keyword
https://read.qxmd.com/read/38538753/brain-magnetic-resonance-imaging-findings-in-children-with-neurological-complications-of-coronavirus-disease-2019-omicron-variant-a-multicenter-retrospective-observational-study
#1
JOURNAL ARTICLE
Chun Zhao, Yujuan Wang, Jian Hou, Meiyun Xin, Qin Jiang, Mingying Han, Xiaomei Li, Yelong Shen, Ximing Wang, Mo Wang, Youpeng Jin
BACKGROUND: An increasing rate of encephalopathy associated with coronavirus disease 2019 (COVID-19) has been observed among children. However, the literature on neuroimaging data in children with COVID-19 is limited. OBJECTIVE: To analyze brain magnetic resonance imaging (MRI) of pediatric COVID-19 patients with neurological complications. MATERIALS AND METHODS: This multicenter retrospective observational study analyzed clinical (n=102, 100%) and neuroimaging (n=93, 91...
March 28, 2024: Pediatric Radiology
https://read.qxmd.com/read/38533411/bickerstaff-encephalitis-in-childhood-a-review-of-74-cases-in-the-literature-from-1951-to-today
#2
REVIEW
Luca Gregorio Giaccari, Donatella Mastria, Rosella Barbieri, Rossella De Maglio, Francesca Madaro, Gianfranco Paiano, Maria Caterina Pace, Pasquale Sansone, Giuseppe Pulito, Luciana Mascia
Bickerstaff brainstem encephalitis (BBE) is a rare autoimmune disease characterized by the subacute onset of bilateral external ophthalmoplegia, ataxia, and decreased level of consciousness. BBE is part of a group of rare autoimmune diseases in children that can affect the nervous system at any level. The onset of neurological deficits is often sudden and nonspecific. The diagnosis is based on clinical findings and abnormal findings on cerebrospinal fluid (CSF), electroencephalography (EEG), electromyography (EMG), and magnetic resonance imaging (MRI)...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38528535/predicting-factors-for-acute-encephalopathy-in-febrile-seizure-children-with-sars-cov-2-omicron-variant-a-retrospective-study
#3
JOURNAL ARTICLE
Ching-Min Tang, Cheng-Yen Kuo, Chen-Wei Yen, Jainn-Jim Lin, Yu-Chia Hsieh, Shao-Hsuan Hsia, Oi-Wa Chan, En-Pei Lee, Po-Cheng Hung, Huei-Shyong Wang, Kuang-Lin Lin, Cheng-Hsun Chiu
BACKGROUND: SARS-CoV-2 posed a threat to children during the early phase of Omicron wave because many patients presented with febrile seizures. The study aimed to investigate predicting factors for acute encephalopathy of children infected by SARS-CoV-2 Omicron variant presenting with febrile seizures. METHODS: The retrospective study analyzed data from pediatric patients who visited the emergency department of Chang Gung Memorial Hospital in Taiwan between April and July 2022...
March 25, 2024: BMC Pediatrics
https://read.qxmd.com/read/38527973/transition-to-adult-rheumatology-care-a-disease-specific-guide
#4
JOURNAL ARTICLE
Dahima Cintron, Joyce C Chang, Rebecca E Sadun
Young adults with childhood-onset rheumatic diseases are more frequently establishing and continuing care with adult rheumatologists. The transfer of care can be challenging for both the young adult patients and their adult rheumatologists, in large part due to differences between pediatric-onset rheumatic diseases and their adult-onset counterparts, or due to the rarity of some pediatric-onset rheumatic conditions. Other challenges are due to cultural differences between pediatric and adult medical care and to the young adult needing to increasingly perform self-management skills that were previously managed by parents or other caregivers...
March 26, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38518418/autoimmune-encephalitis-in-israeli-children-a-retrospective-nationwide-study
#5
JOURNAL ARTICLE
Nimrod Sachs, Efrat Zohar-Dayan, Bruria Ben Zeev, Tal Gilboa, Mohammad Kurd, Itay Tokatly Latzer, Hadas Meirson, Irit Krause, Yotam Dizitzer, Esther Ganelin Cohen
Immune-mediated or autoimmune encephalitis (AE) is a relatively new, rare and elusive form of encephalitis in children. We retrospectively collected seropositive children (0-18 years old) with well characterized antibodies through 3 reference laboratories in Israel. Clinical symptoms, MRI and EEG findings and treatment courses were described. A total of 16 patients were included in the study, with 10 females. Anti NMDA encephalitis was most common followed by anti HU and anti mGLuR1. Psychiatric symptoms, abnormal movements, seizures and behavioral changes were the most common presentation...
