give rise to resistance against penicillin and cephalosporin antibiotics in multiple bacterial species. The present study was conducted to map genetic determinants and related attributes of ESBL-producing bacteria in three wild aquatic bird species and chickens at the "Trimmu Barrage" in district Jhang, Punjab province, Pakistan. To study the prevalence of ESBL-producing bacteria, a total of 280 representative samples were collected from wild bird species; cattle egrets ( Bubulcus ibis ), little egrets ( Egretta garzetta ) and common teals ( Anas crecca ) as well as from indigenous chickens ( Gallus gallus domesticus ) originating from a local wet market...
August 28, 2023: Antibiotics
https://read.qxmd.com/read/37734627/an-integrated-quorum-quenching-biocatalytic-nanoplatform-for-synergistic-chemo-photothermal-eradication-of-p-aeruginosa-biofilm-infections
#33
JOURNAL ARTICLE
Yue Song, Rui Wang, Yuanzhi Pan, Dan Fang, Yuan Tian, Shaobing Zhou
Decontamination of biofilm-associated infections presents a significant challenge due to the physical and chemical barrier created by the formation of extracellular matrices. This barrier restricts the access of antibiotics to the bacterial communities within the biofilm and provides protection to the persister cells, potentially leading to antibiotic resistance. In this study, we have developed an integrated quorum quenching biocatalytic nanoplatform for the synergistic chemo-photothermal eradication of P...
September 19, 2023: Acta Biomaterialia
https://read.qxmd.com/read/37727767/-in-vitro-in-vivo-and-clinical-studies-comparing-the-efficacy-of-ceftazidime-avibactam-monotherapy-with-ceftazidime-avibactam-containing-combination-regimens-against-carbapenem-resistant-enterobacterales-and-multidrug-resistant-pseudomonas-aeruginosa-isolates
#34
Abdullah Tarık Aslan, Yukiko Ezure, Juan Pablo Horcajada, Patrick N A Harris, David L Paterson
INTRODUCTION: Carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity, mortality, and treatment costs. We aimed to evaluate in vitro , in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam (CZA) combination regimens with CZA alone against CRE and/or MDR-PA isolates or infections. METHODS: We systematically reviewed the relevant literature in CINAHL/MEDLINE, Pubmed, Cochrane, Web of Science, Embase, and Scopus until December 1, 2022...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37707450/eugenol-works-synergistically-with-colistin-against-colistin-resistant-pseudomonas-aeruginosa-and-klebsiella-pneumoniae-isolates-by-enhancing-membrane-permeability
#35
JOURNAL ARTICLE
Jingchun Kong, Yue Wang, Zhuocheng Yao, Yishuai Lin, Yi Zhang, Yijia Han, Tieli Zhou, Jianzhong Ye, Jianming Cao
Colistin is a potent antibiotic for the treatment of carbapenem-resistant Gram-negative bacteria and is considered a last-resort drug. Unfortunately, the incidence of colistin-resistant bacteria isolated from patients is continuously growing due to clinical reuse of colistin. In this study, we found that the combination of colistin and eugenol has a significant synergistic antibacterial effect and reverses the sensitivity of colistin-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae against colistin, as confirmed by checkerboard and time-kill assays...
September 14, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37692466/synergistic-effects-of-gentamicin-cefepime-and-ciprofloxacin-on-biofilm-of-pseudomonas-aeruginosa
#36
JOURNAL ARTICLE
Muhammad Usman, Arooj Marcus, Aimen Fatima, Bushra Aslam, Maryam Zaid, Muska Khattak, Sidra Bashir, Safia Masood, Zara Rafaque, Javid Iqbal Dasti
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen involved in number of hospital-acquired infections such as catheter-associated urinary tract infections, bacteremia, septicemia, skin infections, and ventilator-associated pneumoniae. Biofilm formation is an important trait implicated in chronic infections, such as cystic fibrosis and chronic pulmonary obstruction. We evaluated effects of gentamicin, cefepime, and ciprofloxacin on biofilm of P. aeruginosa. MATERIALS AND METHODS: A total of 266 isolates were collected from the Armed Forces Institute of Pathology (AFIP)...
