keyword
https://read.qxmd.com/read/38212795/angptl4-accelerates-ovarian-serous-cystadenocarcinoma-carcinogenesis-and-angiogenesis-in-the-tumor-microenvironment-by-activating-the-jak2-stat3-pathway-and-interacting-with-esm1
#21
JOURNAL ARTICLE
Yu-Kun Li, An-Bo Gao, Tian Zeng, Dan Liu, Qun-Feng Zhang, Xiao-Min Ran, Zhen-Zi Tang, Yan Li, Jue Liu, Ting Zhang, Gang-Qing Shi, Wen-Chao Zhou, Wen-da Zou, Juan Peng, Juan Zhang, Hui Li, Juan Zou
BACKGROUND: Ovarian cancer (OC) is a malignant neoplasm that displays increased vascularization. Angiopoietin-like 4 (ANGPTL4) is a secreted glycoprotein that functions as a regulator of cell metabolism and angiogenesis and plays a critical role in tumorigenesis. However, the precise role of ANGPTL4 in the OC microenvironment, particularly its involvement in angiogenesis, has not been fully elucidated. METHODS: The expression of ANGPTL4 was confirmed by bioinformatics and IHC in OC...
January 11, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38201550/assessment-of-an-anticancer-effect-of-the-simultaneous-administration-of-mm-129-and-indoximod-in-the-colorectal-cancer-model
#22
JOURNAL ARTICLE
Iwona Kwiatkowska, Justyna Magdalena Hermanowicz, Robert Czarnomysy, Arkadiusz Surażyński, Krystyna Kowalczuk, Joanna Kałafut, Alicja Przybyszewska-Podstawka, Krzysztof Bielawski, Adolfo Rivero-Müller, Mariusz Mojzych, Dariusz Pawlak
(1) Background: The purpose of the given study was to examine the antitumor activity of the simultaneous administration of MM-129, a 1,2,4-triazine derivative, and indoximod (IND), the kynurenine pathway inhibitor, toward colon cancer. (2) Methods: The efficiency of the co-administration of the studied compounds was assessed in xenografted zebrafish embryos. Then, the effects of the combined administration of compounds on cellular processes such as cell viability, apoptosis, and intracellular signaling pathways were evaluated...
December 26, 2023: Cancers
https://read.qxmd.com/read/38195619/zebrafish-xenograft-as-a-tool-for-the-study-of-colorectal-cancer-a-review
#23
REVIEW
Camilla Maria Fontana, Hien Van Doan
Colorectal cancer (CRC) is the second leading cause of cancer-related death, mostly due to metastatic disease and the fact that many patients already show signs of metastasis at the time of first diagnosis. Current CRC therapies negatively impact patients' quality of life and have little to no effect on combating the tumor once the dissemination has started. Danio rerio (zebrafish) is a popular animal model utilized in cancer research. One of its main advantages is the ease of xenograft transplantation due to the fact that zebrafish larvae lack the adaptative immune system, guaranteeing the impossibility of rejection...
January 9, 2024: Cell Death & Disease
https://read.qxmd.com/read/38194027/single-cell-recovery-from-tumor-cell-xenotransplanted-zebrafish-embryos-for-the-study-of-metastasis-initiating-cells
#24
JOURNAL ARTICLE
Pablo Hurtado, Inés Martínez-Pena, Roberto Piñeiro
The study of metastasis-competent cells at the single-cell level represents an opportunity to decipher the molecular mechanisms associated with the metastatic cascade as well as to understand the functional and molecular heterogeneity of these cells. In this context, preclinical in vivo models of cancer metastasis are valuable tools to understand the behavior of cancer cells throughout the process. Here we describe a detailed protocol for the isolation and recovery of individual viable human metastatic cells from zebrafish embryos xenotransplanted with cancer cells for downstream molecular analysis...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38184222/exploring-the-in-vivo-anti-cancer-potential-of-neosetophomone-b-in-leukemic-cells-using-a-zebrafish-xenograft-model
#25
JOURNAL ARTICLE
Shilpa Kuttikrishnan, Maram Hasan, Kirti S Prabhu, Tamam El-Elimat, Nicholas H Oberlies, Cedric J Pearce, Feras Q Alali, Aamir Ahmad, Ehsan P Daryakenari, Ajaz A Bhat, Huseyin C Yalcin, Shahab Uddin
Neosetophomone B (NSP-B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer potential remaines unexplored. To fill this gap in our knowledge, we tested NSP-B's in vivo anti-cancer activity using a zebrafish model, an organism that has gained significant traction in biomedical research due to its genetic similarities with humans and its transparent nature, allowing real-time tumor growth observation...
