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Response evaluation

Y L Sun, T K Li, C S Li, S G Lü, L Wang, X H Lu
Objective: To evaluate the effects of penehyclidine hydrochloride on the nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) signaling pathway during endotoxin-induced acute lung injury(ALI) in neonate rats. Methods: Forty 7-day-old Wistar rats weighing 12-18 g were randomly divided into 4 groups ( n= 10) using a random number table: normal saline group(NS group), acute lung injury(ALI group), penehyclidine hydrochloride group(PHC group) and penehyclidine hydrochloride+ Nrf2 siRNA plasmid group(PNS group)...
February 12, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Johannes Westhofen, Marie-Therese Puth, Henrike Steudel, Eva Münster, Klaus Weckbecker
OBJECTIVE: For the first time, the level of knowledge and attitude towards vaccinations in general as well as seasonal influenza vaccination of midwife trainees in Germany was assessed. METHODS: The cross-sectional study was conducted between May and July 2017. The written standardized questionnaire was completed by all midwife-trainees in North Rhine-Westphalia. The statistical analysis included frequency tables and multiple logistic regression models. RESULTS: All of the 10 Schools for Midwifery in North Rhine-Westphalia participated in the survey and 315 questionnaires (response rate: 95...
February 20, 2019: Das Gesundheitswesen
Peter L Nesper, Hee Eun Lee, Alaa E Fayed, Gregory W Schwartz, Fei Yu, Amani A Fawzi
Purpose: To assess retinal microvascular reactivity during dark adaptation and the transition to ambient light and after flicker stimulation using optical coherence tomography angiography (OCTA). Methods: Fifteen eyes of 15 healthy participants were dark adapted for 45 minutes followed by OCTA imaging in the dark-adapted state. After 5 minutes of normal lighting, subjects underwent OCTA imaging. Participants were then subjected to a flashing light-emitting diode (LED) light and repeat OCTA...
February 1, 2019: Investigative Ophthalmology & Visual Science
Aditya Bardia, Ingrid A Mayer, Linda T Vahdat, Sara M Tolaney, Steven J Isakoff, Jennifer R Diamond, Joyce O'Shaughnessy, Rebecca L Moroose, Alessandro D Santin, Vandana G Abramson, Nikita C Shah, Hope S Rugo, David M Goldenberg, Ala M Sweidan, Robert Iannone, Sarah Washkowitz, Robert M Sharkey, William A Wegener, Kevin Kalinsky
BACKGROUND: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors...
February 21, 2019: New England Journal of Medicine
Sana Asif, Kenta Asawa, Yuuki Inoue, Kazuhiko Ishihara, Björn Lindell, Robin Holmgren, Bo Nilsson, Anneli Rydén, Marianne Jensen-Waern, Yuji Teramura, Kristina N Ekdahl
Artificial surfaces that come into contact with blood induce an immediate activation of the cascade systems of the blood, leading to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Heparin coating has been used to improve hemocompatibility, and another approach is 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings. Here, the aim is to evaluate the hemocompatibility of MPC polymer coating by studying the interactions with coagulation and complement systems using human blood in vitro model and pig in vivo model...
February 20, 2019: Macromolecular Bioscience
L Jay Roberts, Ryan Burnett, James Tietz, Sam Veloz
Birds respond rapidly to changes in both habitat and climate conditions and thus are good indicators of the ecological effects of a changing climate, which may include warmer temperatures, changing habitat conditions, and increased frequency and magnitude of extreme events like drought. We investigated how a widespread tree mortality event concurrent with a severe drought influenced the avian community of the Sierra Nevada mountain range in California. We assessed and compared the separate effects of climate stresses and altered habitat conditions on the avian community and used this information to evaluate the changes that are likely to occur in the near future...
February 20, 2019: Ecological Applications: a Publication of the Ecological Society of America
Martha M Moore, Lynn H Pottenger, Tamara House-Knight
Styrene is an important high production volume chemical used to manufacture polymeric products. In 2018, IARC classified styrene as probably carcinogenic to humans; NTP lists styrene as reasonably anticipated to be a human carcinogen. The genotoxicity literature for styrene and its primary metabolite, styrene 7,8-oxide (SO), begins in the 1970s. OECD recently updated most genotoxicity test guidelines (TGs), making substantial new recommendations for assay conduct and data evaluation for the standard mutagenicity/clastogenicity assays...