March 15, 2024: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/38515059/the-assessment-of-microbial-infection-in-children-with-autism-spectrum-disorders-and-genetic-folate-cycle-deficiency
#6
JOURNAL ARTICLE
Dmitry Maltsev, Iryna Solonko, Olena Sydorenko
BACKGROUND: The results of disparate clinical studies indicate abnormally frequent cases of certain microorganisms in children with autism spectrum disorders (ASD). However, these data require clarification and systematization. The study aims to study the structure of the microbial profile in children with ASD and genetic folate cycle deficiency (GFCD) and consider differences in diagnostic approaches for identifying microorganisms of different types. METHODS: The study analyzed medical data from 240 children (187 boys and 63 girls) with GFCD aged 2 to 9 years...
March 21, 2024: BMC Pediatrics
https://read.qxmd.com/read/38513189/teaching-neuroimage-anti-nmda-receptor-encephalitis-presenting-with-cerebellitis-in-a-pediatric-patient
#7
JOURNAL ARTICLE
Molly Moehlman, Alexandra B Kornbluh
No abstract text is available yet for this article.
April 23, 2024: Neurology
https://read.qxmd.com/read/38498052/investigating-nonspecific-effects-of-the-live-attenuated-japanese-encephalitis-vaccine-on-lower-respiratory-tract-infections-in-children-aged-25-35-months-retrospective-cohort-study
#8
JOURNAL ARTICLE
Siyi Zhan, Hongbo Lin, Yingying Yang, Tao Chen, Sheng Mao, Chuanxi Fu
BACKGROUND: Live attenuated vaccines may be used to prevent nontargeted diseases such as lower respiratory tract infections (LRTIs) due to their nonspecific effects (NSEs). OBJECTIVE: We aimed to analyze the NSEs of the Japanese encephalitis vaccine on pediatric LRTIs in children aged 25 months to 35 months. METHODS: A retrospective cohort study was conducted by using a population-based electronic health record database in Zhejiang, China...
March 18, 2024: JMIR Public Health and Surveillance
https://read.qxmd.com/read/38494280/movement-disorders-associated-with-pediatric-encephalitis
#9
REVIEW
Russell C Dale, Shekeeb S Mohammad
New onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38494276/paraneoplastic-cerebellar-and-brainstem-disorders
#10
REVIEW
Justin R Abbatemarco, Christian A Vedeler, John E Greenlee
Paraneoplastic cerebellar and brainstem disorders are a heterogeneous group that requires prompt recognition and treatment to help prevent irreversible neurologic injury. Paraneoplastic cerebellar degeneration is best characterized by Yo antibodies in patients with breast or ovarian cancer. Tr (DNER) antibodies in patients with Hodgkin lymphoma can also present with a pure cerebellar syndrome and is one of the few paraneoplastic syndromes found with hematological malignancy. Opsoclonus-myoclonus-ataxia syndrome presents in both pediatric and adult patients with characteristic clinical findings...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38492030/clinical-course-and-peculiarities-of-parechovirus-and-enterovirus-central-nervous-system-infections-in-newborns-a-single-center-experience
#11
JOURNAL ARTICLE
Giacomo Brisca, Tommaso Bellini, Mattia Pasquinucci, Marcello Mariani, Marta Romanengo, Isabella Buffoni, Domenico Tortora, Alessandro Parodi, Elena Fueri, Alessio Mesini, Jessica Tibaldi, Emanuela Piccotti, Luca Antonio Ramenghi, Andrea Moscatelli
Parechovirus (HpEV) and Enterovirus (EV) infections in children mostly have a mild course but are particularly fearsome in newborns in whom they may cause aseptic meningitis, encephalitis, and myocarditis. Our study aimed to describe the clinical presentations and peculiarities of CNS infection by HpEV and EV in neonates. This is a single-center retrospective study at Istituto Gaslini, Genoa, Italy. Infants aged ≤ 30 days with a CSF RTq-PCR positive for EV or HpEV from January 1, 2022, to December 1, 2023, were enrolled...