January 4, 2024: Experimental Cell Research
https://read.qxmd.com/read/38182078/stroma-modulation-of-radiation-response-in-head-and-neck-squamous-cell-carcinoma-insights-from-zebrafish-larvae-xenografts
#26
JOURNAL ARTICLE
Wafa Wahbi, Shady Awad, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: The tumour microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) consists of different subtypes of cells that interact with the tumour or with each other. This study investigates the possibility of co-culturing HNSCC cells with different stroma cells in a zebrafish xenograft model, focusing on the effect of stroma cells on HNSCC growth and response to irradiation. MATERIAL AND METHOD: HNSCC metastatic cell line HSC-3 was used along with five types of stroma cells: normal gingival fibroblasts (NOF), cancer associated fibroblasts (CAF), macrophages, CD4+ T cells, and human umbilical vein endothelial cells (HUVEC)...
January 3, 2024: Experimental Cell Research
https://read.qxmd.com/read/38179601/epitranscriptomics-m-6-a-analyses-reveal-distinct-m-6-a-marks-under-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-induced-apoptotic-conditions-in-hela-cells
#27
JOURNAL ARTICLE
Azime Akçaöz-Alasar, Özge Tüncel, Buket Sağlam, Yasemin Gazaloğlu, Melis Atbinek, Umut Cagiral, Evin Iscan, Gunes Ozhan, Bünyamin Akgül
Tumor necrosis factor-α (TNF-α) is a ligand that induces both intrinsic and extrinsic apoptotic pathways in HeLa cells by modulating complex gene regulatory mechanisms. However, the full spectrum of TNF-α-modulated epitranscriptomic m6 A marks is unknown. We employed a genomewide approach to examine the extent of m6 A RNA modifications under TNF-α-modulated apoptotic conditions in HeLa cells. miCLIP-seq analyses revealed a plethora of m6 A marks on 632 target mRNAs with an enrichment on 99 mRNAs associated with apoptosis...
January 5, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38169509/aldh1a1-drives-prostate-cancer-metastases-and-radioresistance-by-interplay-with-ar-and-rar-dependent-transcription
#28
JOURNAL ARTICLE
Ielizaveta Gorodetska, Anne Offermann, Jakob Püschel, Vasyl Lukiyanchuk, Diana Gaete, Anastasia Kurzyukova, Vera Freytag, Marie-Therese Haider, Christina S Fjeldbo, Simona Di Gaetano, Franziska Maria Schwarz, Shivaprasad Patil, Angelika Borkowetz, Holger H H Erb, Aria Baniahmad, Jovan Mircetic, Heidi Lyng, Steffen Löck, Annett Linge, Tobias Lange, Franziska Knopf, Ben Wielockx, Mechthild Krause, Sven Perner, Anna Dubrovska
Rationale: Current therapies for metastatic osseous disease frequently fail to provide a durable treatment response. To date, there are only limited therapeutic options for metastatic prostate cancer, the mechanisms that drive the survival of metastasis-initiating cells are poorly characterized, and reliable prognostic markers are missing. A high aldehyde dehydrogenase (ALDH) activity has been long considered a marker of cancer stem cells (CSC). Our study characterized a differential role of ALDH1A1 and ALDH1A3 genes as regulators of prostate cancer progression and metastatic growth...