February 20, 2019: Environmental and Molecular Mutagenesis
Bertrand Barres, Antony Kelly, Fabrice Kwiatkowski, Marie Batisse-Lignier, Geneviève Fouilhoux, Bernadette Aubert, Frédéric Dutheil, Igor Tauveron, Florent Cachin, Salwan Maqdasy
INTRODUCTION: Despite its good prognosis, differentiated thyroid cancer (DTC) is characterized by a high risk of disease persistence and/or recurrence. Estimation of long-term remission (excellent response) thanks to specific parameters could help to personalize the schedule of active surveillance. OBJECTIVE: Evaluation of the value of stimulated thyroglobulin and thyroglobulin reduction index (TRI) to predict long-term remission in patients with DTC managed by thyroidectomy and radioactive iodine (RAI) remnant ablation...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
Qian Wang, Bing Sun, Xiangying Meng, Chao Liu, Yang Cong, Shikai Wu
The aim of this study was to assess local response to radiotherapy (RT) in a quantitative manner by evaluating the bone density of metastases. Spinal and pelvic bone metastases in 44 patients with breast cancer who were treated between May 2010 and December 2016 were retrospectively assessed. Bone density values of irradiated and unirradiated bone metastases before, 1-3 months after, 4-6 months after, and 7-9 months after RT were compared. At each time point, mean bone density ± standard deviation values were measured in Hounsfield units (HU) from computed tomography (CT) scans...
February 20, 2019: Journal of Radiation Research
Martial Caillaud, Jérôme Guillard, Damien Richard, Serge Milin, Damien Chassaing, Marc Paccalin, Guylène Page, Agnès Rioux Bilan
As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age...
2019: PloS One
Paul Gillard, Tsuyoshi Tamura, Haruo Kuroki, Yoshiyuki Morikawa, Leentje Moerman, Jose Parra, Yurina Kitamura, Kazuko Mihara, Arisa Okamasa
Rotavirus infections have been reported to account for 40-50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. In this open-label, randomized, controlled, multicenter study, we evaluated the immunogenicity and safety of the DPT-IPV vaccine (Squarekids) administered concomitantly or staggered with the liquid HRV (Rotarix) vaccine in healthy Japanese infants...
February 20, 2019: Human Vaccines & Immunotherapeutics
Märt Reinvee, Sander Aia, Mati Pääsuke
OBJECTIVE: The aim of this study was to evaluate the ergonomic benefits of an angle grinder with a rotatable main handle in a cutting task. BACKGROUND: Angle grinder manufacturers rarely address ergonomic features in their advertisements, and if they do, the benefits are expressed in a qualitative manner. Meanwhile, quantitative information about the effects of the device on the worker is required to make informed decisions during tool selection and cumulative trauma prevention...
February 20, 2019: Human Factors
Neal Ready, Matthew D Hellmann, Mark M Awad, Gregory A Otterson, Martin Gutierrez, Justin F Gainor, Hossein Borghaei, Jacques Jolivet, Leora Horn, Mihaela Mates, Julie Brahmer, Ian Rabinowitz, Pavan S Reddy, Jason Chesney, James Orcutt, David R Spigel, Martin Reck, Kenneth John O'Byrne, Luis Paz-Ares, Wenhua Hu, Kim Zerba, Xuemei Li, Brian Lestini, William J Geese, Joseph D Szustakowski, George Green, Han Chang, Suresh S Ramalingam
PURPOSE: CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety of nivolumab plus low-dose ipilimumab as first-line treatment of advanced/metastatic non-small-cell lung cancer (NSCLC). We assessed the association of efficacy with programmed death ligand 1 (PD-L1) expression and tumor mutational burden (TMB). PATIENTS AND METHODS: Two hundred eighty-eight patients with previously untreated, recurrent stage IIIB/IV NSCLC received nivolumab 3 mg/kg every 2 weeks plus ipilimumab 1 mg/kg every 6 weeks...
February 20, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Leandro Koifman, Daniel Hampl, Maria Isabel Silva, Paulo Gabriel Antunes Pessoa, Antonio Augusto Ornellas, Rodrigo Barros
PURPOSE: To study the effect of penile constriction devices used on a large series of patients who presented at our emergency facility. We explored treatment options to prevent a wide range of vascular and mechanical injuries occurring due to penile entrapment. MATERIALS AND METHODS: Between January 2001 and March 2016, 26 patients with penile entrapment were admitted to our facility and prospectively evaluated. RESULTS: The time that elapsed from penile constrictor application to hospital admission varied from 10 hours to 6 weeks (mean: 22...
