keyword
https://read.qxmd.com/read/38547106/transcriptomics-analysis-of-the-bovine-endometrium-during-the-perioestrus-period
#1
JOURNAL ARTICLE
Mohammed A Alfattah, Carolina N Correia, John A Browne, Paul A McGettigan, Katarzyna Pluta, Stephen D Carrington, David E MacHugh, Jane A Irwin
During the oestrous cycle, the bovine endometrium undergoes morphological and functional changes, which are regulated by alterations in the levels of oestrogen and progesterone and consequent changes in gene expression. To clarify these changes before and after oestrus, RNA-seq was used to profile the transcriptome of oestrus-synchronized beef heifers. Endometrial samples were collected from 29 animals, which were slaughtered in six groups beginning 12 h after the withdrawal of intravaginal progesterone releasing devices until seven days post-oestrus onset (luteal phase)...
2024: PloS One
https://read.qxmd.com/read/38546522/knowledge-mapping-of-cowden-syndrome-a-bibliometric-analysis
#2
JOURNAL ARTICLE
Qiao Peng, Ning Duan, Xiang Wang, Wen Mei Wang
OBJECTIVE: To provide a comprehensive overview of the current knowledge structure and research hotspots of Cowden syndrome via bibliometrics. METHODS: The articles and reviews related to Cowden syndrome were included from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace and GraphPad Prism were used to conduct the bibliometric analysis. RESULTS: The number of papers focusing on Cowden syndrome was relatively low initially but increased rapidly from 1997 to 1999, and then maintained small-scale fluctuation...
March 28, 2024: Chinese Journal of Dental Research
https://read.qxmd.com/read/38544333/the-dysfunction-of-cd8-t-cells-triggered-by-endometriotic-stromal-cells-promotes-the-immune-survival-of-endometriosis
#3
JOURNAL ARTICLE
Zhi-Xiong Huang, Dian-Chao Lin, Hua-Ying Zhang, Meng-Jie Yang, Jia-Hao Chen, Xin-Yu Ding, Song-Juan Dai, Yi-Huang Hong, Gui-Shuang Liang, Qi-Yuan Li, Qiong-Hua Chen
Endometriosis is defined as an oestrogen-dependent and inflammatory gynaecological disease of which the pathogenesis remains unclear. This study aimed to investigate the cellular heterogeneity and reveal the effect of CD8+ T cells on the progress of endometriosis. Three ovarian endometriosis patients were collected, and single-cell RNA sequencing (scRNA-seq) progressed and delineated the cellular landscape of endometriosis containing five cell clusters. The endometrial cells (EMCs) were the major component, of which the mesenchymal cells were preponderant and characterized with increased inflammation and oestrogen synthesis in endometriosis...
March 27, 2024: Immunology
https://read.qxmd.com/read/38543097/shared-pathogenic-and-therapeutic-characteristics-of-endometriosis-adenomyosis-and-endometrial-cancer-a-comprehensive-literature-review
#4
REVIEW
Melinda-Ildiko Mitranovici, Diana Maria Chiorean, Liviu Moraru, Raluca Moraru, Laura Caravia, Andreea Taisia Tiron, Titiana Cornelia Cotoi, Havva Serap Toru, Ovidiu Simion Cotoi
Endometriosis and adenomyosis behave similarly to cancer. No current treatments represent a cure, even if there are several options, including hormonal and surgical therapy. In advanced or recurrent pathologies, however, personalized treatment is necessary. We have found that due to the multiple common features, various therapeutic options have been used or studied for all three pathologies, with varying results. The objective of this review is to extract from the relevant literature the compounds that are used for endometriosis and adenomyosis characterized by malignant behavior, with some of these drugs being studied first in the treatment of endometrial cancer...