2024: Theranostics
https://read.qxmd.com/read/38163890/rptor-blockade-suppresses-brain-metastases-of-nsclc-by-interfering-the-ceramide-metabolism-via-hijacking-yy1-binding
#29
JOURNAL ARTICLE
Ying Lin, Yun Wu, Qiangzu Zhang, Xunwei Tu, Sufang Chen, Junfan Pan, Nengluan Xu, Ming Lin, Peiwei She, Gang Niu, Yusheng Chen, Hongru Li
BACKGROUND: Ceramide metabolism is crucial in the progress of brain metastasis (BM). However, it remains unexplored whether targeting ceramide metabolism may arrest BM. METHODS: RNA sequencing was applied to screen different genes in primary and metastatic foci and whole-exome sequencing (WES) to seek crucial abnormal pathway in BM + and BM-patients. Cellular arrays were applied to analyze the permeability of blood-brain barrier (BBB) and the activation or inhibition of pathway...
January 2, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38132928/a-novel-anticancer-peptide-derived-from-bryopsis-plumosa-regulates-proliferation-and-invasion-in-non-small-cell-lung-cancer-cells
#30
JOURNAL ARTICLE
Heabin Kim, Hyun-Taek Kim, Seung-Hyun Jung, Jong Won Han, Seonmi Jo, In-Gyu Kim, Rae-Kwon Kim, Yeon-Jee Kahm, Tae-Ik Choi, Cheol-Hee Kim, Jei Ha Lee
The discovery of new highly effective anticancer drugs with few side effects is a challenge for drug development research. Natural or synthetic anticancer peptides (ACPs) represent a new generation of anticancer agents with high selectivity and specificity. The rapid emergence of chemoradiation-resistant lung cancer has necessitated the discovery of novel anticancer agents as alternatives to conventional therapeutics. In this study, we synthesized a peptide containing 22 amino acids and characterized it as a novel ACP (MP06) derived from green sea algae, Bryopsis plumosa ...
November 24, 2023: Marine Drugs
https://read.qxmd.com/read/38129926/capsaicin-orchestrates-metastasis-in-gastric-cancer-via-modulating-expression-of-trpv1-channels-and-driving-gut-microbiota-disorder
#31
JOURNAL ARTICLE
Rui Deng, Suyun Yu, Xingqiu Ruan, Huan Liu, Gangfan Zong, Peng Cheng, Ruizhi Tao, Wenxing Chen, Aiyun Wang, Yang Zhao, Zhonghong Wei, Yin Lu
The association between capsaicin, the major natural pungent compound of chili peppers, and gastric cancer progression has engendered conflicting findings. In this work, we sought to explore the character of a high capsaicin diet in gastric cancer metastasis and its possible mechanism. The impact of high capsaicin consumption on gastric cancer metastasis was investigated in vivo (xenograft mouse and zebrafish models) and in vitro (biochemical and molecular assays). It was demonstrated that high diet of capsaicin gave rise to accelerate tumor metastasis, which was partially mediated by elevating the expression of transient receptor potential vanilloid 1 (TRPV1) in gastric cancer cells...
December 21, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38093368/nutlin-3a-induces-kras-mutant-p53-wild-type-lung-cancer-specific-methuosis-like-cell-death-that-is-dependent-on-gfpt2
#32
JOURNAL ARTICLE
Dasom Kim, Dongwha Min, Joohee Kim, Min Jung Kim, Yerim Seo, Byung Hwa Jung, Seung-Hae Kwon, Hyunju Ro, Seoee Lee, Jason K Sa, Ji-Yun Lee
BACKGROUND: Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and glycolysis. Lately, sotorasib was approved by the FDA as a first-in-class KRAS-G12C inhibitor. However, sotorasib still has a derivative barrier, which is not effective for other KRAS mutation types, except for G12C. Additionally, resistance to sotorasib is likely to develop, demanding the need for alternative therapeutic strategies...