February 10, 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Marco Racioppi, Luca Di Gianfrancesco, Mauro Ragonese, Giuseppe Palermo, Emilio Sacco, Pier Francesco Bassi
OBJECTIVES: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy. MATERIALS AND METHODS: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyzed. Patients were divided according to NLR value: 46 patients with NLR value less than 3 (NLR < 3 group), and 54 patients with NLR value more than 3 (NLR ≥ 3 group)...
November 3, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Hoon Choi
OBJECTIVE: To evaluate the treatment effect of genital warts, we investigated the quadrivalent HPV vaccine injection compared with surgical excision. MATERIALS AND METHODS: This prospective study included 26 patients (M:F = 24:2) who received HPV vaccine or surgical excision. After explanation of surgical excision or HPV vaccine, 16 patients underwent surgical excision and the others received HPV vaccine injections. Based on gross findings of genital warts, treatment outcomes were classified as complete response (no wart), partial response, and failed treatment...
February 10, 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
I C Molina-Botero, M D Montoya-Flores, L M Zavala-Escalante, R Barahona-Rosales, J Arango, J C Ku-Vera
In the last decades, strategies have been evaluated to reduce rumen methane (CH4) production by supplementing tropical forages rich in secondary compounds; however, most of these beneficial effects need to be validated in terms of their persistence over time. The aim of this study was to assess CH4 emissions over time in heifers fed with and without Gliricidia sepium foliage (G) mixed with ground pods of Enterolobium cyclocarpum(E). Two groups of four crossbred (Bos taurus x Bos indicus) heifers (284 ±17 kg initial weight) were fed with two diets (0 and 15% of a mixture of the pods and foliage [E+G:0 and E+G:15, respectively] over 80 days, plus two weeks before the experiment, in which every animal was fed a legume and pod-free diet...
February 19, 2019: Journal of Animal Science
Cláudio Franco do Amaral Kfouri, Welington Lombardi, Maria Clara Ferreira Nonato Romania, Matheus Lopes Puls, Rodrigo Amaral Martins-Ferreira, Luciana Borges Lombardi, Jurandyr Moreira de Andrade
OBJECTIVE: to analyze the expression of Vascular Endothelial Growth Factor (VEGF), its receptor (VEGFR-2), age and histological type of advanced cervical carcinomas with respect to the clinical response to neoadjuvant chemotherapy. METHODS: we studied 40 patients with cervical carcinoma (IB2 and IVA) diagnosed by biopsies prior to treatment. All patients underwent neoadjuvant chemotherapy and evaluation for clinical response and expression of VEGF. We considered a tumor regression greater than 50% as a good clinical response...
February 18, 2019: Revista do Colégio Brasileiro de Cirurgiões
Edilamar Silva de Alecrim, Ana Thereza Chaves, Luiz Alberto Bomjardim Pôrto, Maria Aparecida de Faria Grossi, Sandra Lyon, Manoel Otávio da Costa Rocha
The Mitsuda test is a skin test based on the individual's immune response through late and highly specific hypersensitivity reaction to the Mycobacterium leprae bacillus. A negative reaction identifies individuals who present a higher risk of becoming ill if exposed to M. leprae and, if they become ill, to develop the virchowian form of disease. The Mitsuda test reading is performed by means of a millimeter ruler. The dermatoscopy is a method that has not been used in the evaluation of cutaneous tests, although its use has increased in several areas...
February 14, 2019: Revista do Instituto de Medicina Tropical de São Paulo
Marcos J Migliorini, Marcel M Boiago, Lenilson F Roza, Mauricio Barreta, Alessandra Arno, Weber S Robazza, Alessandro C Galvão, Gabriela M Galli, Gustavo Machado, Matheus D Baldissera, Roger Wagner, Lenita C M Stefani, Aleksandro S DA Silva
This study evaluated the effect of oregano essential oil added to the feed of commercial laying hens. This research was focused on the analysis of biochemical changes linked to hepatic function, and protein and lipid metabolism. It was used 240 laying hens (59 weeks-old) distributed in a completely randomized design of six treatments (five repetitions with eight birds each). The experiments were constituted by a control treatment (CT) with the inclusion of zinc bacitracin and five treatments of oregano essential oil (OEO: 0, 50, 100, 150, and 200 mg...
February 14, 2019: Anais da Academia Brasileira de Ciências
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