2023: Infection and Drug Resistance
https://read.qxmd.com/read/37687119/molecular-profiling-characterization-and-antimicrobial-efficacy-of-silver-nanoparticles-synthesized-from-calvatia-gigantea-and-mycena-leaiana-against-multidrug-resistant-pathogens
#37
JOURNAL ARTICLE
Sayab Khan, Muhammad Fiaz, Humaira Yasmin, Junaid Ahmad, Amin Ullah, Zeeshan Niaz, Shubana Hayat, Ajaz Ahmad, Prashant Kaushik, Arshad Farid
The use of natural products isolated from mushrooms against infection, cancer diseases and other oxidative-stress-related diseases is one of the cornerstones of modern medicine. Therefore, we tried to establish a combination of medicinal mushrooms and nanotechnology possibly with the field of medicine for the development of antibacterial agents against these MDR strains. The aim of the research was to understand the molecular identification, characterization and antibacterial action of Calvatia gigantea and Mycena leaiana ...
August 28, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37662851/combining-phages-and-antibiotic-to-enhance-antibiofilm-efficacy-against-an-in-vitro-dual-species-wound-biofilm
#38
JOURNAL ARTICLE
Ergun Akturk, Luís D R Melo, Hugo Oliveira, Aurélie Crabbé, Tom Coenye, Joana Azeredo
Chronic wound management is extremely challenging because of the persistence of biofilm-forming pathogens, such as Pseudomonas aeruginosa and Staphylococcus aureus , which are the prevailing bacterial species that co-infect chronic wounds. Phage therapy has gained an increased interest to treat biofilm-associated infections, namely when combined with antibiotics. Here, we tested the effect of gentamicin as a co-adjuvant of phages in a dual species-biofilm wound model formed on artificial dermis. The biofilm-killing capacity of the tested treatments was significantly increased when phages were combined with gentamicin and applied multiple times as multiple dose (three doses, every 8 h)...
December 15, 2023: Biofilm
https://read.qxmd.com/read/37646077/insights-into-the-antimicrobial-properties-of-a-cationic-steroid-and-antibiofilm-performance-in-pdms-based-coatings-to-potentially-treat-urinary-infections
#39
JOURNAL ARTICLE
Ana Rita Neves, Joana Freitas-Silva, Fernando Durães, Elisabete R Silva, Inês C Rodrigues, Filipe Mergulhão, Marisa Gomes, Rita Teixeira-Santos, Maria Bernardes André, Renata Silva, Fernando Remião, Eugénia Pinto, Paulo Martins da Costa, Emília Sousa, Marta Correia da Silva
Currently, multidrug-resistant (MDR) infections are one of the most important threats, driving the search for new antimicrobial compounds. Cationic peptide antibiotics (CPAs) and ceragenins (CSAs) contain in their structures cationic groups and adopt a facially amphiphilic conformation, conferring the ability to permeate the membranes of bacteria and fungi. Keeping these features in mind, an amine steroid, DOCA-NH2, was found to be active against reference strains and MDR isolates of Gram-positive Enterococcus faecalis and Staphylococcus aureus and Gram-negative Escherichia coli and Pseudomonas aeruginosa ...
August 30, 2023: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/37627656/combination-therapy-with-ciprofloxacin-and-pentamidine-against-multidrug-resistant-pseudomonas-aeruginosa-assessment-of-in-vitro-and-in-vivo-efficacy-and-the-role-of-resistance-nodulation-division-rnd-efflux-pumps
#40
JOURNAL ARTICLE
Megan Fletcher, Alex McCormack, Benjamin J Parcell, Peter J Coote
The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P. aeruginosa and (ii) determine if pentamidine acts as an efflux-pump inhibitor. Resistant clinical isolates, mutant strains overexpressing one of three RND efflux pumps (MexAB-OprM, MexCD-OprJ, and MexEF-OprN), and a strain with the same three pumps deleted were used. MIC assays confirmed that the clinical isolates and the mutants overexpressing efflux pumps were resistant to ciprofloxacin and pentamidine...
July 26, 2023: Antibiotics
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