December 14, 2023: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38091824/piperlongumine-based-nanomedicine-impairs-glycolytic-metabolism-in-triple-negative-breast-cancer-stem-cells-through-modulation-of-gapdh-fbp1
#33
JOURNAL ARTICLE
Priya Singh, Kaushik Sen, Pratikshya Sa, Auromira Khuntia, Sunil K Raghav, Rajeeb K Swain, Sanjeeb Kumar Sahoo
BACKGROUND: Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and exhibits high rate of chemoresistance, metastasis, and relapse. This can be attributed to the failure of conventional therapeutics to target a sub-population of slow cycling or quiescent cells called as cancer stem cells (CSCs). Therefore, elimination of CSCs is essential for effective TNBC treatment. PURPOSE: Research suggests that breast CSCs exhibit elevated glycolytic metabolism which directly contributes in maintenance of stemness, self-renewability and chemoresistance as well as in tumor progression...
November 2, 2023: Phytomedicine
https://read.qxmd.com/read/38071055/-establishment-of-patient-derived-xenograft-pdx-zebrafish-model-of-multiple-myeloma-and-its-application-in-drug-screening
#34
JOURNAL ARTICLE
Zhen Yu, Ying Li, Ke-Fei Wang, Lu Wang, Mu Hao
OBJECTIVE: To establish a MM patient-derived tumor xenograft model (MM-PDX) in zebrafish, and to evaluate the anti-myeloma activity of indirubin-3'-monoxime(I3MO) using this model. METHODS: Zebrafish embryos 2 days after fertilization were transplanted with fluorescence labeled myeloma primary tumor cells, the survival of primary tumor cells in zebrafish was observed at 0,16 and 24 hours after cell injection. The zebrafish embryos after tumor cell transplantation were randomly divided into control group, BTZ treatment and I3MO treatment group...
December 2023: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/38067413/effusanin-b-inhibits-lung-cancer-by-prompting-apoptosis-and-inhibiting-angiogenesis
#35
JOURNAL ARTICLE
Jiantong Hou, Ying Li, Honghong Xing, Ruyu Cao, Xiaomeng Jin, Jing Xu, Yuanqiang Guo
Cancer is one of the deadliest human diseases, causing high rates of illness and death. Lung cancer has the highest mortality rate among all malignancies worldwide. Effusanin B, a diterpenoid derived from Isodon serra , showed therapeutic potential in treating non-small-cell lung cancer (NSCLC). Further research on the mechanism indicated that effusanin B inhibited the proliferation and migration of A549 cells both in vivo and in vitro. The in vitro activity assay demonstrated that effusanin B exhibited significant anticancer activity...
November 21, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38032104/shp2-inhibition-with-tno155-increases-efficacy-and-overcomes-resistance-of-alk-inhibitors-in-neuroblastoma
#36
JOURNAL ARTICLE
Ivette Valencia-Sama, Lynn Kee, Gabriella Christopher, Michael Ohh, Mehdi Layeghifard, Adam Shlien, Madeline N Hayes, Meredith S Irwin
Survival rates among high-risk neuroblastoma patients remain low and novel therapies for recurrent neuroblastomas are required. ALK is commonly mutated in primary and relapsed neuroblastoma tumors and ALK tyrosine kinase inhibitors (TKIs) are promising treatments for ALK-driven neuroblastoma; however, innate or adaptive resistance to single agent ALK-TKIs remain a clinical challenge. Recently, SHP2 inhibitors have been shown to overcome ALK-TKI resistance in lung tumors harboring ALK rearrangements. Here, we have assessed the efficacy of the SHP2 inhibitor TNO155 alone and in combination with the ALK-TKIs crizotinib, ceritinib, or lorlatinib for the treatment of ALK-driven neuroblastoma using in vitro and in vivo models...