February 28, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542414/atlas-of-tumor-and-tumor-microenvironment-cells-of-lymphovascular-space-invasion-lvsi-in-high-grade-serous-endometrial-adenocarcinoma-a-case-study
#5
Raed Sulaiman, Adam Dale, Xiaoqian Lin, Jennifer C Aske, Kris Gaster, David Starks, Luis Rojas Espaillat, Pradip De, Nandini Dey
Lymphovascular invasion (LVSI) is defined as the presence of tumor cells within a definite endothelial-lined space (lymphatics or blood vessels) in the organ surrounding invasive carcinoma. The presence of LVI is associated with an increased risk of lymph nodes and distant metastases. Lymphovascular invasion is described as cancer within blood or lymph vessels and is an independent risk factor for metastasis, recurrence, and mortality. This study aims to present the marker-based immunohistological characterization of cells around LVSI in a high-grade adenocarcinoma of the endometrium to build a cellular atlas of cells of LVSI...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541711/uncommon-morphologic-types-of-endometrial-cancer-and-their-mimickers-how-much-does-molecular-classification-improve-the-practice-for-challenging-cases
#6
REVIEW
Ozlen Saglam
The previous endometrial cancer (EC) FIGO staging primarily relied on the extent of the disease spread into the anatomical sites at diagnosis. The most recent one (2023) incorporates clinicopathological features such as histological subtype, tumor grade, the extent of lymphovascular space invasion (LVI), and, when available, molecular subtypes of EC. The emphasis on accurate histological typing, tumor grading, and the molecular features of the cancer is stronger than ever. This review addresses challenging diagnostic patterns in the histologic subtyping and grading EC under five categories: 1...
March 14, 2024: Life
https://read.qxmd.com/read/38541353/prevalence-and-diagnosis-of-pcos-using-electronic-health-records-a-scoping-review-and-a-database-analysis
#7
JOURNAL ARTICLE
William Atiomo, Mohamed Nor Haq Rizwan, Muhammad Hamza Bajwa, Hussain Juzer Furniturewala, Komal Sundeep Hazari, Deemah Harab, Widad Abdelkareem, Sumayya Inuwa, Amar Hassan Khamis, Muna Tahlak, Fadi G Mirza
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. It increases the risk of type 2 diabetes, cardiovascular disease, endometrial cancer, infertility, gestational diabetes, preeclampsia, and preterm birth. Accurately identifying predictors of these health risks is crucial. Electronic health records (EHRs) offer an affordable approach, however, the validity and reliability of EHRs for PCOS diagnosis are unclear. A scoping review of the literature on the prevalence and reliability of the diagnosis of PCOS using EHRs was performed...
March 15, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38540726/reproductive-and-oncologic-outcomes-in-young-women-with-stage-ia-and-grade-2-endometrial-carcinoma-undergoing-fertility-sparing-treatment-a-systematic-review
#8
REVIEW
Andrea Etrusco, Antonio Simone Laganà, Vito Chiantera, Mislav Mikuš, Hafiz Muhammad Arsalan, Antonio d'Amati, Amerigo Vitagliano, Ettore Cicinelli, Alessandro Favilli, Antonio D'Amato
BACKGROUND: Endometrial cancer (EC) is the most common gynecological malignancy in both Europe and the USA. Approximately 3-5% of cases occur in women of reproductive age. Fertility-sparing treatment (FST) options are available, but very limited evidence regarding grade 2 (G2) ECs exists in the current literature. This systematic review aimed to comprehensively evaluate reproductive and oncologic outcomes among young women diagnosed with stage IA or G2EC disease who underwent FST. METHODS: A comprehensive search of the literature was carried out on the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), the Health Technology Assessment Database, and Web of Science...
March 5, 2024: Biomolecules
https://read.qxmd.com/read/38540637/low-diet-quality-and-nutritional-knowledge-in-women-with-endometriosis-a-pilot-study
#9
JOURNAL ARTICLE
Angelika Bogusz, Magdalena Górnicka
Endometriosis is a chronic gynecological disease characterized by ectopic endometrial tissue outside the uterus that can cause chronic pain, dysmenorrhea, fatigue, and infertility. The aim of this study was to assess diet quality and nutritional knowledge of women with endometriosis. A questionnaire was used to collect data on lifestyle, dietary habits and nutritional knowledge from 90 women. More than 80% of women with endometriosis (82.2%) confirmed that diet and lifestyle are related to the progression of endometriosis...
March 17, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38539507/emerging-advances-in-endometrial-cancer-integration-of-molecular-classification-into-staging-for-enhanced-prognostic-accuracy-and-implications-for-racial-disparities
#10
REVIEW
Joy Ogunmuyiwa, Vonetta Williams
Since the 2009 FIGO staging update, focused exclusively on the anatomic extent of disease, there have been several advances in the understanding of the pathologic and molecular features of endometrial cancer. In a significant departure from the 2009 FIGO staging system, the 2023 FIGO staging update integrates both histopathological and molecular classification. With the inclusion of non-anatomic pathologic parameters such as histology, tumor grade, lymphovascular space invasion, and molecular subtype, the 2023 FIGO staging update aims to create more clinically relevant substages that improve prognostic value and allows for more individualized treatment paradigms...