March 16, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38489698/the-incidence-and-risk-factors-of-secondary-epilepsy-after-viral-encephalitis-in-children-a-10-year-single-center-retrospective-analysis
#12
JOURNAL ARTICLE
Yang Hu, Bo Huang, Mengsha Zhu, Suzhen Sun, Guiying Zhang
Secondary epilepsy is a common concomitant disease of viral encephalitis (VE) in children. However, the risk factors for secondary epilepsy after VE remain debated. The aim of this study was to perform a 10-year single-center retrospective analysis to investigate the incidence and risk factors of secondary epilepsy after VE in children. A total of 8691 patients suffered from VE in our hospital between December 2011 and February 2022 were included. The patients were divided into control group (Group C) and epilepsy group (Group E) according to whether they followed secondary epilepsy...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489033/mri-and-pathology-comparisons-in-rasmussen-s-encephalitis-a-multi-institutional-examination-of-hemispherotomy-outcomes-relative-to-imaging-and-histological-severity
#13
JOURNAL ARTICLE
Alexander Doherty, Kathleen Knudson, Christine Fuller, James L Leach, Anthony C Wang, Neena Marupudi, Rowland H Han, Stuart Tomko, Jeff Ojemann, Matthew D Smyth, Francesco Mangano, Jesse Skoch
PURPOSE: Rasmussen encephalitis (RE) is a very rare chronic neurological disorder of unilateral inflammation of the cerebral cortex. Hemispherotomy provides the best chance at achieving seizure freedom in RE patients, but with significant risks and variable long-term outcomes. The goal of this study is to utilize our multicenter pediatric cohort to characterize if differences in pathology and/or imaging characterization of RE may provide a window into post-operative seizure outcomes, which in turn could guide decision-making for parents and healthcare providers...
March 15, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38465024/endocrinopathies-in-a-pediatric-patient-post-anatomical-hemispherectomy-for-rasmussen-s-encephalitis-treatment-a-case-report
#14
Jaron C Sanchez, Markeeta T Belmar, Jason C Sanchez, Kenny Nguygen
Hemispherectomy is a neurosurgical procedure that is frequently performed in pediatric patients diagnosed with Rasmussen's encephalitis. Postoperative complications include immediate complications such as hydrocephalus and hemorrhage and behavioral complications such as language impairments and contralateral weakness. However, there are limited studies or case reports that address the potential endocrinopathies associated with this and other pediatric epileptic surgeries. This case report describes the endocrinopathies following an anatomical hemispherectomy procedure...
February 2024: Curēus
https://read.qxmd.com/read/38464900/practice-patterns-in-pediatric-infectious-encephalopathy-in-four-centers-in-africa
#15
JOURNAL ARTICLE
Tigist Bacha, Alexandra Obremskey, Jessica Buxton, Ericka L Fink, Amelie von Saint Andre-von Arnim, Madiha Raees
INTRODUCTION: Infectious encephalopathy (IE), including meningitis, infectious encephalitis, and cerebral abscess, remains prevalent and carries high mortality and morbidity in children, especially in low and middle income countries (LMIC). This study aims to describe the usual care and outcomes of pediatric IE in four LMIC hospitals in sub-Saharan Africa to support evidence-based care guideline development. METHODS: This is a secondary analysis of the Prevalence of Acute Critical Neurological disease in children: A Global Epidemiological Assessment-Developing Countries study, a 4-week, prospective, observational study in children (1 week to 17 years) with IE presenting to referral hospitals in Ethiopia, Kenya, Rwanda, and Ghana...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38462578/unusual-imaging-findings-associated-with-abdominal-pediatric-germ-cell-tumors
#16
JOURNAL ARTICLE
Marie-Helene Gagnon, Paul-Robert Derenoncourt, Sampanna Rayamahi, Susan Taylor, Ashishkumar K Parikh, Maria R Ponisio, Geetika Khanna
Germ cell tumors of childhood are tumors arising from germline cells in gonadal or extragonadal locations. Extragonadal germ cell tumors are characteristically located in the midline, arising intracranially or in the mediastinum, retroperitoneum, or pelvis. These tumors are generally easily diagnosed due to typical sites of origin, characteristic imaging findings, and laboratory markers. However, germ cell tumors can be associated with unusual clinical syndromes or imaging features that can perplex the radiologist...