November 30, 2023: Cancer Res Commun
https://read.qxmd.com/read/38006807/mosloflavone-from-fissistigma-petelotii-ameliorates-oncogenic-multidrug-resistance-by-stat3-signaling-modulation-and-p-glycoprotein-blockade
#37
JOURNAL ARTICLE
Po-Yu Chien, Yu-Hsuan Lan, I-Ting Wu, Yu-Pin Huang, Chin-Chuan Hung
BACKGROUND: Oncogenic multidrug resistance (MDR) is a tough question in cancer therapy. However, no effective medications targeting oncogenic MDR are currently available. Studies have demonstrated that mosloflavone exerts anti-inflammatory effects, yet, its potential to ameliorate MDR remains unclear. PURPOSE: This study aimed to access the capability and elucidate molecular mechanisms of mosloflavone as a MDR resensitizing candidate. METHODS: We investigated the ability of mosloflavone to reverse oncogenic MDR and investigated its underlying mechanisms through cytotoxicity assay, cell cycle assay, apoptosis assay, and zebrafish xenograft model...
November 10, 2023: Phytomedicine
https://read.qxmd.com/read/38001672/danioctc-analysis-of-circulating-tumor-cells-from-metastatic-breast-cancer-patients-in-zebrafish-xenografts
#38
JOURNAL ARTICLE
Florian Reinhardt, Luisa Coen, Mahdi Rivandi, André Franken, Eunike Sawitning Ayu Setyono, Tobias Lindenberg, Jens Eberhardt, Tanja Fehm, Dieter Niederacher, Franziska Knopf, Hans Neubauer
Circulating tumor cells (CTCs) serve as crucial metastatic precursor cells, but their study in animal models has been hindered by their low numbers. To address this challenge, we present DanioCTC, an innovative xenograft workflow that overcomes the scarcity of patient-derived CTCs in animal models. By combining diagnostic leukapheresis (DLA), the Parsortix microfluidic system, flow cytometry, and the CellCelector setup, DanioCTC effectively enriches and isolates CTCs from metastatic breast cancer (MBC) patients for injection into zebrafish embryos...
November 14, 2023: Cancers
https://read.qxmd.com/read/38001635/antitumor-activity-of-axitinib-in-lung-carcinoids-a-preclinical-study
#39
JOURNAL ARTICLE
Alessandra Dicitore, Germano Gaudenzi, Silvia Carra, Maria Celeste Cantone, Monica Oldani, Davide Saronni, Maria Orietta Borghi, Jacopo Grotteschi, Luca Persani, Giovanni Vitale
Lung carcinoids (LCs) comprise well-differentiated neuroendocrine tumors classified as typical (TCs) and atypical (ACs) carcinoids. Unfortunately, curative therapies remain elusive for metastatic LCs, which account for 25-30% of cases. This study evaluated the antitumor activity of axitinib (AXI), a second-generation tyrosine kinase inhibitor selectively targeting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3) in human lung TC (NCI-H727, UMC-11, NCI-H835) and AC (NCI-H720) cell lines...
November 12, 2023: Cancers
https://read.qxmd.com/read/37998746/modelling-3d-tumour-microenvironment-in-vivo-a-tool-to-predict-cancer-fate
#40
JOURNAL ARTICLE
Johanna Marines, Francesca Lorenzini, Karima Kissa, Laura Fontenille
Recently, many studies demonstrated the fundamental role of the tumour microenvironment (TME) in cancer progression. Here, we describe a method to visualize in 3D the behaviour of tumours in zebrafish embryos. We highlight two major actors of the TME, macrophages and vessels. This valuable tool is transposable to Patient-Derived Xenograft imaging in order to predict the fate of malignant tumours according to the dynamics of their TME.
November 14, 2023: Current Issues in Molecular Biology
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