March 16, 2024: Cancers
https://read.qxmd.com/read/38539477/performance-of-mri-for-detection-of-%C3%A2-pt1b-disease-in-local-staging-of-endometrial-cancer
#11
JOURNAL ARTICLE
Leonie Van Vynckt, Philippe Tummers, Hannelore Denys, Menekse Göker, Sigi Hendrickx, Eline Naert, Rawand Salihi, Koen Van de Vijver, Gabriëlle H van Ramshorst, Donatienne Van Weehaeghe, Katrien Vandecasteele, Geert M Villeirs, Pieter J L De Visschere
Magnetic resonance imaging (MRI) can be used for the preoperative local staging of endometrial cancer (EC). The presence of ≥pT1b disease (i.e., tumor invasion in ≥50% of the myometrium, into the cervical stroma or spread outside the uterus) has important prognostic value and implications for the decision to perform lymphadenectomy. The purpose of this study was to assess the performance of MRI for the detection of ≥pT1b disease and to evaluate whether tumor size measured via MRI was predictive for ≥pT1b disease, independent of imaging signs of deep invasion...
March 13, 2024: Cancers
https://read.qxmd.com/read/38539423/where-morphological-and-molecular-classifications-meet-the-role-of-p53-immunohistochemistry-in-the-prognosis-of-low-risk-endometrial-carcinoma-glamour-study
#12
JOURNAL ARTICLE
Andrea Puppo, Giulio Fraternali Orcioni, Valentino Clignon, Yuri Musizzano, Carla Angela Zavattero, Giulia Vocino Trucco, Giacomo Maria Benazzo, Giuseppe Vizzielli, Stefano Restaino, Laura Mariuzzi, Maria Orsaria, Renato Seracchioli, Diego Raimondo, Linda Bertoldo, Stefano Uccella, Anna Caliò, Giulia Vittori Antisari, Simone Garzon, Vito Andrea Capozzi, Roberto Berretta, Francesco Cosentino, Alfredo Ercoli, Antonio Ieni, Martina Arcieri, Marcello Ceccaroni, Anna Pesci, Giulia Mantovani, Francesco Bruni, Giovanni Roviglione, Pio Zeppa, Antonio Raffone, Marco Camanni, Elena Maria Delpiano, Claudia Provenza, Martina Borghese, Giuseppe Migliaretti
No prospective study has validated molecular classification to guide adjuvant treatment in endometrial cancer (EC), and not even retrospective data are present for patients with morphological low-risk EC. We conducted a retrospective, multicenter, observational study including 370 patients with low-risk endometrioid EC to evaluate the incidence and prognostic role of p53 abnormal expression (p53abn) in this specific subgroup. Among 370 patients, 18 had abnormal expressions of p53 (4.9%). In 13 out of 370 patients (3...
March 7, 2024: Cancers
https://read.qxmd.com/read/38538000/clinicopathological-significance-of-nucleosome-remodeling-and-deacetylase-complex-expression-in-endometrial-carcinoma
#13
JOURNAL ARTICLE
Jinah Chu, Sang Hwa Lee, Sung-Im DO, Hyun-Soo Kim
BACKGROUND/AIM: Only a few studies have examined the expression of nucleosome remodeling and deacetylase complex in endometrial carcinoma (EC). The aim of this study was to analyze the expressions of histone deacetylase (HDAC1), HDAC2, and chromodomain helicase DNA-binding protein 4 (CHD4) in EC. PATIENTS AND METHODS: Sixty cases of EC were categorized into two clusters based on the expression levels of the three proteins. RESULTS: Cluster 1 (C1) exhibited elevated expressions of HDAC2 and CHD4 compared with cluster 2 (C2)...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537663/enhanced-glycolysis-in-the-myometrium-with-ectopic-endometrium-of-patients-with-adenomyosis-a-preliminary-study
#14
JOURNAL ARTICLE
Shiya Huang, Xueqian Huang, Xiaohui Wen, Xuehong Liu, Hongxia Ma, Linling Xie, Yishu Wang, Shanjia Liu, Yongge Guan, Kunyin Li
OBJECTIVES: The objective of this study was to investigate the glycolytic activity of adenomyosis, which is characterized by malignant biological behaviors including abnormal cell proliferation, migration, invasion, cell regulation, and epithelial-mesenchymal transition. METHODS: From January 2021 to August 2022, a total of 15 patients who underwent total hysterectomy for adenomyosis and 14 patients who had non-endometrial diseases, specifically with cervical squamous intraepithelial neoplasia and uterine myoma, were included in this study...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38536596/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer-potential-etiologies-and-strategies-for-prevention
#15
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In the first of two companion papers, we comprehensively reviewed the recent evidence in the primary literature, which addressed the increased prevalence of hypertensive disorders of pregnancy, late-onset or term preeclampsia, fetal overgrowth, postterm birth, and placenta accreta in women conceiving by in vitro fertilization. The preponderance of evidence implicated frozen embryo transfer cycles and, specifically, those employing programmed endometrial preparations, in the higher risk for these adverse maternal and neonatal pregnancy outcomes...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536594/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer
#16
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In this first of two companion papers, we critically review the evidence recently published in the primary literature, which addresses adverse maternal and neonatal pregnancy outcomes associated with programmed embryo transfer cycles. We next consider whether these pathological pregnancy outcomes might be attributable to traditional risk factors, unknown parental factors, embryo culture, culture duration, or cryopreservation. Finally, in the second companion article, we explore potential etiologies and suggest strategies for prevention...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38531788/rare-but-still-there-a-scoping-review-on-endometriosis-associated-ovarian-cancer
#17
JOURNAL ARTICLE
Karl Livori, Jean Calleja-Agius
Endometriosis is a medical condition affecting at least up to 10% of women of reproductive age. This condition occurs when ectopic endometrial glands and stroma implant outside the uterus and there are several theories regarding the underlying origins of the disease. Endometriosis is one of the major causes of severe dysmenorrhoea, chronic pelvic pain and infertility. While endometriosis is generally a non-malignant condition, it rarely may transform into an invasive cancer, and increase the risk for epithelial ovarian cancer, notably endometrioid or clear cell ovarian cancer...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38530846/a-phase-i-trial-of-nab-paclitaxel-bevacizumab-ab160-nano-immunoconjugate-therapy-for-gynecologic-malignancies
#18
JOURNAL ARTICLE
Eleftheria Kalogera, Wendy K Nevala, Heidi D Finnes, Vera J Suman, Jill M Schimke, Carrie A Strand, Lisa A Kottschade, Rachel A Kudgus, Sarah A Buhrow, Laura R Becher, Liyi Geng, Gretchen E Glaser, Megan E Grudem, Aminah Jatoi, Carolyn M Klampe, Amanika Kumar, Carrie L Langstraat, Robert R McWilliams, Andrea E Wahner Hendrickson, S John Weroha, Yiyi Yan, Joel M Reid, Svetomir N Markovic, Matthew S Block
PURPOSE: AB160 is a 160 nm nano-immunoconjugate consisting of nab-paclitaxel (ABX) nanoparticles non-covalently coated with bevacizumab (BEV) for targeted delivery into tissues expressing high levels of VEGF. Preclinical data showed that AB160 resulted in greater tumor targeting and tumor inhibition compared to sequential treatment with ABX then BEV. Given individual drug activity, we investigated the safety and toxicity of AB160 in patients with gynecologic cancers. PATIENTS AND METHODS: A 3+3 phase I trial was conducted with 3 potential dose levels in patients with previously treated endometrial (EC), cervical (CC), and platinum-resistant ovarian cancer (OC) patients to ascertain the recommended Phase II dose (RP2D)...
March 26, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38530759/proposed-classification-of-adenomyosis-in-infertile-women-to-simplify-management-options-undergoing-art
#19
EDITORIAL
Sunita Tandulwadkar, Sneha Mishra, Swapnil Langde, Mily Pandey, Rashmika Gandhi
OBJECTIVE: Adenomyosis associated with subfertility is a situation of a dilemma for the treating clinician as the treatment is highly controversial and there remains an overall lack of consensus regarding the value of conservative surgery with or without medical management to improve reproductive out-comes. Hence we proposed this classification based on mapping of the size of adenomyoma, its location, distance from the endometrial cavity, and any associated endometriosis by studying 100 women with adenomyosis undergoing IVF...
March 26, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38530620/sodium-glucose-cotransporter-2-inhibitors-and-cancer-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
B Xu, B Kang, S Li, S Fan, J Zhou
BACKGROUND: The effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cancer has yet to be fully elucidated. OBJECTIVE: This systematic review and meta-analysis investigated the effects of SGLT2 inhibitors on cancer. METHODS: We searched the PubMed and ClinicalTrials.gov databases up to July 15, 2023, to identify eligible randomized, double-blind, placebo-controlled trials that lasted at least ≥24 weeks. The primary outcome was the overall cancer incidence, and the secondary outcomes were the incidences of various types of cancer...
March 26, 2024: Journal of Endocrinological Investigation
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