March 11, 2024: Pediatric Radiology
https://read.qxmd.com/read/38461760/efficacy-and-safety-of-ketamine-for-pediatric-and-adolescent-super-refractory-status-epilepticus-and-the-effect-of-cerebral-inflammatory-conditions
#17
JOURNAL ARTICLE
Ichiro Kuki, Takeshi Inoue, Masataka Fukuoka, Megumi Nukui, Hideo Okuno, Kiyoko Amo, Yasunori Otsuka, Junichi Ishikawa, Hiroshi Rinka, Atushi Ujiro, Masao Togawa, Masashi Shiomi, Shin Okazaki
OBJECTIVE: To investigate the short-term benefits and adverse effects of ketamine in the treatment of pediatric and adolescent super-refractory status epilepticus (SRSE), with a focus on the inflammatory etiology. METHODS: This retrospective observational cohort study included a consecutive series of 18 pediatric to adolescent patients with SRSE admitted between 2008 and 2023 and treated with ketamine. Seizure frequency per hour before and after ketamine administration and response rate were calculated...
March 6, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38447115/mog-antibodies-restricted-to-csf-in-children-with-inflammatory-cns-disorders
#18
MULTICENTER STUDY
Gemma Olivé-Cirera, Arlette L Bruijstens, Elianet G Fonseca, Li-Wen Chen, Eva Caballero, Eugenia Martinez-Hernandez, Mar Guasp, Maria Sepúlveda, Laura Naranjo, Raquel Ruiz-García, Yolanda Blanco, Albert Saiz, Josep O Dalmau, Thaís Armangue
OBJECTIVES: To assess the clinical significance of myelin oligodendrocyte glycoprotein antibodies (MOG-abs) restricted to CSF in children with inflammatory CNS disorders. METHODS: Patients included 760 children (younger than 18 years) from 3 multicenter prospective cohort studies: (A) acquired demyelinating syndromes, including acute disseminated encephalomyelitis (ADEM); (B) non-ADEM encephalitis; and (C) noninflammatory neurologic disorders. For all cases, paired serum/CSF samples were systematically examined using brain immunohistochemistry and live cell-based assays...
April 9, 2024: Neurology
https://read.qxmd.com/read/38438553/less-common-phenotypes-of-myelin-oligodendrocyte-glycoprotein-antibody-related-diseases-in-children-deserve-more-attention
#19
JOURNAL ARTICLE
Xiao-Yu Wang, Yan Jiang, Peng Wu, Jian-Nan Ma, Ping Yuan, Xiu-Juan Li, Li Jiang
BACKGROUND: To facilitate the identification of less common clinical phenotypes of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in children. METHODS: We retrospectively reviewed medical records of 236 patients with MOGAD. The following phenotypes were considered to be typical for MOGAD: ADEM, ON, TM, and NMOSD. Less common onset clinical phenotypes were screened out; their clinical and magnetic resonance imaging (MRI), diagnosis, treatment, and prognosis were summarized and analyzed...
March 4, 2024: Pediatric Research
https://read.qxmd.com/read/38429545/neurological-manifestations-and-risk-factors-associated-with-poor-prognosis-in-hospitalized-children-with-omicron-variant-infection
#20
JOURNAL ARTICLE
Li Tang, Yuxin Guo, Chang Shu, Xiaokang Peng, Sikai Qiu, Ruina Li, Pan Liu, Huijing Wei, Shan Liao, Yali Du, Dandan Guo, Ning Gao, Qing-Lei Zeng, Xiaoguai Liu, Fanpu Ji
There are increasing reports of neurological manifestation in children with coronavirus disease 2019 (COVID-19). However, the frequency and clinical outcomes of in hospitalized children infected with the Omicron variant are unknown. The aim of this study was to describe the clinical characteristics, neurological manifestations, and risk factor associated with poor prognosis of hospitalized children suffering from COVID-19 due to the Omicron variant. Participants included children older than 28 days and younger than 18 years...
March 2, 2024: European Journal of Pediatrics
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